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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA5A Gene

protein-coding   GIFtS: 59
GCID: GC16M087921

carbonic anhydrase VA, mitochondrial


(Previous symbol: CA5)
 Explore 6 diseases affiliated with
CA5A via our new
 Human Malady Compendium 
Biological research products
for CA5A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Carbonic Anhydrase VA, Mitochondrial1 2     EC 4.2.1.13 8
CA51 2 3 5     Carbonic Anhydrase 5A, Mitochondrial2
CAV1 2     Carbonic Anhydrase V, Mitochondrial2
CAVA1 2     Carbonic Dehydratase2
Carbonate Dehydratase VA2 3     Carbonic Anhydrase VA3
CA-VA2 3     

External Ids:    HGNC: 13771   Entrez Gene: 7632   Ensembl: ENSG000001749907   OMIM: 1147615   UniProtKB: P352183   

Export aliases for CA5A gene to outside databases

Previous GC identifers: GC16P028774 GC16M088952 GC16M087662 GC16M087703 GC16M086479 GC16M073662


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA5A:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon
dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base
balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show
extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the
mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis.
CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218
Function: Reversible hydration of carbon dioxide. Low activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA5A gene promoter:
         p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA5A promoter sequence
   Search SABiosciences Chromatin IP Primers for CA5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

CA5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA5A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M087921:  view genomic region     (about GC identifiers)

Start:
87,921,625 bp from pter      End:
87,970,135 bp from pter
Size:
48,511 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218 (See protein sequence)
Recommended Name: Carbonic anhydrase 5A, mitochondrial precursor  
Size: 305 amino acids; 34750 Da
Cofactor: Zinc (By similarity)
Subcellular location: Mitochondrion
Secondary accessions: B2RPF2

Explore the universe of human proteins at neXtProt for CA5A: NX_P35218

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35218

  • 4/5 DME Specific Peptides for CA5A (P35218) (see all 5)
     QFHFHWG  AELHLVH  GSLTTPPL  FDPSTLLP 

    CA5A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001730.1  
    ENSEMBL proteins: 
     ENSP00000309649  
    Reactome Protein details: P35218
    Human Recombinant Protein Products: 
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    Uscn Proteins for CA5A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS8356065
    GO:0005759mitochondrial matrix TAS--


    CA5A for ontologies           About GeneDecksing



    CA5A Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CA5A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018437 CA-V_mt
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class

    Graphical View of Domain Structure for InterPro Entry P35218

    ProtoNet protein and cluster: P35218

    UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218
    Similarity: Belongs to the alpha-carbonic anhydrase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218
    Function: Reversible hydration of carbon dioxide. Low activity
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by
    coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt)
    Biophysicochemical properties: Kinetic parameters: KM=10.0 mM for CO(2);

    Enzyme Number (IUBMB): EC 4.2.1.11 2

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA5A
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CA5A:
    hsa-miR-4277
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0008270zinc ion binding IEA--


    CA5A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CA5A:
     Synthetic lethal with imatinib 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Reversible Hydration of Carbon Dioxide
    Reversible Hydration of Carbon Dioxide1.00
    Nitrogen metabolism0.52
    2Metabolism
    Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CA5A
        Reversible Hydration of Carbon Dioxide
    Metabolism


    1         Kegg Pathway  (Kegg details for CA5A):
        Nitrogen metabolism


    CA5A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA5A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA5A (ENSP000003096494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--


    CA5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CA5A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CA5A

    4 HMDB Compounds for CA5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    3 DrugBank Compounds for CA5A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 15837316 18782051 17582922
    4-Methylimidazole-- --target--17139284 17016423 10592235
    Brinzolamide-- 138890-62-7targetinhibitor14971907

    5 Novoseek chemical compound relationships for CA5A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetazolamide 75.7 1 10409679 (1)
    carbamoyl phosphate 72.5 1 10082753 (1)
    bicarbonate 63.2 3 11928941 (1), 10082753 (1)
    pyruvate 51.8 2 11928941 (1), 10082753 (1)
    hydrogen 16.3 2 11851394 (2)

    Search CenterWatch for drugs/clinical trials and news about CA5A / CAH5A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CA5A gene: 
    NM_001739.1  

    Unigene Cluster for CA5A:

    Carbonic anhydrase VA, mitochondrial
    Hs.177446  [show with all ESTs]
    Unigene Representative Sequence: NM_001739
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309893(uc002fkn.1) ENST00000566402 ENST00000568801

    miRNA
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    hsa-miR-4277
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA5A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA5A

    Additional cDNA sequence: 

