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CAB39 Gene

protein-coding   GIFtS: 58
GCID: GC02P231577

Calcium Binding Protein 39

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Binding Protein 391 2
MO252 3
MO25alpha2 3
Calcium-Binding Protein 392
Protein Mo253

External Ids:    HGNC: 202921   Entrez Gene: 517192   Ensembl: ENSG000001359327   OMIM: 6121745   UniProtKB: Q9Y3763   

Export aliases for CAB39 gene to outside databases

Previous GC identifers: GC00U916965 GC02P231403 GC02P231285 GC02P223417


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAB39 Gene:
CAB39 (calcium binding protein 39) is a protein-coding gene. Diseases associated with CAB39 include polyhydramnios, and peutz-jeghers syndrome. GO annotations related to this gene include protein kinase activator activity and protein serine/threonine kinase activity. An important paralog of this gene is CAB39L.

UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376
Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

Gene Wiki entry for CAB39 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAB39 gene promoter:
         TBP   S8   FAC1   Pax-2   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAB39 promoter sequence
   Search Chromatin IP Primers for CAB39

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAB39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

CAB39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAB39 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P231577:  view genomic region     (about GC identifiers)

Start:
231,577,557 bp from pter      End:
231,685,790 bp from pter
Size:
108,234 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376 (See protein sequence)
Recommended Name: Calcium-binding protein 39  
Size: 341 amino acids; 39869 Da
Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25
(CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
catalytic activity
Selected PDB 3D structures from and Proteopedia for CAB39 (see all 7):
1UPK (3D)        1UPL (3D)        2WTK (3D)        3GNI (3D)        4FZA (3D)        4FZD (3D)    
Secondary accessions: A8K8L7

Explore the universe of human proteins at neXtProt for CAB39: NX_Q9Y376

Explore proteomics data for CAB39 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys301
  • Modification sites at PhosphoSitePlus

  • See CAB39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124321.1  NP_001124322.1  NP_057373.1  

    ENSEMBL proteins: 
     ENSP00000258418   ENSP00000386642   ENSP00000386238  
    Reactome Protein details: Q9Y376

    CAB39 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CAB39
    OriGene MassSpec for CAB39
    OriGene Custom Protein Services for CAB39
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    Novus Biologicals CAB39 Proteins
    Novus Biologicals CAB39 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CAB39
    Browse Proteins at Cloud-Clone Corp.

    CAB39 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for CAB39

    CAB39 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013878 Mo25
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y376

    ProtoNet protein and cluster: Q9Y376

    1 Blocks protein domain: IPB013878 Mo25-like

    UniProtKB/Swiss-Prot: CAB39_HUMAN, Q9Y376
    Similarity: Belongs to the Mo25 family


    CAB39 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAB39_HUMAN, Q9Y376
    Function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the
    interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674contributes to protein serine/threonine kinase activity IDA19892943
    GO:0005488binding ----
    GO:0005515protein binding IPI14676191
    GO:0019900kinase binding IPI19892943
    GO:0030295protein kinase activator activity IDA19892943
         
    CAB39 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAB39:
     Increased cell number in G2M,   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAB39
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAB39

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAB39
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAB39

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAB39:
    hsa-mir-195-5p (MIRT007054), hsa-mir-451a (MIRT000500), hsa-mir-877-5p (MIRT037258), hsa-mir-155-5p (MIRT020562), hsa-mir-375 (MIRT019792)

    Block miRNA regulation of human, mouse, rat CAB39 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAB39 (see all 85):
    hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCAB39 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAB39
    Predesigned siRNA for gene silencing in human, mouse, rat CAB39

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAB39

    Clone
    Products:
         
    OriGene clones in human, mouse for CAB39 (see all 18)
    OriGene ORF clones in mouse, rat for CAB39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CAB39
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAB39 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAB39_HUMAN, Q9Y376: Cytoplasm (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0043234protein complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CAB39 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAB39 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    PI3K Cascade0.87
    IRS-related events0.94
    Signaling by Insulin receptor0.80
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PKB-mediated events0.41
    IRS-mediated signalling0.92
    mTOR signalling0.39
    2Signaling by GPCR
    Signal Transduction0.58
    3Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    4LKB1 signaling events
    LKB1 signaling events
    5Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CAB39
        AMPK Enzyme Complex Pathway

