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Aliases for CA7 Gene

Aliases for CA7 Gene

  • Carbonic Anhydrase VII 2 3 4
  • Carbonate Dehydratase VII 3 4
  • EC 4 63
  • CA-VII 3 4
  • Carbonic Dehydratase VII 3
  • CAVII 3

External Ids for CA7 Gene

Previous GeneCards Identifiers for CA7 Gene

  • GC16P057573
  • GC16P067256
  • GC16P066613
  • GC16P066654
  • GC16P065435
  • GC16P052752

Summaries for CA7 Gene

Entrez Gene Summary for CA7 Gene

  • Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA7 Gene

CA7 (Carbonic Anhydrase VII) is a Protein Coding gene. Diseases associated with CA7 include trichosporonosis. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA7 Gene

  • Reversible hydration of carbon dioxide

Gene Wiki entry for CA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA7 Gene

Genomics for CA7 Gene

Regulatory Elements for CA7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CA7 Gene

66,844,379 bp from pter
66,854,153 bp from pter
9,775 bases
Plus strand

Genomic View for CA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA7 Gene

Proteins for CA7 Gene

  • Protein details for CA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 7
    Protein Accession:
    Secondary Accessions:
    • Q541F0
    • Q86YU0

    Protein attributes for CA7 Gene

    264 amino acids
    Molecular mass:
    29658 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA7 Gene

    Alternative splice isoforms for CA7 Gene


neXtProt entry for CA7 Gene

Proteomics data for CA7 Gene at MOPED

Selected DME Specific Peptides for CA7 Gene

Post-translational modifications for CA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA7 Gene

Domains & Families for CA7 Gene

Gene Families for CA7 Gene

Suggested Antigen Peptide Sequences for CA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA7: view

Function for CA7 Gene

Molecular function for CA7 Gene

GENATLAS Biochemistry:
carbonic anhydrase VII,cytosolic,salivary glands
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide

Enzyme Numbers (IUBMB) for CA7 Gene

Gene Ontology (GO) - Molecular Function for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA7: view
genes like me logo Genes that share phenotypes with CA7: view

Animal Models for CA7 Gene

MGI Knock Outs for CA7:

Animal Model Products

miRNA for CA7 Gene

miRTarBase miRNAs that target CA7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CA7 Gene

Localization for CA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA7 Gene


Subcellular locations from

Jensen Localization Image for CA7 Gene COMPARTMENTS Subcellular localization image for CA7 gene
Compartment Confidence
cytosol 4
chloroplast 2
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CA7: view

Pathways & Interactions for CA7 Gene

genes like me logo Genes that share pathways with CA7: view

Pathways by source for CA7 Gene

2 Reactome pathways for CA7 Gene
1 KEGG pathway for CA7 Gene

Interacting Proteins for CA7 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000345659 for CA7 Gene via STRING

Gene Ontology (GO) - Biological Process for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0032230 positive regulation of synaptic transmission, GABAergic IEA --
GO:0032849 positive regulation of cellular pH reduction IEA --
genes like me logo Genes that share ontologies with CA7: view

No data available for SIGNOR curated interactions for CA7 Gene

Drugs & Compounds for CA7 Gene

(13) Drugs for CA7 Gene - From: HMDB, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetazolamide Approved Pharma inhibitor, Target 61
Methazolamide Approved Pharma inhibitor, Target Carbonic anhydrase inhibitor 5
Zonisamide Approved, Investigational Pharma blocker, Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 63
Dichlorphenamide Approved Pharma Target, inhibitor 2
Brinzolamide Approved Pharma inhibitor CA II inhibitor 57

(3) Additional Compounds for CA7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Carbonic acid
  • Acid of air
  • Aerial acid
  • Bisodium carbonate
  • Calcined
  • Carbonic acid sodium salt
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with CA7: view

Transcripts for CA7 Gene

mRNA/cDNA for CA7 Gene

Unigene Clusters for CA7 Gene

Carbonic anhydrase VII:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP3: -
SP4: -

Relevant External Links for CA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA7 Gene

mRNA expression in normal human tissues for CA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA7 Gene

This gene is overexpressed in Colon - Transverse (x21.0) and Brain - Cortex (x4.0).

