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CA5A Gene

protein-coding   GIFtS: 60
GCID: GC16M087921

Carbonic Anhydrase VA, Mitochondrial


(Previous symbol: CA5)
  See CA5A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbonic Anhydrase VA, Mitochondrial1 2     CAVA2
CA51 2 3 5     Carbonic Anhydrase 5A, Mitochondrial2
Carbonate Dehydratase VA2 3     Carbonic Anhydrase V, Mitochondrial2
CA-VA2 3     Carbonic Dehydratase2
EC 4.2.1.13 8     Carbonic Anhydrase VA3
CAV2     

External Ids:    HGNC: 13771   Entrez Gene: 7632   Ensembl: ENSG000001749907   OMIM: 1147615   UniProtKB: P352183   

Export aliases for CA5A gene to outside databases

Previous GC identifers: GC16P028774 GC16M088952 GC16M087662 GC16M087703 GC16M086479 GC16M073662


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CA5A Gene:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of
carbon dioxide. They participate in a variety of biological processes, including respiration, calcification,
acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric
acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is
localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis
and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to
16p12-p11.2. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA5A Gene:
CA5A (carbonic anhydrase VA, mitochondrial) is a protein-coding gene. Diseases associated with CA5A include hyperammonemia due to carbonic anhydrase va deficiency. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218
Function: Reversible hydration of carbon dioxide. Low activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CA5A gene promoter:
         p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA5A promoter sequence
   Search Chromatin IP Primers for CA5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CA5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

CA5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA5A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M087921:  view genomic region     (about GC identifiers)

Start:
87,921,625 bp from pter      End:
87,970,135 bp from pter
Size:
48,511 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218 (See protein sequence)
Recommended Name: Carbonic anhydrase 5A, mitochondrial precursor  
Size: 305 amino acids; 34750 Da
Cofactor: Zinc (By similarity)
Secondary accessions: B2RPF2

Explore the universe of human proteins at neXtProt for CA5A: NX_P35218

Explore proteomics data for CA5A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CA5A (P35218) (see all 5)
     QFHFHWG  AELHLVH  GSLTTPPL  FDPSTLLP 


    See CA5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001730.1  
    ENSEMBL proteins: 
     ENSP00000309649  
    Reactome Protein details: P35218

    CA5A Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CA5A
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    Cloud-Clone Corp. Proteins for CA5A

     
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    Cloud-Clone Corp. ELISAs for CA5A
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    Search eBioscience for ELISAs for CA5A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CA: Carbonic anhydrases

    4 InterPro protein domains:
     IPR018437 CA-VB_mt
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class

    Graphical View of Domain Structure for InterPro Entry P35218

    ProtoNet protein and cluster: P35218

    UniProtKB/Swiss-Prot: CAH5A_HUMAN, P35218
    Similarity: Belongs to the alpha-carbonic anhydrase family


    Find genes that share domains with CA5A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH5A_HUMAN, P35218
    Function: Reversible hydration of carbon dioxide. Low activity
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited
    by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt)
    Biophysicochemical properties: Kinetic parameters: KM=10.0 mM for CO(2);

         Enzyme Number (IUBMB): EC 4.2.1.11 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CA5A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CA5A:
     Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Car5a):
     cellular  growth/size/body  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with CA5A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Car5atm1Sly for CA5A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CA5A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA5A

    miRNA
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    miRTarBase miRNAs that target CA5A:
    hsa-mir-335-5p (MIRT018476)

    Block miRNA regulation of human, mouse, rat CA5A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CA5A:
    hsa-miR-4277
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CA5A

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    GenScript: all cDNA clones in your preferred vector: CA5A (NM_001739)
    Sino Biological Human cDNA Clone for CA5A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA5A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAH5A_HUMAN, P35218: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast2
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS8356065
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with CA5A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CA5A About    
    See pathways by source

    SuperPathContained pathways About
    1Nitrogen metabolism
    Reversible Hydration of Carbon Dioxide0.00
    Nitrogen metabolism
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with CA5A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CA5A
        Reversible hydration of carbon dioxide


    1 Kegg Pathway  (Kegg details for CA5A):
        Nitrogen metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CA5A
    Interactions:

        Search GeneGlobe Interaction Network for CA5A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA5A (ENSP000003096494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with CA5A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CA5A (CAH5A)

    4 HMDB Compounds for CA5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    4 DrugBank Compounds for CA5A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 15837316 18782051 17582922
    4-Methylimidazole-- --target--17139284 17016423 10592235
    Brinzolamide-- 138890-62-7targetinhibitor14971907
    Ellagic Acid-- 476-66-4targetinhibitor20185318

    5 Novoseek inferred chemical compound relationships for CA5A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetazolamide 75.7 1 10409679 (1)
    carbamoyl phosphate 72.5 1 10082753 (1)
    bicarbonate 63.2 3 11928941 (1), 10082753 (1)
    pyruvate 51.8 2 11928941 (1), 10082753 (1)
    hydrogen 16.3 2 11851394 (2)



    Find genes that share compounds with CA5A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CA5A gene: 
    NM_001739.1  

    Unigene Cluster for CA5A:

    Carbonic anhydrase VA, mitochondrial
    Hs.177446  [show with all ESTs]
    Unigene Representative Sequence: NM_001739
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309893(uc002fkn.1) ENST00000566402 ENST00000568801
    miRNA
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    Block miRNA regulation of human, mouse, rat CA5A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CA5A:
    hsa-miR-4277
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CA5A
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CA5A
      QuantiTect SYBR Green Assays in human, mouse, rat CA5A
      QuantiFast Probe-based Assays in human, mouse, rat CA5A

