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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CA3 Gene

protein-coding GIFtS: 63
GCID: GC08P086285

carbonic anhydrase III, muscle specific

Explore 32 diseases affiliated with
CA3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Carbonic Anhydrase III, Muscle Specific¹ ²		CA-III² ³
CAIII¹ ²		EC 4.2.1.1³ ⁸
Car3¹ ²		Carbonic Anhydrase 3²
Carbonate Dehydratase III² ³		Carbonic Anhydrase III³

External Ids:	HGNC: 1374¹	Entrez Gene: 761²	Ensembl: ENSG00000164879⁷	OMIM: 114750⁵	UniProtKB: P07451³

Export aliases for CA3 gene to outside databases

Previous GC identifers: GC08P085174 GC08P086090 GC08P086425 GC08P086537 GC08P081845

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA3:

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes

carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible

hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene

is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth

muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3

kb and contains seven exons and six introns. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: CAH3_HUMAN, P07451

Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA3 (Carbonic anhydrase III, muscle specific)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CA3 gene promoter:
GR HNF-1A C/EBPalpha Evi-1 GATA-2 E47 CHOP-10 Hand1 ZIC2/Zic2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CA3 promoter sequence

Search SABiosciences Chromatin IP Primers for CA3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.2 Ensembl cytogenetic band: 8q21.2 HGNC cytogenetic band: 8q21.2

CA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA3 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P086285: view genomic region (about GC identifiers)

Start:	86,285,665 bp from pter	End:	86,361,269 bp from pter
Size:	75,605 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAH3_HUMAN, P07451 (See protein sequence)

Recommended Name: Carbonic anhydrase 3

Size: 260 amino acids; 29557 Da

Cofactor: Zinc

Subcellular location: Cytoplasm

Developmental stage: At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels

throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues

at high to moderate levels in the notochord

5 PDB 3D structures from and Proteopedia for CA3:

1Z93 (3D)

1Z97 (3D)

2HFW (3D)

3UYN (3D)

3UYQ (3D)

Secondary accessions: B2R867 B3KUC8 O60842

Explore the universe of human proteins at neXtProt for CA3: NX_P07451

Post-translational modifications:

S-glutathionylated in hepatocytes under oxidative stress (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07451

4/8 DME Specific Peptides for CA3 (P07451) (see all 8)

HWGSSDD

AELHLVH

GIFLKIG

ELHLVHWN

CA3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005172.1

ENSEMBL proteins:

ENSP00000429760 ENSP00000285381

Reactome Protein details: P07451
Human Recombinant Protein Products for CA3:

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	R&D Systems Recombinant & Natural Proteins for CA3 (Carbonic Anhydrase III/CA3)
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	GenScript Custom Purified and Recombinant Proteins Services for CA3
	Novus Biologicals CA3 Proteins Novus Biologicals CA3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CA3
	Uscn Proteins for CA3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

CA3 for ontologies About GeneDecksing

CA3 Antibody Products:

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	ThermoFisher Antibodies for CA3

Assay Products for CA3:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for CA3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CA3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CA3 for domains About GeneDecksing

4 InterPro domains/families:

IPR018441 Carbonic_anhydrase_CA3

IPR001148 Carbonic_anhydrase_a

IPR018338 Carbonic_anhydrase_a-class_CS

IPR023561 Carbonic_anhydrase_a-class

Graphical View of Domain Structure for InterPro Entry P07451

ProtoNet protein and cluster: P07451

1 Blocks protein family: IPB001148 Carbonic anhydrase

UniProtKB/Swiss-Prot: CAH3_HUMAN, P07451

Similarity: Belongs to the alpha-carbonic anhydrase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CAH3_HUMAN, P07451

Function: Reversible hydration of carbon dioxide

Catalytic activity: H(2)CO(3) = CO(2) + H(2)O

Enzyme regulation: Activated by proton donors such as imidazole and the dipeptide histidylhistidine. Inhibited by

coumarins and sulfonamide derivatives such as acetazolamide

Biophysicochemical properties: Kinetic parameters: KM=52.0 mM for CO(2);

