Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA7 Gene

protein-coding   GIFtS: 59
GCID: GC16P066880

carbonic anhydrase VII

 Explore 4 diseases affiliated with
CA7 via our new
 Human Malady Compendium 
Biological research products
for CA7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Carbonic Anhydrase VII1 2 3     CAVII2
Carbonate Dehydratase VII2 3     Carbonic Anhydrase 72
CA-VII2 3     Carbonic Dehydratase VII2
EC 4.2.1.13 8     

External Ids:    HGNC: 13811   Entrez Gene: 7662   Ensembl: ENSG000001687487   OMIM: 1147705   UniProtKB: P431663   

Export aliases for CA7 gene to outside databases

Previous GC identifers: GC16P057573 GC16P067256 GC16P066613 GC16P066654 GC16P065435 GC16P052752


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA7:
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.
They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone
resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive
diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is
predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAH7_HUMAN, P43166
Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA7 gene promoter:
         RFX1   Tal-1   p53   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066880:  view genomic region     (about GC identifiers)

Start:
66,878,282 bp from pter      End:
66,888,056 bp from pter
Size:
9,775 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAH7_HUMAN, P43166 (See protein sequence)
Recommended Name: Carbonic anhydrase 7  
Size: 264 amino acids; 29658 Da
Cofactor: Zinc
Subcellular location: Cytoplasm (Probable)
2 PDB 3D structures from and Proteopedia for CA7:
3MDZ (3D)        3ML5 (3D)    
Secondary accessions: Q541F0 Q86YU0
Alternative splicing: 2 isoforms:  P43166-1   P43166-2   

Explore the universe of human proteins at neXtProt for CA7: NX_P43166

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43166

  • 4/5 DME Specific Peptides for CA7 (P43166) (see all 5)
     QFHFHWG  TYPGSLT  RPPQPLK  GSLTTPPL 

    CA7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014435.1  NP_005173.1  

    ENSEMBL proteins: 
     ENSP00000345659   ENSP00000447178   ENSP00000377632  
    Reactome Protein details: P43166
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CA7 (Carbonic Anhydrase VII/CA7)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CA7
    OriGene Protein Over-expression Lysate: CA7
    OriGene Custom Protein Services for CA7 
    GenScript Custom Purified and Recombinant Proteins Services for CA7
    Novus Biologicals CA7 Protein
    Novus Biologicals CA7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CA7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    CA7 for ontologies           About GeneDecksing



    CA7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CA7 
    GenScript Custom Superior Antibodies Services for CA7
    Novus Biologicals CA7 Antibodies
    Search for Antibodies for CA7 at Abcam  
    Uscn Antibodies for CA7
    ThermoFisher Antibody for CA7

    Assay Products for CA7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CA7
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CA7


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CA7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class
     IPR018438 Carbonic_anhydrase_CA7

    Graphical View of Domain Structure for InterPro Entry P43166

    ProtoNet protein and cluster: P43166

    1 Blocks protein family: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH7_HUMAN, P43166
    Similarity: Belongs to the alpha-carbonic anhydrase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CAH7_HUMAN, P43166
    Function: Reversible hydration of carbon dioxide
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited
    coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium
    salt)

         Genatlas biochemistry entry for CA7:
    carbonic anhydrase VII,cytosolic,salivary glands

    Enzyme Number (IUBMB): EC 4.2.1.11 2

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA7
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CA7 (see all 38):
    hsa-miR-194* hsa-miR-1224-3p hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-766 hsa-miR-449a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCA7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA7 (see all 7)
    OriGene shRNA RFP: CA7
    OriGene siRNA: CA7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CA7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA7 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CA7 (NM_005182)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CA7
    Search LifeMap BioReagents cell lines for CA7

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA7

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0008270zinc ion binding IEA--


    CA7 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Reversible Hydration of Carbon Dioxide
    Reversible Hydration of Carbon Dioxide1.00
    Nitrogen metabolism0.52
    2Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CA7
        Reversible Hydration of Carbon Dioxide
    Metabolism