    Additional mRNA sequence: 

    BC137405.1 BC137411.1 L19297.1 

    2 DOTS entries:

    DT.106277  DT.95070712 

    14 AceView cDNA sequences:

    NM_001739 L19297 C20973 CD612739 BX281874 CD612732 AA699469 CD612737 
    CD612748 CD612734 CD612741 AA682554 CD612745 CD612743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CA5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CA5A Expression
    About this image

    CA5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CA5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.177446
        Custom PCR Arrays for CA5A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CA5A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car5a1 , 5 carbonic anhydrase 5a, mitochondrial1, 5 76.81(n)1
    75.72(a)1
      8 (70.81 cM)5
    123521  NM_007608.21  NP_031634.21 
     1219161265 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    62(a)
    1 → many
    11(17466270-17479304)
    zebrafish
    (Danio rerio)
    Actinopterygii ca56
    carbonic anhydrase V
    48(a)
    1 → many
    25(13142009-13152469) ENSDARG00000051884
    fruit fly
    (Drosophila melanogaster)
    Insecta CAH13 carbonate dehydratase 41(a)   34D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cah-33
    cah-41
    carbonic anhydrase3
    cah-41
    37(a)3
    48.46(n)1
    37.04(a)1
      X(16518334-16519911)3
    1814781  NM_077863.61  NP_510264.11 


    ENSEMBL Gene Tree for CA5A (if available)
    TreeFam Gene Tree for CA5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CA5A gene
    CA22  CA122  CA72  CA32  CA62  CA5B2  CA142  CA82  
    CA42  CA12  CA92  CA132  
    12 SIMAP similar genes for CA5A using alignment to 1 protein entry:     CAH5A_HUMAN:
    CA5B    CA7    CA13    CA2    CA1    CA3
    CA10    CA11    DKFZp686I20267    CA14    CA8    CA6

    Find genes that share paralogs with CA5A           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CA5A
    PGOHUM00000259022 PGOHUM00000248796 PGOHUM00000249048


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CA5A (see all 1800)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342710251,2
    F--73664949(+) GTTGTG/CCAGGC 1 -- int12Minor allele frequency- C:0.50NA 4
    rs25499641,2
    C,H--73667504(+) atgttG/Aggatt 1 -- int11Minor allele frequency- A:0.50NA 2
    rs620441641,2
    C,F--73667984(+) TCAAGC/TGATCC 1 -- int13Minor allele frequency- T:0.33NA 6
    rs25499651,2
    C--73668056(+) AGCCAA/GGGGGT 1 -- int12Minor allele frequency- G:0.25NA 4
    rs29113281,2
    C,A--73669202(-) TTTGTG/ATTTTT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs557210351,2
    C--87928180(+) AAAAA-/ACAGCA 1 -- int10--------
    rs580818971,2
    C--87928468(+) AGAGA-/GACTCTG 1 -- int10--------
    rs1124794341,2
    C,F--87930421(+) TTCTGG/TTTTTA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs671244171,2
    C--87935180(+) TTTCT-/TTTCT 
            
    TTCTT
    1 -- int10--------
    rs58186511,2
    C--87935958(+) aaaaaA/-GCAAT 1 -- int1 trp31Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CA5A (87921625 - 87970135 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CA5A (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657678CNV Deletion23128226
    esv2714939CNV Deletion23290073
    nsv907213CNV Loss21882294
    nsv907182CNV Loss21882294
    nsv907212CNV Loss21882294
    dgv36n68CNV Loss17160897
    dgv2962n71CNV Loss21882294
    nsv907210CNV Loss21882294
    nsv907211CNV Loss21882294
    nsv457616CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CA5A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114761    OMIM disorders: --

    1 disease for CA5A:    
    About MalaCards
    hyperammonemia due to carbonic anhydrase va deficiency

    1 disease from the University of Copenhagen DISEASES database for CA5A:
    Glaucoma

    Find genes that share disorders with CA5A           About GenesLikeMe

    Genetic Association Database (GAD): CA5A
    Human Genome Epidemiology (HuGE) Navigator: CA5A (1 document)

    Export disorders for CA5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CA5A gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CA5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p. (PubMed id 7490083)1, 2, 3, 9 Nagao Y.... Sly W.S. (Genomics 1995)
    2. Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16. (PubMed id 8356065)1, 2, 3 Nagao Y.... Sly W.S. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Cell-specific expression of mitochondrial carbonic anhydrase in the human and rat gastrointestinal tract. (PubMed id 10082753)1, 9 Saarnio J....Sly W.S. (J. Histochem. Cytochem. 1999)
    5. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (J Drug Target 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. (PubMed id 20185318)7 Innocenti A....Supuran C.T. (amp 2010)
    8. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (amp 2009)
    9. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (PubMed id 19206230)2 Maresca A.... Supuran C.T. (J. Am. Chem. Soc. 2009)
    10. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. (PubMed id 19186056)2 Crocetti L.... Supuran C.T. (Bioorg. Med. Chem. Lett. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 763 HGNC: 1377 AceView: CA5A Ensembl:ENSG00000174990 euGenes: HUgn763
    ECgene: CA5A Kegg: 763 H-InvDB: CA5A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CA5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CA5A gene:
    Search GeneIP for patents involving CA5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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