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CA7 Gene

protein-coding   GIFtS: 61
GCID: GC16P066880

Carbonic Anhydrase VII

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbonic Anhydrase VII1 2 3     CAVII2
Carbonate Dehydratase VII2 3     Carbonic Anhydrase 72
CA-VII2 3     Carbonic Dehydratase VII2
EC 4.2.1.13 8     

External Ids:    HGNC: 13811   Entrez Gene: 7662   Ensembl: ENSG000001687487   OMIM: 1147705   UniProtKB: P431663   

Export aliases for CA7 gene to outside databases

Previous GC identifers: GC16P057573 GC16P067256 GC16P066613 GC16P066654 GC16P065435 GC16P052752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CA7 Gene:
Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon
dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base
balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They
show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein
encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region
results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA7 Gene:
CA7 (carbonic anhydrase VII) is a protein-coding gene. Diseases associated with CA7 include north american indian childhood cirrhosis, and glaucoma. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH7_HUMAN, P43166
Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CA7 gene promoter:
         RFX1   Tal-1   p53   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA7 promoter sequence
   Search Chromatin IP Primers for CA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066880:  view genomic region     (about GC identifiers)

Start:
66,878,282 bp from pter      End:
66,888,056 bp from pter
Size:
9,775 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAH7_HUMAN, P43166 (See protein sequence)
Recommended Name: Carbonic anhydrase 7  
Size: 264 amino acids; 29658 Da
Cofactor: Zinc
2 PDB 3D structures from and Proteopedia for CA7:
3MDZ (3D)        3ML5 (3D)    
Secondary accessions: Q541F0 Q86YU0
Alternative splicing: 2 isoforms:  P43166-1   P43166-2   

Explore the universe of human proteins at neXtProt for CA7: NX_P43166

Explore proteomics data for CA7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CA7 (P43166) (see all 5)
     QFHFHWG  TYPGSLT  RPPQPLK  GSLTTPPL 


    See CA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014435.1  NP_005173.1  

    ENSEMBL proteins: 
     ENSP00000345659   ENSP00000447178   ENSP00000377632  
    Reactome Protein details: P43166

    CA7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CA7
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    Novus Biologicals CA7 Protein
    Novus Biologicals CA7 Lysates
    Sino Biological Recombinant Protein for CA7
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CA7

    CA7 Antibody Products:

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    CA7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CA7
    Cloud-Clone Corp. CLIAs for CA7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CA: Carbonic anhydrases

    4 InterPro protein domains:
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class
     IPR018438 Carbonic_anhydrase_CA7

    Graphical View of Domain Structure for InterPro Entry P43166

    ProtoNet protein and cluster: P43166

    1 Blocks protein domain: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH7_HUMAN, P43166
    Similarity: Belongs to the alpha-carbonic anhydrase family


    CA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH7_HUMAN, P43166
    Function: Reversible hydration of carbon dioxide
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited
    coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate
    trisodium salt)

         Genatlas biochemistry entry for CA7:
    carbonic anhydrase VII,cytosolic,salivary glands

         Enzyme Number (IUBMB): EC 4.2.1.11 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CA7 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Car7):
     behavior/neurological  nervous system 

    CA7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Car7tm1.1Kkai for CA7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CA7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA7

    miRNA
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    Block miRNA regulation of human, mouse, rat CA7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CA7 (see all 38):
    hsa-miR-194* hsa-miR-1224-3p hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-766 hsa-miR-449a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCA7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CA7
    Predesigned siRNA for gene silencing in human, mouse, rat CA7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CA7

    Clone
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    OriGene clones in human, mouse for CA7 (see all 11)
    OriGene ORF clones in mouse, rat for CA7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CA7 (NM_005182)
    Sino Biological Human cDNA Clone for CA7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CA7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAH7_HUMAN, P43166: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    chloroplast2
    nucleus2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    CA7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CA7 About    
    See pathways by source

    SuperPathContained pathways About
    1Nitrogen metabolism
    Reversible Hydration of Carbon Dioxide0.00
    Nitrogen metabolism
    2Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CA7
        Reversible hydration of carbon dioxide


    1 Kegg Pathway  (Kegg details for CA7):
        Nitrogen metabolism


    CA7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CA7
    Interactions:

        GeneGlobe Interaction Network for CA7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA7 (ENSP000003456594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000003295284STRING: ENSP00000329528
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    CA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CA7 (CAH7)

    4 HMDB Compounds for CA7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    6 DrugBank Compounds for CA7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    AcetazolamideAcetamidothiadiazolesulfonamide (see all 7)59-66-5targetinhibitor18336310
    Dichlorphenamide4,5-Dicholorobenzene-1,3-disulfonamide (see all 7)120-97-8targetinhibitor18336310
    Ellagic Acid-- 476-66-4targetinhibitor20185318
    Ethoxzolamide6-Ethoxy-1,3-benzothiazole-2-sulfonamide (see all 4)452-35-7targetinhibitor18336310
    Methazolamide-- 554-57-4targetinhibitor18336310



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CA7 gene (2 alternative transcripts): 
    NM_001014435.1  NM_005182.2  

    Unigene Cluster for CA7:

    Carbonic anhydrase VII
    Hs.37014  [show with all ESTs]
    Unigene Representative Sequence: AY075020
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338437(uc002eqi.3) ENST00000548332 ENST00000394069(uc002eqj.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CA7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CA7 (see all 38):
    hsa-miR-194* hsa-miR-1224-3p hsa-miR-128 hsa-miR-632 hsa-miR-346 hsa-miR-766 hsa-miR-449a hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidCA7 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CA7 (NM_005182)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA7
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CA7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CA7
      QuantiTect SYBR Green Assays in human, mouse, rat CA7
      QuantiFast Probe-based Assays in human, mouse, rat CA7

