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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CAB39 Gene

protein-coding GIFtS: 58
GCID: GC02P231577

Calcium Binding Protein 39

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Calcium Binding Protein 39¹ ²
MO25² ³
MO25alpha² ³
Calcium-Binding Protein 39²
Protein Mo25³

External Ids:	HGNC: 20292¹	Entrez Gene: 51719²	Ensembl: ENSG00000135932⁷	OMIM: 612174⁵	UniProtKB: Q9Y376³

Export aliases for CAB39 gene to outside databases

Previous GC identifers: GC00U916965 GC02P231403 GC02P231285 GC02P223417

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CAB39 Gene:

CAB39 (calcium binding protein 39) is a protein-coding gene. Diseases associated with CAB39 include polyhydramnios, and peutz-jeghers syndrome, and among its related super-pathways are Insulin receptor signalling cascade and Energy dependent regulation of mTOR by LKB1-AMPK. GO annotations related to this gene include protein kinase activator activity and protein serine/threonine kinase activity. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376

Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the

interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Gene Wiki entry for CAB39 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.2 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CAB39 gene promoter:
TBP S8 FAC1 Pax-2 Pax-2a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAB39 promoter sequence

Search SABiosciences Chromatin IP Primers for CAB39

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAB39

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

CAB39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAB39 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P231577: view genomic region (about GC identifiers)

Start:	231,577,557 bp from pter	End:	231,685,790 bp from pter
Size:	108,234 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376 (See protein sequence)

Recommended Name: Calcium-binding protein 39

Size: 341 amino acids; 39869 Da

Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25

(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its

catalytic activity

Subcellular location: Cytoplasm (Potential)

6/7 PDB 3D structures from and Proteopedia for CAB39 (see all 7):

1UPK (3D)

1UPL (3D)

2WTK (3D)

3GNI (3D)

4FZA (3D)

4FZD (3D)

Explore the universe of human proteins at neXtProt for CAB39: NX_Q9Y376

Explore proteomics data for CAB39 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9Y376

CAB39 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001124321.1 NP_001124322.1 NP_057373.1

ENSEMBL proteins:

ENSP00000258418 ENSP00000386642 ENSP00000386238

Reactome Protein details: Q9Y376
Human Recombinant Protein Products for CAB39:

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	Novus Biologicals CAB39 Proteins Novus Biologicals CAB39 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for CAB39
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

CAB39 for ontologies About GeneDecksing

CAB39 Antibody Products:

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Assay Products for CAB39:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR013878 Mo25

IPR011989 ARM-like

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q9Y376

ProtoNet protein and cluster: Q9Y376

1 Blocks protein domain: IPB013878 Mo25-like

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376

Similarity: Belongs to the Mo25 family

CAB39 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CAB39_HUMAN, Q9Y376

Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the

interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	contributes to protein serine/threonine kinase activity	IDA	19892943
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	14676191
GO:0019900	kinase binding	IPI	19892943
GO:0030295	protein kinase activator activity	IDA	19892943

CAB39 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CAB39:

Increased cell number in G2M,

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for CAB39

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAB39

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAB39

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAB39

miRNA Products:		miRTarBase miRNAs that target CAB39: hsa-mir-451 (MIRT000500)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAB39
		8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate CAB39 (see all 85):
		hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CAB39 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CAB39
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CAB39
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for CAB39 (see all 20) OriGene ORF clones in mouse, rat for CAB39 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39
		Sirion Biotech Customized lentivirus for stable overexpression of CAB39 Customized lentivirus expression plasmids for stable overexpression of CAB39

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CAB39
		Search LifeMap BioReagents cell lines for CAB39

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CAB39 About (see all 9)

See pathways by source

SuperPath

Contained pathways About

IRS-related events

Insulin receptor signalling cascade	0.94	IGF1R signaling cascade	0.92
IRS-related events	0.94	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.92
IRS-related events triggered by IGF1R	0.93	PI3K Cascade	0.86
IRS-mediated signalling	0.92	Signaling by Insulin receptor	0.79

Energy dependent regulation of mTOR by LKB1-AMPK

	Energy dependent regulation of mTOR by LKB1-AMPK	0.82			mTOR signalling	0.63
	Regulation of AMPK activity via LKB1	0.82			PKB-mediated events	0.61

