Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAB39 Gene

protein-coding   GIFtS: 58
GCID: GC02P231577

Calcium Binding Protein 39

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium Binding Protein 391 2
MO252 3
MO25alpha2 3
Calcium-Binding Protein 392
Protein Mo253

External Ids:    HGNC: 202921   Entrez Gene: 517192   Ensembl: ENSG000001359327   OMIM: 6121745   UniProtKB: Q9Y3763   

Export aliases for CAB39 gene to outside databases

Previous GC identifers: GC00U916965 GC02P231403 GC02P231285 GC02P223417


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CAB39 Gene: 
CAB39 (calcium binding protein 39) is a protein-coding gene. Diseases associated with CAB39 include polyhydramnios, and peutz-jeghers syndrome, and among its related super-pathways are Insulin receptor signalling cascade and Energy dependent regulation of mTOR by LKB1-AMPK. GO annotations related to this gene include protein kinase activator activity and protein serine/threonine kinase activity. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376
Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Gene Wiki entry for CAB39 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAB39 gene promoter:
         TBP   S8   FAC1   Pax-2   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAB39 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAB39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAB39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

CAB39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAB39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P231577:  view genomic region     (about GC identifiers)

Start:
231,577,557 bp from pter      End:
231,685,790 bp from pter
Size:
108,234 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376 (See protein sequence)
Recommended Name: Calcium-binding protein 39  
Size: 341 amino acids; 39869 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
catalytic activity
Subcellular location: Cytoplasm (Potential)
6/7 PDB 3D structures from and Proteopedia for CAB39 (see all 7):
1UPK (3D)        1UPL (3D)        2WTK (3D)        3GNI (3D)        4FZA (3D)        4FZD (3D)    

Explore the universe of human proteins at neXtProt for CAB39: NX_Q9Y376

Explore proteomics data for CAB39 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y376

  • CAB39 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAB39 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001124321.1  NP_001124322.1  NP_057373.1  

    ENSEMBL proteins: 
     ENSP00000258418   ENSP00000386642   ENSP00000386238  
    Reactome Protein details: Q9Y376
    Human Recombinant Protein Products for CAB39: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CAB39
    OriGene Protein Over-expression Lysate for CAB39
    OriGene MassSpec for CAB39 
    OriGene Custom Protein Services for CAB39
    GenScript Custom Purified and Recombinant Proteins Services for CAB39
    Novus Biologicals CAB39 Proteins
    Novus Biologicals CAB39 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CAB39
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    CAB39 for ontologies           About GeneDecksing



    CAB39 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CAB39 
    OriGene Antibodies for CAB39
    OriGene Custom Antibody Services for CAB39
    GenScript Custom Superior Antibodies Services for CAB39
    Novus Biologicals CAB39 Antibodies
    Abcam antibodies for CAB39
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CAB39
    LSBio Antibodies in human, mouse, rat for CAB39 

    Assay Products for CAB39: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAB39
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAB39
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013878 Mo25
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y376

    ProtoNet protein and cluster: Q9Y376

    1 Blocks protein domain: IPB013878 Mo25-like

    UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376
    Similarity: Belongs to the Mo25 family


    CAB39 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAB39_HUMAN, Q9Y376
    Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
    interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674contributes to protein serine/threonine kinase activity IDA19892943
    GO:0005488binding ----
    GO:0005515protein binding IPI14676191
    GO:0019900kinase binding IPI19892943
    GO:0030295protein kinase activator activity IDA19892943
         
    CAB39 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAB39:
     Increased cell number in G2M,   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAB39 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAB39

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAB39 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAB39 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAB39:
    hsa-mir-451 (MIRT000500)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAB39
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate CAB39 (see all 85):
    hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCAB39 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAB39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAB39
    Sirion Biotech Customized adenovirus for overexpression of CAB39

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CAB39 (see all 20)
    OriGene ORF clones in mouse, rat for CAB39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39
    Sirion Biotech Customized lentivirus for stable overexpression of CAB39 
                         Customized lentivirus expression plasmids for stable overexpression of CAB39 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAB39
    Search LifeMap BioReagents cell lines for CAB39
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAB39 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    2Energy dependent regulation of mTOR by LKB1-AMPK
    Energy dependent regulation of mTOR by LKB1-AMPK0.82
    mTOR signalling0.63
    Regulation of AMPK activity via LKB10.82
    PKB-mediated events0.61
    3Signaling by GPCR
    Signal Transduction0.55
    4Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    5LKB1 signaling events
    LKB1 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CAB39
        Glucose / Energy Metabolism

    4 BioSystems Pathways for CAB39
        AMPK signaling
    Endochondral Ossification
    Integrated Pancreatic Cancer Pathway
    LKB1 signaling events

    5/13        Reactome Pathways for CAB39 (see all 13)
        PI3K Cascade
    Regulation of AMPK activity via LKB1
    IGF1R signaling cascade
    mTOR signalling
    Energy dependent regulation of mTOR by LKB1-AMPK


