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Set Analyses:

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CAB39 Gene

protein-coding GIFtS: 58
GCID: GC02P231577

Calcium Binding Protein 39

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Calcium Binding Protein 39¹ ²
MO25² ³
MO25alpha² ³
Calcium-Binding Protein 39²
Protein Mo25³

External Ids:	HGNC: 20292¹	Entrez Gene: 51719²	Ensembl: ENSG00000135932⁷	OMIM: 612174⁵	UniProtKB: Q9Y376³

Export aliases for CAB39 gene to outside databases

Previous GC identifers: GC00U916965 GC02P231403 GC02P231285 GC02P223417

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAB39 Gene:

CAB39 (calcium binding protein 39) is a protein-coding gene. Diseases associated with CAB39 include polyhydramnios, and peutz-jeghers syndrome. GO annotations related to this gene include protein kinase activator activity and protein serine/threonine kinase activity. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376

Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the

interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Gene Wiki entry for CAB39 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NC_018913.2 NT_005403.18

Regulatory elements:

Regulatory transcription factor binding sites in the CAB39 gene promoter:
TBP S8 FAC1 Pax-2 Pax-2a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAB39 promoter sequence

Search Chromatin IP Primers for CAB39

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAB39

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1 Ensembl cytogenetic band: 2q37.1 HGNC cytogenetic band: 2q37.1

CAB39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAB39 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P231577: view genomic region (about GC identifiers)

Start:	231,577,557 bp from pter	End:	231,685,790 bp from pter
Size:	108,234 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376 (See protein sequence)

Recommended Name: Calcium-binding protein 39

Size: 341 amino acids; 39869 Da

Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25

(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its

catalytic activity

Selected PDB 3D structures from and Proteopedia for CAB39 (see all 7):

1UPK (3D)

1UPL (3D)

2WTK (3D)

3GNI (3D)

4FZA (3D)

4FZD (3D)

Secondary accessions: A8K8L7

Explore the universe of human proteins at neXtProt for CAB39: NX_Q9Y376

Explore proteomics data for CAB39 at MOPED

Post-translational modifications:

Ubiquitination² at Lys301

Modification sites at PhosphoSitePlus

See CAB39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001124321.1 NP_001124322.1 NP_057373.1

ENSEMBL proteins:

ENSP00000258418 ENSP00000386642 ENSP00000386238

Reactome Protein details: Q9Y376

CAB39 Human Recombinant Protein Products:

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	OriGene Purified Proteins for CAB39 OriGene Protein Over-expression Lysate for CAB39 OriGene MassSpec for CAB39 OriGene Custom Protein Services for CAB39
	GenScript Custom Purified and Recombinant Proteins Services for CAB39
	Novus Biologicals CAB39 Proteins Novus Biologicals CAB39 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for CAB39
	Browse Proteins at Cloud-Clone Corp.

CAB39 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CAB39
	OriGene Antibodies for CAB39 OriGene Custom Antibody Services for CAB39
	Novus Biologicals CAB39 Antibodies
	Abcam antibodies for CAB39
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for CAB39
	LSBio Antibodies in human, mouse, rat for CAB39

CAB39 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CAB39
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CAB39
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR011989 ARM-like

IPR013878 Mo25

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q9Y376

ProtoNet protein and cluster: Q9Y376

1 Blocks protein domain: IPB013878 Mo25-like

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376

Similarity: Belongs to the Mo25 family

CAB39 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CAB39_HUMAN, Q9Y376

Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the

interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	contributes to protein serine/threonine kinase activity	IDA	19892943
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	14676191
GO:0019900	kinase binding	IPI	19892943
GO:0030295	protein kinase activator activity	IDA	19892943

CAB39 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CAB39:

Increased cell number in G2M,

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAB39

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAB39

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAB39

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAB39

miRNA Products:		miRTarBase miRNAs that target CAB39: hsa-mir-195-5p (MIRT007054), hsa-mir-451a (MIRT000500), hsa-mir-877-5p (MIRT037258), hsa-mir-155-5p (MIRT020562), hsa-mir-375 (MIRT019792)

		Block miRNA regulation of human, mouse, rat CAB39 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CAB39 (see all 85):
		hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CAB39 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CAB39
		Predesigned siRNA for gene silencing in human, mouse, rat CAB39

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CAB39

Clone Products:		OriGene clones in human, mouse for CAB39 (see all 18) OriGene ORF clones in mouse, rat for CAB39 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CAB39
		Browse ESI BIO Cell Lines and PureStem Progenitors for CAB39

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CAB39_HUMAN, Q9Y376: Cytoplasm (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
nucleus	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0043234	protein complex	IEA	--
GO:0070062	extracellular vesicular exosome	IDA	19056867

CAB39 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CAB39 About (see all 8)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Insulin receptor signalling cascade

Insulin receptor signalling cascade	0.94	PI3K Cascade	0.87
IRS-related events	0.94	Signaling by Insulin receptor	0.80
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.92	PKB-mediated events	0.41
IRS-mediated signalling	0.92	mTOR signalling	0.39