    BC137405.1 BC137411.1 L19297.1 

    2 DOTS entries:

    DT.106277  DT.95070712 

    14 AceView cDNA sequences:

    C20973 L19297 NM_001739 BX281874 CD612748 CD612737 CD612734 CD612739 
    CD612732 AA699469 CD612741 AA682554 CD612745 CD612743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CA5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CA5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CA5A

    SOURCE GeneReport for Unigene cluster: Hs.177446
        SABiosciences Custom PCR Arrays for CA5A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CA5A gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CA5B6
    Uncharacterized protein
    62(a)
    1 → many
    11(19967982-19980176)
    zebrafish
    (Danio rerio)
    Actinopterygii ca56
    carbonic anhydrase V
    48(a)
    1 → many
    25(13142009-13152469)
    fruit fly
    (Drosophila melanogaster)
    Insecta CAH13 carbonate dehydratase 41(a)   34D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cah-33 carbonic anhydrase 37(a)   X(16518334-16519911)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATACA56
    ATACA26
    (see all 8)
    carbonic anhydrase
    (see all 8)
    24(a)
    24(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    1(2511647-2513454)
    2(12029997-12032420)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 10)
    bifunctional monodehydroascorbate reductase and ca...
    bifunctional monodehydroascorbate reductase and ca...
    (see all 10)
    27(a)
    26(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    2(19630403-19632986)
    8(20348392-20351041)


    ENSEMBL Gene Tree for CA5A (if available)
    TreeFam Gene Tree for CA5A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CA5A gene
    CA22  CA122  CA72  CA62  CA32  CA112  CA5B2  CA142  
    CA82  CA42  CA12  CA92  CA132  CA102  
    12 SIMAP similar genes for CA5A using alignment to 1 protein entry:     CAH5A_HUMAN:
    CA5B    CA7    CA13    CA2    CA1    CA3
    CA10    CA11    DKFZp686I20267    CA14    CA8    CA6

    CA5A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CA5A
    PGOHUM00000259022 PGOHUM00000248796 PGOHUM00000249048


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1471 NCBI SNPs in CA5A are shown (see all 1471    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413081651,2
    --87921156(+) GCTGGG/TATTAC 1 -- ds50010--------
    rs599872551,2
    --87921282(+) CCAAAG/TTGCTG 1 -- ds50010--------
    rs1381278281,2
    --87921333(+) AAGGAA/GGAGGC 1 -- ds50010--------
    rs48437281,2
    F,A,--87921399(+) CCGTGA/CGGACA 1 -- ds50016Minor allele frequency- C:0.35NA CSA 129
    rs1932899561,2
    --87921521(+) CGTTGC/GGTGCC 1 -- ds50010--------
    rs1837170271,2
    --87921563(+) CCCCAA/CGGTAC 1 -- ds50010--------
    rs1887479691,2
    --87921564(+) CCCACA/GGTACT 1 -- ds50010--------
    rs1414455541,2
    --87921569(+) GGTACC/TTACAC 1 -- ds50010--------
    rs616070561,2
    --87921607(+) TACTTC/TGACTA 1 -- ds50014Minor allele frequency- T:0.19CSA EA 125
    rs588004531,2
    C,F,,--87921654(+) GTCATG/ATACAA 1 -- ut313Minor allele frequency- A:0.19WA NA EA 358

    HapMap Linkage Disequilibrium report for CA5A (87921625 - 87970135 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CA5A
         4 CNVs: 30796 4016 4972 72670

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA5A
    DNA2.0 Custom Variant and Variant Library Synthesis for CA5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CA5A for disorders           About GeneDecksing

    OMIM gene information: 114761    OMIM disorders: --

    6 diseases for CA5A:    About MalaCards
    portal hypertension    vaccinia    glaucoma    hypertension
    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CA5A:
    Glaucoma
    Human Genome Epidemiology (HuGE) Navigator: CA5A (1 document)

    Export disorders for CA5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CA5A gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with CA5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p. (PubMed id 7490083)1, 2, 3, 9 Nagao Y.... Sly W.S. (1995)
    2. Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16. (PubMed id 8356065)1, 2, 3 Nagao Y.... Sly W.S. (1993)
    3. Cell-specific expression of mitochondrial carbonic anhydrase in the human and rat gastrointestinal tract. (PubMed id 10082753)1, 9 Saarnio J....Sly W.S. (1999)
    4. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    7. Which carbonic anhydrases are targeted by the antiepi leptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (2009)
    8. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)2 Maresca A.... Supuran C.T. (2009)
    9. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)2 Crocetti L.... Supuran C.T. (2009)
    10. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. (PubMed id 18618712)2 Di Fiore A.... De Simone G. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 763 HGNC: 1377 AceView: CA5A Ensembl:ENSG00000174990 euGenes: HUgn763
    ECgene: CA5A Kegg: 763 H-InvDB: CA5A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CA5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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