Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA14 Gene

protein-coding   GIFtS: 62
GCID: GC01P150230

carbonic anhydrase XIV
 Explore 9 diseases affiliated with
CA14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CA14    

Aliases
for CA14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carbonic Anhydrase XIV1 2 3     Carbonic Anhydrase 142
Carbonate Dehydratase XIV2 3     Carbonic Dehydratase2
CA-XIV2 3     EC 4.2.1.13
CAXiV2     

External Ids:    HGNC: 13721   Entrez Gene: 236322   Ensembl: ENSG000001182987   OMIM: 6048325   UniProtKB: Q9ULX73   

Export aliases for CA14 gene to outside databases

Previous GC identifers: GC01P147881 GC01P145972 GC01P147005 GC01P147446 GC01P147043 GC01P148488 GC01P121608


Summaries
for CA14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CA14:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon
dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base
balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show
extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I
membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they
have different patterns of tissue-specific expression and thus may play different physiologic roles. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA14


Genomic Views
for CA14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA14 gene promoter:
         AhR   C/EBPbeta   RREB-1   Bach2   GATA-2   Arnt   AREB6   RORalpha1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CA14 promoter sequence
   Search SABiosciences Chromatin IP Primers for CA14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

CA14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA14 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150230:  view genomic region     (about GC identifiers)

Start:
 150,230,169 bp from pter      End:
 150,237,478 bp from pter
Size:
 7,310 bases      Orientation:
 plus strand

Proteins
for CA14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7 (See protein sequence)
Recommended Name: Carbonic anhydrase 14 precursor  
Size: 337 amino acids; 37668 Da
Cofactor: Zinc (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q5TB24 Q8NCF4

Explore the universe of human proteins at neXtProt for CA14: NX_Q9ULX7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULX7

    • CA14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036245.1  
    ENSEMBL proteins: 
     ENSP00000358107  
    Reactome Protein details: Q9ULX7
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CA14 (Carbonic Anhydrase XIV/CA14)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CA14
    OriGene Protein Over-expression Lysate: CA14
    OriGene Custom Protein Services for CA14 
    GenScript Custom Purified and Recombinant Proteins Services for CA14
    Novus Biologicals CA14 Protein
    Novus Biologicals CA14 Lysates
    Sino Biological Recombinant Protein for CA14
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CA14

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    CA14 for ontologies           About GeneDecksing



    CA14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CA14 (Carbonic Anhydrase XIV/CA14)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CA14 
    GenScript Custom Superior Antibodies Services for CA14
    Novus Biologicals CA14 Antibodies
    Search for Antibodies for CA14 at Abcam  
    Uscn Antibodies for CA14
    ThermoFisher Antibody for CA14

    Assay Products for CA14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CA14
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CA14

    Protein Domains /
    Families
    for CA14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CA14 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR018431 Carbonic_anhydrase_CA14
     IPR001148 Carbonic_anhydrase_a
     IPR023561 Carbonic_anhydrase_a-class

    Graphical View of Domain Structure for InterPro Entry Q9ULX7

    ProtoNet protein and cluster: Q9ULX7

    1 Blocks protein family: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
    Similarity: Belongs to the alpha-carbonic anhydrase family


    Function
    for CA14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
    Function: Reversible hydration of carbon dioxide
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by
    coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium
    salt)
    Biophysicochemical properties: Kinetic parameters: KM=7.9 mM for CO(2);

         Genatlas biochemistry entry for CA14:
    carbonic anhydrase XIV,expressed in adult heart,brain,kidney,liver and skeletal muscle,highly homolog to CA12

    Enzyme Number (IUBMB): EC 4.2.1.11

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA14
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CA14:
    hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CA14 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA14 (see all 7)
    OriGene shRNA RFP: CA14
    OriGene siRNA: CA14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA14

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CA14

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA14 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA14
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CA14 (NM_012113)
    Sino Biological Human cDNA Clone for CA14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA14 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CA14
    Search LifeMap BioReagents cell lines for CA14

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA14

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0046872metal ion binding IEA--


    CA14 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CA14:
     Decreased cell number and incr  Increased G1 DNA content  Increased cell number in G1, s 

    Animal Models:
         Mouse knock-out Car14tm1Sly for CA14
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Car14):
     growth/size  homeostasis/metabolism  mortality/aging  normal  reproductive system 

    CA14 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CA14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Reversible Hydration of Carbon Dioxide
    		Reversible Hydration of Carbon Dioxide1.00
    		Nitrogen metabolism0.52
    2Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CA14
        Reversible Hydration of Carbon Dioxide
    Metabolism