    1         Kegg Pathway  (Kegg details for CA7):
        Nitrogen metabolism


    CA7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CA7

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--


    CA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CA7

    4 HMDB Compounds for CA7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    5 DrugBank Compounds for CA7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    AcetazolamideAcetamidothiadiazolesulfonamide (see all 7)59-66-5targetinhibitor18336310
    Dichlorphenamide4,5-Dicholorobenzene-1,3-disulfonamide (see all 7)120-97-8targetinhibitor18336310
    Ethoxzolamide6-Ethoxy-1,3-benzothiazole-2-sulfonamide (see all 4)452-35-7targetinhibitor18336310
    Methazolamide-- 554-57-4targetinhibitor18336310

    Search CenterWatch for drugs/clinical trials and news about CA7 / CAH7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CA7 gene (2 alternative transcripts): 
    NM_001014435.1  NM_005182.2  

    Unigene Cluster for CA7:

    Carbonic anhydrase VII
    Hs.37014  [show with all ESTs]
    Unigene Representative Sequence: AY075020
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338437(uc002eqi.3) ENST00000548332 ENST00000394069(uc002eqj.3)


    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA7
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CA7 (see all 38):
    hsa-miR-194* hsa-miR-1224-3p hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-766 hsa-miR-449a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCA7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA7 (see all 7)
    OriGene shRNA RFP: CA7
    OriGene siRNA: CA7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA7
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA7 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA7 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CA7 (NM_005182)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA7 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA7

    Additional cDNA sequence: 

    AY075019.1 AY075020.1 BC033865.1 

    3 DOTS entries:

    DT.454288  DT.95263253  DT.95263252 

    19 AceView cDNA sequences:

    BI752037 AY075019 BC033865 AY075020 BI758664 BM988252 N78377 NM_005182 
    BM987669 BI820671 BI760583 BM987921 BI819404 BI457808 N62608 BI753786 
    BI599872 AW001212 BX279833 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CA7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:        -                                             
    SP2:                                                      
    SP3:                    -                                 
    SP4:                    -                                 


    ECgene alternative splicing isoforms for CA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAACAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CA7

    SOURCE GeneReport for Unigene cluster: Hs.37014
        SABiosciences Custom PCR Arrays for CA7
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CA7 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CA71 carbonic anhydrase VII 70.71(n)
    76.52(a)
      415791  XM_414152.3  XP_414152.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.82092 Xenopus laevis transcribed sequence with weak similarity to protein pirCRHU7 (H.sapiens) CRHU7 carbonate dehydratase (EC 4.2.1.1) VII - human less 71.96(n)    BJ625262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733852 hypothetical protein MGC73385 74.78(n)   393786  BC049309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CAH11 , 3 carbonate dehydratase3
    Carbonic anhydrase 11
    46(a)
    (best of 4)3
    57.14(n)1
    49.21(a)1
      34D43
    347861  NM_078837.31  NP_523561.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cah-31 , 3 carbonic anhydrase3
    Protein CAH-31
    36(a)3
    51.27(n)1
    40.68(a)1
      X(16518334-16519911)3
    1817131  NM_078273.51  NP_510674.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATACA26
    ACA16
    (see all 8)
    carbonic anhydrase
    (see all 8)
    24(a)
    24(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    2(12029997-12032420)
    3(19538690-19541284)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 10)
    bifunctional monodehydroascorbate reductase and ca...
    bifunctional monodehydroascorbate reductase and ca...
    (see all 10)
    26(a)
    24(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    11(2485289-2485837)
    12(2642977-2644316)


    ENSEMBL Gene Tree for CA7 (if available)
    TreeFam Gene Tree for CA7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CA7 gene
    CA22  CA122  CA62  CA32  CA112  CA5B2  CA142  CA5A2  
    CA82  CA42  CA12  CA92  CA132  CA102  
    16 SIMAP similar genes for CA7 using alignment to 2 protein entries:     CAH7_HUMAN (see all proteins):
    CA3    CA2    CA13    CA5B    CA1    CA5A
    CA8    CA10    CA6    DKFZp686I20267    CA12    CA14
    CA11    PTPRZ1    PTPRG    CA4

