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CAB39L Gene

protein-coding   GIFtS: 54
GCID: GC13M049882

Calcium Binding Protein 39-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Binding Protein 39-Like1 2     MO2L2
Antigen MLAA-342 3     bA103J18.32
Mo25-Like Protein2 3     Calcium-Binding Protein 39-Like2
MO25beta2 3     Sarcoma Antigen NY-SAR-792
MO25-BETA2     U937-Associated Antigen2

External Ids:    HGNC: 202901   Entrez Gene: 816172   Ensembl: ENSG000001025477   OMIM: 6121755   UniProtKB: Q9H9S43   

Export aliases for CAB39L gene to outside databases

Previous GC identifers: GC13M047682 GC13M048781 GC13M030678


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAB39L Gene:
CAB39L (calcium binding protein 39-like) is a protein-coding gene. Diseases associated with CAB39L include acute monocytic leukemia, and monocytic leukemia. An important paralog of this gene is CAB39.

UniProtKB/Swiss-Prot: CB39L_HUMAN, Q9H9S4
Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)

Gene Wiki entry for CAB39L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAB39L gene promoter:
         FOXD1   E4BP4   HNF-1A   C/EBPalpha   MEF-2A   POU2F1   POU2F1b   HNF-1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAB39L promoter sequence
   Search Chromatin IP Primers for CAB39L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAB39L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.11

CAB39L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAB39L gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M049882:  view genomic region     (about GC identifiers)

Start:
49,882,786 bp from pter      End:
50,018,262 bp from pter
Size:
135,477 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CB39L_HUMAN, Q9H9S4 (See protein sequence)
Recommended Name: Calcium-binding protein 39-like  
Size: 337 amino acids; 39088 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
catalytic activity (By similarity)
Miscellaneous: Found in serum of 50% of patients with acute monocytic leukemia
Sequence caution: Sequence=BAB14147.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CAB39L:
3ZHP (3D)    
Secondary accessions: Q5TAW6 Q6WG71 Q96FG1 Q9BZ33

Explore the universe of human proteins at neXtProt for CAB39L: NX_Q9H9S4

Explore proteomics data for CAB39L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAB39L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001073138.1  NP_001274266.1  NP_001274267.1  NP_001274268.1  NP_112187.2  

    ENSEMBL proteins: 
     ENSP00000348113   ENSP00000386375   ENSP00000387245   ENSP00000416719   ENSP00000386328  
     ENSP00000409253   ENSP00000404028   ENSP00000386979   ENSP00000261669  
    Reactome Protein details: Q9H9S4

    CAB39L Human Recombinant Protein Products:

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    OriGene MassSpec for CAB39L
    OriGene Custom Protein Services for CAB39L
    GenScript Custom Purified and Recombinant Proteins Services for CAB39L
    Novus Biologicals CAB39L Proteins
    Novus Biologicals CAB39L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CAB39L
    Cloud-Clone Corp. Proteins for CAB39L

    CAB39L Antibody Products:

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    Abcam antibodies for CAB39L
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    LSBio Antibodies in human, mouse, rat for CAB39L

    CAB39L Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAB39L
    Cloud-Clone Corp. CLIAs for CAB39L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013878 Mo25
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H9S4

    ProtoNet protein and cluster: Q9H9S4

    1 Blocks protein domain: IPB013878 Mo25-like

    UniProtKB/Swiss-Prot: CB39L_HUMAN, Q9H9S4
    Similarity: Belongs to the Mo25 family


    CAB39L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CB39L_HUMAN, Q9H9S4
    Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
    interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    CAB39L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CAB39L:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAB39L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAB39L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAB39L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAB39L

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAB39L:
    hsa-mir-10a-5p (MIRT047664), hsa-mir-26b-5p (MIRT028849), hsa-mir-155-5p (MIRT020525), hsa-mir-192-5p (MIRT026134)

    Block miRNA regulation of human, mouse, rat CAB39L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAB39L (see all 10):
    hsa-miR-3140-3p hsa-miR-425 hsa-miR-218 hsa-miR-656 hsa-miR-582-5p hsa-miR-19b hsa-miR-2276 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidCAB39L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAB39L
    Predesigned siRNA for gene silencing in human, mouse, rat CAB39L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAB39L

