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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA6 Gene

protein-coding   GIFtS: 63
GCID: GC01P009005

Carbonic Anhydrase VI

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbonic Anhydrase VI1 2 3     CA-VI2 3
Carbonate Dehydratase VI2 3     GUSTIN2
Salivary Carbonic Anhydrase2 3     Carbonic Anhydrase 62
Secreted Carbonic Anhydrase2 3     EC 4.2.1.13

External Ids:    HGNC: 13801   Entrez Gene: 7652   Ensembl: ENSG000001316867   OMIM: 1147805   UniProtKB: P232803   

Export aliases for CA6 gene to outside databases

Previous GC identifers: GC01P008626 GC01P008816 GC01P008715 GC01P008940 GC01P008928 GC01P008155


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA6 Gene:
The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in
salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its
function in saliva is unknown. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA6 Gene: 
CA6 (carbonic anhydrase VI) is a protein-coding gene. Diseases associated with CA6 include multilocular clear cell renal cell carcinoma, and herpangina, and among its related super-pathways are Nitrogen metabolism and Metabolic pathways. GO annotations related to this gene include carbonate dehydratase activity and zinc ion binding. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280
Function: Reversible hydration of carbon dioxide. Its role in saliva is unknown

Gene Wiki entry for CA6 (Carbonic anhydrase VI) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA6 gene promoter:
         AML1a   JunB   FosB   Fra-1   MEF-2A   JunD   c-Myb   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

CA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P009005:  view genomic region     (about GC identifiers)

Start:
9,005,922 bp from pter      End:
9,035,151 bp from pter
Size:
29,230 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280 (See protein sequence)
Recommended Name: Carbonic anhydrase 6 precursor  
Size: 308 amino acids; 35367 Da
Cofactor: Zinc (By similarity)
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for CA6:
3FE4 (3D)    
Secondary accessions: E7EMQ1 Q5FBW3 Q5FC00 Q96QX8 Q9UF03
Alternative splicing: 3 isoforms:  P23280-1   P23280-2   P23280-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CA6: NX_P23280

Explore proteomics data for CA6 at MOPED 

CA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CA6 Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_001206.2  NP_001257429.1  NP_001257430.1  NP_001257431.1  

ENSEMBL proteins: 
 ENSP00000447108   ENSP00000435280   ENSP00000366662   ENSP00000366654   ENSP00000366661  
 ENSP00000325786  
Reactome Protein details: P23280
Human Recombinant Protein Products for CA6: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CA6 (Carbonic Anhydrase VI)
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CA6
OriGene Protein Over-expression Lysate for CA6
OriGene MassSpec for CA6 
OriGene Custom Protein Services for CA6
GenScript Custom Purified and Recombinant Proteins Services for CA6
Novus Biologicals CA6 Proteins
Novus Biologicals CA6 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CA6 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005737cytoplasm IEA--

CA6 for ontologies           About GeneDecksing



CA6 Antibody Products: 
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R&D Systems Antibodies for CA6 (Carbonic Anhydrase VI)
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ThermoFisher Antibody for CA6
LSBio Antibodies in human, mouse, rat for CA6 

Assay Products for CA6: 
Browse Kits and Assays available from EMD Millipore
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CA6
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Cloud-Clone Corp. ELISAs for CA6 
Cloud-Clone Corp. CLIAs for CA6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CA: Carbonic anhydrases

4 InterPro protein domains:
 IPR018428 Carbonic_anhydrase_CA6
 IPR001148 Carbonic_anhydrase_a
 IPR018338 Carbonic_anhydrase_a-class_CS
 IPR023561 Carbonic_anhydrase_a-class

Graphical View of Domain Structure for InterPro Entry P23280

ProtoNet protein and cluster: P23280

1 Blocks protein domain: IPB001148 Carbonic anhydrase

UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280
Similarity: Belongs to the alpha-carbonic anhydrase family


CA6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CAH6_HUMAN, P23280
Function: Reversible hydration of carbon dioxide. Its role in saliva is unknown
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
Enzyme regulation: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and
Foscarnet (phosphonoformate trisodium salt)

     Genatlas biochemistry entry for CA6:
carbonic anhydrase VI,secretory granules,parotid and submaxillar glands

     Enzyme Number (IUBMB): EC 4.2.1.11

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004089carbonate dehydratase activity TAS--
GO:0008270zinc ion binding IEA--
     
CA6 for ontologies           About GeneDecksing


Phenotypes:
     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Car6):
 digestive/alimentary  immune system 

CA6 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Car6tm1Pwp for CA6

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CA6 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CA6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA6 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA6 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA6
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CA6:
hsa-miR-513a-3p hsa-miR-556-3p
SwitchGear 3'UTR luciferase reporter plasmidCA6 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CA6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA6

