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Aliases for CA7 Gene

Aliases for CA7 Gene

  • Carbonic Anhydrase VII 2 3 4
  • Carbonate Dehydratase VII 3 4
  • EC 4.2.1.1 4 63
  • CA-VII 3 4
  • Carbonic Dehydratase VII 3
  • Carbonic Anhydrase 7 3
  • CAVII 3

External Ids for CA7 Gene

Previous GeneCards Identifiers for CA7 Gene

  • GC16P057573
  • GC16P067256
  • GC16P066613
  • GC16P066654
  • GC16P065435
  • GC16P052752

Summaries for CA7 Gene

Entrez Gene Summary for CA7 Gene

  • Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA7 Gene

CA7 (Carbonic Anhydrase VII) is a Protein Coding gene. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA7 Gene

  • Reversible hydration of carbon dioxide

Gene Wiki entry for CA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA7 Gene

Genomics for CA7 Gene

Regulatory Elements for CA7 Gene

Genomic Location for CA7 Gene

Start:
66,844,379 bp from pter
End:
66,854,153 bp from pter
Size:
9,775 bases
Orientation:
Plus strand

Genomic View for CA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA7 Gene

Proteins for CA7 Gene

  • Protein details for CA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43166-CAH7_HUMAN
    Recommended name:
    Carbonic anhydrase 7
    Protein Accession:
    P43166
    Secondary Accessions:
    • Q541F0
    • Q86YU0

    Protein attributes for CA7 Gene

    Size:
    264 amino acids
    Molecular mass:
    29658 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA7 Gene

    Alternative splice isoforms for CA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CA7 Gene

Proteomics data for CA7 Gene at MOPED

Selected DME Specific Peptides for CA7 Gene

Post-translational modifications for CA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CA7 Gene

Gene Families for CA7 Gene

HGNC:
  • CA :Carbonic anhydrases

Suggested Antigen Peptide Sequences for CA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43166

UniProtKB/Swiss-Prot:

CAH7_HUMAN :
  • P43166
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA7: view

Function for CA7 Gene

Molecular function for CA7 Gene

GENATLAS Biochemistry: carbonic anhydrase VII,cytosolic,salivary glands
UniProtKB/Swiss-Prot CatalyticActivity: H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function: Reversible hydration of carbon dioxide

Enzyme Numbers (IUBMB) for CA7 Gene

Gene Ontology (GO) - Molecular Function for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA7: view

Phenotypes for CA7 Gene

genes like me logo Genes that share phenotypes with CA7: view

Animal Models for CA7 Gene

MGI Knock Outs for CA7:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CA7 Gene

Localization for CA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CA7 Gene COMPARTMENTS Subcellular localization image for CA7 gene
Compartment Confidence
cytosol 4
chloroplast 2
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CA7: view

Pathways for CA7 Gene

genes like me logo Genes that share pathways with CA7: view

Pathways by source for CA7 Gene

2 Reactome pathways for CA7 Gene
1 KEGG pathway for CA7 Gene

Interacting Proteins for CA7 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345659%0d%0a9606.ENSP00000375977%0d%0a9606.ENSP00000263980%0d%0a9606.ENSP00000262033%0d%0a
Selected Interacting proteins: ENSP00000345659 for CA7 Gene via STRING

Gene Ontology (GO) - Biological Process for CA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0032230 positive regulation of synaptic transmission, GABAergic IEA --
GO:0032849 positive regulation of cellular pH reduction IEA --
genes like me logo Genes that share ontologies with CA7: view

Compounds for CA7 Gene

(4) HMDB Compounds for CA7 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
Carbonic acid
  • acid of air
463-79-6
Water
  • Dihydrogen oxide
7732-18-5
Zinc
  • Zinc
7440-66-6

(6) Drugbank Compounds for CA7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acetazolamide
  • Acetamidothiadiazolesulfonamide
59-66-5 target inhibitor
Dichlorphenamide
  • 4,5-Dicholorobenzene-1,3-disulfonamide
120-97-8 target inhibitor
Ellagic Acid
476-66-4 target inhibitor
Ethoxzolamide
  • 6-Ethoxy-1,3-benzothiazole-2-sulfonamide
452-35-7 target inhibitor
Methazolamide
554-57-4 target inhibitor
genes like me logo Genes that share compounds with CA7: view