    1 Cell Signaling Technology (CST) Pathway for CAB39
        Glucose / Energy Metabolism

    4 BioSystems Pathways for CAB39
        AMPK signaling
    Endochondral Ossification
    Integrated Pancreatic Cancer Pathway
    LKB1 signaling events

    1 Reactome Pathway for CAB39
        Regulation of AMPK activity via LKB1


    1 Kegg Pathway  (Kegg details for CAB39):
        mTOR signaling pathway


    CAB39 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CAB39: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CAB39

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAB39 (Q9Y3761, 2, 3 ENSP000002584184) via UniProtKB, MINT, STRING, and/or I2D (see all 205)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK39Q9UEW81, 2, 3, ENSP000003482784EBI-306905,EBI-2680974 MINT-8186640 MINT-8186728 MINT-8186626 MINT-8186556 I2D: score=1 STRING: ENSP00000348278
    STK25O005061, 2, 3, ENSP000003257484EBI-306905,EBI-618295 MINT-8186866 MINT-8186834 MINT-8186850 I2D: score=1 STRING: ENSP00000325748
    STRADBQ9C0K71, 3, ENSP000001945304EBI-306905,EBI-306893 I2D: score=2 STRING: ENSP00000194530
    MST4Q9P2891, 2, 3, ENSP000003778674EBI-306905,EBI-618239 MINT-8186588 MINT-8186788 MINT-8186577 MINT-8186607 MINT-8186820 MINT-8186804 I2D: score=1 STRING: ENSP00000377867
    STRADAQ7RTN61, 2, 3, ENSP000003366554EBI-306905,EBI-1109114 MINT-8186774 MINT-8186758 MINT-8186742 I2D: score=3 STRING: ENSP00000336655
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA19892943
    GO:0007050cell cycle arrest TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0032147activation of protein kinase activity IEA--
    GO:0045860positive regulation of protein kinase activity ----

    CAB39 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAB39



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAB39 gene (3 alternative transcripts): 
    NM_001130849.1  NM_001130850.1  NM_016289.3  

    Unigene Cluster for CAB39:

    Calcium binding protein 39
    Hs.603930  [show with all ESTs]
    Unigene Representative Sequence: NM_001130849
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258418(uc002vqx.3 uc010fxr.3 uc010fxq.3 uc002vqy.3)
    ENST00000410084 ENST00000409788 ENST00000484398 ENST00000478152 ENST00000493540

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAB39 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAB39 (see all 85):
    hsa-miR-548j hsa-miR-3194-5p hsa-miR-300 hsa-miR-15a hsa-miR-4275 hsa-miR-4274 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCAB39 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAB39
    Clone
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    OriGene clones in human, mouse for CAB39 (see all 18)
    OriGene ORF clones in mouse, rat for CAB39
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CAB39 (NM_001130849)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAB39
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAB39
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAB39
    OriGene qSTAR qPCR primer pairs in human, mouse for CAB39
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAB39
      QuantiTect SYBR Green Assays in human, mouse, rat CAB39
      QuantiFast Probe-based Assays in human, mouse, rat CAB39

    Additional mRNA sequence: 

    AB073893.1 AF113536.1 AF134480.1 AF151824.1 AK000804.1 AK026335.1 AK292382.1 AK315692.1 
    BC020570.1 

    12 DOTS entries:

    DT.452018  DT.100822140  DT.95110075  DT.120962265  DT.120962298  DT.91706491  DT.95318837  DT.95362906 
    DT.120962272  DT.120962275  DT.86840836  DT.91757552 

    Selected AceView cDNA sequences (see all 305):

    BM982100 AA307914 BM458866 AA741258 AA584934 BU615412 AA961656 CA393940 
    AA280522 AA936676 AI796239 CD105997 BM927264 CR597291 BG679680 BU429359 
    BQ433038 BM711209 CA944579 AA748352 AI590081 AA324907 AA769550 AI350893 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAB39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCATTTT
    CAB39 Expression
    About this image

