CAB39L Gene
protein-coding GIFtS: 52
GCID: GC13M049882
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|
calcium binding protein 39-like
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Aliases
for CAB39L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium Binding Protein 39-Like1 2 | | FLJ125771 | | MO2L1 2 | | MO25-BETA2 | | BA103J18.31 | | Calcium-Binding Protein 39-Like2 | | Antigen MLAA-342 3 | | Sarcoma Antigen NY-SAR-792 | | Mo25-Like Protein2 3 | | U937-Associated Antigen2 | | MO25beta2 3 | | |
Export aliases for CAB39L gene to outside databasesPrevious GC identifers: GC13M047682 GC13M048781 GC13M030678 |
Summaries
for CAB39L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CB39L_HUMAN, Q9H9S4Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize theinteraction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)
Gene Wiki entry for CAB39L
|
Genomic Views
for CAB39L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAB39L gene promoter:
FOXD1 E4BP4 HNF-1A C/EBPalpha MEF-2A POU2F1 POU2F1b HNF-1 POU2F1a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAB39L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAB39L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.2 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.11CAB39L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M049882: view genomic region
(about GC identifiers)
Start:
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49,882,786 bp from pter |
End:
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50,018,262 bp from pter |
Size:
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135,477 bases |
Orientation:
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minus strand |
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Proteins
for CAB39L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CB39L_HUMAN, Q9H9S4 (See
protein sequence)Recommended Name: Calcium-binding protein 39-like Size: 337 amino acids; 39088 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalyticactivity (By similarity)
Miscellaneous: Found in serum of 50% of patients with acute monocytic leukemia
Sequence caution: Sequence=BAB14147.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for CAB39L:3ZHP (3D)
Secondary accessions: Q5TAW6 Q6WG71 Q96FG1 Q9BZ33Explore the universe of human proteins at neXtProt for CAB39L: NX_Q9H9S4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9S4
CAB39L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001073138.1 NP_112187.2
ENSEMBL proteins: ENSP00000348113 ENSP00000386375 ENSP00000387245 ENSP00000416719 ENSP00000386328 ENSP00000409253 ENSP00000404028 ENSP00000386979 ENSP00000261669 Reactome Protein details: Q9H9S4
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
CAB39L for ontologies About GeneDecksing
CAB39L Antibody Products:
Assay Products for CAB39L: |
Protein
Domains /
Families
for CAB39L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAB39L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9S4ProtoNet protein and cluster: Q9H9S4 1 Blocks protein family: IPB013878 Mo25-like
UniProtKB/Swiss-Prot: CB39L_HUMAN, Q9H9S4Similarity: Belongs to the Mo25 family |
Function
for CAB39L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CB39L_HUMAN, Q9H9S4Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize theinteraction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39L (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CAB39L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39L |
1 GenomeRNAi human phenotype for CAB39L:
|
Pathways & Interactions
for CAB39L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | Energy dependent regulation of mTOR by LKB1-AMPK | | | 3 | mTOR signalling | | | 4 | Signaling by GPCR | | | 5 | Development_CNTF receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/13 
Reactome Pathways for CAB39L (see all 13)
1 
Kegg Pathway (Kegg details for CAB39L):
CAB39L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAB39L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/16 Interacting proteins for CAB39L (Q9H9S43 ENSP000002616694) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007050 | cell cycle arrest |
TAS | -- | | GO:0008286 | insulin receptor signaling pathway |
TAS | -- | | GO:0046320 | regulation of fatty acid oxidation |
TAS | -- |
CAB39L for ontologies About GeneDecksing
|
Drugs & Compounds
for CAB39L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CAB39L
Search CenterWatch for drugs/clinical trials and news about CAB39L / CB39L
|
Transcripts
for CAB39L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAB39L gene (2 alternative transcripts): NM_001079670.1 NM_030925.2 Unigene Cluster for CAB39L: Calcium binding protein 39-like Hs.87159 [show with all ESTs]Unigene Representative Sequence: NM_03092511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355854(uc001vcw.3) ENST00000409308 ENST00000409130 ENST00000425242
ENST00000410043 ENST00000457041 ENST00000413278 ENST00000409082 ENST00000476943
ENST00000470410 ENST00000347776(uc001vcx.3 uc010adf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39L (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CAB39L (NM_030925) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAB39L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39L |
Additional cDNA sequence: AK022639.1 AK309011.1 AY211923.1 BC010993.2 BX647518.1 6 DOTS entries: DT.99941016 DT.211963 DT.100752247 DT.100727438 DT.120771102 DT.95356687 24/121 AceView cDNA sequences (see all 121): BX647518 AW074239 NM_030925 BQ021348 AK022639 AI917304 BX108507 AW264209 BQ880200 AW593476 AA233483 AW264306 AA234362 BM820071 AA279145 AW445109 BQ576107 AI536545 BM831835 AA018841 AA781806 AW008806 C17262 AI095742
GeneLoc Exon Structure
|
Expression
for CAB39L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAB39L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CAB39L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAB39L
SOURCE GeneReport for Unigene cluster: Hs.87159
SABiosciences Expression via Pathway-Focused PCR Array including CAB39L:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAB39L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAB39L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAB39L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39L |
Orthologs
for CAB39L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CAB39L gene from 8/27 species (see all 27) About this table
ENSEMBL Gene Tree for CAB39L (if available)
TreeFam Gene Tree for CAB39L (if available) |
Paralogs
for CAB39L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CAB39L gene
- CAB392
2 SIMAP similar genes for CAB39L using alignment to 6 protein entries: CB39L_HUMAN (see all proteins):CAB39 MO25
CAB39L for paralogs About GeneDecksing
|
Genomic Variants
for CAB39L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAB39L (49882786 - 50018262 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CAB39L
4 CNVs: 22996 5709 43881 101736
2 Indels: 42142 45179 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAB39L |
|
Disorders
/ Diseases
for CAB39L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAB39L for disorders About GeneDecksing
OMIM gene information: 612175
OMIM disorders: --
5  diseases for CAB39L: About MalaCardspeutz-jeghers syndrome sarcoma monocytic leukemia acute monocytic leukemia
leukemia
Human Genome Epidemiology (HuGE) Navigator: CAB39L (1 document)
Export disorders for CAB39L gene to outside databases
|
Publications
for CAB39L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAB39L gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CAB39L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (PubMed id 18592235)1, 9 Zhang P.Y....Li W.B. (2009)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Quantitative assessment of MLAA-34 expression in diag nosis and prognosis of acute monocytic leukemia. (PubMed id 21240483)1 Zhao J....Gu L. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for CAB39L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAB39L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAB39L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAB39L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAB39L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CAB39L gene:
Search GeneIP for patents involving CAB39L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAB39L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CAB39L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAB39L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAB39L | | | OriGene Protein Over-expression Lysate for CAB39L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAB39L | | OriGene 3'-UTR Clone for CAB39L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CAB39L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAB39L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAB39L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAB39L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAB39L |
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 | | | CAB39L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39L |
|  |  |  | | | | Search ThermoFisher Antibodies for CAB39L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39L |
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