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CA5B Gene

protein-coding   GIFtS: 62
GCID: GC0XP015706

Carbonic Anhydrase VB, Mitochondrial

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbonic Anhydrase VB, Mitochondrial1 2     Carbonic Anhydrase 5B, Mitochondrial2
Carbonate Dehydratase VB2 3     Carbonic Dehydratase2
CA-VB2 3     Carbonic Anhydrase VB3
EC 4.2.1.13 8     

External Ids:    HGNC: 13781   Entrez Gene: 112382   Ensembl: ENSG000001692397   OMIM: 3002305   UniProtKB: Q9Y2D03   

Export aliases for CA5B gene to outside databases

Previous GC identifers: GC0XP015466 GC0XP014582 GC0XP014941 GC0XP015117 GC0XP015516 GC0XP015666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CA5B Gene:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of
carbon dioxide. They participate in a variety of biological processes, including respiration, calcification,
acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric
acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is
localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It
has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue
distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic
roles. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA5B Gene:
CA5B (carbonic anhydrase VB, mitochondrial) is a protein-coding gene. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0
Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CA5B gene promoter:
         RP58   AML1a   p53   FAC1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA5B promoter sequence
   Search Chromatin IP Primers for CA5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CA5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.1

CA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA5B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP015706:  view genomic region     (about GC identifiers)

Start:
15,706,953 bp from pter      End:
15,805,748 bp from pter
Size:
98,796 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0 (See protein sequence)
Recommended Name: Carbonic anhydrase 5B, mitochondrial precursor  
Size: 317 amino acids; 36434 Da
Cofactor: Zinc (By similarity)
Secondary accessions: A8K4T5

Explore the universe of human proteins at neXtProt for CA5B: NX_Q9Y2D0

Explore proteomics data for CA5B at MOPED

4 DME Specific Peptides for CA5B (Q9Y2D0)
 QFHFHWG  AELHLVH  GSLTTPPL  ELHLVHWN 


See CA5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_009151.1  
ENSEMBL proteins: 
 ENSP00000418622   ENSP00000314099   ENSP00000417553   ENSP00000417236   ENSP00000417021  
Reactome Protein details: Q9Y2D0

CA5B Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CA: Carbonic anhydrases

4 InterPro protein domains:
 IPR018437 CA-VB_mt
 IPR001148 Carbonic_anhydrase_a
 IPR018338 Carbonic_anhydrase_a-class_CS
 IPR023561 Carbonic_anhydrase_a-class

Graphical View of Domain Structure for InterPro Entry Q9Y2D0

ProtoNet protein and cluster: Q9Y2D0

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0
Similarity: Belongs to the alpha-carbonic anhydrase family


Find genes that share domains with CA5B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CAH5B_HUMAN, Q9Y2D0
Function: Reversible hydration of carbon dioxide
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
Enzyme regulation: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and
Foscarnet (phosphonoformate trisodium salt)

     Genatlas biochemistry entry for CA5B:
carbonic anhydrase VB,mitochondrial,expressed in heart,skeletal muscle,pancreas,kidney,salivary glands,spinal cord
but not in liver

     Enzyme Number (IUBMB): EC 4.2.1.11 2

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004089carbonate dehydratase activity IEA--
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with CA5B           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for CA5B:
 Increased gamma-H2AX phosphory  Lamellipodia cells 

     4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Car5b):
 cellular  growth/size/body  homeostasis/metabolism  mortality/aging 

Find genes that share phenotypes with CA5B           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Car5btm1Sly for CA5B

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CA5B
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA5B
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA5B

miRNA
Products:
    
miRTarBase miRNAs that target CA5B:
hsa-let-7e-5p (MIRT051681), hsa-mir-335-5p (MIRT018795), hsa-mir-92a-3p (MIRT049682), hsa-mir-124-3p (MIRT023038), hsa-mir-142-3p (MIRT021623)

Block miRNA regulation of human, mouse, rat CA5B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CA5B (see all 43):
hsa-miR-411* hsa-miR-579 hsa-miR-379* hsa-miR-199a-3p hsa-miR-605 hsa-miR-374c hsa-miR-186 hsa-miR-181b
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat CA5B

Gene Editing
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GenScript: all cDNA clones in your preferred vector: CA5B (NM_007220)
Sino Biological Human cDNA Clone for CA5B
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA5B

