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Aliases for CA6 Gene

Aliases for CA6 Gene

  • Carbonic Anhydrase VI 2 3 4
  • Salivary Carbonic Anhydrase 3 4
  • Secreted Carbonic Anhydrase 3 4
  • Carbonate Dehydratase VI 3 4
  • CA-VI 3 4
  • Carbonic Anhydrase 6 3
  • EC 4.2.1.1 4
  • GUSTIN 3

External Ids for CA6 Gene

Summaries for CA6 Gene

Entrez Gene Summary for CA6 Gene

  • The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA6 Gene

CA6 (Carbonic Anhydrase VI) is a Protein Coding gene. Diseases associated with CA6 include multilocular clear cell renal cell carcinoma and hand, foot and mouth disease. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA6 Gene

  • Reversible hydration of carbon dioxide. Its role in saliva is unknown

Gene Wiki entry for CA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA6 Gene

Genomics for CA6 Gene

Genomic Location for CA6 Gene

Start:
8,945,834 bp from pter
End:
8,975,092 bp from pter
Size:
29,259 bases
Orientation:
Plus strand

Genomic View for CA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA6 Gene

Regulatory Elements for CA6 Gene

Proteins for CA6 Gene

  • Protein details for CA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23280-CAH6_HUMAN
    Recommended name:
    Carbonic anhydrase 6
    Protein Accession:
    P23280
    Secondary Accessions:
    • E7EMQ1
    • Q5FBW3
    • Q5FC00
    • Q96QX8
    • Q9UF03

    Protein attributes for CA6 Gene

    Size:
    308 amino acids
    Molecular mass:
    35367 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA6 Gene

    Alternative splice isoforms for CA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CA6 Gene

Proteomics data for CA6 Gene at MOPED

Post-translational modifications for CA6 Gene

  • Glycosylation at Asn67 and Asn256

Other Protein References for CA6 Gene

No data available for DME Specific Peptides for CA6 Gene

Domains for CA6 Gene

Gene Families for CA6 Gene

HGNC:
  • CA :Carbonic anhydrases

UniProtKB/Swiss-Prot:

CAH6_HUMAN
Family:
  • Belongs to the alpha-carbonic anhydrase family.:
    • P23280
genes like me logo Genes that share domains with CA6: view

Function for CA6 Gene

Molecular function for CA6 Gene

GENATLAS Biochemistry: carbonic anhydrase VI,secretory granules,parotid and submaxillar glands
UniProtKB/Swiss-Prot CatalyticActivity: H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function: Reversible hydration of carbon dioxide. Its role in saliva is unknown

Enzyme Numbers (IUBMB) for CA6 Gene

Gene Ontology (GO) - Molecular Function for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity TAS --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA6: view

Phenotypes for CA6 Gene

genes like me logo Genes that share phenotypes with CA6: view

Animal Models for CA6 Gene

MGI Knock Outs for CA6:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CA6 Gene

Localization for CA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CA6 Gene COMPARTMENTS Subcellular localization image for CA6 gene
Compartment Confidence
extracellular 5
chloroplast 2
cytosol 2
nucleus 2
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CA6: view

Pathways for CA6 Gene

genes like me logo Genes that share pathways with CA6: view

Pathways by source for CA6 Gene

2 Reactome pathways for CA6 Gene
1 KEGG pathway for CA6 Gene

Interacting Proteins for CA6 Gene

Gene Ontology (GO) - Biological Process for CA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA6: view

Compounds for CA6 Gene

(4) HMDB Compounds for CA6 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
Carbonic acid
  • acid of air
463-79-6
Water
  • Dihydrogen oxide
7732-18-5
Zinc
  • Zinc
7440-66-6

(2) Drugbank Compounds for CA6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ellagic Acid
476-66-4 target inhibitor
Zonisamide
  • Zonisamida [Spanish]
68291-97-4 target inhibitor

(3) Novoseek inferred chemical compound relationships for CA6 Gene

Compound -log(P) Hits PubMed IDs
chondroitin 55.3 2
zinc 49 4
sialic acid 30.5 1
genes like me logo Genes that share compounds with CA6: view

