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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA5B Gene

protein-coding   GIFtS: 62
GCID: GC0XP015706

Carbonic Anhydrase VB, Mitochondrial

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbonic Anhydrase VB, Mitochondrial1 2     Carbonic Anhydrase 5B, Mitochondrial2
Carbonate Dehydratase VB2 3     Carbonic Dehydratase2
CA-VB2 3     Carbonic Anhydrase VB3
EC 4.2.1.13 8     

External Ids:    HGNC: 13781   Entrez Gene: 112382   Ensembl: ENSG000001692397   OMIM: 3002305   UniProtKB: Q9Y2D03   

Export aliases for CA5B gene to outside databases

Previous GC identifers: GC0XP015466 GC0XP014582 GC0XP014941 GC0XP015117 GC0XP015516 GC0XP015666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA5B Gene:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of
carbon dioxide. They participate in a variety of biological processes, including respiration, calcification,
acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric
acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is
localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It
has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue
distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic
roles. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA5B Gene: 
CA5B (carbonic anhydrase VB, mitochondrial) is a protein-coding gene. Diseases associated with CA5B include congenital heart block, and glaucoma, and among its related super-pathways are Nitrogen metabolism and Metabolic pathways. GO annotations related to this gene include carbonate dehydratase activity and zinc ion binding. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0
Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA5B gene promoter:
         RP58   AML1a   p53   FAC1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA5B promoter sequence
   Search SABiosciences Chromatin IP Primers for CA5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.1

CA5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA5B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP015706:  view genomic region     (about GC identifiers)

Start:
15,706,953 bp from pter      End:
15,805,748 bp from pter
Size:
98,796 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0 (See protein sequence)
Recommended Name: Carbonic anhydrase 5B, mitochondrial precursor  
Size: 317 amino acids; 36434 Da
Cofactor: Zinc (By similarity)
Subcellular location: Mitochondrion
Secondary accessions: A8K4T5

Explore the universe of human proteins at neXtProt for CA5B: NX_Q9Y2D0

Explore proteomics data for CA5B at MOPED 

4 DME Specific Peptides for CA5B (Q9Y2D0)
 QFHFHWG  AELHLVH  GSLTTPPL  ELHLVHWN 

CA5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CA5B Protein Expression
REFSEQ proteins: NP_009151.1  
ENSEMBL proteins: 
 ENSP00000418622   ENSP00000314099   ENSP00000417553   ENSP00000417236   ENSP00000417021  
Reactome Protein details: Q9Y2D0
Human Recombinant Protein Products for CA5B: 
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Novus Biologicals CA5B Proteins
Novus Biologicals CA5B Lysate
Sino Biological Recombinant Protein for CA5B
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Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CA5B 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion TAS10409679
GO:0005759mitochondrial matrix TAS--

CA5B for ontologies           About GeneDecksing



CA5B Antibody Products: 
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Cloud-Clone Corp. CLIAs for CA5B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CA: Carbonic anhydrases

4 InterPro protein domains:
 IPR018437 CA-V_mt
 IPR001148 Carbonic_anhydrase_a
 IPR018338 Carbonic_anhydrase_a-class_CS
 IPR023561 Carbonic_anhydrase_a-class

Graphical View of Domain Structure for InterPro Entry Q9Y2D0

ProtoNet protein and cluster: Q9Y2D0

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0
Similarity: Belongs to the alpha-carbonic anhydrase family


CA5B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CAH5B_HUMAN, Q9Y2D0
Function: Reversible hydration of carbon dioxide
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
Enzyme regulation: Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and
Foscarnet (phosphonoformate trisodium salt)

     Genatlas biochemistry entry for CA5B:
carbonic anhydrase VB,mitochondrial,expressed in heart,skeletal muscle,pancreas,kidney,salivary glands,spinal cord
but not in liver

     Enzyme Number (IUBMB): EC 4.2.1.11 2

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004089carbonate dehydratase activity IEA--
GO:0008270zinc ion binding IEA--
     
CA5B for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CA5B:
 Increased gamma-H2AX phosphory  Lamellipodia cells 

