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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CA5B Gene

protein-coding GIFtS: 62
GCID: GC0XP015706

carbonic anhydrase VB, mitochondrial

Explore 4 diseases affiliated with
CA5B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Carbonic Anhydrase VB, Mitochondrial¹ ²		Carbonic Anhydrase 5B, Mitochondrial²
Carbonate Dehydratase VB² ³		Carbonic Dehydratase²
CA-VB² ³		Carbonic Anhydrase VB³
EC 4.2.1.1³ ⁸

External Ids:	HGNC: 1378¹	Entrez Gene: 11238²	Ensembl: ENSG00000169239⁷	OMIM: 300230⁵	UniProtKB: Q9Y2D0³

Export aliases for CA5B gene to outside databases

Previous GC identifers: GC0XP015466 GC0XP014582 GC0XP014941 GC0XP015117 GC0XP015516 GC0XP015666

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA5B:

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon

dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base

balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show

extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the

mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue

distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two

mitochondrial carbonic anhydrases evolved to assume different physiologic roles. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0

Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA5B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CA5B gene promoter:
RP58 AML1a p53 FAC1 POU2F1 POU2F1a FOXJ2 (long isoform) FOXJ2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CA5B promoter sequence

Search SABiosciences Chromatin IP Primers for CA5B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA5B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.1

CA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA5B gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP015706: view genomic region (about GC identifiers)

Start:	15,706,953 bp from pter	End:	15,805,748 bp from pter
Size:	98,796 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0 (See protein sequence)

Recommended Name: Carbonic anhydrase 5B, mitochondrial precursor

Size: 317 amino acids; 36434 Da

Cofactor: Zinc (By similarity)

Subcellular location: Mitochondrion

Secondary accessions: A8K4T5

Explore the universe of human proteins at neXtProt for CA5B: NX_Q9Y2D0

4 DME Specific Peptides for CA5B (Q9Y2D0)

QFHFHWG

AELHLVH

GSLTTPPL

ELHLVHWN

CA5B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_009151.1

ENSEMBL proteins:

ENSP00000418622 ENSP00000314099 ENSP00000417553 ENSP00000417236 ENSP00000417021

Reactome Protein details: Q9Y2D0
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CA5B (Carbonic Anhydrase VB/CA5B)
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	Novus Biologicals CA5B Proteins Novus Biologicals CA5B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CA5B

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	10409679
GO:0005759	mitochondrial matrix	TAS	--

CA5B for ontologies About GeneDecksing

CA5B Antibody Products:

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	Uscn ELISAs and CLIAs for CA5B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CA5B for domains About GeneDecksing

4 InterPro domains/families:

IPR018437 CA-V_mt

IPR001148 Carbonic_anhydrase_a

IPR018338 Carbonic_anhydrase_a-class_CS

IPR023561 Carbonic_anhydrase_a-class

Graphical View of Domain Structure for InterPro Entry Q9Y2D0

ProtoNet protein and cluster: Q9Y2D0

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0

Similarity: Belongs to the alpha-carbonic anhydrase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0

Function: Reversible hydration of carbon dioxide

Catalytic activity: H(2)CO(3) = CO(2) + H(2)O

Enzyme regulation: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet

(phosphonoformate trisodium salt)

Genatlas biochemistry entry for CA5B:

carbonic anhydrase VB,mitochondrial,expressed in heart,skeletal muscle,pancreas,kidney,salivary glands,spinal cord but

not in liver

Enzyme Number (IUBMB): EC 4.2.1.1¹ ²

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA5B
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CA5B (see all 43):
		hsa-miR-411* hsa-miR-579 hsa-miR-379* hsa-miR-199a-3p hsa-miR-605 hsa-miR-374c hsa-miR-186 hsa-miR-181b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA5B (see all 7) OriGene shRNA RFP: CA5B OriGene siRNA: CA5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA5B

Gene Editing
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		GenScript: all cDNA clones in your preferred vector: CA5B (NM_007220)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA5B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CA5B
		Search LifeMap BioReagents cell lines for CA5B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004089	carbonate dehydratase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

CA5B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CA5B:

Increased gamma-H2AX phosphory

Lamellipodia cells

Animal Models:
1 MGI phenotypic allele

for Car5b (no phenotypes)

CA5B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Reversible Hydration of Carbon Dioxide

Reversible Hydration of Carbon Dioxide

1.00

Nitrogen metabolism

0.52

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for CA5B

	Reversible Hydration of Carbon Dioxide
	Metabolism

1 Kegg Pathway (Kegg details for CA5B):

Nitrogen metabolism

CA5B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CA5B

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CA5B (ENSP00000314099⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006730	one-carbon metabolic process	IEA	--
GO:0015701	bicarbonate transport	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

CA5B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CA5B

4 HMDB Compounds for CA5B About this table

Compound	Synonyms	CAS #	PubMed Ids
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
Carbonic acid	acid of air (see all 24)	463-79-6	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--
Zinc	Zinc (see all 2)	7440-66-6	--

1 DrugBank Compound for CA5B About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Zonisamide	Zonisamida [Spanish] (see all 2)	68291-97-4	target	inhibitor	18537527 17762320 19703035 15837316 18782051 17582922

Search CenterWatch for drugs/clinical trials and news about CA5B / CAH5B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CA5B gene:

NM_007220.3

Unigene Cluster for CA5B:

Carbonic anhydrase VB, mitochondrial

Hs.744128 [show with all ESTs]

Unigene Representative Sequence: NM_007220

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000498004 ENST00000318636(uc004cxe.3) ENST00000478923 ENST00000474624

ENST00000380319 ENST00000479740 ENST00000380313 ENST00000478341 ENST00000496188

ENST00000454127

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA5B
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CA5B (see all 43):
		hsa-miR-411* hsa-miR-579 hsa-miR-379* hsa-miR-199a-3p hsa-miR-605 hsa-miR-374c hsa-miR-186 hsa-miR-181b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA5B (see all 7) OriGene shRNA RFP: CA5B OriGene siRNA: CA5B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA5B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA5B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA5B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CA5B (NM_007220)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA5B
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA5B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA5B

Additional cDNA sequence:

AB021660.1 AK057568.1 AK291050.1

8 DOTS entries:

DT.429971 DT.108740 DT.121314614 DT.40213312 DT.91796884 DT.101982938 DT.121314648 DT.97763776

24/219 AceView cDNA sequences (see all 219):

AA576865 BM314182 AA811880 AW501870 BP371510 AA206778 AK125384 AA975463

BC028142 AI738626 AI801563 BX112738 BG032690 BC021816 AW772284 BU542020

BX113332 AI860158 CK821282 BQ919066 AW503003 BI333715 AI086962 AA442626

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CA5B (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11
SP1:													-		-		-				-
SP2:							-		-				-		-		-				-
SP3:																	-				-
SP4:									-				-		-		-
SP5:									-

ECgene alternative splicing isoforms for CA5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CA5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAAAAAAAG

About this image

CA5B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

White adipocyte-like cells (Differentiation of ...)

Adipose

Definitive endoderm-like cells (A scalable, suspensi...)

See CA5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CA5B

SOURCE GeneReport for Unigene cluster: Hs.744128

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0

Tissue specificity: Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed

in liver

SABiosciences Custom PCR Arrays for CA5B

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA5B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CA5B gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CA5B¹	carbonic anhydrase VB, mitochondrial	71.4(n) 74.05(a)		415833 XM_414195.3 XP_414195.3
African clawed frog (Xenopus laevis)	Amphibia	Xl.25642²	Xenopus laevis transcribed sequence with moderate similarity more	73.16(n)		CA789030.1
zebrafish (Danio rerio)	Actinopterygii	ca5¹	carbonic anhydrase V	60.36(n) 56.76(a)		569989 NM_001111201.1 NP_001104671.1
fruit fly (Drosophila melanogaster)	Insecta	CAH1⁶	Carbonic anhydrase 1	38(a)	1 → many	2L(13803626-13809994)
worm (Caenorhabditis elegans)	Secernentea	cah-3³	carbonic anhydrase	40(a)		X(16518334-16519911) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ATACA5⁶ ATACA2⁶ (see all 8)	carbonic anhydrase (see all 8)	25(a) 24(a) (see all 8)	many ↔ many many ↔ many (see all 8)	1(2511647-2513454) 2(12029997-12032420)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	bifunctional monodehydroascorbate reductase and ca... bifunctional monodehydroascorbate reductase and ca... (see all 10)	26(a) 26(a) (see all 10)	many ↔ many many ↔ many (see all 10)	8(20348392-20351041) 8(20309869-20312003)