Genatlas biochemistry entry for CA3:

carbonic anhydrase III,cytosolic,expressed in skeletal muscle and notochord,involved in cellular ion transport and PH

homeostasis

Enzyme Number (IUBMB): EC 4.2.1.1¹ ²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004089	carbonate dehydratase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016151	nickel cation binding	IEA	--

CA3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CA3:

Increased cell number in G2M,

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Car3):

muscle

CA3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Car3^tm1Gkim for CA3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CA3

miRNA Products:		OriGene 3'-UTR Clone: CA3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA3
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CA3:
		hsa-miR-3671 hsa-miR-328 hsa-miR-518a-5p hsa-miR-3185
		SwitchGear 3'UTR luciferase reporter plasmid: CA3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA3 (see all 7) OriGene shRNA RFP: CA3 OriGene siRNA: CA3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CA3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CA3
			Sirion Biotech Customized adenovirus for overexpression of CA3 Sirion Biotech Customized adenovirus for potent knockdown of CA3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CA3 (NM_001089)
		Sino Biological Human cDNA Clone for CA3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA3

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		Sirion Biotech Customized stable knockdown cell line services for CA3 Sirion Biotech Customized inducible knockdown cell line services for CA3 Sirion Biotech Customized stable overexpressing cell line services for CA3 Sirion Biotech Customized inducible overexpressing cell line services for CA3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Reversible Hydration of Carbon Dioxide

Reversible Hydration of Carbon Dioxide

1.00

Nitrogen metabolism

0.52

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for CA3

	Reversible Hydration of Carbon Dioxide
	Metabolism

1 Kegg Pathway (Kegg details for CA3):

Nitrogen metabolism

CA3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CA3

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006730	one-carbon metabolic process	IEA	--
GO:0006979	response to oxidative stress	IEA	--
GO:0015701	bicarbonate transport	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

CA3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CA3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CA3

4 HMDB Compounds for CA3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Carbon dioxide	Carbon oxide (see all 5)	124-38-9	--
Carbonic acid	acid of air (see all 24)	463-79-6	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--
Zinc	Zinc (see all 2)	7440-66-6	--

2 DrugBank Compounds for CA3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Zonisamide	Zonisamida [Spanish] (see all 2)	68291-97-4	target	inhibitor	18537527 17762320 19703035 18162396 18782051 17582922
Acetazolamide	Acetamidothiadiazolesulfonamide (see all 7)	59-66-5	target	inhibitor	20605094

10/18 Novoseek chemical compound relationships for CA3 gene (see all 18) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acetazolamide	62	7	10768298 (1), 8506074 (1), 1909176 (1), 18444244 (1)
hydroxide	48.6	3	9398305 (1), 9635771 (1)
bicarbonate	43.8	4	9651514 (1), 2169869 (1)
sulfonamide	43.6	2	8485108 (1), 1935938 (1)
imidazole	41.6	1	2169869 (1)
histidine	40.2	2	17427958 (1), 7599138 (1)
hydrogen	36.5	16	9398305 (3), 17427958 (2), 7599138 (2), 9635771 (2) (see all 10)
creatinine	33.8	15	14559123 (2), 18636795 (1), 7717578 (1), 10541924 (1) (see all 11)
zinc	33.3	3	9398305 (2)
aspartate	17	1	7717578 (1)

Search CenterWatch for drugs/clinical trials and news about CA3 / CAH3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CA3 gene:

NM_005181.3

Unigene Cluster for CA3:

Carbonic anhydrase III, muscle specific

Hs.82129 [show with all ESTs]

Unigene Representative Sequence: NM_005181

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000520921 ENST00000285381(uc003ydj.3 uc011lfv.2) ENST00000522207

miRNA Products:		OriGene 3'-UTR Clone: CA3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA3
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CA3:
		hsa-miR-3671 hsa-miR-328 hsa-miR-518a-5p hsa-miR-3185
		SwitchGear 3'UTR luciferase reporter plasmid: CA3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA3 (see all 7) OriGene shRNA RFP: CA3 OriGene siRNA: CA3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CA3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CA3 (NM_001089)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CA3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA3