    Clone
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    OriGene clones in human, mouse for CAB39L (see all 15)
    OriGene ORF clones in mouse, rat for CAB39L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CAB39L (NM_030925)
    Sino Biological Human cDNA Clone for CAB39L
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAB39L
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAB39L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    CAB39L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAB39L About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.87
    IRS-related events0.94
    Signaling by Insulin receptor0.80
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    2Signaling by GPCR
    Signal Transduction0.58
    3Translation Insulin regulation of translation
    mTOR signaling pathway0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CAB39L
        Regulation of AMPK activity via LKB1


    1 Kegg Pathway  (Kegg details for CAB39L):
        mTOR signaling pathway


    CAB39L for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CAB39L: 
              mTOR Signaling in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CAB39L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAB39L (Q9H9S43 ENSP000002616694) via UniProtKB, MINT, STRING, and/or I2D (see all 178)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158313, ENSP000003248564I2D: score=3 STRING: ENSP00000324856
    BCKDKO148743, ENSP000002197944I2D: score=2 STRING: ENSP00000219794
    MLH1P406923I2D: score=1 
    CAB39ENSP000002584184STRING: ENSP00000258418
    PPM1AENSP000003272554STRING: ENSP00000327255
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest TAS--
    GO:0008286insulin receptor signaling pathway TAS--

    CAB39L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAB39L (CB39L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAB39L gene (5 alternative transcripts): 
    NM_001079670.2  NM_001287337.1  NM_001287338.1  NM_001287339.1  NM_030925.3  

    Unigene Cluster for CAB39L:

    Calcium binding protein 39-like
    Hs.87159  [show with all ESTs]
    Unigene Representative Sequence: NM_030925
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355854(uc001vcw.3) ENST00000409308 ENST00000409130 ENST00000425242
    ENST00000410043 ENST00000457041 ENST00000413278 ENST00000409082 ENST00000476943
    ENST00000470410 ENST00000347776(uc001vcx.3 uc010adf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAB39L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAB39L (see all 10):
    hsa-miR-3140-3p hsa-miR-425 hsa-miR-218 hsa-miR-656 hsa-miR-582-5p hsa-miR-19b hsa-miR-2276 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidCAB39L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAB39L
    Clone
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    OriGene ORF clones in mouse, rat for CAB39L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CAB39L (NM_030925)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39L
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAB39L
    OriGene qSTAR qPCR primer pairs in human, mouse for CAB39L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAB39L
      QuantiTect SYBR Green Assays in human, mouse, rat CAB39L
      QuantiFast Probe-based Assays in human, mouse, rat CAB39L

    Additional mRNA sequence: 

    AK022639.1 AK309011.1 AY211923.1 BC010993.2 BX647518.1 

    6 DOTS entries:

    DT.99941016  DT.211963  DT.100752247  DT.100727438  DT.120771102  DT.95356687 

    Selected AceView cDNA sequences (see all 121):

    AI917304 AA279145 AA233483 AA234362 BQ021348 AA781806 BX108507 BX647518 
    AW264306 AW264209 BM831835 AW593476 NM_030925 AK022639 BM820071 AW445109 
    BQ880200 BQ576107 AW074239 AI536545 AA018841 BP375998 BM976125 BI913082 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAB39L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CAB39L Expression
    About this image

    CAB39L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAB39L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.87159
        Pathway & Disease-focused RT2 Profiler PCR Array including CAB39L: 
              mTOR Signaling in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CAB39L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAB39L gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cab39l1 , 5 calcium binding protein 39-like1, 5 90.5(n)1
    98.52(a)1
      14 (31.48 cM)5
    690081  NM_026908.31  NP_081184.31 
     594409815 
    chicken
    (Gallus gallus)
    Aves CAB39L1 calcium binding protein 39-like 83.99(n)
    94.26(a)
      418865  NM_001006272.2  NP_001006272.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686742 hypothetical protein MGC68674 80.08(n)    BC060384.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cab39l1 calcium binding protein 39-like 74.47(n)
    81.68(a)
      492361  NM_001007327.1  NP_001007328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mo256
    Mo25
    64(a)
    1 → many
    3L(16606318-16608572)
    worm
    (Caenorhabditis elegans)
    Secernentea mop-25.26
    mop-25.16
    Protein MOP-25.1, isoform a
    56(a)
    33(a)
    many ↔ many
    many ↔ many
    II(9701412-9703732) WBGene00013140
    X(4012230-4022181) WBGene00019827
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HYM16
    Component of the RAM signaling network that is inv...
    28(a)
    1 → many
    XI(84704-85903) YKL189W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G189401 AT5G18940 52.54(n)
    43.61(a)
      832012  NM_121899.3  NP_568368.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03597001 Os03g0359700 51.04(n)
    41.25(a)
      4332884  NM_001056687.1  NP_001050152.1 