     1 MGI phenotypic allele for Car5b (no phenotypes)

CA5B for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CA5B 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CA5B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA5B 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA5B 

miRNA
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hsa-miR-411* hsa-miR-579 hsa-miR-379* hsa-miR-199a-3p hsa-miR-605 hsa-miR-374c hsa-miR-186 hsa-miR-181b
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Gene Editing
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GenScript: all cDNA clones in your preferred vector: CA5B (NM_007220)
Sino Biological Human cDNA Clone for CA5B
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA5B
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Cell Line
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Search LifeMap BioReagents cell lines for CA5B
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CA5B About                                                                                                See pathways by source

SuperPathContained pathways About
1Reversible Hydration of Carbon Dioxide
Reversible Hydration of Carbon Dioxide0.67
Nitrogen metabolism0.67
2Metabolism
Metabolism0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2        Reactome Pathways for CA5B
    Reversible Hydration of Carbon Dioxide
Metabolism


1         Kegg Pathway  (Kegg details for CA5B):
    Nitrogen metabolism


CA5B for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA5B

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CA5B (ENSP000003140994) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ELAVL1ENSP000003852694STRING: ENSP00000385269
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006730one-carbon metabolic process IEA--
GO:0015701bicarbonate transport TAS--
GO:0044281small molecule metabolic process TAS--

CA5B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CA5B (CAH5B)

4 HMDB Compounds for CA5B    About this table
CompoundSynonyms CAS #PubMed Ids
Carbon dioxideCarbon oxide (see all 5)124-38-9--
Carbonic acidacid of air (see all 24)463-79-6--
WaterDihydrogen oxide (see all 2)7732-18-5--
ZincZinc (see all 2)7440-66-6--

2 DrugBank Compounds for CA5B    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 15837316 18782051 17582922
Ellagic Acid-- 476-66-4targetinhibitor20185318

Search CenterWatch for drugs/clinical trials and news about CA5B / CAH5B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CA5B gene: 
NM_007220.3  

Unigene Cluster for CA5B:

Carbonic anhydrase VB, mitochondrial
Hs.653287  [show with all ESTs]
Unigene Representative Sequence: NM_007220
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000498004 ENST00000318636(uc004cxe.3) ENST00000478923 ENST00000474624
ENST00000380319 ENST00000479740 ENST00000380313 ENST00000478341 ENST00000496188
ENST00000454127
miRNA
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8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate CA5B (see all 43):
hsa-miR-411* hsa-miR-579 hsa-miR-379* hsa-miR-199a-3p hsa-miR-605 hsa-miR-374c hsa-miR-186 hsa-miR-181b
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA5B
Clone
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OriGene ORF clones in mouse, rat for CA5B
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA5B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA5B
Sirion Biotech Customized lentivirus for stable overexpression of CA5B 
                     Customized lentivirus expression plasmids for stable overexpression of CA5B 
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for CA5B
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA5B
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA5B
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA5B

Additional mRNA sequence: 

AB021660.1 AK057568.1 AK291050.1 NR_002725.2 Y10697.1 

8 DOTS entries:

DT.429971  DT.108740  DT.121314614  DT.40213312  DT.91796884  DT.101982938  DT.121314648  DT.97763776 

24/219 AceView cDNA sequences (see all 219):

AI479230 AA975463 AI738626 BC021816 AW772284 AA418122 AI830821 BQ919066 
NM_007220 AI801563 BP335358 AW503003 BM794644 AI342518 AA576865 AI565614 
BQ439983 BP371510 AA811880 AI086962 AA206778 AK125384 AA284040 BU161068 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CA5B (see all 8)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1:                                      -     -     -           -                                       
SP2:                    -     -           -     -     -           -                                       
SP3:                                                  -           -                                       
SP4:                          -           -     -     -                                                   
SP5:                          -                                                                           


ECgene alternative splicing isoforms for CA5B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CA5B expression in normal human tissues (normalized intensities)      CA5B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTAAAAAAAG
CA5B Expression
About this image


CA5B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Kidney (Urinary System)
         Ureteric Bud Cells Ureteric Bud
 
 Choroid Plexus (Nervous System)
         Mature Choroid Plexus Cells Choroid Plexus
 
 Brain (Nervous System)
         Mature Choroid Plexus Cells Choroid Plexus

See CA5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CA5B

SOURCE GeneReport for Unigene cluster: Hs.653287

UniProtKB/Swiss-Prot: CAH5B_HUMAN, Q9Y2D0
Tissue specificity: Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not
expressed in liver

