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CA6 Gene

protein-coding   GIFtS: 64
GCID: GC01P009005

Carbonic Anhydrase VI

  See CA6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbonic Anhydrase VI1 2 3     CA-VI2 3
Carbonate Dehydratase VI2 3     GUSTIN2
Salivary Carbonic Anhydrase2 3     Carbonic Anhydrase 62
Secreted Carbonic Anhydrase2 3     EC 4.2.1.13

External Ids:    HGNC: 13801   Entrez Gene: 7652   Ensembl: ENSG000001316867   OMIM: 1147805   UniProtKB: P232803   

Export aliases for CA6 gene to outside databases

Previous GC identifers: GC01P008626 GC01P008816 GC01P008715 GC01P008940 GC01P008928 GC01P008155


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CA6 Gene:
The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in
salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its
function in saliva is unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA6 Gene:
CA6 (carbonic anhydrase VI) is a protein-coding gene. Diseases associated with CA6 include multilocular clear cell renal cell carcinoma, and clear cell renal cell carcinoma. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280
Function: Reversible hydration of carbon dioxide. Its role in saliva is unknown

Gene Wiki entry for CA6 (Carbonic anhydrase VI) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CA6 gene promoter:
         AML1a   JunB   FosB   Fra-1   MEF-2A   JunD   c-Myb   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA6 promoter sequence
   Search Chromatin IP Primers for CA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

CA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P009005:  view genomic region     (about GC identifiers)

Start:
9,005,922 bp from pter      End:
9,035,151 bp from pter
Size:
29,230 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280 (See protein sequence)
Recommended Name: Carbonic anhydrase 6 precursor  
Size: 308 amino acids; 35367 Da
Cofactor: Zinc (By similarity)
1 PDB 3D structure from and Proteopedia for CA6:
3FE4 (3D)    
Secondary accessions: E7EMQ1 Q5FBW3 Q5FC00 Q96QX8 Q9UF03
Alternative splicing: 3 isoforms:  P23280-1   P23280-2   P23280-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CA6: NX_P23280

Explore proteomics data for CA6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn67, Asn256

  • See CA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001206.2  NP_001257429.1  NP_001257430.1  NP_001257431.1  

    ENSEMBL proteins: 
     ENSP00000447108   ENSP00000435280   ENSP00000366662   ENSP00000366654   ENSP00000366661  
    Reactome Protein details: P23280

    CA6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CA6

     
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    CA6 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CA: Carbonic anhydrases

    4 InterPro protein domains:
     IPR018428 Carbonic_anhydrase_CA6
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class

    Graphical View of Domain Structure for InterPro Entry P23280

    ProtoNet protein and cluster: P23280

    1 Blocks protein domain: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280
    Similarity: Belongs to the alpha-carbonic anhydrase family


    Find genes that share domains with CA6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH6_HUMAN, P23280
    Function: Reversible hydration of carbon dioxide. Its role in saliva is unknown
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and
    Foscarnet (phosphonoformate trisodium salt)

         Genatlas biochemistry entry for CA6:
    carbonic anhydrase VI,secretory granules,parotid and submaxillar glands

         Enzyme Number (IUBMB): EC 4.2.1.11

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity TAS--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CA6           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Car6):
     digestive/alimentary  immune system 

    Find genes that share phenotypes with CA6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Car6tm1Pwp for CA6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CA6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA6
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CA6:
    hsa-miR-513a-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidCA6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CA6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CA6 (NM_001215)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA6
    Addgene plasmids for CA6 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAH6_HUMAN, P23280: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    chloroplast2
    cytosol2
    nucleus2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with CA6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CA6 About    
    See pathways by source

    SuperPathContained pathways About
    1Nitrogen metabolism
    Reversible Hydration of Carbon Dioxide0.00
    Nitrogen metabolism
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with CA6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CA6
        Reversible hydration of carbon dioxide


    1 Kegg Pathway  (Kegg details for CA6):
        Nitrogen metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CA6
    Interactions:

        Search GeneGlobe Interaction Network for CA6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for CA6 (P232803 ENSP000003666624) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCGRTP558993, ENSP000002214664I2D: score=1 STRING: ENSP00000221466
    HNRNPCP079103I2D: score=1 
    KCTD17Q8N5Z53I2D: score=1 
    MDFIQ997503I2D: score=1 
    PLSCR1O151623I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA--
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with CA6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CA6 (CAH6)

    4 HMDB Compounds for CA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for CA6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    Ellagic Acid-- 476-66-4targetinhibitor20185318

    3 Novoseek inferred chemical compound relationships for CA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 55.3 2 12944377 (1), 11001942 (1)
    zinc 49 5 19824891 (1), 10616164 (1), 9784398 (1), 20180965 (1)
    sialic acid 30.5 1 11093807 (1)



    Find genes that share compounds with CA6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CA6 gene (4 alternative transcripts): 
    NM_001215.3  NM_001270500.1  NM_001270501.1  NM_001270502.1  

    Unigene Cluster for CA6:

    Carbonic anhydrase VI
    Hs.100322  [show with all ESTs]
    Unigene Representative Sequence: AK130528
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549778 ENST00000476083 ENST00000480186(uc021ofu.1) ENST00000377443(uc001apm.3 uc009vmn.3)
    ENST00000377436 ENST00000377442
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CA6:
    hsa-miR-513a-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidCA6 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB102863.1 AB103090.1 AB103091.1 AK130528.1 AK300652.1 BC034350.1 M57892.1 

