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Aliases for CAB39L Gene

Aliases for CAB39L Gene

  • Calcium Binding Protein 39 Like 2 3 5
  • Calcium Binding Protein 39-Like 2 3
  • Mo25-Like Protein 3 4
  • Antigen MLAA-34 3 4
  • MO25beta 3 4
  • Sarcoma Antigen NY-SAR-79 3
  • U937-Associated Antigen 3
  • BA103J18.3 3
  • MO25-BETA 3
  • MO2L 3

External Ids for CAB39L Gene

Previous GeneCards Identifiers for CAB39L Gene

  • GC13M047682
  • GC13M048781
  • GC13M049882
  • GC13M030678

Summaries for CAB39L Gene

GeneCards Summary for CAB39L Gene

CAB39L (Calcium Binding Protein 39 Like) is a Protein Coding gene. Diseases associated with CAB39L include Acute Monocytic Leukemia. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and AMPK signaling pathway. GO annotations related to this gene include binding. An important paralog of this gene is CAB39.

UniProtKB/Swiss-Prot for CAB39L Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).

Gene Wiki entry for CAB39L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAB39L Gene

Genomics for CAB39L Gene

Regulatory Elements for CAB39L Gene

Enhancers for CAB39L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAB39L on UCSC Golden Path with GeneCards custom track

Promoters for CAB39L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAB39L on UCSC Golden Path with GeneCards custom track

Genomic Location for CAB39L Gene

49,308,647 bp from pter
49,444,134 bp from pter
135,488 bases
Minus strand

Genomic View for CAB39L Gene

Genes around CAB39L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAB39L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAB39L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39L Gene

Proteins for CAB39L Gene

  • Protein details for CAB39L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium-binding protein 39-like
    Protein Accession:
    Secondary Accessions:
    • Q5TAW6
    • Q6WG71
    • Q96FG1
    • Q9BZ33

    Protein attributes for CAB39L Gene

    337 amino acids
    Molecular mass:
    39088 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.
    • Found in serum of 50% of patients with acute monocytic leukemia.
    • Sequence=BAB14147.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAB39L Gene

neXtProt entry for CAB39L Gene

Proteomics data for CAB39L Gene at MOPED

Post-translational modifications for CAB39L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAB39L Gene

Domains & Families for CAB39L Gene

Protein Domains for CAB39L Gene


Suggested Antigen Peptide Sequences for CAB39L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Mo25 family.
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39L: view

No data available for Gene Families for CAB39L Gene

Function for CAB39L Gene

Molecular function for CAB39L Gene

UniProtKB/Swiss-Prot Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).
genes like me logo Genes that share phenotypes with CAB39L: view

Animal Models for CAB39L Gene

MGI Knock Outs for CAB39L:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAB39L Gene

Localization for CAB39L Gene

Subcellular locations from

Jensen Localization Image for CAB39L Gene COMPARTMENTS Subcellular localization image for CAB39L gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAB39L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CAB39L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CAB39L Gene

Pathways & Interactions for CAB39L Gene

genes like me logo Genes that share pathways with CAB39L: view

Gene Ontology (GO) - Biological Process for CAB39L Gene


No data available for SIGNOR curated interactions for CAB39L Gene

Drugs & Compounds for CAB39L Gene

No Compound Related Data Available

Transcripts for CAB39L Gene

Unigene Clusters for CAB39L Gene

Calcium binding protein 39-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39L Gene

No ASD Table

Relevant External Links for CAB39L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAB39L Gene

mRNA expression in normal human tissues for CAB39L Gene

Protein differential expression in normal tissues from HIPED for CAB39L Gene

This gene is overexpressed in Cardia (17.3) and Colon muscle (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAB39L Gene

SOURCE GeneReport for Unigene cluster for CAB39L Gene Hs.87159

genes like me logo Genes that share expression patterns with CAB39L: view

Protein tissue co-expression partners for CAB39L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAB39L Gene

Orthologs for CAB39L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAB39L 35
  • 91.02 (n)
  • 95.81 (a)
CAB39L 36
  • 96 (a)
(Canis familiaris)
Mammalia CAB39L 35
  • 90.6 (n)
  • 95.55 (a)
CAB39L 36
  • 96 (a)
(Mus musculus)
Mammalia Cab39l 35
  • 90.5 (n)
  • 98.52 (a)
Cab39l 16
Cab39l 36
  • 99 (a)
(Pan troglodytes)
Mammalia CAB39L 35
  • 99.8 (n)
  • 100 (a)
CAB39L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cab39l 35
  • 89.91 (n)
  • 97.03 (a)
(Monodelphis domestica)
Mammalia CAB39L 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia CAB39L 36
  • 63 (a)
(Gallus gallus)
Aves CAB39L 35
  • 83.99 (n)
  • 94.26 (a)
CAB39L 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cab39l 35
  • 78.44 (n)
  • 87.83 (a)
Str.15219 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68674 35
(Danio rerio)
Actinopterygii cab39l 35
  • 74.47 (n)
  • 81.68 (a)
cab39l 36
  • 81 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mo25 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea mop-25.1 36
  • 33 (a)
mop-25.2 36
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 36
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G18940 35
  • 52.54 (n)
  • 43.61 (a)
(Oryza sativa)
Liliopsida Os03g0359700 35
  • 51.04 (n)
  • 41.25 (a)
(Zea mays)
Liliopsida Zm.3116 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pmo25 35
  • 54.26 (n)
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3108 36
  • 63 (a)
Species with no ortholog for CAB39L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAB39L Gene

Gene Tree for CAB39L (if available)
Gene Tree for CAB39L (if available)

Paralogs for CAB39L Gene

Paralogs for CAB39L Gene

(2) SIMAP similar genes for CAB39L Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CAB39L: view

Variants for CAB39L Gene

Sequence variations from dbSNP and Humsavar for CAB39L Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs912547 -- 49,311,080(+) CCCAC(A/G)CTACT intron-variant
rs730924 -- 49,376,236(+) AAATT(C/T)GTATT intron-variant
rs1322787 -- 49,436,063(+) AGTCA(C/T)AGTta intron-variant
rs1322789 -- 49,394,749(+) GCTTA(A/G)GTGTG intron-variant
rs1322790 -- 49,416,086(+) CCTAA(A/C/T)AAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAB39L Gene

Variant ID Type Subtype PubMed ID
nsv832607 CNV Loss 17160897
nsv900069 CNV Gain 21882294
esv2747391 CNV Deletion 23290073
esv1939259 CNV Deletion 18987734
esv4504 CNV Deletion 18987735
esv2747392 CNV Deletion 23290073
nsv1037 CNV Loss 18451855
esv997002 CNV Deletion 20482838
nsv435647 CNV Deletion 17901297
esv2539030 CNV Deletion 19546169
esv2273400 CNV Deletion 18987734
nsv512316 CNV Loss 21212237
esv2747393 CNV Deletion 23290073
esv2675887 CNV Deletion 23128226
esv989296 CNV Deletion 20482838
nsv64662 CNV Loss 16902084
esv268291 CNV Insertion 20981092
esv272188 CNV Insertion 20981092
nsv523648 CNV Gain 19592680
nsv900070 CNV Loss 21882294

Variation tolerance for CAB39L Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CAB39L Gene

Disorders for CAB39L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAB39L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute monocytic leukemia
  • acute monoblastic leukemia and acute monocytic leukemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAB39L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAB39L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAB39L Gene

Publications for CAB39L Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (PMID: 18592235) Zhang P.Y. … Li W.B. (Cancer Immunol. Immunother. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CAB39L Gene

Sources for CAB39L Gene