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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA5A Gene

protein-coding   GIFtS: 60
GCID: GC16M087921

Carbonic Anhydrase VA, Mitochondrial


(Previous symbol: CA5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbonic Anhydrase VA, Mitochondrial1 2     CAVA2
CA51 2 3 5     Carbonic Anhydrase 5A, Mitochondrial2
Carbonate Dehydratase VA2 3     Carbonic Anhydrase V, Mitochondrial2
CA-VA2 3     Carbonic Dehydratase2
EC 4.2.1.13 8     Carbonic Anhydrase VA3
CAV2     

External Ids:    HGNC: 13771   Entrez Gene: 7632   Ensembl: ENSG000001749907   OMIM: 1147615   UniProtKB: P352183   

Export aliases for CA5A gene to outside databases

Previous GC identifers: GC16P028774 GC16M088952 GC16M087662 GC16M087703 GC16M086479 GC16M073662


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA5A Gene:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of
carbon dioxide. They participate in a variety of biological processes, including respiration, calcification,
acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric
acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is
localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis
and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to
16p12-p11.2. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA5A Gene: 
CA5A (carbonic anhydrase VA, mitochondrial) is a protein-coding gene. Diseases associated with CA5A include portal hypertension, and vaccinia, and among its related super-pathways are Nitrogen metabolism and Metabolic pathways. GO annotations related to this gene include carbonate dehydratase activity and zinc ion binding. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218
Function: Reversible hydration of carbon dioxide. Low activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA5A gene promoter:
         p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA5A promoter sequence
   Search SABiosciences Chromatin IP Primers for CA5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

CA5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA5A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M087921:  view genomic region     (about GC identifiers)

Start:
87,921,625 bp from pter      End:
87,970,135 bp from pter
Size:
48,511 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218 (See protein sequence)
Recommended Name: Carbonic anhydrase 5A, mitochondrial precursor  
Size: 305 amino acids; 34750 Da
Cofactor: Zinc (By similarity)
Subcellular location: Mitochondrion
Secondary accessions: B2RPF2

Explore the universe of human proteins at neXtProt for CA5A: NX_P35218

Explore proteomics data for CA5A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35218

  • 4/5 DME Specific Peptides for CA5A (P35218) (see all 5)
     QFHFHWG  AELHLVH  GSLTTPPL  FDPSTLLP 

    CA5A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CA5A Protein Expression
    REFSEQ proteins: NP_001730.1  
    ENSEMBL proteins: 
     ENSP00000309649  
    Reactome Protein details: P35218
    Human Recombinant Protein Products for CA5A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for CA5A
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    Novus Biologicals CA5A Protein
    Sino Biological Recombinant Protein for CA5A
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CA5A 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS8356065
    GO:0005759mitochondrial matrix TAS--

    CA5A for ontologies           About GeneDecksing



    CA5A Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CA5A 

    Assay Products for CA5A: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CA: Carbonic anhydrases

    4 InterPro protein domains:
     IPR018437 CA-V_mt
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class

    Graphical View of Domain Structure for InterPro Entry P35218

    ProtoNet protein and cluster: P35218

    UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218
    Similarity: Belongs to the alpha-carbonic anhydrase family


    CA5A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH5A_HUMAN, P35218
    Function: Reversible hydration of carbon dioxide. Low activity
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited
    by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt)
    Biophysicochemical properties: Kinetic parameters: KM=10.0 mM for CO(2);

         Enzyme Number (IUBMB): EC 4.2.1.11 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CA5A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CA5A:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CA5A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CA5A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA5A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA5A 

    miRNA
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    hsa-miR-4277
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CA5A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Reversible Hydration of Carbon Dioxide
    Reversible Hydration of Carbon Dioxide0.67
    Nitrogen metabolism0.67
    2Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for CA5A
        Reversible Hydration of Carbon Dioxide
    Metabolism


    1         Kegg Pathway  (Kegg details for CA5A):
        Nitrogen metabolism


    CA5A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA5A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA5A (ENSP000003096494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    CA5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CA5A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CA5A (CAH5A)

    4 HMDB Compounds for CA5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    4 DrugBank Compounds for CA5A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 15837316 18782051 17582922
    4-Methylimidazole-- --target--17139284 17016423 10592235
    Brinzolamide-- 138890-62-7targetinhibitor14971907
    Ellagic Acid-- 476-66-4targetinhibitor20185318

    5 Novoseek inferred chemical compound relationships for CA5A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetazolamide 75.7 1 10409679 (1)
    carbamoyl phosphate 72.5 1 10082753 (1)
    bicarbonate 63.2 3 11928941 (1), 10082753 (1)
    pyruvate 51.8 2 11928941 (1), 10082753 (1)
    hydrogen 16.3 2 11851394 (2)

    Search CenterWatch for drugs/clinical trials and news about CA5A / CAH5A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CA5A gene: 
    NM_001739.1  

    Unigene Cluster for CA5A:

    Carbonic anhydrase VA, mitochondrial
    Hs.177446  [show with all ESTs]
    Unigene Representative Sequence: NM_001739
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309893(uc002fkn.1) ENST00000566402 ENST00000568801
    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CA5A:
    hsa-miR-4277
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CA5A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA5A
    Clone
    Products:
         