    SABiosciences Custom PCR Arrays for CA5B
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA5B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CA5B gene from 5/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Car5b1 , 5 carbonic anhydrase 5b, mitochondrial1, 5 87.59(n)1
89.27(a)1
  X (76.03 cM)5
560781  NM_181315.41  NP_851832.21 
 1639768225 
chicken
(Gallus gallus)
Aves CA5B1 carbonic anhydrase VB, mitochondrial 71.4(n)
74.05(a)
  415833  XM_414195.3  XP_414195.3 
African clawed frog
(Xenopus laevis)
Amphibia Xl.256422 Xenopus laevis transcribed sequence with moderate similarity more 73.16(n)    CA789030.1 
zebrafish
(Danio rerio)
Actinopterygii ca51 carbonic anhydrase V 60.36(n)
56.76(a)
  569989  NM_001111201.1  NP_001104671.1 
fruit fly
(Drosophila melanogaster)
Insecta CAH16
Carbonic anhydrase 1
39(a)
1 → many
2L(13803626-13809994)


ENSEMBL Gene Tree for CA5B (if available)
TreeFam Gene Tree for CA5B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CA5B gene
CA22  CA122  CA72  CA32  CA62  CA112  CA5A2  CA142  
CA82  CA42  CA12  CA92  CA132  CA102  
10 SIMAP similar genes for CA5B using alignment to 4 protein entries:     CAH5B_HUMAN (see all proteins):
CA5A    CA7    CA1    CA13    CA3    CA2
CA8    CA10    CA14    DKFZp686I20267

CA5B for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CA5B
PGOHUM00000250066


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/746 SNPs in CA5B are shown (see all 746)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1837365721,2
C--15669682(+) AGTGCA/CAAACT 1 -- us2k10--------
rs779632141,2
C--15669726(+) AGAAAA/TAAAGC 1 -- us2k10--------
rs1424108541,2
C--15669726(+) GAAAA-/AAA   
  T
/TAAA
AAAGC
1 -- us2k10--------
rs2000500991,2
C--15669729(+) AAAAA-/TAAA  
        
GCCAG
1 -- us2k10--------
rs1891850941,2
--15669909(+) CTTCCA/TTTAAG 1 -- us2k10--------
rs1400301251,2
--15669911(+) TCCATG/TAAGCT 1 -- us2k10--------
rs1925866761,2
--15669974(+) TAGGAC/TGCTGC 1 -- us2k10--------
rs1841734541,2
--15669976(+) GGACGC/TTGCCT 1 -- us2k10--------
rs1426758671,2
--15670010(+) AAGTAC/GAACTA 1 -- us2k10--------
rs1473531901,2
C--15670431(+) ATACTA/GTAAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CA5B (15706953 - 15805748 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CA5B:    About this table     
Variant IDTypeSubtypePubMed ID
esv2739978CNV Deletion23290073


Locus Specific Mutation Databases (LSDB): CA5B
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 300230    OMIM disorders: --

2 diseases for CA5B:    About MalaCards
congenital heart block    glaucoma

2 diseases from the University of Copenhagen DISEASES database for CA5B:
Congenital heart block     Heart disease

CA5B for disorders           About GeneDecksing


Export disorders for CA5B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CA5B gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with CA5B)
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  1. Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X. (PubMed id 10409679)1, 2, 3, 9 Fujikawa-Adachi K.... Onishi S. (1999)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. (PubMed id 10677517)1, 9 Shah G.N....Sly W.S. (2000)
  5. Carbonic anhydrase isozymes in the human pancreas. (PubMed id 11303978)1, 9 Nishimori I. and Onishi S. (2001)
  6. Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. (PubMed id 20185318)7 Innocenti A....Supuran C.T. (2010)
  7. Which carbonic anhydrases are targeted by the antiepi leptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (2009)
  8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  9. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)2 Maresca A.... Supuran C.T. (2009)
  10. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)2 Crocetti L.... Supuran C.T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 11238 HGNC: 1378 AceView: CA5BandCA5BL Ensembl:ENSG00000169239 euGenes: HUgn11238
ECgene: CA5B Kegg: 11238 H-InvDB: CA5B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CA5B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CA5B gene:
Search GeneIP for patents involving CA5B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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