Transcripts for CA6 Gene

Unigene Clusters for CA6 Gene

Carbonic anhydrase VI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3: - - -
SP4: - - - -

Relevant External Links for CA6 Gene

GeneLoc Exon Structure for
CA6
ECgene alternative splicing isoforms for
CA6

Expression for CA6 Gene

mRNA expression in normal human tissues for CA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA6 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (31.7) and Skin - Not Sun Exposed (Suprapubic) (18.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CA6 Gene

SOURCE GeneReport for Unigene cluster for CA6 Gene Hs.100322

mRNA Expression by UniProt/SwissProt for CA6 Gene

P23280-CAH6_HUMAN
Tissue specificity: Major constituent of saliva
genes like me logo Genes that share expressions with CA6: view

Orthologs for CA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA6 36
  • 98.46 (n)
  • 97.86 (a)
CA6 37
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CA6 36
  • 78.59 (n)
  • 70.53 (a)
CA6 37
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CA6 36
  • 80.28 (n)
  • 75.78 (a)
CA6 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Car6 36
  • 67.79 (n)
  • 54.55 (a)
Car6 16
Car6 37
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CA6 37
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CA6 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Car6 36
  • 70.16 (n)
  • 57.4 (a)
chicken
(Gallus gallus)
Aves CA6 36
  • 61.23 (n)
  • 52.08 (a)
CA6 37
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ca6 37
  • 30 (a)
OneToOne
LOC100006448 36
  • 60.5 (n)
  • 55.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8628 37
  • 16 (a)
OneToMany
Species with no ortholog for CA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA6 Gene

ENSEMBL:
Gene Tree for CA6 (if available)
TreeFam:
Gene Tree for CA6 (if available)

Paralogs for CA6 Gene

Paralogs for CA6 Gene

Selected SIMAP similar genes for CA6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CA6: view

Variants for CA6 Gene

Sequence variations from dbSNP and Humsavar for CA6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs942969 -- 8,947,497(+) CTGAG(C/G)ACAGT intron-variant
rs1409147 -- 8,945,261(+) ACACC(A/G)GCTTG upstream-variant-2KB
rs1832261 -- 8,960,789(+) acaca(C/T)atata intron-variant
rs1832262 -- 8,960,846(+) aaaca(C/T)gaaac intron-variant
rs2004078 -- 8,947,986(-) ATGCC(A/G)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA6 Gene

Variant ID Type Subtype PubMed ID
nsv871694 CNV Gain 21882294
nsv1965 CNV Insertion 18451855
nsv516097 CNV Loss 19592680
nsv871338 CNV Loss 21882294

Relevant External Links for CA6 Gene

HapMap Linkage Disequilibrium report
CA6
Human Gene Mutation Database (HGMD)
CA6

Disorders for CA6 Gene

Relevant External Links for CA6

Genetic Association Database (GAD)
CA6
Human Genome Epidemiology (HuGE) Navigator
CA6
genes like me logo Genes that share disorders with CA6: view

No data available for UniProtKB/Swiss-Prot for CA6 Gene

Publications for CA6 Gene

  1. Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry. (PMID: 1899030) Aldred P. … Fernley R.T. (Biochemistry 1991) 3 4 23
  2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PMID: 9691177) White P.S. … Brodeur G.M. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Association of polymorphisms in the carbonic anhydrase 6 gene with salivary buffer capacity, dental plaque pH, and caries index in children aged 7-9 years. (PMID: 19721466) Peres R.C. … Line S.R. (Pharmacogenomics J. 2010) 3 23 49
  4. Carbonic anhydrase isozymes in the human pancreas. (PMID: 11303978) Nishimori I. … Onishi S. (Dig Liver Dis 2001) 3 23
  5. Gustin from human parotid saliva is carbonic anhydrase VI. (PMID: 9784398) Thatcher B.J. … Henkin R.I. (Biochem. Biophys. Res. Commun. 1998) 3 23

Products for CA6 Gene

  • Addgene plasmids for CA6

Sources for CA6 Gene

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