Additional cDNA sequence:

AK096880.1 AK300670.1 AK300677.1 AK313254.1 BC004897.2

14 DOTS entries:

DT.316128 DT.101983583 DT.92444302 DT.121483042 DT.101956736 DT.121482843 DT.99929917 DT.121482842

DT.121482905 DT.95351375 DT.100681508 DT.100786810 DT.100786809 DT.92444297

24/234 AceView cDNA sequences (see all 234):

BM720604 BI495173 AW102768 AW950045 CF551842 BI830861 AW301200 AA702404

BF790332 NM_198584 CF552553 AW952139 AA464972 BE552131 T27858 BU169155

AA305658 BX093441 BF576371 AI807047 AK095314 AI417190 AI057175 BQ924401

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CA3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTATTAAAA

About this image

CA3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Limb

Stylopod Synovial Joint

Interzone Cells

Cartilage

Adipose

Body Subcutaneous White Adipose

Adipose

Visceral White Adipose

Adipose

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Bone

Bone

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CA3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CA3

SOURCE GeneReport for Unigene cluster: Hs.82129

UniProtKB/Swiss-Prot: CAH3_HUMAN, P07451

Tissue specificity: Muscle specific

SABiosciences Expression via Pathway-Focused PCR Array including CA3:

Hepatotoxicity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CA3 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CA3¹	carbonic anhydrase III, muscle specific	69.27(n) 69.92(a)		420208 XM_418319.2 XP_418319.1
lizard (Anolis carolinensis)	Reptilia	CA3⁶	--	57(a)	1 ↔ 1	4(23132617-23152358)
zebrafish (Danio rerio)	Actinopterygii	cahz⁶ ca2⁶	carbonic anhydrase II	56(a) 53(a)	many ↔ many many ↔ many	2(29192215-29200240) 24(33852211-33870040)
fruit fly (Drosophila melanogaster)	Insecta	CAH1³ CAH2¹	carbonate dehydratase³ Carbonic anhydrase 2¹	40(a) (best of 3)³ 45.85(n)¹ 33.99(a)¹		34D4³ 39390¹ NM_140298.2¹ NP_648555.1¹
worm (Caenorhabditis elegans)	Secernentea	cah-3³	carbonic anhydrase	32(a)		X(16518334-16519911) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ATACA2⁶ ATACA7⁶ (see all 8)	carbonic anhydrase (see all 8)	25(a) 24(a) (see all 8)	many ↔ many many ↔ many (see all 8)	2(12029997-12032420) 1(2516991-2518546)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	bifunctional monodehydroascorbate reductase and ca... bifunctional monodehydroascorbate reductase and ca... (see all 10)	26(a) 25(a) (see all 10)	many ↔ many many ↔ many (see all 10)	8(20309869-20312003) 11(2485289-2485837)

ENSEMBL Gene Tree for CA3 (if available)
TreeFam Gene Tree for CA3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CA3 gene

