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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAB39 Gene

protein-coding   GIFtS: 59
GCID: GC02P231577

calcium binding protein 39
 Explore 2 diseases affiliated with
CAB39 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAB39    

Aliases
for CAB39 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium Binding Protein 391 2
MO251 2 3
MO25alpha2 3
CGI-661
Calcium-Binding Protein 392
Protein Mo253

External Ids:    HGNC: 202921   Entrez Gene: 517192   Ensembl: ENSG000001359327   OMIM: 6121745   UniProtKB: Q9Y3763   

Export aliases for CAB39 gene to outside databases

Previous GC identifers: GC00U916965 GC02P231403 GC02P231285 GC02P223417


Summaries
for CAB39 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376
Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Gene Wiki entry for CAB39


Genomic Views
for CAB39 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAB39 gene promoter:
         TBP   S8   FAC1   Pax-2   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAB39 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAB39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAB39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

CAB39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAB39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P231577:  view genomic region     (about GC identifiers)

Start:
 231,577,557 bp from pter      End:
 231,685,790 bp from pter
Size:
 108,234 bases      Orientation:
 plus strand

Proteins
for CAB39 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376 (See protein sequence)
Recommended Name: Calcium-binding protein 39  
Size: 341 amino acids; 39869 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic
activity
Subcellular location: Cytoplasm (Potential)
4 PDB 3D structures from and Proteopedia for CAB39:
1UPK (3D)        1UPL (3D)        2WTK (3D)        3GNI (3D)    

Explore the universe of human proteins at neXtProt for CAB39: NX_Q9Y376

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y376

    • CAB39 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124321.1  NP_001124322.1  NP_057373.1  

    ENSEMBL proteins: 
     ENSP00000258418   ENSP00000386238   ENSP00000386642  
    Reactome Protein details: Q9Y376
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins (see all 3): CAB39
    OriGene Protein Over-expression Lysate (see all 3): CAB39
    OriGene Custom Protein Services for CAB39 
    GenScript Custom Purified and Recombinant Proteins Services for CAB39
    Novus Biologicals CAB39 Proteins
    Novus Biologicals CAB39 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CAB39
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0043234protein complex ----


    CAB39 for ontologies           About GeneDecksing



    CAB39 Antibody Products: 
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    Cell Signaling Technology (CST) Antibodies for CAB39 
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    Novus Biologicals CAB39 Antibodies
    Abcam antibodies for CAB39 
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    ThermoFisher Antibody for CAB39

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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CAB39 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAB39 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013878 Mo25
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y376

    ProtoNet protein and cluster: Q9Y376

    1 Blocks protein family: IPB013878 Mo25-like

    UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376
    Similarity: Belongs to the Mo25 family


    Function
    for CAB39 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376
    Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
    interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

    miRNA
    Products:            		miRTarBase miRNAs that target CAB39:
    hsa-mir-451 (MIRT000500)

    OriGene 3'-UTR Clone (see all 3): CAB39
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAB39
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate CAB39 (see all 85):
    hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CAB39 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAB39 (see all 7)
    OriGene shRNA RFP: CAB39
    OriGene siRNA: CAB39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CAB39

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CAB39
    Search LifeMap BioReagents cell lines for CAB39

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674contributes to protein serine/threonine kinase activity IDA19892943
    GO:0005515protein binding IPI--
    GO:0019900kinase binding IPI19892943
    GO:0030295protein kinase activator activity IDA19892943


    CAB39 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CAB39:
     Increased cell number in G2M,   Synthetic lethal with Ras 


    Pathways & Interactions
    for CAB39 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74
    2Energy dependent regulation of mTOR by LKB1-AMPK
    		Energy dependent regulation of mTOR by LKB1-AMPK1.00
    		Regulation of AMPK activity via LKB10.82
    3Integrated Pancreatic Cancer Pathway
    		Integrated Pancreatic Cancer Pathway1.00
    		Integrated Pancreatic Cancer Pathway0.99
    4mTOR signalling
    		mTOR signalling1.00
    		PKB-mediated events0.96
    5Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CAB39
        Glucose / Energy Metabolism

