CA6 Gene
protein-coding GIFtS: 62
GCID: GC01P009005
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|
carbonic anhydrase VI
| |
Aliases
for CA6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carbonic Anhydrase VI1 2 3 | | CA-VI2 3 | | Carbonate Dehydratase VI2 3 | | GUSTIN2 | | Salivary Carbonic Anhydrase2 3 | | Carbonic Anhydrase 62 | | Secreted Carbonic Anhydrase2 3 | | EC 4.2.1.13 |
Export aliases for CA6 gene to outside databasesPrevious GC identifers: GC01P008626 GC01P008816 GC01P008715 GC01P008940 GC01P008928 GC01P008155 |
Summaries
for CA6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CA6:
The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only insalivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though itsfunction in saliva is unknown. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280Function: Reversible hydration of carbon dioxide. Its role in saliva is unknown
Gene Wiki entry for CA6 (Carbonic anhydrase VI)
|
Genomic Views
for CA6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CA6 gene promoter:
AML1a JunB FosB Fra-1 MEF-2A JunD c-Myb FOXO1a aMEF-2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CA6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.2CA6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P009005: view genomic region
(about GC identifiers)
Start:
|
9,005,922 bp from pter |
End:
|
9,035,151 bp from pter |
Size:
|
29,230 bases |
Orientation:
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plus strand |
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Proteins
for CA6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280 (See
protein sequence)Recommended Name: Carbonic anhydrase 6 precursor Size: 308 amino acids; 35367 Da
Cofactor: Zinc (By similarity)
Subcellular location: Secreted
1 PDB 3D structure from  and Proteopedia  for CA6:3FE4 (3D)
Secondary accessions: Q5FC00 Q96QX8 Q9UF03Alternative splicing: 2 isoforms: P23280-1 P23280-2 Explore the universe of human proteins at neXtProt for CA6: NX_P23280
CA6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001206.2 NP_001257429.1 NP_001257430.1 NP_001257431.1
ENSEMBL proteins: ENSP00000447108 ENSP00000435280 ENSP00000366662 ENSP00000366654 ENSP00000366661 ENSP00000325786 Reactome Protein details: P23280
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CA6 for ontologies About GeneDecksing
CA6 Antibody Products:
Assay Products for CA6: |
Protein
Domains /
Families
for CA6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CA6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P23280ProtoNet protein and cluster: P23280 1 Blocks protein family: IPB001148 Carbonic anhydrase
UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280Similarity: Belongs to the alpha-carbonic anhydrase family |
Function
for CA6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280Function: Reversible hydration of carbon dioxide. Its role in saliva is unknownCatalytic activity: H(2)CO(3) = CO(2) + H(2)OEnzyme regulation: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet(phosphonoformate trisodium salt) Genatlas biochemistry entry for CA6:carbonic anhydrase VI,secretory granules,parotid and submaxillar glands
Enzyme Number (IUBMB): EC 4.2.1.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CA6 (NM_001215) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CA6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004089 | carbonate dehydratase activity |
TAS | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
CA6 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Car6tm1Pwp for CA6
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Car6):
CA6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CA6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Reversible Hydration of Carbon Dioxide | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for CA6
1 
Kegg Pathway (Kegg details for CA6):
CA6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA6
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/6 Interacting proteins for CA6 (P232803 ENSP000003666624) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006730 | one-carbon metabolic process |
IEA | -- | | GO:0015701 | bicarbonate transport |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
CA6 for ontologies About GeneDecksing
|
Drugs & Compounds
for CA6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CA6 for compounds About GeneDecksing
 Browse Tocris compounds for CA6
4 HMDB Compounds for CA6 About this table
1 DrugBank Compound for CA6 About this table
3 Novoseek chemical compound relationships for CA6 gene About this table
Search CenterWatch for drugs/clinical trials and news about CA6 / CAH6
|
Transcripts