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of CA6

Clone
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OriGene clones in human, mouse for CA6 (see all 7)
OriGene ORF clones in mouse, rat for CA6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CA6 (NM_001215)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA6
Sirion Biotech Customized lentivirus for stable overexpression of CA6 
                     Customized lentivirus expression plasmids for stable overexpression of CA6 

Cell Line
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GenScript Custom overexpressing Cell Line Services for CA6
Search LifeMap BioReagents cell lines for CA6
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA6


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CA6 About                                                                                                See pathways by source

SuperPathContained pathways About
1Reversible Hydration of Carbon Dioxide
Reversible Hydration of Carbon Dioxide0.67
Nitrogen metabolism0.67
2Metabolism
Metabolism0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2        Reactome Pathways for CA6
    Reversible Hydration of Carbon Dioxide
Metabolism


1         Kegg Pathway  (Kegg details for CA6):
    Nitrogen metabolism


CA6 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA6

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/6 Interacting proteins for CA6 (P232803 ENSP000003666624) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
FCGRTP558993, ENSP000002214664I2D: score=1 STRING: ENSP00000221466
HNRNPCP079103I2D: score=1 
KCTD17Q8N5Z53I2D: score=1 
MDFIQ997503I2D: score=1 
PLSCR1O151623I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006730one-carbon metabolic process IEA--
GO:0015701bicarbonate transport TAS--
GO:0044281small molecule metabolic process TAS--

CA6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CA6 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CA6 (CAH6)

4 HMDB Compounds for CA6    About this table
CompoundSynonyms CAS #PubMed Ids
Carbon dioxideCarbon oxide (see all 5)124-38-9--
Carbonic acidacid of air (see all 24)463-79-6--
WaterDihydrogen oxide (see all 2)7732-18-5--
ZincZinc (see all 2)7440-66-6--

2 DrugBank Compounds for CA6    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
Ellagic Acid-- 476-66-4targetinhibitor20185318

3 Novoseek inferred chemical compound relationships for CA6 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
chondroitin 55.3 2 12944377 (1), 11001942 (1)
zinc 49 5 19824891 (1), 10616164 (1), 9784398 (1), 20180965 (1)
sialic acid 30.5 1 11093807 (1)

Search CenterWatch for drugs/clinical trials and news about CA6 / CAH6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CA6 gene (4 alternative transcripts): 
NM_001215.3  NM_001270500.1  NM_001270501.1  NM_001270502.1  

Unigene Cluster for CA6:

Carbonic anhydrase VI
Hs.100322  [show with all ESTs]
Unigene Representative Sequence: AK130528
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000549778 ENST00000476083 ENST00000480186(uc021ofu.1) ENST00000377443(uc001apm.3 uc009vmn.3)
ENST00000377436 ENST00000377442 ENST00000319474
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA6
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CA6:
hsa-miR-513a-3p hsa-miR-556-3p
SwitchGear 3'UTR luciferase reporter plasmidCA6 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CA6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA6
Clone
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OriGene ORF clones in mouse, rat for CA6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CA6 (NM_001215)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA6
Sirion Biotech Customized lentivirus for stable overexpression of CA6 
                     Customized lentivirus expression plasmids for stable overexpression of CA6 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CA6
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA6
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA6
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA6

Additional mRNA sequence: 

AB102863.1 AB103090.1 AB103091.1 AK130528.1 AK300652.1 BC034350.1 M57892.1 

6 DOTS entries:

DT.107537  DT.121389729  DT.121389701  DT.121389706  DT.91656704  DT.121389699 

24 AceView cDNA sequences:

CB986787 BX282262 AA489653 AA489834 BG675052 CB957335 CB956732 CB958858 
CB986048 BP334519 M57892 BP334093 AW951476 BP334640 CB985290 NM_001215 
AK130528 T29646 BC034350 C00723 CB987092 CB955924 CD706017 CB956681 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CA6    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1:                                                                        
SP2:                                                              -         
SP3:              -     -     -                                             
SP4:                          -     -     -     -                           


ECgene alternative splicing isoforms for CA6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CA6 expression in normal human tissues (normalized intensities)      CA6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTGTCTGGA
CA6 Expression
About this image


CA6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Oral Cavity (Gastrointestinal Tract)    fully expand to see all 5 entries
         salivary gland ; glandular cells   
         salivary gland   
 
 Peripheral Nervous System (Nervous System)
         Schwann Precursor Cells Peripheral Nerve Domain
 
 Lymph (Hematopoietic System)
         lymph node   
 
 Eye (Sensory Organs)
         cornea   

 -- (Integumentary System)
         skin   

See CA6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CA6

SOURCE GeneReport for Unigene cluster: Hs.100322

UniProtKB/Swiss-Prot: CAH6_HUMAN, P23280
Tissue specificity: Major constituent of saliva