Signaling by GPCR

Signal Transduction

0.55

Translation Insulin regulation of translation

mTOR signaling pathway

0.34

LKB1 signaling events

LKB1 signaling events

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for CAB39

Glucose / Energy Metabolism

4 BioSystems Pathways for CAB39

	AMPK signaling
	Endochondral Ossification
	Integrated Pancreatic Cancer Pathway
	LKB1 signaling events

5/13 Reactome Pathways for CAB39 (see all 13)

	PI3K Cascade
	Regulation of AMPK activity via LKB1
	IGF1R signaling cascade
	mTOR signalling
	Energy dependent regulation of mTOR by LKB1-AMPK

1 Kegg Pathway (Kegg details for CAB39):

mTOR signaling pathway

CAB39 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CAB39

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for CAB39 (Q9Y376^{1, 2, 3} ENSP00000258418⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STK11	Q15831¹^,²^,³, ENSP00000324856⁴	EBI-306905,EBI-306838 MINT-56667 MINT-56668 I2D: score=6 STRING: ENSP00000324856
OXSR1	O95747²^,³, ENSP00000311713⁴	MINT-8186566 MINT-8186657 MINT-8186672 I2D: score=1 STRING: ENSP00000311713
MST4	Q9P289²^,³, ENSP00000377867⁴	MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000377867
STK39	Q9UEW8²^,³, ENSP00000348278⁴	MINT-8186640 MINT-8186728 MINT-8186626 MINT-8186556 I2D: score=1 STRING: ENSP00000348278
STRADA	Q7RTN6²^,³, ENSP00000336655⁴	MINT-8186774 MINT-8186758 MINT-8186742 I2D: score=3 STRING: ENSP00000336655

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007050	cell cycle arrest	TAS	--
GO:0008286	insulin receptor signaling pathway	TAS	--
GO:0045860	positive regulation of protein kinase activity	IDA	19892943

CAB39 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CAB39

Search CenterWatch for drugs/clinical trials and news about CAB39

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CAB39 gene (3 alternative transcripts):

NM_001130849.1 NM_001130850.1 NM_016289.3

Unigene Cluster for CAB39:

Calcium binding protein 39

Hs.603930 [show with all ESTs]

Unigene Representative Sequence: NM_001130849

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000258418(uc002vqx.3 uc010fxr.3 uc010fxq.3 uc002vqy.3)

ENST00000410084 ENST00000409788 ENST00000484398 ENST00000478152 ENST00000493540

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAB39
		8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate CAB39 (see all 85):
		hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CAB39 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39

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		GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CAB39
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAB39
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39

Additional mRNA sequence:

AB073893.1 AF113536.1 AF134480.1 AF151824.1 AK000804.1 AK026335.1 AK292382.1 AK315692.1

BC020570.1

12 DOTS entries:

DT.452018 DT.100822140 DT.95110075 DT.120962265 DT.120962298 DT.91706491 DT.95318837 DT.95362906

DT.120962272 DT.120962275 DT.86840836 DT.91757552

24/305 AceView cDNA sequences (see all 305):

AA307914 AA255507 AA324907 AI590081 BM982100 CD251716 AV729226 BG289225

AW629742 AA748352 CA944579 BM711209 AA769550 AA961656 BU615412 AA584934

AA741258 BG679680 BM458866 AA255535 CD105997 AI932723 CF126779 BG259357

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CAB39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAAGCATTTT

About this image

See CAB39 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAB39

SOURCE GeneReport for Unigene cluster: Hs.603930

SABiosciences Expression via Pathway-Focused PCR Array including CAB39:

mTOR Signaling in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39 gene from 9/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cab39^{1 , 5}	calcium binding protein 39^{1, 5}	92.47(n)¹ 99.12(a)¹		1 (43.94 cM)⁵ 12283¹ NM_133781.4¹ NP_598542.3¹ 85793441⁵
chicken (Gallus gallus)	Aves	CAB39¹	calcium binding protein 39	88.17(n) 99.71(a)		424830 XM_003641738.1 XP_003641786.1
lizard (Anolis carolinensis)	Reptilia	CAB39⁶	Uncharacterized protein	99(a)	1 ↔ 1	3(28160170-28230511)
zebrafish (Danio rerio)	Actinopterygii	Dr.9072²	Danio rerio mRNA similar to MO25 protein (cDNA clone more	73.38(n)		BC044172.1
fruit fly (Drosophila melanogaster)	Insecta	Mo25¹	CG4083-PA	63.81(n) 71.87(a)		39858 NM_079393.2 NP_524117.1
worm (Caenorhabditis elegans)	Secernentea	mop-25.1¹	Protein MOP-25.1	61.68(n) 65.27(a)		180685 NM_001029648.2 NP_001024819.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	HYM1(YKL189W)⁴	Component of the RAM signaling network that is involved more	--		11(84704-85903) 853646 NP_012732.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G17270¹	putative MO25-like protein	52.38(n) 44.68(a)		827441 NM_117833.3 NP_193460.1
rice (Oryza sativa)	Liliopsida	NM_187000.1²	--	72.06(n)		NM_187000.1

