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Aliases for CA5B Gene

Aliases for CA5B Gene

  • Carbonic Anhydrase VB, Mitochondrial 2 3
  • Carbonate Dehydratase VB 3 4
  • EC 4 63
  • CA-VB 3 4
  • Carbonic Anhydrase 5B, Mitochondrial 3
  • Carbonic Anhydrase VB 4
  • Carbonic Dehydratase 3

External Ids for CA5B Gene

Previous GeneCards Identifiers for CA5B Gene

  • GC0XP015466
  • GC0XP014582
  • GC0XP014941
  • GC0XP015117
  • GC0XP015516
  • GC0XP015666

Summaries for CA5B Gene

Entrez Gene Summary for CA5B Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA5B Gene

CA5B (Carbonic Anhydrase VB, Mitochondrial) is a Protein Coding gene. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA5B Gene

  • Reversible hydration of carbon dioxide

Gene Wiki entry for CA5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA5B Gene

Genomics for CA5B Gene

Regulatory Elements for CA5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CA5B Gene

15,688,830 bp from pter
15,787,625 bp from pter
98,796 bases
Plus strand

Genomic View for CA5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA5B Gene

Proteins for CA5B Gene

  • Protein details for CA5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 5B, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K4T5

    Protein attributes for CA5B Gene

    317 amino acids
    Molecular mass:
    36434 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for CA5B Gene

Proteomics data for CA5B Gene at MOPED

Selected DME Specific Peptides for CA5B Gene

Post-translational modifications for CA5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA5B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CA5B (Carbonic Anhydrase VB/CA5B)

Domains for CA5B Gene

Gene Families for CA5B Gene

  • CA :Carbonic anhydrases

Suggested Antigen Peptide Sequences for CA5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2D0
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA5B: view

Function for CA5B Gene

Molecular function for CA5B Gene

GENATLAS Biochemistry:
carbonic anhydrase VB,mitochondrial,expressed in heart,skeletal muscle,pancreas,kidney,salivary glands,spinal cord but not in liver
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide

Enzyme Numbers (IUBMB) for CA5B Gene

Gene Ontology (GO) - Molecular Function for CA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA5B: view
genes like me logo Genes that share phenotypes with CA5B: view

Animal Models for CA5B Gene

MGI Knock Outs for CA5B:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA5B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CA5B Gene

Localization for CA5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA5B Gene


Subcellular locations from

Jensen Localization Image for CA5B Gene COMPARTMENTS Subcellular localization image for CA5B gene
Compartment Confidence
mitochondrion 5
chloroplast 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 10409679
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with CA5B: view

Pathways for CA5B Gene

genes like me logo Genes that share pathways with CA5B: view

Pathways by source for CA5B Gene

2 Reactome pathways for CA5B Gene
1 KEGG pathway for CA5B Gene

Interacting Proteins for CA5B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000314099 for CA5B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CA5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0008152 metabolic process --
GO:0015701 bicarbonate transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA5B: view

Compounds for CA5B Gene

(4) HMDB Compounds for CA5B Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
Carbonic acid
  • acid of air
  • Dihydrogen oxide
  • Zinc

(2) Drugbank Compounds for CA5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ellagic Acid
476-66-4 target inhibitor
  • Zonisamida [Spanish]
68291-97-4 target inhibitor
genes like me logo Genes that share compounds with CA5B: view

Transcripts for CA5B Gene

Unigene Clusters for CA5B Gene

Carbonic anhydrase VB, mitochondrial:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA5B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA5B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - -
SP8: - -

Relevant External Links for CA5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA5B Gene

mRNA expression in normal human tissues for CA5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CA5B Gene

This gene is overexpressed in Lymph node (10.4), Testis (7.9), Thyroid (7.2), and CD8 Tcells (6.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CA5B Gene

SOURCE GeneReport for Unigene cluster for CA5B Gene Hs.653287

mRNA Expression by UniProt/SwissProt for CA5B Gene

Tissue specificity: Strongest expression in heart, pancreas, kidney, placenta, lung, and skeletal muscle. Not expressed in liver
genes like me logo Genes that share expressions with CA5B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for CA5B Gene

Orthologs for CA5B Gene

This gene was present in the common ancestor of animals.

Orthologs for CA5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CA5B 35
  • 89.06 (n)
  • 90.54 (a)
CA5B 36
  • 91 (a)
(Canis familiaris)
Mammalia CA5B 35
  • 89.48 (n)
  • 92.43 (a)
CA5B 36
  • 92 (a)
(Mus musculus)
Mammalia Car5b 35
  • 87.59 (n)
  • 89.27 (a)
Car5b 16
Car5b 36
  • 89 (a)
(Pan troglodytes)
Mammalia CA5B 35
  • 99.89 (n)
  • 100 (a)
CA5B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Car5b 35
  • 86.54 (n)
  • 88.64 (a)
(Monodelphis domestica)
Mammalia CA5B 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CA5B 36
  • 79 (a)
(Gallus gallus)
Aves CA5B 35
  • 71.4 (n)
  • 74.05 (a)
-- 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca5b 35
  • 67.15 (n)
  • 68.73 (a)
Str.16738 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25642 35
(Danio rerio)
Actinopterygii ca5 35
  • 60.36 (n)
  • 56.76 (a)
ca5 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CAH1 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea cah-3 37
  • 40 (a)
Species with no ortholog for CA5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA5B Gene

Gene Tree for CA5B (if available)
Gene Tree for CA5B (if available)

Paralogs for CA5B Gene

Paralogs for CA5B Gene

Selected SIMAP similar genes for CA5B Gene using alignment to 4 proteins: Pseudogenes for CA5B Gene

genes like me logo Genes that share paralogs with CA5B: view

Variants for CA5B Gene

Sequence variations from dbSNP and Humsavar for CA5B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1808 -- 15,782,628(-) GGTTT(C/T)GCTTG synonymous-codon, reference
rs2257278 -- 15,764,624(+) GATCG(A/C)CAGTC synonymous-codon, reference
rs2316879 -- 15,764,558(-) GTCAG(C/G)CTATT intron-variant
rs2316880 -- 15,759,114(-) GGGCT(A/G)GCTCC intron-variant
rs3968388 -- 15,755,496(-) TACTG(A/C)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA5B Gene

Variant ID Type Subtype PubMed ID
esv2739978 CNV Deletion 23290073

Relevant External Links for CA5B Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA5B Gene

Disorders for CA5B Gene

(2) University of Copenhagen DISEASES for CA5B Gene

genes like me logo Genes that share disorders with CA5B: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for CA5B Gene

Publications for CA5B Gene

  1. Human mitochondrial carbonic anhydrase VB: cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome X. (PMID: 10409679) Fujikawa-Adachi K. … Onishi S. (J. Biol. Chem. 1999) 2 3 4 23
  2. Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles. (PMID: 10677517) Shah G.N. … Sly W.S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 23
  3. Carbonic anhydrase isozymes in the human pancreas. (PMID: 11303978) Nishimori I. … Onishi S. (Dig Liver Dis 2001) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CA5B Gene

Sources for CA5B Gene

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