Signaling by GPCR

Signal Transduction

0.58

Translation Insulin regulation of translation

mTOR signaling pathway

0.34

LKB1 signaling events

LKB1 signaling events

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CAB39

AMPK Enzyme Complex Pathway

1 Cell Signaling Technology (CST) Pathway for CAB39

Glucose / Energy Metabolism

4 BioSystems Pathways for CAB39

	AMPK signaling
	Endochondral Ossification
	Integrated Pancreatic Cancer Pathway
	LKB1 signaling events

1 Reactome Pathway for CAB39

Regulation of AMPK activity via LKB1

1 Kegg Pathway (Kegg details for CAB39):

mTOR signaling pathway

CAB39 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including CAB39:

mTOR Signaling in human mouse rat

Interactions:

GeneGlobe Interaction Network for CAB39

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CAB39 (Q9Y376^{1, 2, 3} ENSP00000258418⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 205)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STK39	Q9UEW8¹^,²^,³, ENSP00000348278⁴	EBI-306905,EBI-2680974 MINT-8186640 MINT-8186728 MINT-8186626 MINT-8186556 I2D: score=1 STRING: ENSP00000348278
STK25	O00506¹^,²^,³, ENSP00000325748⁴	EBI-306905,EBI-618295 MINT-8186866 MINT-8186834 MINT-8186850 I2D: score=1 STRING: ENSP00000325748
STRADB	Q9C0K7¹^,³, ENSP00000194530⁴	EBI-306905,EBI-306893 I2D: score=2 STRING: ENSP00000194530
MST4	Q9P289¹^,²^,³, ENSP00000377867⁴	EBI-306905,EBI-618239 MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000377867
STRADA	Q7RTN6¹^,²^,³, ENSP00000336655⁴	EBI-306905,EBI-1109114 MINT-8186774 MINT-8186758 MINT-8186742 I2D: score=3 STRING: ENSP00000336655

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IDA	19892943
GO:0007050	cell cycle arrest	TAS	--
GO:0008286	insulin receptor signaling pathway	TAS	--
GO:0032147	activation of protein kinase activity	IEA	--
GO:0045860	positive regulation of protein kinase activity	--	--

CAB39 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CAB39

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CAB39 gene (3 alternative transcripts):

NM_001130849.1 NM_001130850.1 NM_016289.3

Unigene Cluster for CAB39:

Calcium binding protein 39

Hs.603930 [show with all ESTs]

Unigene Representative Sequence: NM_001130849

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000258418(uc002vqx.3 uc010fxr.3 uc010fxq.3 uc002vqy.3)

ENST00000410084 ENST00000409788 ENST00000484398 ENST00000478152 ENST00000493540

miRNA Products:		Block miRNA regulation of human, mouse, rat CAB39 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CAB39 (see all 85):
		hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CAB39 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CAB39
		Predesigned siRNA for gene silencing in human, mouse, rat CAB39

Clone Products:		OriGene clones in human, mouse for CAB39 (see all 18) OriGene ORF clones in mouse, rat for CAB39 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39

Primer Products:		OriGene qPCR primer pairs and template standards for CAB39 OriGene qSTAR qPCR primer pairs in human, mouse for CAB39
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CAB39
		QuantiTect SYBR Green Assays in human, mouse, rat CAB39
		QuantiFast Probe-based Assays in human, mouse, rat CAB39

Additional mRNA sequence:

AB073893.1 AF113536.1 AF134480.1 AF151824.1 AK000804.1 AK026335.1 AK292382.1 AK315692.1

BC020570.1

12 DOTS entries:

DT.452018 DT.100822140 DT.95110075 DT.120962265 DT.120962298 DT.91706491 DT.95318837 DT.95362906

DT.120962272 DT.120962275 DT.86840836 DT.91757552

Selected AceView cDNA sequences (see all 305):

BM982100 AA307914 BM458866 AA741258 AA584934 BU615412 AA961656 CA393940

AA280522 AA936676 AI796239 CD105997 BM927264 CR597291 BG679680 BU429359

BQ433038 BM711209 CA944579 AA748352 AI590081 AA324907 AA769550 AI350893

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CAB39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAAGCATTTT

About this image

CAB39 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CAB39 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.603930

Pathway & Disease-focused RT² Profiler PCR Array including CAB39:

mTOR Signaling in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CAB39 OriGene qSTAR qPCR primer pairs in human, mouse for CAB39
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CAB39
		QuantiTect SYBR Green Assays in human, mouse, rat CAB39
		QuantiFast Probe-based Assays in human, mouse, rat CAB39