    1         Kegg Pathway  (Kegg details for CAB39):
        mTOR signaling pathway


    CAB39 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAB39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for CAB39 (Q9Y3761, 2, 3 ENSP000002584184) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 2, 3, ENSP000003248564EBI-306905,EBI-306838 MINT-56667 MINT-56668 I2D: score=6 STRING: ENSP00000324856
    OXSR1O957472, 3, ENSP000003117134MINT-8186566 MINT-8186657 MINT-8186672 I2D: score=1 STRING: ENSP00000311713
    MST4Q9P2892, 3, ENSP000003778674MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000377867
    STK39Q9UEW82, 3, ENSP000003482784MINT-8186640 MINT-8186728 MINT-8186626 MINT-8186556 I2D: score=1 STRING: ENSP00000348278
    STRADAQ7RTN62, 3, ENSP000003366554MINT-8186774 MINT-8186758 MINT-8186742 I2D: score=3 STRING: ENSP00000336655
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0045860positive regulation of protein kinase activity IDA19892943

    CAB39 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAB39

    Search CenterWatch for drugs/clinical trials and news about CAB39

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAB39 gene (3 alternative transcripts): 
    NM_001130849.1  NM_001130850.1  NM_016289.3  

    Unigene Cluster for CAB39:

    Calcium binding protein 39
    Hs.603930  [show with all ESTs]
    Unigene Representative Sequence: NM_001130849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258418(uc002vqx.3 uc010fxr.3 uc010fxq.3 uc002vqy.3)
    ENST00000410084 ENST00000409788 ENST00000484398 ENST00000478152 ENST00000493540

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAB39
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate CAB39 (see all 85):
    hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCAB39 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAB39
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39
    Clone
    Products:
         
    OriGene clones in human, mouse for CAB39 (see all 20)
    OriGene ORF clones in mouse, rat for CAB39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39
    Sirion Biotech Customized lentivirus for stable overexpression of CAB39 
                         Customized lentivirus expression plasmids for stable overexpression of CAB39 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAB39
    OriGene qSTAR qPCR primer pairs in human, mouse for CAB39
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAB39
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAB39
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39

    Additional mRNA sequence: 

    AB073893.1 AF113536.1 AF134480.1 AF151824.1 AK000804.1 AK026335.1 AK292382.1 AK315692.1 
    BC020570.1 

    12 DOTS entries:

    DT.452018  DT.100822140  DT.95110075  DT.120962265  DT.120962298  DT.91706491  DT.95318837  DT.95362906 
    DT.120962272  DT.120962275  DT.86840836  DT.91757552 

    24/305 AceView cDNA sequences (see all 305):

    AA307914 AA255507 AA324907 AI590081 BM982100 CD251716 AV729226 BG289225 
    AW629742 AA748352 CA944579 BM711209 AA769550 AA961656 BU615412 AA584934 
    AA741258 BG679680 BM458866 AA255535 CD105997 AI932723 CF126779 BG259357 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAB39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCATTTT
    CAB39 Expression
    About this image


    See CAB39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAB39

    SOURCE GeneReport for Unigene cluster: Hs.603930
        SABiosciences Expression via Pathway-Focused PCR Array including CAB39: 
              mTOR Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CAB39
    OriGene qSTAR qPCR primer pairs in human, mouse for CAB39
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAB39
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAB39
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAB39 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cab391 , 5 calcium binding protein 391, 5 92.47(n)1
    99.12(a)1
      1 (43.94 cM)5
    122831  NM_133781.41  NP_598542.31 
     857934415 
    chicken
    (Gallus gallus)
    Aves CAB391 calcium binding protein 39 88.17(n)
    99.71(a)
      424830  XM_003641738.1  XP_003641786.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAB396
    Uncharacterized protein
    99(a)
    1 ↔ 1
    3(28160170-28230511)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.90722 Danio rerio mRNA similar to MO25 protein (cDNA clone more 73.38(n)    BC044172.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mo251 CG4083-PA 63.81(n)
    71.87(a)
      39858  NM_079393.2  NP_524117.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mop-25.11 Protein MOP-25.1 61.68(n)
    65.27(a)
      180685  NM_001029648.2  NP_001024819.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HYM1(YKL189W)4 Component of the RAM signaling network that is involved more   --   11(84704-85903) 853646  NP_012732.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G172701 putative MO25-like protein 52.38(n)
    44.68(a)
      827441  NM_117833.3  NP_193460.1 
    rice
    (Oryza sativa)
    Liliopsida NM_187000.12   -- 72.06(n)    NM_187000.1 


    ENSEMBL Gene Tree for CAB39 (if available)
    TreeFam Gene Tree for CAB39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAB39 gene
    CAB39L2  
    1 SIMAP similar gene for CAB39 using alignment to 2 protein entries:     CAB39_HUMAN (see all proteins):
    CAB39L

