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Aliases for CAB39 Gene

Aliases for CAB39 Gene

  • Calcium Binding Protein 39 2 3 5
  • MO25alpha 3 4
  • MO25 3 4
  • Calcium-Binding Protein 39 3
  • Protein Mo25 4
  • CGI-66 3

External Ids for CAB39 Gene

Previous GeneCards Identifiers for CAB39 Gene

  • GC00U916965
  • GC02P231403
  • GC02P231285
  • GC02P231577
  • GC02P223417

Summaries for CAB39 Gene

GeneCards Summary for CAB39 Gene

CAB39 (Calcium Binding Protein 39) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. GO annotations related to this gene include binding and kinase binding. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot for CAB39 Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Gene Wiki entry for CAB39 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAB39 Gene

Genomics for CAB39 Gene

Regulatory Elements for CAB39 Gene

Enhancers for CAB39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G230792 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +82.0 81990 4.6 HDGF PKNOX1 SIN3A ZBTB40 ZSCAN9 ZNF48 RARA GATA2 FOS RCOR1 CAB39 SP100 RNU6-268P SPATA3 SPATA3-AS1 SP140L GC02P230779 ENSG00000270891
GH02G230656 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -52.0 -51997 8.4 HDGF PKNOX1 ARNT YBX1 ZNF766 ZNF143 ZNF207 ZNF263 JUNB REST CAB39 LOC101928816 RNU6-451P ZBTB8OSP2 LINC00471 SP110 SP140 GPR55 ARMC9 SP140L
GH02G230666 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -44.6 -44584 3.6 HDGF ATF1 WRNIP1 ZFP64 ZNF766 GLIS2 ELK1 NCOA1 JUNB REST CAB39 RNU6-451P RNU6-268P GPR55 SP100 SP110 SP140 LINC01907 GC02P230588
GH02G230773 1.4 Ensembl ENCODE dbSUPER 16.1 +63.9 63906 6.8 SIN3A TCF12 ZNF121 FOS ZHX2 JUNB TBX21 ZNF592 SREBF1 MEF2D CAB39 RNU6-268P LINC01907 GC02P230779
GH02G230650 1.4 FANTOM5 ENCODE dbSUPER 11.5 -61.9 -61888 0.7 HDGF PKNOX1 WRNIP1 GATA2 TBX21 ZNF592 SMARCA4 GLIS1 NBN PRDM4 CAB39 SP140 SP110 GPR55 LINC01907 GC02P230588
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAB39 on UCSC Golden Path with GeneCards custom track

Promoters for CAB39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000131711 958 3201 HDGF FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2

Genomic Location for CAB39 Gene

Chromosome:
2
Start:
230,712,842 bp from pter
End:
230,821,075 bp from pter
Size:
108,234 bases
Orientation:
Plus strand

Genomic View for CAB39 Gene

Genes around CAB39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAB39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAB39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39 Gene

Proteins for CAB39 Gene

  • Protein details for CAB39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y376-CAB39_HUMAN
    Recommended name:
    Calcium-binding protein 39
    Protein Accession:
    Q9Y376
    Secondary Accessions:
    • A8K8L7

    Protein attributes for CAB39 Gene

    Size:
    341 amino acids
    Molecular mass:
    39869 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

    Three dimensional structures from OCA and Proteopedia for CAB39 Gene

neXtProt entry for CAB39 Gene

Post-translational modifications for CAB39 Gene

  • Ubiquitination at posLast=301301
  • Modification sites at PhosphoSitePlus

Other Protein References for CAB39 Gene

No data available for DME Specific Peptides for CAB39 Gene

Domains & Families for CAB39 Gene

Protein Domains for CAB39 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CAB39 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y376

UniProtKB/Swiss-Prot:

CAB39_HUMAN :
  • Belongs to the Mo25 family.
Family:
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39: view

No data available for Gene Families for CAB39 Gene

Function for CAB39 Gene

Molecular function for CAB39 Gene

UniProtKB/Swiss-Prot Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Gene Ontology (GO) - Molecular Function for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 contributes_to protein serine/threonine kinase activity IDA 24393035
GO:0005515 protein binding IPI 14676191
GO:0019900 kinase binding IPI 19892943
GO:0030295 protein kinase activator activity IDA 19892943
GO:0043539 protein serine/threonine kinase activator activity IDA 19892943
genes like me logo Genes that share ontologies with CAB39: view
genes like me logo Genes that share phenotypes with CAB39: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAB39 Gene

Localization for CAB39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAB39 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAB39 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0034774 secretory granule lumen TAS --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with CAB39: view