    5 BioSystems Pathways for CAB39 
        AMPK signaling
    Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Endochondral Ossification
    LKB1 signaling events

    5/13        Reactome Pathways for CAB39 (see all 13)
        PI3K Cascade
    Regulation of AMPK activity via LKB1
    IGF1R signaling cascade
    mTOR signalling
    Energy dependent regulation of mTOR by LKB1-AMPK


    1         Kegg Pathway  (Kegg details for CAB39):
        mTOR signaling pathway


    CAB39 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAB39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for CAB39 (Q9Y3761, 2, 3 ENSP000002584184) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 2, 3, ENSP000003248564EBI-306905,EBI-306838 MINT-56667 MINT-56668 I2D: score=6 STRING: ENSP00000324856
    OXSR1O957472, 3, ENSP000003117134MINT-8186566 MINT-8186657 MINT-8186672 I2D: score=1 STRING: ENSP00000311713
    MST4Q9P2892, 3, ENSP000003778674MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000377867
    STK39Q9UEW82, 3, ENSP000003482784MINT-8186640 MINT-8186728 MINT-8186626 MINT-8186556 I2D: score=1 STRING: ENSP00000348278
    STRADAQ7RTN62, 3, ENSP000003366554MINT-8186774 MINT-8186758 MINT-8186742 I2D: score=3 STRING: ENSP00000336655
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0045860positive regulation of protein kinase activity IDA19892943
    GO:0046320regulation of fatty acid oxidation TAS--
    GO:0051291protein heterooligomerization ----


    CAB39 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAB39 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAB39
    Search CenterWatch for drugs/clinical trials and news about CAB39 

    Transcripts
    for CAB39 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAB39 gene (3 alternative transcripts): 
    NM_001130849.1  NM_001130850.1  NM_016289.3  

    Unigene Cluster for CAB39:

    Calcium binding protein 39
    Hs.603930  [show with all ESTs]
    Unigene Representative Sequence: NM_001130849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258418(uc002vqx.3 uc010fxr.3 uc010fxq.3 uc002vqy.3)
    ENST00000409788 ENST00000410084 ENST00000484398 ENST00000478152 ENST00000493540


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): CAB39
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAB39
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate CAB39 (see all 85):
    hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CAB39 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAB39 (see all 7)
    OriGene shRNA RFP: CAB39
    OriGene siRNA: CAB39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAB39 (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAB39
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39

    Additional cDNA sequence: 

    AB073893.1 AF113536.1 AF134480.1 AF151824.1 AK000804.1 AK026335.1 AK292382.1 AK315692.1 
    BC020570.1 

    11 DOTS entries:

    DT.452018  DT.100822140  DT.95110075  DT.120962265  DT.120962298  DT.91706491  DT.95318837  DT.95362906 
    DT.120962275  DT.91757552  DT.86840836 

    24/305 AceView cDNA sequences (see all 305):

    AA252676 CF126779 AW615199 NM_016289 BU615412 AI590081 AA584934 CA420365 
    AA324907 AA937171 AI670811 AA344335 BQ446059 AA769550 AI127853 AK026335 
    BQ718408 BM985320 AI985524 BM711209 AI566689 BU429359 BM741188 AW235071 

    GeneLoc Exon Structure


    Expression
    for CAB39 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAB39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGCATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CAB39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAB39

    SOURCE GeneReport for Unigene cluster: Hs.603930
        SABiosciences Expression via Pathway-Focused PCR Array including CAB39: 
              mTOR Signaling in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAB39
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