SOURCE GeneReport for Unigene cluster for CA7 Gene Hs.37014

genes like me logo Genes that share expression patterns with CA7: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CA7 Gene

Orthologs for CA7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CA7 35
  • 90.91 (n)
  • 95.08 (a)
CA7 36
  • 95 (a)
(Canis familiaris)
Mammalia CA7 35
  • 89.65 (n)
  • 94.7 (a)
CA7 36
  • 95 (a)
(Mus musculus)
Mammalia Car7 35
  • 90.78 (n)
  • 94.7 (a)
Car7 16
Car7 36
  • 95 (a)
(Pan troglodytes)
Mammalia CA7 35
  • 99.62 (n)
  • 99.62 (a)
CA7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Car7 35
  • 90.03 (n)
  • 94.7 (a)
(Monodelphis domestica)
Mammalia CA7 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CA7 36
  • 66 (a)
(Gallus gallus)
Aves CA7 35
  • 70.71 (n)
  • 76.52 (a)
CA7 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca7 35
  • 67.05 (n)
  • 72.35 (a)
Str.15944 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8209 35
(Danio rerio)
Actinopterygii ca7 35
  • 68.19 (n)
  • 71.37 (a)
zgc73385 35
ca7 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12059 35
fruit fly
(Drosophila melanogaster)
Insecta CAH1 37
  • 46 (a)
CG11284 37
  • 37 (a)
CG6074 37
  • 33 (a)
CG6906 37
  • 37 (a)
CAH1 35
  • 56.79 (n)
  • 48.62 (a)
CAH1 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010052 35
  • 52.29 (n)
  • 42.2 (a)
(Caenorhabditis elegans)
Secernentea cah-3 37
  • 36 (a)
cah-3 35
  • 51.27 (n)
  • 40.68 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACA1 35
  • 44.59 (n)
  • 36.04 (a)
(Oryza sativa)
Liliopsida Os02g0533300 35
  • 46.22 (n)
  • 37.78 (a)
Species with no ortholog for CA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA7 Gene

Gene Tree for CA7 (if available)
Gene Tree for CA7 (if available)

Paralogs for CA7 Gene

Paralogs for CA7 Gene

(16) SIMAP similar genes for CA7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA7: view

Variants for CA7 Gene

Sequence variations from dbSNP and Humsavar for CA7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs36685 -- 66,847,963(+) CCTTA(C/T)GACTG intron-variant
rs151460 -- 66,851,749(-) CTGCT(C/T)GGGTC intron-variant
rs152165 -- 66,848,627(+) CTCAC(C/T)CACTG intron-variant
rs152166 -- 66,848,789(+) TAGGA(A/G)CCCAC intron-variant
rs152167 -- 66,849,640(+) CAGTG(A/G)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA7 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv510690 CNV Loss 20534489

Variation tolerance for CA7 Gene

Residual Variation Intolerance Score: 23.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA7 Gene

Disorders for CA7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CA7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
- elite association
Search CA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA7 Gene

Publications for CA7 Gene

  1. Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. (PMID: 1783392) Montgomery J.C. … Tashian R.E. (Genomics 1991) 2 23 67
  2. Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes. (PMID: 19549076) Carta F. … Supuran C.T. (Chem Biol Drug Des 2009) 23 67
  3. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PMID: 19703035) De Simone G. … Supuran C.T. (Chem Biol Drug Des 2009) 25 26
  4. The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. (PMID: 18336310) Mincione F. … Supuran C.T. (Curr. Pharm. Des. 2008) 25 26
  5. Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. (PMID: 18537527) Supuran C.T. … De Simone G. (Expert Opin Emerg Drugs 2008) 25 26

Products for CA7 Gene

Sources for CA7 Gene

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