    CAB39 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAB39 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.603930
        Pathway & Disease-focused RT2 Profiler PCR Array including CAB39: 
              mTOR Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CAB39
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAB39
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    QuantiFast Probe-based Assays in human, mouse, rat CAB39
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAB39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAB39 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cab391 , 5 calcium binding protein 391, 5 92.47(n)1
    99.12(a)1
      1 (43.94 cM)5
    122831  NM_133781.41  NP_598542.31 
     857934415 
    chicken
    (Gallus gallus)
    Aves CAB391 calcium binding protein 39 88.17(n)
    99.71(a)
      424830  XM_003641738.2  XP_003641786.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAB396
    calcium binding protein 39
    99(a)
    1 ↔ 1
    3(28160170-28230511)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004865691 calcium-binding protein 39-like 80.45(n)
    98.53(a)
      100486569  XM_002933348.2  XP_002933394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.90722 Danio rerio mRNA similar to MO25 protein (cDNA clone more 73.38(n)    BC044172.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mo251 Mo25 63.84(n)
    71.82(a)
      39858  NM_079393.2  NP_524117.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mop-25.11 mop-25.1 61.68(n)
    65.27(a)
      180685  NM_001029648.3  NP_001024819.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HYM1(YKL189W)4 Component of the RAM signaling network that is involved more   --   11(84704-85903) 853646  NP_012732.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G172701 AT4G17270 52.38(n)
    44.68(a)
      827441  NM_117833.3  NP_193460.1 
    rice
    (Oryza sativa)
    Liliopsida NM_187000.12   -- 72.06(n)    NM_187000.1 


    ENSEMBL Gene Tree for CAB39 (if available)
    TreeFam Gene Tree for CAB39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAB39 gene
    CAB39L2  
    1 SIMAP similar gene for CAB39 using alignment to 1 protein entry:     CAB39_HUMAN:
    CAB39L

    CAB39 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CAB39
    PGOHUM00000235602


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAB39 (see all 2318)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1136142981,2
    C,F--231575924(+) GTCAGA/TCTGGT 1 -- us2k14Minor allele frequency- T:0.11WA CSA NA EA 244
    rs1904544431,2
    --231575998(+) GCGAGC/GCACCA 1 -- us2k10--------
    rs580640531,2
    F--231576004(+) CACCAC/TGCCCG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs621935991,2
    C,F--231576102(+) CCTCAT/CACCAC 1 -- us2k12Minor allele frequency- C:0.07NA 122
    rs1457125011,2
    --231576140(+) TTCCAA/CGTCCT 1 -- us2k10--------
    rs1822786131,2
    --231576180(+) CCCATA/CTCCTT 1 -- us2k10--------
    rs1163621521,2
    F--231576186(+) TCCTTG/CAGAGT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1871107911,2
    --231576200(+) AACAGC/GAAGTC 1 -- us2k10--------
    rs749205351,2
    F--231576207(+) AGTCCT/GAACTT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1920228431,2
    --231576221(+) TTGGTA/GGGGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAB39 (231577557 - 231685790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CAB39:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674961CNV Deletion23128226
    esv2671712CNV Deletion23128226
    nsv834565CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612174    OMIM disorders: --

    5 diseases for CAB39:    
    About MalaCards
    polyhydramnios    peutz-jeghers syndrome    pancreatic cancer    pancreatitis
    malaria

    1 disease from the University of Copenhagen DISEASES database for CAB39:
    Peutz-Jeghers syndrome

    CAB39 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CAB39 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.42 1 15561763 (1)


    Export disorders for CAB39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAB39 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with CAB39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. (PubMed id 19892943)1, 2 Zeqiraj E.... van Aalten D.M. (Science 2009)
    2. Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor. (PubMed id 14730349)1, 2 Milburn C.C.... van Aalten D.M. (Nat. Struct. Mol. Biol. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    5. Analysis of the LKB1-STRAD-MO25 complex. (PubMed id 15561763)1, 9 Boudeau J....Alessi D.R. (J. Cell. Sci. 2004)
    6. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 9 Lizcano J.M....Alessi D.R. (EMBO J. 2004)
    7. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. (PubMed id 14517248)1, 9 Boudeau J.... Alessi D.R. (EMBO J. 2003)
    8. ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. (PubMed id 19513107)1, 9 Zeqiraj E....van Aalten D.M. (PLoS Biol. 2009)
    9. LKB1 tumor suppressor protein: PARtaker in cell polarity. (PubMed id 15183188)1, 9 Baas A.F....Clevers H. (Trends Cell Biol. 2004)
    10. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51719 HGNC: 20292 AceView: CAB39 Ensembl:ENSG00000135932 euGenes: HUgn51719
    ECgene: CAB39 Kegg: 51719 H-InvDB: CAB39

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAB39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CAB39 gene:
    Search GeneIP for patents involving CAB39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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