    CA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 NCBI SNPs in CA7 are shown (see all 167    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37599961,2
    C,F,H,--66876300(+) CTTTGT/CCTTCT 1 -- us2k111Minor allele frequency- C:0.08EA NS NA 2356
    rs1401957631,2
    --66876454(+) TCCTGC/TTCCTG 1 -- us2k10--------
    rs1912887981,2
    --66876470(+) GAGAGA/GGCCAT 1 -- us2k10--------
    rs1842557611,2
    --66876492(+) TGGGCA/GGTCAC 1 -- us2k10--------
    rs1887813191,2
    --66876739(+) AGGACC/TCCGGG 1 -- us2k10--------
    rs1812326691,2
    --66876775(+) CCACCC/TCTCTG 1 -- us2k10--------
    rs1424423221,2
    --66876830(+) CCCTCG/TCCCTG 1 -- us2k10--------
    rs37850941,2
    C,F,--66876941(+) CTCGTG/AGGTGG 2 -- us2k1 int1 tfbs31Minor allele frequency- A:0.03EA 120
    rs1853218151,2
    --66877051(+) GGGACA/GAACAG 2 -- int1 us2k10--------
    rs585360461,2
    F,--66877282(+) GCATCT/CACCCC 2 -- us2k1 int11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for CA7 (66878282 - 66888056 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CA7: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA7
    DNA2.0 Custom Variant and Variant Library Synthesis for CA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CA7 for disorders           About GeneDecksing

    OMIM gene information: 114770    OMIM disorders: --

    4 diseases for CA7:    About MalaCards
    north american indian childhood cirrhosis    insulin resistance    glaucoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CA7:
    Colorectal cancer

    Export disorders for CA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CA7 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with CA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. (PubMed id 1783392)1, 2, 3, 9 Montgomery J.C....Tashian R.E. (1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    4. Analysis of a shortened form of human carbonic anhydr ase VII expressed in vitro compared to the full-length enzyme. (PubMed id 20493921)1 Bootorabi F....Parkkila S. (2010)
    5. Which carbonic anhydrases are targeted by the antiepi leptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (2009)
    6. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)2 Maresca A.... Supuran C.T. (2009)
    7. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)2 Crocetti L.... Supuran C.T. (2009)
    8. Carbonic anhydrase inhibitors as emerging drugs for t he treatment of obesity. (PubMed id 18537527)7 Supuran C.T....De Simone G. (2008)
    9. The development of topically acting carbonic anhydras e inhibitors as antiglaucoma agents. (PubMed id 18336310)7 Mincione F....Supuran C.T. (2008)
    10. Therapeutic role of zonisamide in neuropsychiatric disorders. (PubMed id 18782051)7 Farooq M.U....Kassab M.Y. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 766 HGNC: 1381 AceView: CA7 Ensembl:ENSG00000168748 euGenes: HUgn766
    ECgene: CA7 Kegg: 766 H-InvDB: CA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CA7 gene:
    Search GeneIP for patents involving CA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CA7 (Carbonic Anhydrase VII/CA7)  
     Browse OriGene Antibodies   OriGene shRNA RFP for CA7  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA7   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA7  
     OriGene Protein Over-expression Lysate for CA7   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CA7   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA7   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA7  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CA7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CA7   OriGene Custom Protein Services for CA7  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CA7
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA7
     GenScript Custom Purified and Recombinant Proteins Services for CA7 GenScript cDNA clones with any tag delivered in your preferred vector for CA7
     GenScript Custom Assay Services for CA7 GenScript Custom Superior Antibodies Services for CA7
     GenScript Custom overexpressing Cell Line Services for CA7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CA7 promoter
     Search Chromatin IP Primers for CA7
     RT2 qPCR Primer Assay in human, mouse, rat CA7
     GNC Network for CA7
     SABiosciences Custom PCR Arrays for CA7
     Search Tocris compounds for CA7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CA7 antibodies
     CA7 proteins
     CA7 lysates
     Search for Antibodies for CA7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CA7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CA7 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CA7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA7
     SwitchGear 3'UTR luciferase reporter plasmids for CA7
     SwitchGear Promoter luciferase reporter plasmids for CA7
     ThermoFisher Antibody for CA7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA7
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CA7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4