    Additional mRNA sequence: 

    AY075019.1 AY075020.1 BC033865.1 

    3 DOTS entries:

    DT.454288  DT.95263253  DT.95263252 

    19 AceView cDNA sequences:

    BI752037 BI758664 BM988252 BC033865 AY075020 AY075019 N78377 BI457808 
    BI820671 BM987921 BI819404 BI760583 NM_005182 BM987669 BI599872 N62608 
    AW001212 BI753786 BX279833 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CA7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:        -                                             
    SP2:                                                      
    SP3:                    -                                 
    SP4:                    -                                 


    ECgene alternative splicing isoforms for CA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACAAAAAA
    CA7 Expression
    About this image


    CA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Colon (Gastrointestinal Tract)
    CA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.37014
        Custom PCR Arrays for CA7
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CA7 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car71 , 5 carbonic anhydrase 71, 5 90.78(n)1
    94.7(a)1
      8 (53.04 cM)5
    123541  NM_053070.31  NP_444300.11 
     1045347005 
    chicken
    (Gallus gallus)
    Aves CA71 carbonic anhydrase VII 70.71(n)
    76.52(a)
      415791  XM_414152.4  XP_414152.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.82092 Xenopus laevis transcribed sequence with weak similarity to protein pirCRHU7 (H.sapiens) CRHU7 carbonate dehydratase (EC 4.2.1.1) VII - human less 71.96(n)    BJ625262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733852 hypothetical protein MGC73385 74.78(n)   393786  BC049309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CAH11 , 3 carbonate dehydratase3
    Carbonic anhydrase 11
    46(a)
    (best of 4)3
    56.79(n)1
    48.62(a)1
      34D43
    347861  NM_078837.41  NP_523561.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cah-31 , 3 carbonic anhydrase3
    cah-31
    36(a)3
    51.27(n)1
    40.68(a)1
      X(16518334-16519911)3
    1817131  NM_078273.61  NP_510674.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACA11 ACA1 44.59(n)
    36.04(a)
      824438  NM_115132.2  NP_566971.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g05333001 Os02g0533300 46.22(n)
    37.78(a)
      4329556  NM_001053565.2  NP_001047030.1 


    ENSEMBL Gene Tree for CA7 (if available)
    TreeFam Gene Tree for CA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CA7 gene
    CA22  CA122  CA32  CA62  CA5B2  CA5A2  CA142  CA82  
    CA42  CA12  CA92  CA132  
    16 SIMAP similar genes for CA7 using alignment to 2 protein entries:     CAH7_HUMAN (see all proteins):
    CA3    CA2    CA13    CA5B    CA1    CA5A
    CA8    CA10    CA6    DKFZp686I20267    CA12    CA14
    CA11    PTPRZ1    PTPRG    CA4

    CA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CA7 (see all 229)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37599961,2
    C,F,H--66876300(+) CTTTGT/CCTTCT 1 -- us2k111Minor allele frequency- C:0.08EA NS NA 2356
    rs1401957631,2
    --66876454(+) TCCTGC/TTCCTG 1 -- us2k10--------
    rs1912887981,2
    --66876470(+) GAGAGA/GGCCAT 1 -- us2k10--------
    rs1842557611,2
    --66876492(+) TGGGCA/GGTCAC 1 -- us2k10--------
    rs1887813191,2
    --66876739(+) AGGACC/TCCGGG 1 -- us2k10--------
    rs1812326691,2
    --66876775(+) CCACCC/TCTCTG 1 -- us2k10--------
    rs1424423221,2
    C--66876830(+) CCCTCG/TCCCTG 1 -- us2k10--------
    rs37850941,2
    C,F--66876941(+) CTCGTG/AGGTGG 2 -- us2k1 int1 tfbs31Minor allele frequency- A:0.03EA 120
    rs1853218151,2
    --66877051(+) GGGACA/GAACAG 2 -- us2k1 int10--------
    rs585360461,2
    F--66877282(+) GCATCT/CACCCC 2 -- us2k1 int11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for CA7 (66878282 - 66888056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2885n71CNV Loss21882294
    nsv510690CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114770    OMIM disorders: --

    5 diseases for CA7:    
    About MalaCards
    north american indian childhood cirrhosis    glaucoma    insulin resistance    malaria
    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for CA7:
    Colorectal cancer

    CA7 for disorders           About GeneDecksing


    Export disorders for CA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CA7 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. (PubMed id 1783392)1, 2, 3, 9 Montgomery J.C....Tashian R.E. (Genomics 1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (Genomics 1999)
    4. Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. (PubMed id 20185318)7 Innocenti A....Supuran C.T. (amp 2010)
    5. Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme. (PubMed id 20493921)1 Bootorabi F....Parkkila S. (Biochimie 2010)
    6. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (amp 2009)
    7. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)2 Maresca A.... Supuran C.T. (J. Am. Chem. Soc. 2009)
    8. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)2 Crocetti L.... Supuran C.T. (Bioorg. Med. Chem. Lett. 2009)
    9. Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. (PubMed id 18537527)7 Supuran C.T....De Simone G. (Expert Opin Emerg Drugs 2008)
    10. The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. (PubMed id 18336310)7 Mincione F....Supuran C.T. (Curr. Pharm. Des. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 766 HGNC: 1381 AceView: CA7 Ensembl:ENSG00000168748 euGenes: HUgn766
    ECgene: CA7 Kegg: 766 H-InvDB: CA7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CA7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CA7 gene:
    Search GeneIP for patents involving CA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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