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Aliases for CAB39 Gene

Aliases for CAB39 Gene

  • Calcium Binding Protein 39 2 3 5
  • MO25alpha 3 4
  • MO25 3 4
  • Protein Mo25 4
  • CGI-66 3

External Ids for CAB39 Gene

Previous GeneCards Identifiers for CAB39 Gene

  • GC00U916965
  • GC02P231403
  • GC02P231285
  • GC02P231577
  • GC02P223417

Summaries for CAB39 Gene

GeneCards Summary for CAB39 Gene

CAB39 (Calcium Binding Protein 39) is a Protein Coding gene. Among its related pathways are Endochondral Ossification and Glucose / Energy Metabolism. GO annotations related to this gene include binding and kinase binding. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot for CAB39 Gene

  • Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Gene Wiki entry for CAB39 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAB39 Gene

Genomics for CAB39 Gene

Regulatory Elements for CAB39 Gene

Enhancers for CAB39 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAB39 on UCSC Golden Path with GeneCards custom track

Promoters for CAB39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAB39 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAB39 Gene

Chromosome:
2
Start:
230,712,842 bp from pter
End:
230,821,075 bp from pter
Size:
108,234 bases
Orientation:
Plus strand

Genomic View for CAB39 Gene

Genes around CAB39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAB39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAB39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAB39 Gene

Proteins for CAB39 Gene

  • Protein details for CAB39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y376-CAB39_HUMAN
    Recommended name:
    Calcium-binding protein 39
    Protein Accession:
    Q9Y376
    Secondary Accessions:
    • A8K8L7

    Protein attributes for CAB39 Gene

    Size:
    341 amino acids
    Molecular mass:
    39869 Da
    Quaternary structure:
    • Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

    Three dimensional structures from OCA and Proteopedia for CAB39 Gene

neXtProt entry for CAB39 Gene

Proteomics data for CAB39 Gene at MOPED

Post-translational modifications for CAB39 Gene

  • Ubiquitination at Lys 301
  • Modification sites at PhosphoSitePlus

Other Protein References for CAB39 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAB39 (CAB39)

No data available for DME Specific Peptides for CAB39 Gene

Domains & Families for CAB39 Gene

Protein Domains for CAB39 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CAB39 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y376

UniProtKB/Swiss-Prot:

CAB39_HUMAN :
  • Belongs to the Mo25 family.
Family:
  • Belongs to the Mo25 family.
genes like me logo Genes that share domains with CAB39: view

No data available for Gene Families for CAB39 Gene

Function for CAB39 Gene

Molecular function for CAB39 Gene

UniProtKB/Swiss-Prot Function:
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Gene Ontology (GO) - Molecular Function for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030295 protein kinase activator activity IDA 19892943
genes like me logo Genes that share ontologies with CAB39: view
genes like me logo Genes that share phenotypes with CAB39: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAB39 Gene

Localization for CAB39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAB39 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAB39 Gene COMPARTMENTS Subcellular localization image for CAB39 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for CAB39 Gene

Pathways & Interactions for CAB39 Gene

genes like me logo Genes that share pathways with CAB39: view

Pathways by source for CAB39 Gene

Gene Ontology (GO) - Biological Process for CAB39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 24393035
GO:0018105 peptidyl-serine phosphorylation IDA 24393035
GO:0023014 signal transduction by protein phosphorylation IDA 24393035
GO:0032147 activation of protein kinase activity IEA --
GO:0035556 intracellular signal transduction IDA 24393035
genes like me logo Genes that share ontologies with CAB39: view

No data available for SIGNOR curated interactions for CAB39 Gene

Drugs & Compounds for CAB39 Gene

No Compound Related Data Available

Transcripts for CAB39 Gene

Unigene Clusters for CAB39 Gene

Calcium binding protein 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAB39 Gene

No ASD Table

Relevant External Links for CAB39 Gene

GeneLoc Exon Structure for
CAB39
ECgene alternative splicing isoforms for
CAB39

Expression for CAB39 Gene

mRNA expression in normal human tissues for CAB39 Gene

Protein differential expression in normal tissues from HIPED for CAB39 Gene

This gene is overexpressed in Urine (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAB39 Gene