Pathways & Interactions for CAB39 Gene

genes like me logo Genes that share pathways with CAB39: view

Pathways by source for CAB39 Gene

2 KEGG pathways for CAB39 Gene
1 R&D Systems pathway for CAB39 Gene
1 Qiagen pathway for CAB39 Gene

Gene Ontology (GO) - Biological Process for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007050 cell cycle arrest TAS --
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 24393035
GO:0018105 peptidyl-serine phosphorylation IDA 24393035
GO:0023014 signal transduction by protein phosphorylation IDA 24393035
genes like me logo Genes that share ontologies with CAB39: view

No data available for SIGNOR curated interactions for CAB39 Gene

Transcripts for CAB39 Gene

Unigene Clusters for CAB39 Gene

Calcium binding protein 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39 Gene

No ASD Table

Relevant External Links for CAB39 Gene

GeneLoc Exon Structure for
CAB39
ECgene alternative splicing isoforms for
CAB39

Expression for CAB39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAB39 Gene

Protein differential expression in normal tissues from HIPED for CAB39 Gene

This gene is overexpressed in Urine (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAB39 Gene



Protein tissue co-expression partners for CAB39 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAB39 Gene:

CAB39

SOURCE GeneReport for Unigene cluster for CAB39 Gene:

Hs.603930

Evidence on tissue expression from TISSUES for CAB39 Gene

  • Nervous system(4.8)
  • Intestine(4.4)
  • Liver(4.4)
  • Kidney(2.5)
  • Muscle(2.4)
  • Lung(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CAB39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAB39 Gene

Orthologs for CAB39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia CAB39 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAB39 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAB39 34 35
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia CAB39 34 35
  • 94.82 (n)
cow
(Bos Taurus)
Mammalia CAB39 34 35
  • 94.04 (n)
mouse
(Mus musculus)
Mammalia Cab39 34 16 35
  • 92.47 (n)
chicken
(Gallus gallus)
Aves CAB39 34 35
  • 88.17 (n)
lizard
(Anolis carolinensis)
Reptilia CAB39 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486569 34
  • 80.45 (n)
zebrafish
(Danio rerio)
Actinopterygii cab39 34 35
  • 79.57 (n)
Dr.9072 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000812 34
  • 64.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mo25 34 35
  • 63.84 (n)
worm
(Caenorhabditis elegans)
Secernentea mop-25.1 34 35
  • 61.68 (n)
mop-25.2 35
  • 59 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 35 37
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17270 34
  • 52.38 (n)
soybean
(Glycine max)
eudicotyledons Gma.4699 34
rice
(Oryza sativa)
Liliopsida Os07g0585100 34
  • 54.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3108 35
  • 67 (a)
OneToMany
Species where no ortholog for CAB39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAB39 Gene

ENSEMBL:
Gene Tree for CAB39 (if available)
TreeFam:
Gene Tree for CAB39 (if available)

Paralogs for CAB39 Gene

Paralogs for CAB39 Gene

(1) SIMAP similar genes for CAB39 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CAB39 Gene

genes like me logo Genes that share paralogs with CAB39: view

Variants for CAB39 Gene

Sequence variations from dbSNP and Humsavar for CAB39 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000015704 -- 230,813,230(+) CCTTG(C/G)CCCCC intron-variant, utr-variant-3-prime
rs1000042018 -- 230,803,763(+) CAAAC(A/G)GAAGA intron-variant
rs1000054590 -- 230,722,620(+) AATAG(A/T)ACCTA intron-variant
rs1000100281 -- 230,756,279(+) GTGAT(A/G/T)TAGCC intron-variant
rs1000108818 -- 230,797,617(+) GGCAA(C/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAB39 Gene

Variant ID Type Subtype PubMed ID
esv2671712 CNV deletion 23128226
esv2674961 CNV deletion 23128226
esv2760618 CNV loss 21179565
esv3594611 CNV loss 21293372
esv3594612 CNV loss 21293372
esv3594613 CNV loss 21293372
nsv584675 CNV loss 21841781
nsv834565 CNV gain 17160897
nsv953197 CNV duplication 24416366
nsv961569 CNV duplication 23825009

Variation tolerance for CAB39 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAB39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAB39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAB39 Gene

Disorders for CAB39 Gene

Relevant External Links for CAB39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAB39

No disorders were found for CAB39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAB39 Gene

Publications for CAB39 Gene

  1. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PMID: 19892943) Zeqiraj E. … van Aalten D.M. (Science 2009) 3 4 64
  2. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PMID: 19513107) Zeqiraj E. … van Aalten D.M. (PLoS Biol. 2009) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PMID: 14730349) Milburn C.C. … van Aalten D.M. (Nat. Struct. Mol. Biol. 2004) 3 4 64
  5. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PMID: 14976552) Lizcano J.M. … Alessi D.R. (EMBO J. 2004) 3 22 64

Products for CAB39 Gene

Sources for CAB39 Gene

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