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Aliases for CA3 Gene

Aliases for CA3 Gene

  • Carbonic Anhydrase III 2 3 4
  • Carbonic Anhydrase III, Muscle Specific 2 3
  • Carbonate Dehydratase III 3 4
  • EC 4.2.1.1 4 63
  • CA-III 3 4
  • Epididymis Secretory Sperm Binding Protein Li 167mP 3
  • HEL-S-167mP 3
  • CAIII 3
  • Car3 3

External Ids for CA3 Gene

Previous GeneCards Identifiers for CA3 Gene

  • GC08P085174
  • GC08P086090
  • GC08P086425
  • GC08P086537
  • GC08P081845
  • GC08P086285

Summaries for CA3 Gene

Entrez Gene Summary for CA3 Gene

  • Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]

GeneCards Summary for CA3 Gene

CA3 (Carbonic Anhydrase III) is a Protein Coding gene. Diseases associated with CA3 include hordeolum and auditory agnosia. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity and nickel cation binding. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA3 Gene

  • Reversible hydration of carbon dioxide

Gene Wiki entry for CA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA3 Gene

Genomics for CA3 Gene

Regulatory Elements for CA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CA3 Gene

Chromosome:
8
Start:
85,373,436 bp from pter
End:
85,449,040 bp from pter
Size:
75,605 bases
Orientation:
Plus strand

Genomic View for CA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA3 Gene

Proteins for CA3 Gene

  • Protein details for CA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07451-CAH3_HUMAN
    Recommended name:
    Carbonic anhydrase 3
    Protein Accession:
    P07451
    Secondary Accessions:
    • B2R867
    • B3KUC8
    • O60842

    Protein attributes for CA3 Gene

    Size:
    260 amino acids
    Molecular mass:
    29557 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA3 Gene

neXtProt entry for CA3 Gene

Proteomics data for CA3 Gene at MOPED

Selected DME Specific Peptides for CA3 Gene

Post-translational modifications for CA3 Gene

  • S-glutathionylated in hepatocytes under oxidative stress.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CA3 (Carbonic Anhydrase III/CA3)

Domains & Families for CA3 Gene

Gene Families for CA3 Gene

Suggested Antigen Peptide Sequences for CA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07451

UniProtKB/Swiss-Prot:

CAH3_HUMAN :
  • Belongs to the alpha-carbonic anhydrase family.
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA3: view

Function for CA3 Gene

Molecular function for CA3 Gene

GENATLAS Biochemistry:
carbonic anhydrase III,cytosolic,expressed in skeletal muscle and notochord,involved in cellular ion transport and PH homeostasis
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=52.0 mM for CO(2) {ECO:0000269 PubMed:18618712};
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by proton donors such as imidazole and the dipeptide histidylhistidine. Inhibited by coumarins and sulfonamide derivatives such as acetazolamide.
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide

Enzyme Numbers (IUBMB) for CA3 Gene

Gene Ontology (GO) - Molecular Function for CA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016151 nickel cation binding IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with CA3: view
genes like me logo Genes that share phenotypes with CA3: view

Animal Models for CA3 Gene

MGI Knock Outs for CA3:

Animal Model Products

miRNA for CA3 Gene

miRTarBase miRNAs that target CA3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CA3 Gene

Localization for CA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CA3 Gene COMPARTMENTS Subcellular localization image for CA3 gene
Compartment Confidence
cytosol 4
chloroplast 2
mitochondrion 2
cytoskeleton 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CA3: view

Pathways & Interactions for CA3 Gene

genes like me logo Genes that share pathways with CA3: view

Pathways by source for CA3 Gene

2 Reactome pathways for CA3 Gene
1 KEGG pathway for CA3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CA3 Gene

Gene Ontology (GO) - Biological Process for CA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0006979 response to oxidative stress IEA --
GO:0015701 bicarbonate transport TAS --
GO:0016311 dephosphorylation IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA3: view

No data available for SIGNOR curated interactions for CA3 Gene

Drugs & Compounds for CA3 Gene

(13) Drugs for CA3 Gene - From: NovoSeek, HMDB, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetazolamide Approved Pharma Target, inhibitor 61
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 63
Zinc Approved Pharma 1404
Chlorothiazide Approved Pharma Inhibition, Inhibitor Carbonic anhydrase inhibitor 7
Dichlorphenamide Approved Pharma 2

(12) Additional Compounds for CA3 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
Carbonic acid
  • Acid of air
  • Aerial acid
  • Bisodium carbonate
  • Calcined
  • Carbonic acid sodium salt
463-79-6
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
aspartate
bicarbonate
genes like me logo Genes that share compounds with CA3: view

Transcripts for CA3 Gene

mRNA/cDNA for CA3 Gene

Unigene Clusters for CA3 Gene

Carbonic anhydrase III, muscle specific:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA3 Gene

No ASD Table

Relevant External Links for CA3 Gene

GeneLoc Exon Structure for
CA3
ECgene alternative splicing isoforms for
CA3

Expression for CA3 Gene

mRNA expression in normal human tissues for CA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA3 Gene

This gene is overexpressed in Muscle - Skeletal (x49.4).