    OriGene clones in human, mouse for CA5A (see all 6)
    OriGene ORF clones in mouse, rat for CA5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CA5A (NM_001739)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA5A
    Sirion Biotech Customized lentivirus for stable overexpression of CA5A 
                         Customized lentivirus expression plasmids for stable overexpression of CA5A 
    Primer
    Products:
        
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA5A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA5A

    Additional mRNA sequence: 

    BC137405.1 BC137411.1 L19297.1 

    2 DOTS entries:

    DT.106277  DT.95070712 

    14 AceView cDNA sequences:

    C20973 NM_001739 L19297 CD612734 AA699469 CD612737 CD612739 CD612732 
    BX281874 CD612748 CD612741 AA682554 CD612745 CD612743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CA5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CA5A Expression
    About this image


    See CA5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CA5A

    SOURCE GeneReport for Unigene cluster: Hs.177446
        SABiosciences Custom PCR Arrays for CA5A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CA5A gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car5a1 , 5 carbonic anhydrase 5a, mitochondrial1, 5 76.81(n)1
    75.72(a)1
      8 (70.81 cM)5
    123521  NM_007608.21  NP_031634.21 
     1219161265 
    chicken
    (Gallus gallus)
    Aves CA5B6
    Uncharacterized protein
    62(a)
    1 → many
    11(17466270-17479304)
    zebrafish
    (Danio rerio)
    Actinopterygii ca56
    carbonic anhydrase V
    49(a)
    1 → many
    25(13142009-13152469)
    fruit fly
    (Drosophila melanogaster)
    Insecta CAH13 carbonate dehydratase 41(a)   34D4   --


    ENSEMBL Gene Tree for CA5A (if available)
    TreeFam Gene Tree for CA5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CA5A gene
    CA22  CA122  CA72  CA32  CA62  CA112  CA5B2  CA142  
    CA82  CA42  CA12  CA92  CA132  CA102  
    12 SIMAP similar genes for CA5A using alignment to 1 protein entry:     CAH5A_HUMAN:
    CA5B    CA7    CA13    CA2    CA1    CA3
    CA10    CA11    DKFZp686I20267    CA14    CA8    CA6

    CA5A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CA5A
    PGOHUM00000259022 PGOHUM00000248796 PGOHUM00000249048


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1800 SNPs in CA5A are shown (see all 1800)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342710251,2
    F--73664949(+) GTTGTG/CCAGGC 1 -- int12Minor allele frequency- C:0.50NA 4
    rs25499641,2
    C,H--73667504(+) atgttG/Aggatt 1 -- int11Minor allele frequency- A:0.50NA 2
    rs620441641,2
    C,F--73667984(+) TCAAGC/TGATCC 1 -- int13Minor allele frequency- T:0.33NA 6
    rs25499651,2
    C--73668056(+) AGCCAA/GGGGGT 1 -- int12Minor allele frequency- G:0.25NA 4
    rs29113281,2
    C,A--73669202(-) TTTGTG/ATTTTT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs557210351,2
    C--87928180(+) AAAAA-/ACAGCA 1 -- int10--------
    rs580818971,2
    C--87928468(+) AGAGA-/GACTCTG 1 -- int10--------
    rs1124794341,2
    C,F--87930421(+) TTCTGG/TTTTTA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs671244171,2
    C--87935180(+) TTTCT-/TTTCT 
            
    TTCTT
    1 -- int10--------
    rs58186511,2
    C--87935958(+) aaaaaA/-GCAAT 1 -- int1 trp31Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CA5A (87921625 - 87970135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CA5A (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657678CNV Deletion23128226
    esv2714939CNV Deletion23290073
    nsv907213CNV Loss21882294
    nsv907182CNV Loss21882294
    nsv907212CNV Loss21882294
    dgv36n68CNV Loss17160897
    dgv2962n71CNV Loss21882294
    nsv907210CNV Loss21882294
    nsv907211CNV Loss21882294
    nsv457616CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114761    OMIM disorders: --

    5 diseases for CA5A:    About MalaCards
    portal hypertension    vaccinia    glaucoma    hypertension
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CA5A:
    Glaucoma

    CA5A for disorders           About GeneDecksing

    Genetic Association Database (GAD): CA5A
    Human Genome Epidemiology (HuGE) Navigator: CA5A (1 document)

    Export disorders for CA5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CA5A gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CA5A)
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    1. Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p. (PubMed id 7490083)1, 2, 3, 9 Nagao Y.... Sly W.S. (1995)
    2. Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16. (PubMed id 8356065)1, 2, 3 Nagao Y.... Sly W.S. (1993)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Cell-specific expression of mitochondrial carbonic anhydrase in the human and rat gastrointestinal tract. (PubMed id 10082753)1, 9 Saarnio J....Sly W.S. (1999)
    5. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. (PubMed id 20185318)7 Innocenti A....Supuran C.T. (2010)
    8. Which carbonic anhydrases are targeted by the antiepi leptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (2009)
    9. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)2 Maresca A.... Supuran C.T. (2009)
    10. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)2 Crocetti L.... Supuran C.T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 763 HGNC: 1377 AceView: CA5A Ensembl:ENSG00000174990 euGenes: HUgn763
    ECgene: CA5A Kegg: 763 H-InvDB: CA5A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CA5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CA5A gene:
    Search GeneIP for patents involving CA5A

    GeneCards and IP:
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