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CAH5B_HUMAN, Q9Y2D0: Mitochondrion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
chloroplast2
cytosol1
endoplasmic reticulum1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion TAS10409679
GO:0005759mitochondrial matrix TAS--

Find genes that share ontologies with CA5B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CA5B About    
See pathways by source

SuperPathContained pathways About
1Nitrogen metabolism
Reversible Hydration of Carbon Dioxide0.00
Nitrogen metabolism
2Metabolism
Metabolism0.38


Find genes that share SuperPaths with CA5B           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for CA5B
    Reversible hydration of carbon dioxide


1 Kegg Pathway  (Kegg details for CA5B):
    Nitrogen metabolism

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CA5B
Interactions:

    Search GeneGlobe Interaction Network for CA5B

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CA5B (ENSP000003140994) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ELAVL1ENSP000003852694STRING: ENSP00000385269
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006730one-carbon metabolic process IEA--
GO:0015701bicarbonate transport TAS--
GO:0044281small molecule metabolic process TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CA5B (CAH5B)

4 HMDB Compounds for CA5B    About this table
CompoundSynonyms CAS #PubMed Ids
Carbon dioxideCarbon oxide (see all 5)124-38-9--
Carbonic acidacid of air (see all 24)463-79-6--
WaterDihydrogen oxide (see all 2)7732-18-5--
ZincZinc (see all 2)7440-66-6--

2 DrugBank Compounds for CA5B    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 15837316 18782051 17582922
Ellagic Acid-- 476-66-4targetinhibitor20185318



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CA5B gene: 
NM_007220.3  

Unigene Cluster for CA5B:

Carbonic anhydrase VB, mitochondrial
Hs.653287  [show with all ESTs]
Unigene Representative Sequence: NM_007220
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000498004 ENST00000318636(uc004cxe.3) ENST00000478923 ENST00000474624
ENST00000380319 ENST00000479740 ENST00000380313 ENST00000478341 ENST00000496188
ENST00000454127
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate CA5B (see all 43):
hsa-miR-411* hsa-miR-579 hsa-miR-379* hsa-miR-199a-3p hsa-miR-605 hsa-miR-374c hsa-miR-186 hsa-miR-181b
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CA5B
Predesigned siRNA for gene silencing in human, mouse, rat CA5B
Clone
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OriGene clones in human, mouse for CA5B (see all 5)
OriGene ORF clones in mouse, rat for CA5B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CA5B (NM_007220)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA5B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA5B
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for CA5B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CA5B
  QuantiTect SYBR Green Assays in human, mouse, rat CA5B
  QuantiFast Probe-based Assays in human, mouse, rat CA5B

Additional mRNA sequence: 

AB021660.1 AK057568.1 AK291050.1 NR_002725.2 Y10697.1 

8 DOTS entries:

DT.429971  DT.108740  DT.121314614  DT.40213312  DT.91796884  DT.101982938  DT.121314648  DT.97763776 

Selected AceView cDNA sequences (see all 219):

CK902804 BI333715 BX112738 AA206778 BP371510 AI738626 NM_007220 AI801563 
BU161068 AW503003 BM794644 BP335358 AI086962 AA811880 BQ919066 BX113332 
AA661651 BU542020 AA418122 BE328286 AA576865 BQ439983 CK821282 AI831584 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CA5B (see all 8)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1:                                      -     -     -           -                                       
SP2:                    -     -           -     -     -           -                                       
SP3:                                                  -           -                                       
SP4:                          -           -     -     -                                                   
SP5:                          -                                                                           


ECgene alternative splicing isoforms for CA5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CA5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTAAAAAAAG
CA5B Expression
About this image


CA5B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
         Human embryonic stem cells (family)
 
 Epithelial Cells
         Mature Choroid Plexus Cells Choroid Plexus
 
 Adipose (Muscoskeletal System)
         White adipocyte-like cells
 
 Kidney (Urinary System)
         Ureteric Bud Cells Ureteric Bud
 
 Brain (Nervous System)
         Mature Choroid Plexus Cells Choroid Plexus
CA5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CA5B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.653287

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0
Tissue specificity: Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not
expressed in liver

