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Aliases for CA7 Gene

Aliases for CA7 Gene

  • Carbonic Anhydrase 7 2 3 5
  • Carbonic Anhydrase VII 2 3 4
  • Carbonate Dehydratase VII 3 4
  • EC 4 58
  • CA-VII 3 4
  • Carbonic Dehydratase VII 3
  • CAVII 3

External Ids for CA7 Gene

Previous GeneCards Identifiers for CA7 Gene

  • GC16P057573
  • GC16P067256
  • GC16P066613
  • GC16P066654
  • GC16P065435
  • GC16P052752

Summaries for CA7 Gene

Entrez Gene Summary for CA7 Gene

  • Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA7 Gene

CA7 (Carbonic Anhydrase 7) is a Protein Coding gene. Diseases associated with CA7 include Trichosporonosis. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot for CA7 Gene

  • Reversible hydration of carbon dioxide.

Gene Wiki entry for CA7 Gene

Additional gene information for CA7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA7 Gene

Genomics for CA7 Gene

Regulatory Elements for CA7 Gene

Enhancers for CA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H066406 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -436.3 -436309 4.1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS SP5 LINC00920 CDH5 CMTM2 CMTM4 DYNC1LI2 LOC106699570 CA7 RRAD CMTM3 GC16P066378
GH16H066739 1.4 Ensembl ENCODE dbSUPER 10.9 -103.0 -102951 3.9 RAD21 ZEB1 YY1 ZNF366 ZNF143 ATF7 ZNF654 ZNF362 CEBPB ZEB2 CMTM4 BEAN1 CA7 CES2 TERB1 ENSG00000260558 LOC106699570
GH16H066659 1.3 Ensembl ENCODE 10.1 -183.0 -182990 2.8 PKNOX1 ATF1 ARNT ARID4B YBX1 FEZF1 DMAP1 TCF12 ZNF121 SLC30A9 CMTM4 BEAN1 LOC106699570 DYNC1LI2 CA7 CES2 TK2 GC16P066646 GC16M066667
GH16H066877 1 Ensembl ENCODE 11.9 +33.7 33722 0.6 LEF1 ETV1 ZNF223 CEBPG THRB ZFHX2 POLR2A EED PATZ1 ATF7 CA7 THAP11 CES2 FAM96B PDP2 NAE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CA7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CA7 Gene

Genomic Locations for CA7 Gene
9,775 bases
Plus strand

Genomic View for CA7 Gene

Genes around CA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA7 Gene

Proteins for CA7 Gene

  • Protein details for CA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 7
    Protein Accession:
    Secondary Accessions:
    • Q541F0
    • Q86YU0

    Protein attributes for CA7 Gene

    264 amino acids
    Molecular mass:
    29658 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA7 Gene

    Alternative splice isoforms for CA7 Gene


neXtProt entry for CA7 Gene

Selected DME Specific Peptides for CA7 Gene


Post-translational modifications for CA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA7 Gene

Domains & Families for CA7 Gene

Gene Families for CA7 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA7: view

Function for CA7 Gene

Molecular function for CA7 Gene

GENATLAS Biochemistry:
carbonic anhydrase VII,cytosolic,salivary glands
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide.

Enzyme Numbers (IUBMB) for CA7 Gene

Gene Ontology (GO) - Molecular Function for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CA7: view
genes like me logo Genes that share phenotypes with CA7: view

Animal Models for CA7 Gene

MGI Knock Outs for CA7:

Animal Model Products

CRISPR Products

miRNA for CA7 Gene

miRTarBase miRNAs that target CA7

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CA7 Gene

Localization for CA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA7 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CA7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CA7 Gene

Pathways & Interactions for CA7 Gene

genes like me logo Genes that share pathways with CA7: view

Pathways by source for CA7 Gene

2 Reactome pathways for CA7 Gene
1 KEGG pathway for CA7 Gene

Interacting Proteins for CA7 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)
Selected Interacting proteins: ENSP00000345659 P43166-CAH7_HUMAN for CA7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0032230 positive regulation of synaptic transmission, GABAergic IEA --
GO:0032849 positive regulation of cellular pH reduction IEA --
GO:2001225 regulation of chloride transport IEA --
genes like me logo Genes that share ontologies with CA7: view