SOURCE GeneReport for Unigene cluster for CAB39 Gene Hs.603930

genes like me logo Genes that share expression patterns with CAB39: view

Protein tissue co-expression partners for CAB39 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAB39 Gene

Orthologs for CAB39 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAB39 35
  • 94.04 (n)
  • 100 (a)
CAB39 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAB39 35
  • 94.82 (n)
  • 99.41 (a)
CAB39 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cab39 35
  • 92.47 (n)
  • 99.12 (a)
Cab39 16
Cab39 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAB39 35
  • 99.9 (n)
  • 100 (a)
CAB39 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAB39 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAB39 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAB39 35
  • 88.17 (n)
  • 99.71 (a)
CAB39 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAB39 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486569 35
  • 80.45 (n)
  • 98.53 (a)
zebrafish
(Danio rerio)
Actinopterygii cab39 35
  • 79.57 (n)
  • 92.96 (a)
Dr.9072 35
cab39 36
  • 93 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000812 35
  • 64.46 (n)
  • 73.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mo25 35
  • 63.84 (n)
  • 71.82 (a)
Mo25 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mop-25.1 35
  • 61.68 (n)
  • 65.27 (a)
mop-25.1 36
  • 34 (a)
ManyToMany
mop-25.2 36
  • 59 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HYM1 36
  • 30 (a)
OneToMany
HYM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17270 35
  • 52.38 (n)
  • 44.68 (a)
soybean
(Glycine max)
eudicotyledons Gma.4699 35
rice
(Oryza sativa)
Liliopsida Os07g0585100 35
  • 54.02 (n)
  • 46.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3108 36
  • 67 (a)
OneToMany
Species with no ortholog for CAB39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAB39 Gene

ENSEMBL:
Gene Tree for CAB39 (if available)
TreeFam:
Gene Tree for CAB39 (if available)

Paralogs for CAB39 Gene

Paralogs for CAB39 Gene

(1) SIMAP similar genes for CAB39 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CAB39 Gene

genes like me logo Genes that share paralogs with CAB39: view

Variants for CAB39 Gene

Sequence variations from dbSNP and Humsavar for CAB39 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs726379 -- 230,820,483(-) ATTTT(C/T)TTTTC utr-variant-3-prime
rs1568247 -- 230,756,521(-) CTCCC(C/T)AAAAC intron-variant
rs2720162 -- 230,764,645(+) atcta(G/T)tcaaa intron-variant
rs2720164 -- 230,772,734(+) cctgc(C/T)tcggc intron-variant
rs2945507 -- 230,782,817(+) TCTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAB39 Gene

Variant ID Type Subtype PubMed ID
nsv834565 CNV Gain 17160897
esv2671712 CNV Deletion 23128226
esv2674961 CNV Deletion 23128226

Variation tolerance for CAB39 Gene

Residual Variation Intolerance Score: 31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CAB39 Gene

Disorders for CAB39 Gene

Relevant External Links for CAB39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAB39

No disorders were found for CAB39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAB39 Gene

Publications for CAB39 Gene

  1. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PMID: 19892943) Zeqiraj E. … van Aalten D.M. (Science 2009) 3 4 67
  2. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PMID: 19513107) Zeqiraj E. … van Aalten D.M. (PLoS Biol. 2009) 3 23
  3. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PMID: 14976552) Lizcano J.M. … Alessi D.R. (EMBO J. 2004) 3 23
  4. LKB1 tumor suppressor protein: PARtaker in cell polarity. (PMID: 15183188) Baas A.F. … Clevers H. (Trends Cell Biol. 2004) 3 23
  5. Analysis of the LKB1-STRAD-MO25 complex. (PMID: 15561763) Boudeau J. … Alessi D.R. (J. Cell. Sci. 2004) 3 23

Products for CAB39 Gene

Sources for CAB39 Gene

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