ENSEMBL Gene Tree for CA5B (if available)
TreeFam Gene Tree for CA5B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CA5B gene

CA2² CA12² CA7² CA6² CA3² CA11² CA14² CA5A²

CA8² CA4² CA1² CA13² CA9² CA10²

10 SIMAP similar genes for CA5B using alignment to 4 protein entries: CAH5B_HUMAN (see all proteins):

CA5A CA7 CA1 CA13 CA3 CA2

CA8 CA10 CA14 DKFZp686I20267

CA5B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CA5B
PGOHUM00000250066

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183736572^1,2		--	15754547(+)	`AGTGCA/CAAACT`	1	--	us2k¹		0	--	--	--	--
rs77963214^1,2	C	--	15754591(+)	`AGAAAA/TAAAGC`	1	--	us2k¹		0	--	--	--	--
rs189185094^1,2		--	15754774(+)	`CTTCCA/TTTAAG`	1	--	us2k¹		0	--	--	--	--
rs140030125^1,2		--	15754776(+)	`TCCATG/TAAGCT`	1	--	us2k¹		0	--	--	--	--
rs192586676^1,2		--	15754839(+)	`TAGGAC/TGCTGC`	1	--	us2k¹		0	--	--	--	--
rs184173454^1,2		--	15754841(+)	`GGACGC/TTGCCT`	1	--	us2k¹		0	--	--	--	--
rs142675867^1,2		--	15754875(+)	`AAGTAC/GAACTA`	1	--	us2k¹		0	--	--	--	--
rs147353190^1,2	C,	--	15755296(+)	`ATACTA/GTAAAA`	1	--	us2k¹		0	--	--	--	--
rs190021658^1,2		--	15755756(+)	`AGGTCA/GGCTAA`	1	--	us2k¹		0	--	--	--	--
rs5936035^1,2	C,F,H,	--	15755848(+)	`GTTCAA/GAGGAC`	1	--	us2k¹		25		NS EA NA WA	2603

HapMap Linkage Disequilibrium report for CA5B (15706953 - 15805748 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CA5B: --
Locus Specific Mutation Databases (LSDB): CA5B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA5B

DNA2.0 Custom Variant and Variant Library Synthesis for CA5B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CA5B for disorders           About GeneDecksing

OMIM gene information: 300230    OMIM disorders: --

4 diseases for CA5B:    About MalaCards

heart block congenital heart block glaucoma neuronitis

1 disease from the University of Copenhagen DISEASES database for CA5B:

Congenital heart block

Export disorders for CA5B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CA5B gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with CA5B)

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Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X. (PubMed id 10409679)^{1, 2, 3, 9} Fujikawa-Adachi K.... Onishi S. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. (PubMed id 10677517)^{1, 9} Shah G.N....Sly W.S. (2000)
Carbonic anhydrase isozymes in the human pancreas. (PubMed id 11303978)^{1, 9} Nishimori I. and Onishi S. (2001)
Which carbonic anhydrases are targeted by the antiepi leptic sulfonamides and sulfamates? (PubMed id 19703035)⁷ De Simone G....Supuran C.T. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)² Maresca A.... Supuran C.T. (2009)
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)² Crocetti L.... Supuran C.T. (2009)
Carbonic anhydrase inhibitors as emerging drugs for t he treatment of obesity. (PubMed id 18537527)⁷ Supuran C.T....De Simone G. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11238	HGNC: 1378	AceView: CA5BandCA5BL	Ensembl:ENSG00000169239	euGenes: HUgn11238
ECgene: CA5B	Kegg: 11238	H-InvDB: CA5B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CA5B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CA5B gene
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Patent Information for CA5B gene:
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CA5B Gene

carbonic anhydrase VB, mitochondrial

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CA5B Gene

carbonic anhydrase VB, mitochondrial

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