ENSEMBL Gene Tree for CAB39 (if available)
TreeFam Gene Tree for CAB39 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CAB39 gene

CAB39L²

1 SIMAP similar gene for CAB39 using alignment to 2 protein entries: CAB39_HUMAN (see all proteins):

CAB39L

CAB39 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CAB39
PGOHUM00000235602

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113614298^1,2	C,F	--	231575924(+)	`GTCAGA/TCTGGT`	1	--	us2k¹		4		WA CSA NA EA	244
rs190454443^1,2		--	231575998(+)	`GCGAGC/GCACCA`	1	--	us2k¹		0	--	--	--	--
rs58064053^1,2	F	--	231576004(+)	`CACCAC/TGCCCG`	1	--	us2k¹		1		WA	118
rs62193599^1,2	C,F	--	231576102(+)	`CCTCAT/CACCAC`	1	--	us2k¹		2		NA	122
rs145712501^1,2		--	231576140(+)	`TTCCAA/CGTCCT`	1	--	us2k¹		0	--	--	--	--
rs182278613^1,2		--	231576180(+)	`CCCATA/CTCCTT`	1	--	us2k¹		0	--	--	--	--
rs116362152^1,2	F	--	231576186(+)	`TCCTTG/CAGAGT`	1	--	us2k¹		1		WA	118
rs187110791^1,2		--	231576200(+)	`AACAGC/GAAGTC`	1	--	us2k¹		0	--	--	--	--
rs74920535^1,2	F	--	231576207(+)	`AGTCCT/GAACTT`	1	--	us2k¹		1		WA	118
rs192022843^1,2		--	231576221(+)	`TTGGTA/GGGGCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CAB39 (231577557 - 231685790 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for CAB39: About this table

Variant ID	Type	Subtype	PubMed ID
esv2674961	CNV	Deletion	23128226
esv2671712	CNV	Deletion	23128226
nsv834565	CNV	Gain	17160897

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing CAB39

DNA2.0 Custom Variant and Variant Library Synthesis for CAB39

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 612174 OMIM disorders: --

4 diseases for CAB39: About MalaCards

polyhydramnios peutz-jeghers syndrome pancreatic cancer pancreatitis

1 disease from the University of Copenhagen DISEASES database for CAB39:

Peutz-Jeghers syndrome

CAB39 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for CAB39 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	5.42	1	15561763 (1)

Export disorders for CAB39 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CAB39 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with CAB39)

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Structure of the LKB1-STRAD-MO25 complex reveals an a llosteric mechanism of kinase activation. (PubMed id 19892943)^{1, 2} Zeqiraj E....van Aalten D.M. (2009)
Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PubMed id 14730349)^{1, 2} Milburn C.C.... van Aalten D.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.H....Lin W. (2000)
Analysis of the LKB1-STRAD-MO25 complex. (PubMed id 15561763)^{1, 9} Boudeau J....Alessi D.R. (2004)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)^{1, 9} Lizcano J.M....Alessi D.R. (2004)
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)^{1, 9} Boudeau J.... Alessi D.R. (2003)
ATP and MO25alpha regulate the conformational state o f the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PubMed id 19513107)^{1, 9} Zeqiraj E....van Aalten D.M. (2009)
LKB1 tumor suppressor protein: PARtaker in cell polarity. (PubMed id 15183188)^{1, 9} Baas A.F....Clevers H. (2004)
VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)¹ Yu C.C....Chow L.P. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51719	HGNC: 20292	AceView: CAB39	Ensembl:ENSG00000135932	euGenes: HUgn51719
ECgene: CAB39	Kegg: 51719	H-InvDB: CAB39

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CAB39	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CAB39 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CAB39 gene:
Search GeneIP for patents involving CAB39

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CAB39 Gene

Calcium Binding Protein 39

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CAB39 Gene

Calcium Binding Protein 39

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