    SABiosciences Custom PCR Arrays for CA6
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CA6 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Car61 , 5 carbonic anhydrase 61, 5 67.57(n)1
53.9(a)1
  4 (81.12 cM)5
123531  NM_009802.21  NP_033932.21 
 1501870155 
chicken
(Gallus gallus)
Aves CA61 carbonic anhydrase VI 61.3(n)
53.77(a)
  428187  XM_425745.3  XP_425745.3 
zebrafish
(Danio rerio)
Actinopterygii LOC1000064481 carbonic anhydrase 6-like 62.86(n)
59.06(a)
  100006448  XM_002666479.1  XP_002666525.1 


ENSEMBL Gene Tree for CA6 (if available)
TreeFam Gene Tree for CA6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CA6 gene
CA22  CA122  CA72  CA32  CA112  CA5B2  CA5A2  CA142  
CA82  CA42  CA12  CA92  CA132  CA102  
11 SIMAP similar genes for CA6 using alignment to 4 protein entries:     CAH6_HUMAN (see all proteins):
CA12    CA7    CA14    CA2    CA3    CA9
PTPRZ1    CA5A    CA1    CA13    CA8

CA6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/893 SNPs in CA6 are shown (see all 893)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1998421011,2
--9003919(+) CCAAG-/AAAAAA 4 -- us2k10--------
rs762099791,2
C--9003970(+) TCAGGA/GGTCCT 4 -- us2k10--------
rs614971431,2
C,F--9004048(+) TTTCCG/ACAGGG 4 -- us2k11Minor allele frequency- A:0.21WA 118
rs170328921,2
C,F,H--9004073(+) GTGGGC/TGTCAC 4 -- us2k110Minor allele frequency- T:0.09NA NS EA WA CSA 679
rs1872835691,2
--9004104(+) AGTAGG/TTTTCT 4 -- us2k10--------
rs726415451,2
C--9004120(+) TTGCAA/GAGAAA 4 -- us2k14Minor allele frequency- G:0.09NA WA EA 360
rs1922064311,2
--9004131(+) TGGTCC/TATAAG 4 -- us2k10--------
rs1846790781,2
--9004296(+) ATTGCC/TGAATC 4 -- us2k10--------
rs1884148171,2
--9004347(+) GGAGGC/TGGCCA 4 -- us2k10--------
rs1457950781,2
C--9004367(+) GCTCAC/TGCCTG 4 -- us2k10--------

HapMap Linkage Disequilibrium report for CA6 (9005922 - 9035151 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for CA6:    About this table     
Variant IDTypeSubtypePubMed ID
nsv1965CNV Insertion18451855
nsv516097CNV Loss19592680
nsv871338CNV Loss21882294
nsv871694CNV Gain21882294


Human Gene Mutation Database (HGMD): CA6
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CA6
DNA2.0 Custom Variant and Variant Library Synthesis for CA6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 114780    OMIM disorders: --

10 diseases for CA6:    About MalaCards
multilocular clear cell renal cell carcinoma    herpangina    hand, foot and mouth disease    mouth disease
clear cell renal cell carcinoma    arteriosclerosis    sjogren's syndrome    glaucoma
renal cell carcinoma    diabetes mellitus

3 diseases from the University of Copenhagen DISEASES database for CA6:
hand, foot and mouth disease     Glaucoma     Multilocular clear cell renal cell carcinoma

CA6 for disorders           About GeneDecksing

Genetic Association Database (GAD): CA6
Human Genome Epidemiology (HuGE) Navigator: CA6 (4 documents)

Export disorders for CA6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CA6 gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with CA6)
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  1. Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry. (PubMed id 1899030)1, 2, 9 Aldred P....Fernley R.T. (1991)
  2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PubMed id 9691177)1, 3, 9 White P.S....Brodeur G.M. (1998)
  3. Association of polymorphisms in the carbonic anhydras e 6 gene with salivary buffer capacity, dental plaque pH, and caries index in c hildren aged 7-9 years. (PubMed id 19721466)1, 4, 9 Peres R.C....Line S.R. (2010)
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  6. Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II. (PubMed id 8429198)1, 9 Ogawa Y....Yagi T. (1993)
  7. Gustin from human parotid saliva is carbonic anhydrase VI. (PubMed id 9784398)1, 9 Thatcher B.J....Henkin R.I. (1998)
  8. Carbonic anhydrase isozymes in the human pancreas. (PubMed id 11303978)1, 9 Nishimori I. and Onishi S. (2001)
  9. Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle. (PubMed id 10207193)1, 9 Leinonen J....Rajaniemi H. (1999)
  10. Secretory carbonic anhydrase isoenzyme (CA VI) in human serum. (PubMed id 9439449)1, 9 Kivela J....Rajaniemi H. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 765 HGNC: 1380 AceView: CA6 Ensembl:ENSG00000131686 euGenes: HUgn765
ECgene: CA6 Kegg: 765 H-InvDB: CA6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CA6 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CA6 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CA6 gene:
Search GeneIP for patents involving CA6

GeneCards and IP:
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