    Orthologs
    for CAB39 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAB39 gene from 7/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CAB391 calcium binding protein 39 88.17(n)
    99.71(a)    		   424830  XM_003641738.1  XP_003641786.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CAB396
    		 --
    		 99(a)
    		 1 ↔ 1
    		 3(28206770-28227455)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.90722 Danio rerio mRNA similar to MO25 protein (cDNA clone more 73.38(n)    BC044172.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mo251 CG4083-PA 63.81(n)
    71.87(a)    		   39858  NM_079393.2  NP_524117.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mop-25.11 Protein MOP-25.1 61.68(n)
    65.27(a)    		   180685  NM_001029648.2  NP_001024819.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G172701 putative MO25-like protein 52.38(n)
    44.68(a)    		   827441  NM_117833.3  NP_193460.1 
    rice
    (Oryza sativa)    		 Liliopsida NM_187000.12   -- 72.06(n)    NM_187000.1 


    ENSEMBL Gene Tree for CAB39 (if available)
    TreeFam Gene Tree for CAB39 (if available) 

    Paralogs
    for CAB39 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAB39 gene
    CAB39L2  
    1 SIMAP similar gene for CAB39 using alignment to 2 protein entries:     CAB39_HUMAN (see all proteins):
    CAB39L

    CAB39 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CAB39
    PGOHUM00000235602


    Genomic Variants
    for CAB39 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1853 NCBI SNPs in CAB39 are shown (see all 1853)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1136142981,2
    		C,F,--231575924(+) GTCAGA/TCTGGT 1 -- us2k14Minor allele frequency- T:0.11WA CSA NA EA 244
    rs1904544431,2
    		--231575998(+) GCGAGC/GCACCA 1 -- us2k10--------
    rs580640531,2
    		F,--231576004(+) CACCAC/TGCCCG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs621935991,2
    		C,--231576102(+) CCTCAT/CACCAC 1 -- us2k12Minor allele frequency- C:0.07NA 122
    rs1457125011,2
    		--231576140(+) TTCCAA/CGTCCT 1 -- us2k10--------
    rs1822786131,2
    		--231576180(+) CCCATA/CTCCTT 1 -- us2k10--------
    rs1163621521,2
    		F,--231576186(+) TCCTTG/CAGAGT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1871107911,2
    		--231576200(+) AACAGC/GAAGTC 1 -- us2k10--------
    rs749205351,2
    		F,--231576207(+) AGTCCT/GAACTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1920228431,2
    		--231576221(+) TTGGTA/GGGGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAB39 (231577557 - 231685790 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CAB39: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAB39
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    Disorders / Diseases
    for CAB39 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAB39 for disorders           About GeneDecksing

    OMIM gene information: 612174    OMIM disorders: --

    2 diseases for CAB39:    About MalaCards
    peutz-jeghers syndrome    polyhydramnios

    1 disease from the University of Copenhagen DISEASES database for CAB39:
    Peutz-Jeghers syndrome

    1 Novoseek disease relationship for CAB39 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.42 1 15561763 (1)


    Export disorders for CAB39 gene to outside databases

    Publications
    for CAB39 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAB39 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CAB39)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the LKB1-STRAD-MO25 complex reveals an a llosteric mechanism of kinase activation. (PubMed id 19892943)1, 2 Zeqiraj E....van Aalten D.M. (2009)
    2. Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PubMed id 14730349)1, 2 Milburn C.C.... van Aalten D.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    5. Analysis of the LKB1-STRAD-MO25 complex. (PubMed id 15561763)1, 9 Boudeau J....Alessi D.R. (2004)
    6. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 9 Lizcano J.M....Alessi D.R. (2004)
    7. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 9 Boudeau J.... Alessi D.R. (2003)
    8. ATP and MO25alpha regulate the conformational state o f the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PubMed id 19513107)1, 9 Zeqiraj E....van Aalten D.M. (2009)
    9. LKB1 tumor suppressor protein: PARtaker in cell polarity. (PubMed id 15183188)1, 9 Baas A.F....Clevers H. (2004)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for CAB39 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CAB39 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51719 HGNC: 20292 AceView: CAB39 Ensembl:ENSG00000135932 euGenes: HUgn51719
    ECgene: CAB39 Kegg: 51719 H-InvDB: CAB39

    Other Databases showing CAB39 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CAB39 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAB39 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CAB39 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAB39 gene:
    Search GeneIP for patents involving CAB39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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