    1         Kegg Pathway  (Kegg details for CA14):
        Nitrogen metabolism


    CA14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CA14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA14 (ENSP000003581074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF273ENSP000004187194STRING: ENSP00000418719
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--


    CA14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CA14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CA14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CA14

    4 HMDB Compounds for CA14    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    3 DrugBank Compounds for CA14    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    Beta-D-Mannose-- 7322-31-8target--17139284 17016423 10592235
    AcetazolamideAcetamidothiadiazolesulfonamide (see all 7)59-66-5targetinhibitor10592235

    2 Novoseek chemical compound relationships for CA14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfonamide 71.4 1 10512682 (1)
    bicarbonate 49.4 4 11140614 (1), 12028451 (1), 19692653 (1)

    Search CenterWatch for drugs/clinical trials and news about CA14 / CAH14 

    Transcripts
    for CA14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CA14 gene: 
    NM_012113.1  

    Unigene Cluster for CA14:

    Carbonic anhydrase XIV
    Hs.528988  [show with all ESTs]
    Unigene Representative Sequence: AK074765
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369111(uc009wln.3 uc001etx.3) ENST00000483993

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA14
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CA14:
    hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CA14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA14 (see all 7)
    OriGene shRNA RFP: CA14
    OriGene siRNA: CA14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA14
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA14 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA14
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CA14 (NM_012113)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA14 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA14
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA14

    Additional cDNA sequence: 

    AB025904.1 AK074765.1 AK290609.1 AK295341.1 AK308964.1 AK315469.1 AY358689.1 BC034412.1 
    BT020054.1 

    4 DOTS entries:

    DT.87015226  DT.415663  DT.40109292  DT.40257102 

    24/67 AceView cDNA sequences (see all 67):

    R07653 H60753 BI820831 BQ070550 AI582759 N36146 AY358689 AA418208 
    AA620395 AA418073 AA322820 BM707998 BP361793 AW027850 AA640177 AI015805 
    BC034412 BM670068 AI686505 BM726824 BM548598 BI756209 H59688 AK074765 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CA14    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                              
    SP2:              -                                                               
    SP3:                                      -                                       


    ECgene alternative splicing isoforms for CA14

    Expression
    for CA14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CA14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGAGGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CA14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    OvaryPrimary FollicleGranulosa CellsOvary
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CA14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CA14

    SOURCE GeneReport for Unigene cluster: Hs.528988

    UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
    Tissue specificity: High expression in all parts of the central nervous system and lower expression in adult liver,
    heart, small intestine, colon, kidney, urinary bladder and skeletal muscle

        SABiosciences Custom PCR Arrays for CA14
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA14
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA14
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA14

    Orthologs
    for CA14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CA14 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4314761 carbonic anhydrase 14-like 58.19(n)
    52.92(a)    		   431476  XM_003642665.1  XP_003642713.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CA146
    		 --
    		 53(a)
    		 1 ↔ 1
    		 GL343697.1(15781-34228)
    zebrafish
    (Danio rerio)    		 Actinopterygii ca141 carbonic anhydrase XIV 56.47(n)
    54.79(a)    		   567897  NM_001037693.1  NP_001032782.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 25(a)
    		 possible ortholog
    		 GroupUn.4108(1282-1968)
    worm
    (Caenorhabditis elegans)    		 Secernentea cah-36
    cah-56
    		 Putative carbonic anhydrase 5
    		 28(a)
    25(a)
    		 possible ortholog
    possible ortholog
    		 X(16487406-16489323)
    X(7019981-7023926)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ACA46
    ATACA26
    (see all 8)    		 carbonic anhydrase
    (see all 8)    		 24(a)
    24(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 4(11219772-11221126)
    2(12029997-12032420)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 10)    		 bifunctional monodehydroascorbate reductase and ca...
    bifunctional monodehydroascorbate reductase and ca...
    (see all 10)    		 29(a)
    25(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 11(2485289-2485837)
    12(2642977-2644316)


    ENSEMBL Gene Tree for CA14 (if available)
    TreeFam Gene Tree for CA14 (if available) 

    Paralogs
    for CA14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CA14 gene
    CA22  CA122  CA72  CA62  CA32  CA112  CA5B2  CA5A2  
    CA82  CA42  CA12  CA132  CA92  CA102  
    14 SIMAP similar genes for CA14 using alignment to 2 protein entries:     CAH14_HUMAN (see all proteins):
    CA12    CA6    CA2    CA7    CA8    CA13
    CA5A    CA9    PTPRG    CA1    CA3    CA5B
    PTPRZ1    CA4

