Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAB39L Gene

Aliases for CAB39L Gene

  • Calcium Binding Protein 39-Like 2 3
  • Mo25-Like Protein 3 4
  • Antigen MLAA-34 3 4
  • MO25beta 3 4
  • Calcium-Binding Protein 39-Like 3
  • Sarcoma Antigen NY-SAR-79 3
  • U937-Associated Antigen 3
  • BA103J18.3 3
  • MO25-BETA 3
  • MO2L 3

External Ids for CAB39L Gene

Previous GeneCards Identifiers for CAB39L Gene

  • GC13M047682
  • GC13M048781
  • GC13M049882
  • GC13M030678

Summaries for CAB39L Gene

GeneCards Summary for CAB39L Gene

CAB39L (Calcium Binding Protein 39-Like) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. An important paralog of this gene is CAB39.

UniProtKB/Swiss-Prot for CAB39L Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).

Gene Wiki entry for CAB39L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAB39L Gene

Genomics for CAB39L Gene

Regulatory Elements for CAB39L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAB39L Gene

Start:
49,308,650 bp from pter
End:
49,444,126 bp from pter
Size:
135,477 bases
Orientation:
Minus strand

Genomic View for CAB39L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAB39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39L Gene

Proteins for CAB39L Gene

  • Protein details for CAB39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9S4-CB39L_HUMAN
    Recommended name:
    Calcium-binding protein 39-like
    Protein Accession:
    Q9H9S4
    Secondary Accessions:
    • Q5TAW6
    • Q6WG71
    • Q96FG1
    • Q9BZ33

    Protein attributes for CAB39L Gene

    Size:
    337 amino acids
    Molecular mass:
    39088 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.
    Miscellaneous:
    • Found in serum of 50% of patients with acute monocytic leukemia
    SequenceCaution:
    • Sequence=BAB14147.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAB39L Gene

neXtProt entry for CAB39L Gene

Proteomics data for CAB39L Gene at MOPED

Post-translational modifications for CAB39L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAB39L Gene

Domains for CAB39L Gene

Protein Domains for CAB39L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CAB39L Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9S4

UniProtKB/Swiss-Prot:

CB39L_HUMAN :
  • Q9H9S4
Family:
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39L: view

No data available for Gene Families for CAB39L Gene

Function for CAB39L Gene

Molecular function for CAB39L Gene

UniProtKB/Swiss-Prot Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).

Gene Ontology (GO) - Molecular Function for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CAB39L: view

Phenotypes for CAB39L Gene

GenomeRNAi human phenotypes for CAB39L:
genes like me logo Genes that share phenotypes with CAB39L: view

Animal Model Products

CRISPR Products

miRNA for CAB39L Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAB39L Gene

Localization for CAB39L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAB39L Gene COMPARTMENTS Subcellular localization image for CAB39L gene
Compartment Confidence
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CAB39L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAB39L Gene

Pathways for CAB39L Gene

genes like me logo Genes that share pathways with CAB39L: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS --
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CAB39L: view

Transcripts for CAB39L Gene

Unigene Clusters for CAB39L Gene

Calcium binding protein 39-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAB39L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39L Gene

No ASD Table

Relevant External Links for CAB39L Gene

GeneLoc Exon Structure for
CAB39L
ECgene alternative splicing isoforms for
CAB39L

Expression for CAB39L Gene

mRNA expression in normal human tissues for CAB39L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAB39L Gene

SOURCE GeneReport for Unigene cluster for CAB39L Gene Hs.87159

genes like me logo Genes that share expressions with CAB39L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAB39L Gene

Orthologs for CAB39L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAB39L 35
  • 99.8 (n)
  • 100 (a)
CAB39L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAB39L 35
  • 91.02 (n)
  • 95.81 (a)
CAB39L 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAB39L 35
  • 90.6 (n)
  • 95.55 (a)
CAB39L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cab39l 35
  • 90.5 (n)
  • 98.52 (a)
Cab39l 16
Cab39l 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAB39L 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAB39L 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cab39l 35
  • 89.91 (n)
  • 97.03 (a)
chicken
(Gallus gallus)
Aves CAB39L 35
  • 83.99 (n)
  • 94.26 (a)
CAB39L 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68674 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cab39l 35
  • 78.44 (n)
  • 87.83 (a)
Str.15219 35
zebrafish
(Danio rerio)
Actinopterygii cab39l 35
  • 74.47 (n)
  • 81.68 (a)
cab39l 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mo25 36
  • 64 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mop-25.1 36
  • 33 (a)
ManyToMany
mop-25.2 36
  • 56 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18940 35
  • 52.54 (n)
  • 43.61 (a)
corn
(Zea mays)
Liliopsida Zm.3116 35
rice
(Oryza sativa)
Liliopsida Os03g0359700 35
  • 51.04 (n)
  • 41.25 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pmo25 35
  • 54.26 (n)
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3108 36
  • 63 (a)
OneToMany
Species with no ortholog for CAB39L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAB39L Gene

ENSEMBL:
Gene Tree for CAB39L (if available)
TreeFam:
Gene Tree for CAB39L (if available)

Paralogs for CAB39L Gene

Paralogs for CAB39L Gene

Selected SIMAP similar genes for CAB39L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CAB39L: view

Variants for CAB39L Gene

Sequence variations from dbSNP and Humsavar for CAB39L Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs730924 -- 49,376,236(+) AAATT(C/T)GTATT intron-variant
rs912547 -- 49,311,080(+) CCCAC(A/G)CTACT intron-variant
rs1198499 -- 49,341,314(+) tgtga(C/T)gtgat intron-variant
rs1198500 -- 49,341,498(+) caccc(A/G)cctcT intron-variant
rs1198501 -- 49,341,572(+) gttat(C/T)agagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAB39L Gene

Variant ID Type Subtype PubMed ID
nsv832607 CNV Loss 17160897
nsv900069 CNV Gain 21882294
esv2747391 CNV Deletion 23290073
esv1939259 CNV Deletion 18987734
esv4504 CNV Deletion 18987735
esv2747392 CNV Deletion 23290073
nsv1037 CNV Loss 18451855
esv997002 CNV Deletion 20482838
nsv435647 CNV Deletion 17901297
esv2539030 CNV Deletion 19546169
esv2273400 CNV Deletion 18987734
nsv512316 CNV Loss 21212237
esv2747393 CNV Deletion 23290073
esv2675887 CNV Deletion 23128226
esv989296 CNV Deletion 20482838
nsv64662 CNV Loss 16902084
esv268291 CNV Insertion 20981092
esv272188 CNV Insertion 20981092
nsv523648 CNV Gain 19592680
nsv900070 CNV Loss 21882294

Relevant External Links for CAB39L Gene

HapMap Linkage Disequilibrium report
CAB39L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAB39L Gene

Disorders for CAB39L Gene

Relevant External Links for CAB39L

Genetic Association Database (GAD)
CAB39L
Human Genome Epidemiology (HuGE) Navigator
CAB39L
genes like me logo Genes that share disorders with CAB39L: view

No data available for UniProtKB/Swiss-Prot for CAB39L Gene

Publications for CAB39L Gene

  1. Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (PMID: 18592235) Zhang P.Y. … Li W.B. (Cancer Immunol. Immunother. 2009) 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CAB39L Gene

Sources for CAB39L Gene

Back to Top

Content