Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAAP1 Gene

Aliases for CAAP1 Gene

  • Caspase Activity And Apoptosis Inhibitor 1 2 3 5
  • Conserved Anti-Apoptotic Protein 2 3 4
  • C9orf82 3 4
  • CAAP 3 4
  • Chromosome 9 Open Reading Frame 82 2

External Ids for CAAP1 Gene

Previous HGNC Symbols for CAAP1 Gene

  • C9orf82

Summaries for CAAP1 Gene

GeneCards Summary for CAAP1 Gene

CAAP1 (Caspase Activity And Apoptosis Inhibitor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CAAP1 Gene

  • Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.

Gene Wiki entry for CAAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAAP1 Gene

Genomics for CAAP1 Gene

Regulatory Elements for CAAP1 Gene

Enhancers for CAAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G026945 1.4 FANTOM5 ENCODE 27.4 -54.0 -54005 3.0 HDGF FOXA2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 CAAP1 IFT74 PLAA RN7SL100P
GH09G026953 1.4 FANTOM5 ENCODE 27.1 -62.9 -62942 3.9 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF207 ZNF263 SP3 IFT74 CAAP1 LRRC19 IFT74-AS1 PLAA
GH09G026949 0.8 ENCODE 27.6 -57.2 -57186 1.1 TBP NFIB TAF1 JUN RFX5 GTF3C2 GATA3 POLR3A ZNF366 FOS CAAP1 IFT74 LRRC19 PLAA IFT74-AS1
GH09G026974 0.9 Ensembl ENCODE 15 -83.4 -83350 3.0 CTCF ZNF654 PHF8 MXI1 TEAD4 CHD1 RBBP5 KDM5A RAD21 HDAC2 IFT74 LRRC19 CAAP1 PLAA IFT74-AS1
GH09G027085 0.8 Ensembl ENCODE 11.3 -195.4 -195436 4.8 ZFHX2 ZNF133 FOS MAFK EGR2 TEK CAAP1 EQTN IFT74 LRRC19 ENSG00000254396
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAAP1 on UCSC Golden Path with GeneCards custom track

Promoters for CAAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234125 828 2401 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1

Genomic Location for CAAP1 Gene

Chromosome:
9
Start:
26,840,685 bp from pter
End:
26,892,828 bp from pter
Size:
52,144 bases
Orientation:
Minus strand

Genomic View for CAAP1 Gene

Genes around CAAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAAP1 Gene

Proteins for CAAP1 Gene

  • Protein details for CAAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8G2-CAAP1_HUMAN
    Recommended name:
    Caspase activity and apoptosis inhibitor 1
    Protein Accession:
    Q9H8G2
    Secondary Accessions:
    • B4DWT4
    • D3DRK4
    • Q5VY32
    • Q6IPE6
    • Q96C59

    Protein attributes for CAAP1 Gene

    Size:
    361 amino acids
    Molecular mass:
    38368 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAAP1 Gene

Post-translational modifications for CAAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAAP1 Gene

No data available for DME Specific Peptides for CAAP1 Gene

Domains & Families for CAAP1 Gene

Protein Domains for CAAP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CAAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CAAP1 Gene

Function for CAAP1 Gene

Molecular function for CAAP1 Gene

UniProtKB/Swiss-Prot Function:
Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.
genes like me logo Genes that share phenotypes with CAAP1: view

Animal Model Products

CRISPR Products

miRNA for CAAP1 Gene

miRTarBase miRNAs that target CAAP1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAAP1 Gene

Localization for CAAP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAAP1 gene
Compartment Confidence
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CAAP1 Gene

Pathways & Interactions for CAAP1 Gene

SuperPathways for CAAP1 Gene

No Data Available

Interacting Proteins for CAAP1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369431%0d%0a9606.ENSP00000358622%0d%0a9606.ENSP00000261600%0d%0a
Selected Interacting proteins: ENSP00000369431 Q9H8G2-CAAP1_HUMAN for CAAP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CAAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with CAAP1: view

No data available for Pathways by source and SIGNOR curated interactions for CAAP1 Gene

Drugs & Compounds for CAAP1 Gene

No Compound Related Data Available

Transcripts for CAAP1 Gene

Unigene Clusters for CAAP1 Gene

Caspase activity and apoptosis inhibitor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3: -

Relevant External Links for CAAP1 Gene

GeneLoc Exon Structure for
CAAP1
ECgene alternative splicing isoforms for
CAAP1

Expression for CAAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAAP1 Gene

Protein differential expression in normal tissues from HIPED for CAAP1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAAP1 Gene



Protein tissue co-expression partners for CAAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAAP1 Gene:

CAAP1

SOURCE GeneReport for Unigene cluster for CAAP1 Gene:

Hs.178357

mRNA Expression by UniProt/SwissProt for CAAP1 Gene:

Q9H8G2-CAAP1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CAAP1 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CAAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAAP1 Gene

Orthologs for CAAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAAP1 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia CAAP1 34 35
  • 92.52 (n)
cow
(Bos Taurus)
Mammalia CAAP1 34 35
  • 88.37 (n)
rat
(Rattus norvegicus)
Mammalia Caap1 34
  • 87.61 (n)
mouse
(Mus musculus)
Mammalia Caap1 34 16 35
  • 82.35 (n)
oppossum
(Monodelphis domestica)
Mammalia CAAP1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAAP1 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF82 34
  • 75.49 (n)
CAAP1 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAAP1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia caap1 34
  • 66.25 (n)
Str.10787 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6753 34
zebrafish
(Danio rerio)
Actinopterygii LOC100329847 34
  • 62.09 (n)
FP236812.4 35
  • 46 (a)
OneToOne
Species where no ortholog for CAAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAAP1 Gene

ENSEMBL:
Gene Tree for CAAP1 (if available)
TreeFam:
Gene Tree for CAAP1 (if available)

Paralogs for CAAP1 Gene

No data available for Paralogs for CAAP1 Gene

Variants for CAAP1 Gene

Sequence variations from dbSNP and Humsavar for CAAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000009285 -- 26,892,005(+) GTTTA(A/T)CTTCT intron-variant
rs1000020392 -- 26,850,467(+) GAAAA(C/G)CCCAT intron-variant
rs1000040166 -- 26,861,410(+) CTCCC(G/T)TACAA intron-variant
rs1000117647 -- 26,884,895(+) TAAAT(C/G)AAAGA intron-variant
rs1000138460 -- 26,867,077(+) GATCT(C/T)GGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAAP1 Gene

Variant ID Type Subtype PubMed ID
esv3620120 CNV loss 21293372
esv3891647 CNV gain 25118596
nsv1015259 CNV gain 25217958
nsv1026827 CNV gain 25217958
nsv982204 CNV duplication 23825009

Variation tolerance for CAAP1 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAAP1 Gene

Disorders for CAAP1 Gene

Relevant External Links for CAAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAAP1

No disorders were found for CAAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAAP1 Gene

Publications for CAAP1 Gene

  1. Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. (PMID: 21980415) Zhang Y. … Anderson M.W. (PLoS ONE 2011) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CAAP1 Gene

Sources for CAAP1 Gene

Content
Loading form....