    CA14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CA14
    PGOHUM00000245060


    Genomic Variants
    for CA14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 NCBI SNPs in CA14 are shown (see all 177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs32093951,2
    		C--121616599(-) TTGTAG/TTTTTT 7 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.00MN 184
    rs1925346461,2
    		C,--121616609(+) AAAAAA/GTCTCC 7 -- nc-transcript-variantut310--------
    rs1853743981,2
    		--150228244(+) CCTCTC/GTCCTA 1 -- int10--------
    rs1866854741,2
    		--150228461(+) TAGACA/GAGCCA 1 -- int10--------
    rs1912432751,2
    		--150228476(+) GTGGCA/GCCTGG 1 -- int10--------
    rs1459930681,2
    		--150228542(+) CTCTGC/TTCCGG 1 -- int10--------
    rs1841513451,2
    		--150228546(+) GTTCCA/GGCAGA 1 -- int10--------
    rs1884842741,2
    		--150229027(+) TGCCTC/GTGGTG 1 -- int10--------
    rs1399379061,2
    		--150229159(+) AACATC/TAGTTC 1 -- int10--------
    rs741266301,2
    		C,--150229191(+) TCCATG/CCTCCA 1 -- int12Minor allele frequency- C:0.13WA 120

    HapMap Linkage Disequilibrium report for CA14 (150230169 - 150237478 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CA14: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA14
    DNA2.0 Custom Variant and Variant Library Synthesis for CA14

    Disorders / Diseases
    for CA14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CA14 for disorders           About GeneDecksing

    OMIM gene information: 604832    OMIM disorders: --

    9 diseases for CA14:    About MalaCards
    anterograde amnesia    renal tubular acidosis    renal cell carcinoma    glaucoma
    dementia    hypoxia    retinitis    carcinoma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CA14:
    Glaucoma

    1 Novoseek disease relationship for CA14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11140614 (1)

    Human Genome Epidemiology (HuGE) Navigator: CA14 (4 documents)

    Export disorders for CA14 gene to outside databases

    Publications
    for CA14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CA14 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CA14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. (PubMed id 10512682)1, 2, 3, 9 Fujikawa-Adachi K.... Onishi S. (1999)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. (PubMed id 12028451)1, 9 Kaunisto K....Sly W.S. (2002)
    7. Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. (PubMed id 11172051)1, 9 Parkkila S....Sly W.S. (2001)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfo namides as potent carbonic anhydrase inhibitors: synthesis, biological evaluati on, and enzyme--ligand X-ray studies. (PubMed id 20170095)1 Gitto R....Chimirri A. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for CA14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CA14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23632 HGNC: 1372 AceView: CA14 Ensembl:ENSG00000118298 euGenes: HUgn23632
    ECgene: CA14 Kegg: 23632 H-InvDB: CA14

    Other Databases showing CA14 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CA14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CA14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CA14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CA14 gene:
    Search GeneIP for patents involving CA14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CA14 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CA14 (Carbonic Anhydrase XIV/CA14)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for CA14 (Carbonic Anhydrase XIV/CA14)  
     Browse OriGene Antibodies   OriGene shRNA RFP for CA14  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA14   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA14  
     OriGene Protein Over-expression Lysate for CA14   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CA14   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA14   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA14  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CA14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CA14   OriGene Custom Protein Services for CA14  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CA14
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA14
     GenScript Custom Purified and Recombinant Proteins Services for CA14 GenScript cDNA clones with any tag delivered in your preferred vector for CA14
     GenScript Custom Assay Services for CA14 GenScript Custom Superior Antibodies Services for CA14
     GenScript Custom overexpressing Cell Line Services for CA14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CA14 promoter
     Search Chromatin IP Primers for CA14
     RT2 qPCR Primer Assay in human, mouse, rat CA14
     GNC Network for CA14
     SABiosciences Custom PCR Arrays for CA14
     Search Tocris compounds for CA14
     Proteins and Antibodies for CA14
     cDNA Clones for CA14
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CA14 antibodies
     CA14 proteins
     CA14 lysates
     Search for Antibodies for CA14 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CA14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CA14 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CA14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA14
     SwitchGear 3'UTR luciferase reporter plasmids for CA14
     SwitchGear Promoter luciferase reporter plasmids for CA14
     ThermoFisher Antibody for CA14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA14
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CA14 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4