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Aliases for CA6 Gene

Aliases for CA6 Gene

  • Carbonic Anhydrase VI 2 3 4
  • Salivary Carbonic Anhydrase 3 4
  • Secreted Carbonic Anhydrase 3 4
  • Carbonate Dehydratase VI 3 4
  • CA-VI 3 4
  • Carbonic Anhydrase VI Nirs Variant 2 3
  • EC 4
  • GUSTIN 3

External Ids for CA6 Gene

Previous GeneCards Identifiers for CA6 Gene

  • GC01P008626
  • GC01P008816
  • GC01P008715
  • GC01P008940
  • GC01P008928
  • GC01P008155

Summaries for CA6 Gene

Entrez Gene Summary for CA6 Gene

  • The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA6 Gene

CA6 (Carbonic Anhydrase VI) is a Protein Coding gene. Diseases associated with CA6 include denture stomatitis and multilocular clear cell renal cell carcinoma. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA6 Gene

  • Reversible hydration of carbon dioxide. Its role in saliva is unknown

Gene Wiki entry for CA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA6 Gene

Genomics for CA6 Gene

Regulatory Elements for CA6 Gene

Genomic Location for CA6 Gene

8,945,785 bp from pter
8,975,092 bp from pter
29,308 bases
Plus strand

Genomic View for CA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA6 Gene

Proteins for CA6 Gene

  • Protein details for CA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 6
    Protein Accession:
    Secondary Accessions:
    • E7EMQ1
    • Q5FBW3
    • Q5FC00
    • Q96QX8
    • Q9UF03

    Protein attributes for CA6 Gene

    308 amino acids
    Molecular mass:
    35367 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA6 Gene

    Alternative splice isoforms for CA6 Gene


neXtProt entry for CA6 Gene

Proteomics data for CA6 Gene at MOPED

Post-translational modifications for CA6 Gene

  • Glycosylation at Asn 67 and Asn 256

Antibody Products

  • R&D Systems Antibodies for CA6 (Carbonic Anhydrase VI)

No data available for DME Specific Peptides for CA6 Gene

Domains & Families for CA6 Gene

Gene Families for CA6 Gene

Suggested Antigen Peptide Sequences for CA6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA6: view

Function for CA6 Gene

Molecular function for CA6 Gene

GENATLAS Biochemistry:
carbonic anhydrase VI,secretory granules,parotid and submaxillar glands
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide. Its role in saliva is unknown

Enzyme Numbers (IUBMB) for CA6 Gene

Gene Ontology (GO) - Molecular Function for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity TAS --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA6: view

Phenotypes for CA6 Gene

genes like me logo Genes that share phenotypes with CA6: view

Animal Models for CA6 Gene

MGI Knock Outs for CA6:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA6

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CA6 Gene

Localization for CA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA6 Gene


Subcellular locations from

Jensen Localization Image for CA6 Gene COMPARTMENTS Subcellular localization image for CA6 gene
Compartment Confidence
extracellular 5
chloroplast 2
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CA6: view

Pathways & Interactions for CA6 Gene

genes like me logo Genes that share pathways with CA6: view

Pathways by source for CA6 Gene

2 Reactome pathways for CA6 Gene
1 KEGG pathway for CA6 Gene

Interacting Proteins for CA6 Gene

Gene Ontology (GO) - Biological Process for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA6: view

No data available for SIGNOR curated interactions for CA6 Gene

Drugs & Compounds for CA6 Gene

(6) Drugs for CA6 Gene - From: NovoSeek, HMDB, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 63
Zinc Approved Pharma 1404
Mafenide Approved Pharma Target, antagonist 5
Ellagic acid Investigational Pharma Target, inhibitor Casein kinase 2 (CK2) inhibitor, Selective inhibitor of CK2. Also inhibits glutathione S-transferase 0
SAR566658 Pharma 0

(4) Additional Compounds for CA6 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Carbonic acid
  • Acid of air
  • Aerial acid
  • Bisodium carbonate
  • Calcined
  • Carbonic acid sodium salt
  • Dihydrogen oxide
  • Steam
sialic acid
genes like me logo Genes that share compounds with CA6: view

Transcripts for CA6 Gene

Unigene Clusters for CA6 Gene

Carbonic anhydrase VI:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP2: -
SP3: - - -
SP4: - - - -

Relevant External Links for CA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA6 Gene

mRNA expression in normal human tissues for CA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA6 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x31.7) and Skin - Not Sun Exposed (Suprapubic) (x18.9).