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CAB39 gene from Selected species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cab39^{1 , 5}	calcium binding protein 39^{1, 5}	92.47(n)¹ 99.12(a)¹		1 (43.94 cM)⁵ 12283¹ NM_133781.4¹ NP_598542.3¹ 85793441⁵
chicken (Gallus gallus)	Aves	CAB39¹	calcium binding protein 39	88.17(n) 99.71(a)		424830 XM_003641738.2 XP_003641786.1
lizard (Anolis carolinensis)	Reptilia	CAB39⁶	calcium binding protein 39	99(a)	1 ↔ 1	3(28160170-28230511)
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC100486569¹	calcium-binding protein 39-like	80.45(n) 98.53(a)		100486569 XM_002933348.2 XP_002933394.1
zebrafish (Danio rerio)	Actinopterygii	Dr.9072²	Danio rerio mRNA similar to MO25 protein (cDNA clone more	73.38(n)		BC044172.1
fruit fly (Drosophila melanogaster)	Insecta	Mo25¹	Mo25	63.84(n) 71.82(a)		39858 NM_079393.2 NP_524117.1
worm (Caenorhabditis elegans)	Secernentea	mop-25.1¹	mop-25.1	61.68(n) 65.27(a)		180685 NM_001029648.3 NP_001024819.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	HYM1(YKL189W)⁴	Component of the RAM signaling network that is involved more	--		11(84704-85903) 853646 NP_012732.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G17270¹	AT4G17270	52.38(n) 44.68(a)		827441 NM_117833.3 NP_193460.1
rice (Oryza sativa)	Liliopsida	NM_187000.1²	--	72.06(n)		NM_187000.1

ENSEMBL Gene Tree for CAB39 (if available)
TreeFam Gene Tree for CAB39 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CAB39 gene

CAB39L²

1 SIMAP similar gene for CAB39 using alignment to 1 protein entry: CAB39_HUMAN:

CAB39L

CAB39 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CAB39
PGOHUM00000235602

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113614298^1,2	C,F	--	231575924(+)	`GTCAGA/TCTGGT`	1	--	us2k¹		4		WA CSA NA EA	244
rs190454443^1,2		--	231575998(+)	`GCGAGC/GCACCA`	1	--	us2k¹		0	--	--	--	--
rs58064053^1,2	F	--	231576004(+)	`CACCAC/TGCCCG`	1	--	us2k¹		1		WA	118
rs62193599^1,2	C,F	--	231576102(+)	`CCTCAT/CACCAC`	1	--	us2k¹		2		NA	122
rs145712501^1,2		--	231576140(+)	`TTCCAA/CGTCCT`	1	--	us2k¹		0	--	--	--	--
rs182278613^1,2		--	231576180(+)	`CCCATA/CTCCTT`	1	--	us2k¹		0	--	--	--	--
rs116362152^1,2	F	--	231576186(+)	`TCCTTG/CAGAGT`	1	--	us2k¹		1		WA	118
rs187110791^1,2		--	231576200(+)	`AACAGC/GAAGTC`	1	--	us2k¹		0	--	--	--	--
rs74920535^1,2	F	--	231576207(+)	`AGTCCT/GAACTT`	1	--	us2k¹		1		WA	118
rs192022843^1,2		--	231576221(+)	`TTGGTA/GGGGCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CAB39 (231577557 - 231685790 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for CAB39: About this table

Variant ID	Type	Subtype	PubMed ID
esv2674961	CNV	Deletion	23128226
esv2671712	CNV	Deletion	23128226
nsv834565	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CAB39

DNA2.0 Custom Variant and Variant Library Synthesis for CAB39

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612174 OMIM disorders: --

5 diseases for CAB39:
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polyhydramnios peutz-jeghers syndrome pancreatic cancer pancreatitis

malaria

1 disease from the University of Copenhagen DISEASES database for CAB39:

Peutz-Jeghers syndrome

CAB39 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for CAB39 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	5.42	1	15561763 (1)

Export disorders for CAB39 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CAB39 gene, integrated from 10 sources (see all 33):
(articles sorted by number of sources associating them with CAB39)

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PubMed id 19892943)^{1, 2} Zeqiraj E.... van Aalten D.M. (Science 2009)
Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PubMed id 14730349)^{1, 2} Milburn C.C.... van Aalten D.M. (Nat. Struct. Mol. Biol. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.-H.... Lin W.-C. (Genome Res. 2000)
Analysis of the LKB1-STRAD-MO25 complex. (PubMed id 15561763)^{1, 9} Boudeau J....Alessi D.R. (J. Cell. Sci. 2004)
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)^{1, 9} Lizcano J.M....Alessi D.R. (EMBO J. 2004)
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)^{1, 9} Boudeau J.... Alessi D.R. (EMBO J. 2003)
ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PubMed id 19513107)^{1, 9} Zeqiraj E....van Aalten D.M. (PLoS Biol. 2009)
LKB1 tumor suppressor protein: PARtaker in cell polarity. (PubMed id 15183188)^{1, 9} Baas A.F....Clevers H. (Trends Cell Biol. 2004)
VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)¹ Yu C.C....Chow L.P. (PLoS ONE 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51719	HGNC: 20292	AceView: CAB39	Ensembl:ENSG00000135932	euGenes: HUgn51719
ECgene: CAB39	Kegg: 51719	H-InvDB: CAB39

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CAB39	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CAB39 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CAB39 gene:
Search GeneIP for patents involving CAB39

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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CAB39 Gene

Calcium Binding Protein 39

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CAB39 Gene

Calcium Binding Protein 39

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