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Aliases for CAAP1 Gene

Aliases for CAAP1 Gene

  • Caspase Activity And Apoptosis Inhibitor 1 2 3
  • Conserved Anti-Apoptotic Protein 2 3 4
  • C9orf82 3 4
  • CAAP 3 4
  • Chromosome 9 Open Reading Frame 82 2

External Ids for CAAP1 Gene

Previous Symbols for CAAP1 Gene

  • C9orf82

Summaries for CAAP1 Gene

GeneCards Summary for CAAP1 Gene

CAAP1 (Caspase Activity And Apoptosis Inhibitor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CAAP1 Gene

  • Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.

Gene Wiki entry for CAAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAAP1 Gene

Genomics for CAAP1 Gene

Genomic Location for CAAP1 Gene

Start:
26,840,685 bp from pter
End:
26,892,828 bp from pter
Size:
52,144 bases
Orientation:
Minus strand

Genomic View for CAAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAAP1 Gene

No data available for Regulatory Elements for CAAP1 Gene

Proteins for CAAP1 Gene

  • Protein details for CAAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8G2-CAAP1_HUMAN
    Recommended name:
    Caspase activity and apoptosis inhibitor 1
    Protein Accession:
    Q9H8G2
    Secondary Accessions:
    • B4DWT4
    • D3DRK4
    • Q5VY32
    • Q6IPE6
    • Q96C59

    Protein attributes for CAAP1 Gene

    Size:
    361 amino acids
    Molecular mass:
    38368 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAAP1 Gene

Proteomics data for CAAP1 Gene at MOPED

Post-translational modifications for CAAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAAP1 Gene

No data available for DME Specific Peptides for CAAP1 Gene

Domains for CAAP1 Gene

Protein Domains for CAAP1 Gene

ProtoNet:
genes like me logo Genes that share domains with CAAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CAAP1 Gene

Function for CAAP1 Gene

Molecular function for CAAP1 Gene

UniProtKB/Swiss-Prot Function: Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.

miRNA for CAAP1 Gene

miRTarBase miRNAs that target CAAP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAAP1 Gene

Localization for CAAP1 Gene

No data available for Gene Ontology (GO) - Cellular Components for CAAP1 Gene

Pathways for CAAP1 Gene

SuperPathways for CAAP1 Gene

No Data Available

Interacting Proteins for CAAP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369431%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000369431 Q9H8G2-CAAP1_HUMAN for CAAP1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CAAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with CAAP1: view

No data available for Pathways by source for CAAP1 Gene

Transcripts for CAAP1 Gene

Unigene Clusters for CAAP1 Gene

Caspase activity and apoptosis inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3: -

Relevant External Links for CAAP1 Gene

GeneLoc Exon Structure for
CAAP1
ECgene alternative splicing isoforms for
CAAP1

Expression for CAAP1 Gene

mRNA expression in normal human tissues for CAAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CAAP1 Gene

SOURCE GeneReport for Unigene cluster for CAAP1 Gene Hs.178357

mRNA Expression by UniProt/SwissProt for CAAP1 Gene

Q9H8G2-CAAP1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with CAAP1: view

Orthologs for CAAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAAP1 36
  • 99.45 (n)
  • 99.17 (a)
CAAP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAAP1 36
  • 88.37 (n)
  • 90.58 (a)
CAAP1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAAP1 36
  • 92.52 (n)
  • 92.8 (a)
CAAP1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Caap1 36
  • 82.35 (n)
  • 80.29 (a)
Caap1 16
Caap1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAAP1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAAP1 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Caap1 36
  • 87.61 (n)
  • 85.26 (a)
chicken
(Gallus gallus)
Aves CAAP1 37
  • 70 (a)
OneToOne
CZH9ORF82 36
  • 75.49 (n)
  • 75.1 (a)
lizard
(Anolis carolinensis)
Reptilia CAAP1 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6753 36
tropical clawed frog
(Silurana tropicalis)
Amphibia caap1 36
  • 66.25 (n)
  • 63.18 (a)
Str.10787 36
zebrafish
(Danio rerio)
Actinopterygii FP236812.4 37
  • 46 (a)
OneToOne
LOC100329847 36
  • 62.09 (n)
  • 56.19 (a)
Species with no ortholog for CAAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAAP1 Gene

ENSEMBL:
Gene Tree for CAAP1 (if available)
TreeFam:
Gene Tree for CAAP1 (if available)

Paralogs for CAAP1 Gene

No data available for Paralogs for CAAP1 Gene

Variants for CAAP1 Gene

Sequence variations from dbSNP and Humsavar for CAAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs869057 -- 26,861,605(-) GATTA(C/T)ATATG intron-variant
rs1011358 -- 26,848,907(+) TAAAT(G/T)TTTTT intron-variant
rs1336332 -- 26,843,344(-) GTGGT(C/T)GAGAA intron-variant
rs1414797 -- 26,864,937(-) ATGTA(A/G)AATGT intron-variant
rs1414799 -- 26,888,548(+) GTCAG(C/T)TTTAA intron-variant

Relevant External Links for CAAP1 Gene

HapMap Linkage Disequilibrium report
CAAP1

No data available for Structural Variations from Database of Genomic Variants (DGV) for CAAP1 Gene

Disorders for CAAP1 Gene

No disorders were found for CAAP1 Gene.

No data available for UniProtKB/Swiss-Prot for CAAP1 Gene

Publications for CAAP1 Gene

  1. Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. (PMID: 21980415) Zhang Y. … Anderson M.W. (PLoS ONE 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for CAAP1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CAAP1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CAAP1
    • Block miRNA regulation of CAAP1 using miScript Target Protectors

    Sources for CAAP1 Gene

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