    6 DOTS entries:

    DT.107537  DT.121389729  DT.121389701  DT.121389706  DT.91656704  DT.121389699 

    24 AceView cDNA sequences:

    BX282262 AA489653 CB986787 AW951476 CB956732 M57892 AA489834 BG675052 
    CB985290 BP334519 NM_001215 BP334640 CB957335 BP334093 CB958858 CB986048 
    AK130528 T29646 BC034350 CB987092 C00723 CB955924 CD706017 CB956681 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CA6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                                                              -         
    SP3:              -     -     -                                             
    SP4:                          -     -     -     -                           


    ECgene alternative splicing isoforms for CA6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTCTGGA
    CA6 Expression
    About this image


    CA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    CA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CA6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.100322

    UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280
    Tissue specificity: Major constituent of saliva

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CA6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car61 , 5 carbonic anhydrase 61, 5 67.79(n)1
    54.55(a)1
      4 (81.12 cM)5
    123531  NM_009802.21  NP_033932.21 
     1501870155 
    chicken
    (Gallus gallus)
    Aves CA61 carbonic anhydrase VI 61.23(n)
    52.08(a)
      428187  XM_425745.4  XP_425745.4 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000064481 carbonic anhydrase 6-like 60.5(n)
    55.52(a)
      100006448  XM_002666479.2  XP_002666525.1 


    ENSEMBL Gene Tree for CA6 (if available)
    TreeFam Gene Tree for CA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CA6 gene
    CA22  CA122  CA72  CA32  CA5B2  CA5A2  CA142  CA82  
    CA42  CA12  CA92  CA132  
    11 SIMAP similar genes for CA6 using alignment to 4 protein entries:     CAH6_HUMAN (see all proteins):
    CA12    CA7    CA14    CA2    CA3    CA9
    PTPRZ1    CA5A    CA1    CA13    CA8

    Find genes that share paralogs with CA6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CA6 (see all 893)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998421011,2
    --9003919(+) CCAAG-/AAAAAA 4 -- us2k10--------
    rs762099791,2
    C--9003970(+) TCAGGA/GGTCCT 4 -- us2k10--------
    rs614971431,2
    C,F--9004048(+) TTTCCG/ACAGGG 4 -- us2k11Minor allele frequency- A:0.21WA 118
    rs170328921,2
    C,F,H--9004073(+) GTGGGC/TGTCAC 4 -- us2k110Minor allele frequency- T:0.09NA NS EA WA CSA 679
    rs1872835691,2
    --9004104(+) AGTAGG/TTTTCT 4 -- us2k10--------
    rs726415451,2
    C--9004120(+) TTGCAA/GAGAAA 4 -- us2k14Minor allele frequency- G:0.09NA WA EA 360
    rs1922064311,2
    --9004131(+) TGGTCC/TATAAG 4 -- us2k10--------
    rs1846790781,2
    --9004296(+) ATTGCC/TGAATC 4 -- us2k10--------
    rs1884148171,2
    --9004347(+) GGAGGC/TGGCCA 4 -- us2k10--------
    rs1457950781,2
    C--9004367(+) GCTCAC/TGCCTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CA6 (9005922 - 9035151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CA6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1965CNV Insertion18451855
    nsv516097CNV Loss19592680
    nsv871338CNV Loss21882294
    nsv871694CNV Gain21882294

    Human Gene Mutation Database (HGMD): CA6
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114780    OMIM disorders: --

    4 diseases for CA6:    
    About MalaCards
    multilocular clear cell renal cell carcinoma    clear cell renal cell carcinoma    hand, foot and mouth disease    mouth disease

    3 diseases from the University of Copenhagen DISEASES database for CA6:
    hand, foot and mouth disease     Glaucoma     Multilocular clear cell renal cell carcinoma

    Find genes that share disorders with CA6           About GenesLikeMe

    Genetic Association Database (GAD): CA6
    Human Genome Epidemiology (HuGE) Navigator: CA6 (4 documents)

    Export disorders for CA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CA6 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with CA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry. (PubMed id 1899030)1, 2, 9 Aldred P....Fernley R.T. (Biochemistry 1991)
    2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PubMed id 9691177)1, 3, 9 White P.S....Brodeur G.M. (Cytogenet. Cell Genet. 1998)
    3. Association of polymorphisms in the carbonic anhydrase 6 gene with salivary buffer capacity, dental plaque pH, and caries index in children aged 7-9 years. (PubMed id 19721466)1, 4, 9 Peres R.C....Line S.R. (Pharmacogenomics J. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II. (PubMed id 8429198)1, 9 Ogawa Y....Yagi T. (J. Histochem. Cytochem. 1993)
    7. Gustin from human parotid saliva is carbonic anhydrase VI. (PubMed id 9784398)1, 9 Thatcher B.J....Henkin R.I. (Biochem. Biophys. Res. Commun. 1998)
    8. Carbonic anhydrase isozymes in the human pancreas. (PubMed id 11303978)1, 9 Nishimori I. and Onishi S. (Dig Liver Dis 2001)
    9. Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle. (PubMed id 10207193)1, 9 Leinonen J....Rajaniemi H. (Caries Res. 1999)
    10. Secretory carbonic anhydrase isoenzyme (CA VI) in human serum. (PubMed id 9439449)1, 9 KivelAo J....Rajaniemi H. (Clin. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 765 HGNC: 1380 AceView: CA6 Ensembl:ENSG00000131686 euGenes: HUgn765
    ECgene: CA6 Kegg: 765 H-InvDB: CA6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CA6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CA6 gene:
    Search GeneIP for patents involving CA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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