Protein differential expression in normal tissues from HIPED for CA3 Gene

This gene is overexpressed in Tonsil (18.8), Oral epithelium (14.1), Cerebral cortex (7.8), and Prostate (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CA3 Gene



SOURCE GeneReport for Unigene cluster for CA3 Gene Hs.82129

mRNA Expression by UniProt/SwissProt for CA3 Gene

P07451-CAH3_HUMAN
Tissue specificity: Muscle specific
genes like me logo Genes that share expression patterns with CA3: view

Protein tissue co-expression partners for CA3 Gene

Primer Products

In Situ Assay Products

Orthologs for CA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CA3 35
  • 84.87 (n)
  • 85.38 (a)
CA3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CA3 35
  • 89.74 (n)
  • 90.38 (a)
CA3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Car3 35
  • 87.05 (n)
  • 91.92 (a)
Car3 16
Car3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CA3 35
  • 99.74 (n)
  • 99.23 (a)
CA3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Car3 35
  • 87.56 (n)
  • 91.54 (a)
oppossum
(Monodelphis domestica)
Mammalia CA3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CA3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CA3 35
  • 69.27 (n)
  • 69.92 (a)
-- 36
  • 63 (a)
OneToMany
CA3 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CA3 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ca3 35
  • 64.58 (n)
  • 59.37 (a)
zebrafish
(Danio rerio)
Actinopterygii ca2 36
  • 53 (a)
ManyToMany
cahz 36
  • 56 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CAH1 37
  • 40 (a)
CG6074 37
  • 30 (a)
CG6906 37
  • 31 (a)
CAH1 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cah-3 37
  • 32 (a)
Species with no ortholog for CA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA3 Gene

ENSEMBL:
Gene Tree for CA3 (if available)
TreeFam:
Gene Tree for CA3 (if available)

Paralogs for CA3 Gene

Paralogs for CA3 Gene

(16) SIMAP similar genes for CA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA3: view

Variants for CA3 Gene

Sequence variations from dbSNP and Humsavar for CA3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs20571 - 85,439,768(+) CGCCC(A/G)TTGAG missense, reference
rs1389245 -- 85,440,159(+) ATTCC(C/T)GAAAT intron-variant
rs1493301 -- 85,437,006(+) TGCGC(A/G)TTTAA upstream-variant-2KB
rs1493302 -- 85,437,051(+) TATCC(C/T)TCTAT upstream-variant-2KB
rs1543852 -- 85,440,529(+) TGAAA(A/G)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA3 Gene

Variant ID Type Subtype PubMed ID
nsv831377 CNV Gain 17160897

Variation tolerance for CA3 Gene

Residual Variation Intolerance Score: 40.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.10; 93.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA3 Gene

HapMap Linkage Disequilibrium report
CA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA3 Gene

Disorders for CA3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CA3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hordeolum
  • hordeolum externum
auditory agnosia
optic disk drusen
  • optic nerve head drusen
acute myocardial infarction
myocardial infarction
  • myocardial infarction, protection against
- elite association
Search CA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CA3
genes like me logo Genes that share disorders with CA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA3 Gene

Publications for CA3 Gene

  1. Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. (PMID: 20605094) Avvaru B.S. … McKenna R. (Bioorg. Med. Chem. Lett. 2010) 25 26
  2. Chronic endurance exercise induces quadriceps nitrosative stress in patients with severe COPD. (PMID: 18835959) Barreiro E. … Roca J. (Thorax 2009) 23 67
  3. Carbonic anhydrase III: the new hope for the elimination of exercise-induced muscle fatigue. (PMID: 19135807) Shang X. … Huang H. (Med. Hypotheses 2009) 23 67
  4. Oxidised proteins and superoxide anion production in the diaphragm of severe COPD patients. (PMID: 19196822) Marin-Corral J. … Barreiro E. (Eur. Respir. J. 2009) 23 67
  5. Reflux changes in adenoidal hyperplasia: a controlled prospective study to investigate its aetiology. (PMID: 19413609) Harris P.K. … Carney A.S. (Clin Otolaryngol 2009) 23 67

Products for CA3 Gene

Sources for CA3 Gene

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