    ENSEMBL Gene Tree for CAB39L (if available)
    TreeFam Gene Tree for CAB39L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAB39L gene
    CAB392  
    2 SIMAP similar genes for CAB39L using alignment to 6 protein entries:     CB39L_HUMAN (see all proteins):
    CAB39    MO25

    CAB39L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAB39L (see all 2590)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs583373361,2
    C--30959364(+) TTGTA-/CAGAGTT 1 -- int11Minor allele frequency- CA:0.00NA 2
    rs1460769071,2
    --49882390(+) GGTCCA/GCCTAT 2 -- ds5001 int10--------
    rs752246401,2
    F--49882413(+) CTGGGA/TCATTT 2 -- ds5001 int11Minor allele frequency- T:0.02WA 118
    rs65615161,2
    C,F,H--49882529(+) TCCCTG/ACTGGC 2 -- ds5001 int125Minor allele frequency- A:0.02NA NS EA WA CSA 1938
    rs1390574321,2
    C--49882571(+) TCCCAG/TGCAGC 2 -- ds5001 int10--------
    rs1886268431,2
    --49882655(+) TGCAGG/TGTCAC 2 -- ds5001 int10--------
    rs1404334531,2
    C--49882675(+) GGGCAC/TACAGG 2 -- ds5001 int10--------
    rs2020411401,2
    C--49882741(-) TGTTTG/TTTCTT 2 -- ds5001 int10--------
    rs1167983581,2
    C,F--49882826(+) AATGTG/ATGCTT 2 -- ut311Minor allele frequency- A:0.03WA 118
    rs1932601751,2
    --49882905(+) CAAATA/CCCCCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CAB39L (49882786 - 50018262 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CAB39L (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747391CNV Deletion23290073
    esv2273400CNV Deletion18987734
    esv997002CNV Deletion20482838
    esv989296CNV Deletion20482838
    esv2539030CNV Deletion19546169
    esv2747392CNV Deletion23290073
    esv1939259CNV Deletion18987734
    nsv435647CNV Deletion17901297
    esv2747393CNV Deletion23290073
    esv4504CNV Deletion18987735

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612175    OMIM disorders: --

    6 diseases for CAB39L:    
    About MalaCards
    acute monocytic leukemia    monocytic leukemia    peutz-jeghers syndrome    lynch syndrome
    sarcoma    leukemia


    CAB39L for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAB39L
    Human Genome Epidemiology (HuGE) Navigator: CAB39L (1 document)

    Export disorders for CAB39L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAB39L gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CAB39L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Identification and functional characterization of the novel acute monocytic leukemia associated antigen MLAA-34. (PubMed id 18592235)1, 9 Zhang P.Y....Li W.B. (Cancer Immunol. Immunother. 2009)
    6. The expression and functional characterization associated with cell apoptosis and proteomic analysis of the novel gene MLAA-34 in U937 cells. (PubMed id 23135622)1 Zhang W.J....Gu L.F. (Oncol. Rep. 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Quantitative assessment of MLAA-34 expression in diagnosis and prognosis of acute monocytic leukemia. (PubMed id 21240483)1 Zhao J....Gu L. (Cancer Immunol. Immunother. 2011)
    9. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. (PubMed id 20706999)1 Brieger A....Trojan J. (Proteomics 2010)
    10. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81617 HGNC: 20290 AceView: CAB39L Ensembl:ENSG00000102547 euGenes: HUgn81617
    ECgene: CAB39L Kegg: 81617 H-InvDB: CAB39L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAB39L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAB39L gene:
    Search GeneIP for patents involving CAB39L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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