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QuantiFast Probe-based Assays in human, mouse, rat CA5B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CA5B gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Car5b1 , 5 carbonic anhydrase 5b, mitochondrial1, 5 87.59(n)1
89.27(a)1
  X (76.03 cM)5
560781  NM_181315.41  NP_851832.21 
 1639768225 
chicken
(Gallus gallus)
Aves CA5B1 carbonic anhydrase VB, mitochondrial 71.4(n)
74.05(a)
  415833  XM_414195.4  XP_414195.3 
African clawed frog
(Xenopus laevis)
Amphibia Xl.256422 Xenopus laevis transcribed sequence with moderate similarity more 73.16(n)    CA789030.1 
zebrafish
(Danio rerio)
Actinopterygii ca51 carbonic anhydrase V 60.36(n)
56.76(a)
  569989  NM_001111201.1  NP_001104671.1 
fruit fly
(Drosophila melanogaster)
Insecta CAH16
Carbonic anhydrase 1
39(a)
1 → many
2L(13803626-13809994)


ENSEMBL Gene Tree for CA5B (if available)
TreeFam Gene Tree for CA5B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CA5B gene
CA22  CA122  CA72  CA32  CA62  CA5A2  CA142  CA82  
CA42  CA12  CA92  CA132  
10 SIMAP similar genes for CA5B using alignment to 4 protein entries:     CAH5B_HUMAN (see all proteins):
CA5A    CA7    CA1    CA13    CA3    CA2
CA8    CA10    CA14    DKFZp686I20267

Find genes that share paralogs with CA5B           About GenesLikeMe


1 Pseudogenes.org Pseudogene for CA5B
PGOHUM00000250066


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CA5B (see all 746)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1837365721,2
C--15669682(+) AGTGCA/CAAACT 1 -- us2k10--------
rs779632141,2
C--15669726(+) AGAAAA/TAAAGC 1 -- us2k10--------
rs1424108541,2
C--15669726(+) GAAAA-/AAA   
  T
/TAAA
AAAGC
1 -- us2k10--------
rs2000500991,2
C--15669729(+) AAAAA-/TAAA  
        
GCCAG
1 -- us2k10--------
rs1891850941,2
--15669909(+) CTTCCA/TTTAAG 1 -- us2k10--------
rs1400301251,2
--15669911(+) TCCATG/TAAGCT 1 -- us2k10--------
rs1925866761,2
--15669974(+) TAGGAC/TGCTGC 1 -- us2k10--------
rs1841734541,2
--15669976(+) GGACGC/TTGCCT 1 -- us2k10--------
rs1426758671,2
--15670010(+) AAGTAC/GAACTA 1 -- us2k10--------
rs1473531901,2
C--15670431(+) ATACTA/GTAAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CA5B (15706953 - 15805748 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CA5B:    About this table    
Variant IDTypeSubtypePubMed ID
esv2739978CNV Deletion23290073

Locus Specific Mutation Databases (LSDB): CA5B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300230    OMIM disorders: --

2 diseases from the University of Copenhagen DISEASES database for CA5B:
Congenital heart block     Heart disease

Find genes that share disorders with CA5B           About GenesLikeMe


Export disorders for CA5B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CA5B gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with CA5B)
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world of online information

  1. Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X. (PubMed id 10409679)1, 2, 3, 9 Fujikawa-Adachi K.... Onishi S. (J. Biol. Chem. 1999)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. (PubMed id 10677517)1, 9 Shah G.N....Sly W.S. (Proc. Natl. Acad. Sci. U.S.A. 2000)
  5. Carbonic anhydrase isozymes in the human pancreas. (PubMed id 11303978)1, 9 Nishimori I. and Onishi S. (Dig Liver Dis 2001)
  6. Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. (PubMed id 20185318)7 Innocenti A....Supuran C.T. (amp 2010)
  7. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (amp 2009)
  8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
  9. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)2 Maresca A.... Supuran C.T. (J. Am. Chem. Soc. 2009)
  10. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)2 Crocetti L.... Supuran C.T. (Bioorg. Med. Chem. Lett. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11238 HGNC: 1378 AceView: CA5BandCA5BL Ensembl:ENSG00000169239 euGenes: HUgn11238
ECgene: CA5B Kegg: 11238 H-InvDB: CA5B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CA5B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CA5B gene:
Search GeneIP for patents involving CA5B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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