No data available for SIGNOR curated interactions for CA7 Gene

Drugs & Compounds for CA7 Gene

(15) Drugs for CA7 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetazolamide Approved, Vet_approved Pharma inhibitor, Target 84
Methazolamide Approved Pharma inhibitor, Target Carbonic anhydrase inhibitor 7
Zonisamide Approved, Investigational Pharma blocker, Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 68
Dichlorphenamide Approved Pharma Target, inhibitor 2
Brinzolamide Approved Pharma inhibitor CA II inhibitor 63

(1) Additional Compounds for CA7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbonic acid
  • Acid of air
  • Aerial acid
  • Bisodium carbonate
  • Calcined
  • Carbonic acid sodium salt
genes like me logo Genes that share compounds with CA7: view

Transcripts for CA7 Gene

mRNA/cDNA for CA7 Gene

Unigene Clusters for CA7 Gene

Carbonic anhydrase VII:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP3: -
SP4: -

Relevant External Links for CA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA7 Gene

This gene is overexpressed in Colon - Transverse (x21.0) and Brain - Cortex (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of CA7 Gene:


SOURCE GeneReport for Unigene cluster for CA7 Gene:


Evidence on tissue expression from TISSUES for CA7 Gene

  • Intestine(4.6)
  • Kidney(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with CA7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CA7 Gene

Orthologs for CA7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CA7 33 34
  • 99.62 (n)
(Bos Taurus)
Mammalia CA7 33 34
  • 90.91 (n)
(Mus musculus)
Mammalia Car7 33 16 34
  • 90.78 (n)
(Rattus norvegicus)
Mammalia Car7 33
  • 90.03 (n)
(Canis familiaris)
Mammalia CA7 33 34
  • 89.65 (n)
(Monodelphis domestica)
Mammalia CA7 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CA7 34
  • 66 (a)
(Gallus gallus)
Aves CA7 33 34
  • 70.71 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca7 33
  • 67.05 (n)
Str.15944 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8209 33
(Danio rerio)
Actinopterygii ca7 33 34
  • 68.19 (n)
zgc73385 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12059 33
fruit fly
(Drosophila melanogaster)
Insecta CAH1 35 33 34
  • 56.79 (n)
CG11284 35
  • 37 (a)
CG6906 35
  • 37 (a)
CG6074 35
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010052 33
  • 52.29 (n)
(Caenorhabditis elegans)
Secernentea cah-3 35 33
  • 51.27 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACA1 33
  • 44.59 (n)
(Oryza sativa)
Liliopsida Os02g0533300 33
  • 46.22 (n)
Species where no ortholog for CA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA7 Gene

Gene Tree for CA7 (if available)
Gene Tree for CA7 (if available)

Paralogs for CA7 Gene

Paralogs for CA7 Gene

(16) SIMAP similar genes for CA7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA7: view

Variants for CA7 Gene

Sequence variations from dbSNP and Humsavar for CA7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000291624 -- 66,844,236(+) GTTGG(A/G)GGGAG intron-variant, upstream-variant-2KB
rs1000345053 -- 66,844,348(+) GGGGG(C/G)GGGTC intron-variant, upstream-variant-2KB
rs1000406466 -- 66,850,396(+) TGTTT(-/GCACCATG)GCACT intron-variant
rs1000438836 -- 66,850,673(+) CCTCC(C/T)CCACT intron-variant
rs1000550651 -- 66,845,397(+) GGGAG(A/G)AACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA7 Gene

Variant ID Type Subtype PubMed ID
esv3425981 CNV duplication 20981092
nsv510690 CNV deletion 20534489

Variation tolerance for CA7 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA7 Gene

Disorders for CA7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CA7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search CA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA7 Gene

Publications for CA7 Gene

  1. Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. (PMID: 1783392) Montgomery JC … Tashian RE (Genomics 1991) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4 60
  4. Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas. (PMID: 27688658) Viikilä P … Haglund C (World journal of gastroenterology 2016) 3 60
  5. Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma. (PMID: 25885898) Yang GZ … Gao CF (BMC cancer 2015) 3 60

Products for CA7 Gene

Sources for CA7 Gene

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