for CA6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CA6 gene (4 alternative transcripts): NM_001215.3 NM_001270500.1 NM_001270501.1 NM_001270502.1 Unigene Cluster for CA6: Carbonic anhydrase VI Hs.100322 [show with all ESTs]Unigene Representative Sequence: AK1305287 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000549778 ENST00000476083 ENST00000480186(uc021ofu.1) ENST00000377443(uc001apm.3 uc009vmn.3)
ENST00000377436 ENST00000377442 ENST00000319474
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CA6 (NM_001215) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CA6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA6 |
Additional cDNA sequence: AB102863.1 AB103090.1 AB103091.1 AK130528.1 AK300652.1 BC034350.1 M57892.1 6 DOTS entries: DT.107537 DT.121389729 DT.121389701 DT.121389706 DT.91656704 DT.121389699 24 AceView cDNA sequences: CB986787 BX282262 AA489653 BG675052 CB956732 AA489834 BP334519 BP334640 NM_001215 CB957335 CB958858 M57892 CB985290 BP334093 CB986048 AW951476 T29646 BC034350 AK130528 CB987092 CB955924 C00723 CD706017 CB956681
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CA6 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CA6
|
Expression
for CA6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CA6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTCTGGA
About this image
See CA6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CA6
SOURCE GeneReport for Unigene cluster: Hs.100322
UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280Tissue specificity: Major constituent of saliva
SABiosciences Custom PCR Arrays for CA6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA6
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA6 |
Orthologs
for CA6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CA6 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for CA6 (if available)
TreeFam Gene Tree for CA6 (if available) |
Paralogs
for CA6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CA6 gene
- CA22 CA122 CA72 CA32 CA112 CA5B2 CA142 CA5A2
- CA82 CA42 CA12 CA132 CA92 CA102
11 SIMAP similar genes for CA6 using alignment to 6 protein entries: CAH6_HUMAN (see all proteins):CA12 CA2 CA14 CA7 CA3 CA9
PTPRZ1 CA1 CA13 CA5A CA8
CA6 for paralogs About GeneDecksing
|
Genomic Variants
for CA6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CA6 (9005922 - 9035151 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CA6
1 CNV: 48376
Human Gene Mutation Database (HGMD): CA6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA6 |
|
Disorders
/ Diseases
for CA6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CA6 for disorders About GeneDecksing
OMIM gene information: 114780
OMIM disorders: --
10  diseases for CA6: About MalaCardsmultilocular clear cell renal cell carcinoma hand, foot and mouth disease herpangina sjogren's syndrome
diabetes mellitus arteriosclerosis glaucoma ovarian carcinoma
carcinoma neuronitis
3 diseases from the University of Copenhagen DISEASES database for CA6:"hand, foot and mouth disease" Glaucoma Multilocular clear cell renal cell carcinoma Human Genome Epidemiology (HuGE) Navigator: CA6 (4 documents)
Export disorders for CA6 gene to outside databases
|
Publications
for CA6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CA6 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with CA6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry. (PubMed id 1899030)1, 2, 9 Aldred P....Fernley R.T. (1991)
- Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PubMed id 9691177)1, 3, 9 White P.S....Brodeur G.M. (1998)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II. (PubMed id 8429198)1, 9 Ogawa Y....Yagi T. (1993)
- Gustin from human parotid saliva is carbonic anhydrase VI. (PubMed id 9784398)1, 9 Thatcher B.J....Henkin R.I. (1998)
- Association of polymorphisms in the carbonic anhydras e 6 gene with salivary buffer capacity, dental plaque pH, and caries index in c hildren aged 7-9 years. (PubMed id 19721466)1, 9 Peres R.C....Line S.R. (2010)
- Carbonic anhydrase isozymes in the human pancreas. (PubMed id 11303978)1, 9 Nishimori I. and Onishi S. (2001)
- Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle. (PubMed id 10207193)1, 9 Leinonen J....Rajaniemi H. (1999)
- Secretory carbonic anhydrase isoenzyme (CA VI) in human serum. (PubMed id 9439449)1, 9 Kivela J....Rajaniemi H. (1997)
- Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands. (PubMed id 2113069)1, 9 Parkkila S....Rajaniemi H. (1990)
|
External Searches for CA6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CA6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CA6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CA6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CA6 gene:
Search GeneIP for patents involving CA6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CA6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CA6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA6 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA6 |
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