CA2² CA12² CA7² CA6² CA11² CA5B² CA14² CA5A²

CA8² CA4² CA1² CA9² CA13² CA10²

16 SIMAP similar genes for CA3 using alignment to 2 protein entries: CAH3_HUMAN (see all proteins):

CA1 CA13 CA2 CA7 CA5B CA5A

CA12 CA6 CA8 DKFZp686I20267 CA10 CA14

PTPRG CA11 CA4 CA9

CA3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189170887^1,2		--	86349059(+)	`TGGCCG/TAAAAT`	1	--	us2k¹		0	--	--	--	--
rs3758072^1,2	C,F,H	--	86349140(+)	`TACAAA/TTCGTA`	1	--	us2k¹		14		NS EA NA	1298
rs181539884^1,2		--	86349142(+)	`CAAATC/GGTAAT`	1	--	us2k¹		0	--	--	--	--
rs118105340^1,2	F	--	86349143(+)	`AAATCG/TTAATT`	1	--	us2k¹		1		EA	120
rs3758073^1,2	C,F,H	--	86349163(+)	`GCACAT/CCTAAA`	1	--	us2k¹		10		EA NS	2662
rs117650599^1,2	F	--	86349233(+)	`TGTGCG/ACATTT`	1	--	us2k¹		1		NA	120
rs1493301^1,2	C,F,H	--	86349235(+)	`TGCGCG/ATTTAA`	1	--	us2k¹		29		NS EA NA WA CSA	2589
rs1493302^1,2	C,F,A,H	--	86349280(+)	`TATCCT/CTCTAT`	1	--	us2k¹		13		NS EA NA WA	786
rs2055077^1,2	C,F,O,A,H	--	86349320(+)	`TAGATC/TGTTCT`	1	--	us2k¹		30		NS EA NA WA	3302
rs148852560^1,2		--	86349766(+)	`TGTAAA/TCCCCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CA3 (86285665 - 86361269 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CA3
1 CNV: 4601

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CA3 for disorders           About GeneDecksing

OMIM gene information: 114750    OMIM disorders: --

20/32 diseases for CA3 (see all 32):    About MalaCards

optic disk drusen myocardial infarction acute myocardial infarction proliferative vitreoretinopathy

neuromuscular disease myasthenia gravis chronic obstructive pulmonary disease vitreoretinopathy

pleomorphic adenoma candidiasis myasthenia muscular dystrophy

pulmonary disease autoimmune hepatitis laryngitis rheumatoid arthritis

laryngeal disease adenoiditis hypercholesterolemia copd

2 diseases from the University of Copenhagen DISEASES database for CA3:

Candidiasis Auditory agnosia

7 Novoseek disease relationships for CA3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acute myocardial infarction	36.7	3	8572443 (1), 14559123 (1), 2108824 (1)
reflux	34.7	9	15564833 (4), 17417109 (1), 12834114 (1)
rhabdomyolysis	23.4	3	7717578 (2), 2108827 (1)
neuromuscular diseases	21.5	1	2108824 (1)
cell damage	16.3	5	8572443 (1), 10727678 (1)
renal failure	1.07	1	9352127 (1)
myocardial infarction	0	4	10727678 (2)

Export disorders for CA3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CA3 gene, integrated from 9 sources (see all 131):
(articles sorted by number of sources associating them with CA3)

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world of online information

Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. (PubMed id 9651514)^{1, 2, 9} Sowden J.... Edwards Y. (1998)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human muscle carbonic anhydrase: gene structure and DNA methylation patterns in fetal and adult tissues. (PubMed id 2824285)^{1, 2} Lloyd J.... Edwards Y.H. (1987)
Nucleotide sequence and derived amino acid sequence of a cDNA encoding human muscle carbonic anhydrase. (PubMed id 3086182)^{1, 2} Lloyd J.... Edwards Y.H. (1986)
Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes. (PubMed id 3099285)^{1, 2} Wade R.... Kedes L. (1986)
Carbonic anhydrase-III immunohistochemical localization in human skeletal muscle. (PubMed id 6221502)^{1, 3} Shima K....Hirai H. (1983)
Production and characterization of monoclonal antibodies to human carbonic anhydrase III. (PubMed id 9890711)^{1, 9} Azzazy H.M....Christenson R.H. (1998)
Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway. (PubMed id 18444244)^{1, 9} Dai H.Y....Chuang S.E. (2008)
The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation. (PubMed id 8633035)^{1, 9} Cabiscol E. and Levine R.L. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 761	HGNC: 1374	AceView: CA3andCA13	Ensembl:ENSG00000164879	euGenes: HUgn761
ECgene: CA3	Kegg: 761	H-InvDB: CA3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CA3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CA3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CA3 gene:
Search GeneIP for patents involving CA3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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