    CAB39 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CAB39
    PGOHUM00000235602


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2318 SNPs in CAB39 are shown (see all 2318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136142981,2
    C,F--231575924(+) GTCAGA/TCTGGT 1 -- us2k14Minor allele frequency- T:0.11WA CSA NA EA 244
    rs1904544431,2
    --231575998(+) GCGAGC/GCACCA 1 -- us2k10--------
    rs580640531,2
    F--231576004(+) CACCAC/TGCCCG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs621935991,2
    C,F--231576102(+) CCTCAT/CACCAC 1 -- us2k12Minor allele frequency- C:0.07NA 122
    rs1457125011,2
    --231576140(+) TTCCAA/CGTCCT 1 -- us2k10--------
    rs1822786131,2
    --231576180(+) CCCATA/CTCCTT 1 -- us2k10--------
    rs1163621521,2
    F--231576186(+) TCCTTG/CAGAGT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1871107911,2
    --231576200(+) AACAGC/GAAGTC 1 -- us2k10--------
    rs749205351,2
    F--231576207(+) AGTCCT/GAACTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1920228431,2
    --231576221(+) TTGGTA/GGGGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAB39 (231577557 - 231685790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CAB39:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674961CNV Deletion23128226
    esv2671712CNV Deletion23128226
    nsv834565CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CAB39
    DNA2.0 Custom Variant and Variant Library Synthesis for CAB39

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612174    OMIM disorders: --

    4 diseases for CAB39:    About MalaCards
    polyhydramnios    peutz-jeghers syndrome    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CAB39:
    Peutz-Jeghers syndrome

    CAB39 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CAB39 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.42 1 15561763 (1)


    Export disorders for CAB39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAB39 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CAB39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the LKB1-STRAD-MO25 complex reveals an a llosteric mechanism of kinase activation. (PubMed id 19892943)1, 2 Zeqiraj E....van Aalten D.M. (2009)
    2. Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PubMed id 14730349)1, 2 Milburn C.C.... van Aalten D.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    5. Analysis of the LKB1-STRAD-MO25 complex. (PubMed id 15561763)1, 9 Boudeau J....Alessi D.R. (2004)
    6. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 9 Lizcano J.M....Alessi D.R. (2004)
    7. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 9 Boudeau J.... Alessi D.R. (2003)
    8. ATP and MO25alpha regulate the conformational state o f the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PubMed id 19513107)1, 9 Zeqiraj E....van Aalten D.M. (2009)
    9. LKB1 tumor suppressor protein: PARtaker in cell polarity. (PubMed id 15183188)1, 9 Baas A.F....Clevers H. (2004)
    10. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51719 HGNC: 20292 AceView: CAB39 Ensembl:ENSG00000135932 euGenes: HUgn51719
    ECgene: CAB39 Kegg: 51719 H-InvDB: CAB39

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAB39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAB39 gene:
    Search GeneIP for patents involving CAB39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CAB39   OriGene RNAi products in human, mouse, rat for CAB39  
     OriGene qPCR primer pairs and template standards for CAB39   OriGene Protein Over-expression Lysate for CAB39  
     OriGene MassSpec something-or-other for CAB39   OriGene clones in human, mouse for CAB39  
     OriGene qSTAR qPCR primer pairs in human, mouse for CAB39   OriGene Purified Protein for CAB39  
     OriGene ORF clones in mouse, rat for CAB39   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CAB39   OriGene Custom Protein Services for CAB39  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAB39
     QIAGEN SeqTarget long-range PCR primers for resequencing CAB39
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAB39
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAB39
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAB39
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAB39
     GenScript Custom Purified and Recombinant Proteins Services for CAB39 GenScript cDNA clones with any tag delivered in your preferred vector for CAB39
     GenScript Custom Assay Services for CAB39 GenScript Custom Superior Antibodies Services for CAB39
     GenScript Custom overexpressing Cell Line Services for CAB39 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CAB39 

     Regulatory tfbs in CAB39 promoter
     Search Chromatin IP Primers for CAB39
     RT2 qPCR Primer Assay in human, mouse, rat CAB39
     GNC Network for CAB39
     SABiosciences PCR Arrays including human, mouse, rat CAB39
     Search Tocris compounds for CAB39
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CAB39 antibodies
     CAB39 proteins
     CAB39 lysates
     Antibodies for CAB39
     See all of Abcam's Antibodies, Kits and Proteins for CAB39
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CAB39




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CAB39
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39
     SwitchGear 3'UTR luciferase reporter plasmids for CAB39
     SwitchGear Promoter luciferase reporter plasmids for CAB39
     ThermoFisher Antibody for CAB39
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CAB39
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAB39
    Customized:
     lentivirus for stable overexpression of CAB39
     lentivirus expression plasmids for stable overexpression of CAB39
     adenovirus for overexpression of CAB39
     LSBio Antibodies in human, mouse, rat for CAB39
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CAB39 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4