Transcripts for CA7 Gene

mRNA/cDNA for CA7 Gene

Unigene Clusters for CA7 Gene

Carbonic anhydrase VII:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CA7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for CA7 Gene

GeneLoc Exon Structure for
CA7
ECgene alternative splicing isoforms for
CA7

Expression for CA7 Gene

mRNA expression in normal human tissues for CA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA7 Gene

This gene is overexpressed in Colon - Transverse (21.0) and Brain - Cortex (4.0).

SOURCE GeneReport for Unigene cluster for CA7 Gene Hs.37014

genes like me logo Genes that share expressions with CA7: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CA7 Gene

Orthologs for CA7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA7 35
  • 99.62 (n)
  • 99.62 (a)
CA7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CA7 35
  • 90.91 (n)
  • 95.08 (a)
CA7 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CA7 35
  • 89.65 (n)
  • 94.7 (a)
CA7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Car7 35
  • 90.78 (n)
  • 94.7 (a)
Car7 16
Car7 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CA7 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CA7 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Car7 35
  • 90.03 (n)
  • 94.7 (a)
chicken
(Gallus gallus)
Aves CA7 35
  • 70.71 (n)
  • 76.52 (a)
CA7 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8209 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ca7 35
  • 67.05 (n)
  • 72.35 (a)
Str.15944 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12059 35
zebrafish
(Danio rerio)
Actinopterygii ca7 35
  • 68.19 (n)
  • 71.37 (a)
ca7 36
  • 71 (a)
OneToOne
zgc73385 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010052 35
  • 52.29 (n)
  • 42.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta CAH1 35
  • 56.79 (n)
  • 48.62 (a)
CAH1 36
  • 45 (a)
OneToMany
CG11284 37
  • 37 (a)
CAH1 37
  • 46 (a)
CG6074 37
  • 33 (a)
CG6906 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea cah-3 35
  • 51.27 (n)
  • 40.68 (a)
cah-3 37
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACA1 35
  • 44.59 (n)
  • 36.04 (a)
rice
(Oryza sativa)
Liliopsida Os02g0533300 35
  • 46.22 (n)
  • 37.78 (a)
Species with no ortholog for CA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA7 Gene

ENSEMBL:
Gene Tree for CA7 (if available)
TreeFam:
Gene Tree for CA7 (if available)

Paralogs for CA7 Gene

Paralogs for CA7 Gene

Selected SIMAP similar genes for CA7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA7: view

Variants for CA7 Gene

Sequence variations from dbSNP and Humsavar for CA7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs36685 -- 66,847,963(+) CCTTA(C/T)GACTG intron-variant
rs151460 -- 66,851,749(-) CTGCT(C/T)GGGTC intron-variant
rs152165 -- 66,848,627(+) CTCAC(C/T)CACTG intron-variant
rs152166 -- 66,848,789(+) TAGGA(A/G)CCCAC intron-variant
rs152167 -- 66,849,640(+) CAGTG(A/G)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA7 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv510690 CNV Loss 20534489

Relevant External Links for CA7 Gene

HapMap Linkage Disequilibrium report
CA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA7 Gene

Disorders for CA7 Gene

(1) University of Copenhagen DISEASES for CA7 Gene

genes like me logo Genes that share disorders with CA7: view

No data available for UniProtKB/Swiss-Prot for CA7 Gene

Publications for CA7 Gene

  1. Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16. (PMID: 1783392) Montgomery J.C. … Tashian R.E. (Genomics 1991) 2 3 4 23
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. (PMID: 15528236) Rivera C. … Kaila K. (J. Physiol. (Lond.) 2005) 3
  5. Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. (PMID: 15686895) Vullo D. … Supuran C.T. (Bioorg. Med. Chem. Lett. 2005) 3

Products for CA7 Gene

  • Addgene plasmids for CA7

Sources for CA7 Gene

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