Protein differential expression in normal tissues from HIPED for CA6 Gene

This gene is overexpressed in Skin (41.9), Saliva (15.6), and Salivary gland (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CA6 Gene

SOURCE GeneReport for Unigene cluster for CA6 Gene Hs.100322

mRNA Expression by UniProt/SwissProt for CA6 Gene

Tissue specificity: Major constituent of saliva
genes like me logo Genes that share expression patterns with CA6: view

Protein tissue co-expression partners for CA6 Gene

Primer Products

In Situ Assay Products

Orthologs for CA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CA6 35
  • 78.59 (n)
  • 70.53 (a)
CA6 36
  • 64 (a)
(Canis familiaris)
Mammalia CA6 35
  • 80.28 (n)
  • 75.78 (a)
CA6 36
  • 68 (a)
(Mus musculus)
Mammalia Car6 35
  • 67.79 (n)
  • 54.55 (a)
Car6 16
Car6 36
  • 49 (a)
(Pan troglodytes)
Mammalia CA6 35
  • 98.46 (n)
  • 97.86 (a)
CA6 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Car6 35
  • 70.16 (n)
  • 57.4 (a)
(Monodelphis domestica)
Mammalia CA6 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia CA6 36
  • 51 (a)
(Gallus gallus)
Aves CA6 35
  • 61.23 (n)
  • 52.08 (a)
CA6 36
  • 27 (a)
(Danio rerio)
Actinopterygii LOC100006448 35
  • 60.5 (n)
  • 55.52 (a)
ca6 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8628 36
  • 16 (a)
Species with no ortholog for CA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA6 Gene

Gene Tree for CA6 (if available)
Gene Tree for CA6 (if available)

Paralogs for CA6 Gene

Paralogs for CA6 Gene

(11) SIMAP similar genes for CA6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CA6: view

Variants for CA6 Gene

Sequence variations from dbSNP and Humsavar for CA6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs942969 -- 8,947,497(+) CTGAG(C/G)ACAGT intron-variant
rs1409147 -- 8,945,261(+) ACACC(A/G)GCTTG upstream-variant-2KB
rs2004078 -- 8,947,986(-) ATGCC(A/G)TTAAT intron-variant
rs2274326 -- 8,949,155(+) GCCTC(C/T)GTGGG intron-variant
rs2274327 - 8,949,347(+) GAGGA(C/G/T)GAAGG reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA6 Gene

Variant ID Type Subtype PubMed ID
nsv871694 CNV Gain 21882294
nsv1965 CNV Insertion 18451855
nsv516097 CNV Loss 19592680
nsv871338 CNV Loss 21882294

Variation tolerance for CA6 Gene

Residual Variation Intolerance Score: 57.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.16; 97.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA6 Gene

Disorders for CA6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CA6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
denture stomatitis
  • denture stomatitis [ambiguous]
multilocular clear cell renal cell carcinoma
  • cystadenocarcinoma of kidney
tricuspid valve stenosis
  • tricuspid stenosis
  • vesicular pharyngitis
hand, foot and mouth disease
  • vesicular stomatitis and exanthem
- elite association
Search CA6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA6 Gene

Publications for CA6 Gene

  1. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PMID: 9691177) White P.S. … Brodeur G.M. (Cytogenet. Cell Genet. 1998) 2 23 67
  2. Carbonic anhydrase I, II, and VI, blood plasma, erythrocyte and saliva zinc and copper increase after repetitive transcranial magnetic stimulation. (PMID: 20090508) Henkin R.I. … Martin B.M. (Am. J. Med. Sci. 2010) 23 67
  3. Buccal alterations in diabetes mellitus. (PMID: 20180965) Negrato C.A. … Tarzia O. (Diabetol Metab Syndr 2010) 23 67
  4. Association of polymorphisms in the carbonic anhydrase 6 gene with salivary buffer capacity, dental plaque pH, and caries index in children aged 7-9 years. (PMID: 19721466) Peres R.C. … Line S.R. (Pharmacogenomics J. 2010) 23 67
  5. Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI. (PMID: 19824891) Winum J.Y. … Supuran C.T. (Chem Biol Drug Des 2009) 23 67

Products for CA6 Gene

Sources for CA6 Gene

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