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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA14 Gene

protein-coding   GIFtS: 63
GCID: GC01P150230

Carbonic Anhydrase XIV

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbonic Anhydrase XIV1 2 3     Carbonic Anhydrase 142
Carbonate Dehydratase XIV2 3     Carbonic Dehydratase2
CA-XIV2 3     EC 4.2.1.13
CAXiV2     

External Ids:    HGNC: 13721   Entrez Gene: 236322   Ensembl: ENSG000001182987   OMIM: 6048325   UniProtKB: Q9ULX73   

Export aliases for CA14 gene to outside databases

Previous GC identifers: GC01P147881 GC01P145972 GC01P147005 GC01P147446 GC01P147043 GC01P148488 GC01P121608


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA14 Gene:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of
carbon dioxide. They participate in a variety of biological processes, including respiration, calcification,
acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric
acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is
predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA
isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different
physiologic roles. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA14 Gene: 
CA14 (carbonic anhydrase XIV) is a protein-coding gene. Diseases associated with CA14 include anterograde amnesia, and renal tubular acidosis, and among its related super-pathways are Nitrogen metabolism and Metabolic pathways. GO annotations related to this gene include carbonate dehydratase activity and metal ion binding. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA14 gene promoter:
         AhR   C/EBPbeta   RREB-1   Bach2   GATA-2   Arnt   AREB6   RORalpha1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA14 promoter sequence
   Search SABiosciences Chromatin IP Primers for CA14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

CA14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA14 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150230:  view genomic region     (about GC identifiers)

Start:
150,229,554 bp from pter      End:
150,237,478 bp from pter
Size:
7,925 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7 (See protein sequence)
Recommended Name: Carbonic anhydrase 14 precursor  
Size: 337 amino acids; 37668 Da
Cofactor: Zinc (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q5TB24 Q8NCF4

Explore the universe of human proteins at neXtProt for CA14: NX_Q9ULX7

Explore proteomics data for CA14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULX7

  • CA14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CA14 Protein Expression
    REFSEQ proteins: NP_036245.1  
    ENSEMBL proteins: 
     ENSP00000358107   ENSP00000475869   ENSP00000475238  
    Reactome Protein details: Q9ULX7
    Human Recombinant Protein Products for CA14: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CA14 (Carbonic Anhydrase XIV/CA14)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CA14
    OriGene Protein Over-expression Lysate for CA14
    OriGene MassSpec for CA14 
    OriGene Custom Protein Services for CA14
    GenScript Custom Purified and Recombinant Proteins Services for CA14
    Novus Biologicals CA14 Proteins
    Novus Biologicals CA14 Lysates
    Sino Biological Recombinant Protein for CA14
    Sino Biological Cell Lysate for CA14 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CA14 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    CA14 for ontologies           About GeneDecksing



    CA14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CA14 Antibodies
    Abcam antibodies for CA14
    Cloud-Clone Corp. Antibodies for CA14 
    ThermoFisher Antibody for CA14
    LSBio Antibodies in human, mouse, rat for CA14 

    Assay Products for CA14: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CA14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CA14 
    Cloud-Clone Corp. CLIAs for CA14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CA: Carbonic anhydrases

    3 InterPro protein domains:
     IPR018431 Carbonic_anhydrase_CA14
     IPR001148 Carbonic_anhydrase_a
     IPR023561 Carbonic_anhydrase_a-class

    Graphical View of Domain Structure for InterPro Entry Q9ULX7

    ProtoNet protein and cluster: Q9ULX7

    1 Blocks protein domain: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
    Similarity: Belongs to the alpha-carbonic anhydrase family


    CA14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH14_HUMAN, Q9ULX7
    Function: Reversible hydration of carbon dioxide
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited
    by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate
    trisodium salt)
    Biophysicochemical properties: Kinetic parameters: KM=7.9 mM for CO(2);

         Genatlas biochemistry entry for CA14:
    carbonic anhydrase XIV,expressed in adult heart,brain,kidney,liver and skeletal muscle,highly homolog to CA12

         Enzyme Number (IUBMB): EC 4.2.1.11

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0046872metal ion binding IEA--
         
    CA14 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CA14:
     Decreased cell number and incr  Increased G1 DNA content  Increased cell number in G1, s 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Car14):
     growth/size  homeostasis/metabolism  mortality/aging  normal  reproductive system 

    CA14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Car14tm1Sly for CA14

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CA14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CA14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA14 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA14 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA14
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CA14:
    hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidCA14 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CA14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CA14
    Sirion Biotech Customized adenovirus for overexpression of CA14

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CA14 (see all 6)
    OriGene ORF clones in mouse, rat for CA14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CA14 (NM_012113)
    Sino Biological Human cDNA Clone for CA14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA14
    Sirion Biotech Customized lentivirus for stable overexpression of CA14 
                         Customized lentivirus expression plasmids for stable overexpression of CA14 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CA14
    Search LifeMap BioReagents cell lines for CA14
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA14


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CA14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Reversible Hydration of Carbon Dioxide
    Reversible Hydration of Carbon Dioxide0.67
    Nitrogen metabolism0.67
    2Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for CA14
        Reversible Hydration of Carbon Dioxide
    Metabolism


    1         Kegg Pathway  (Kegg details for CA14):
        Nitrogen metabolism


    CA14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CA14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA14 (ENSP000003581074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF273ENSP000004187194STRING: ENSP00000418719
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    CA14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CA14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CA14 (CAH14)

    4 HMDB Compounds for CA14    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    4 DrugBank Compounds for CA14    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    Beta-D-Mannose-- 7322-31-8target--17139284 17016423 10592235
    AcetazolamideAcetamidothiadiazolesulfonamide (see all 7)59-66-5targetinhibitor10592235
    Ellagic Acid-- 476-66-4targetinhibitor20185318

    2 Novoseek inferred chemical compound relationships for CA14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfonamide 71.4 1 10512682 (1)
    bicarbonate 49.4 4 11140614 (1), 12028451 (1), 19692653 (1)

    Search CenterWatch for drugs/clinical trials and news about CA14 / CAH14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CA14 gene: 
    NM_012113.1  

    Unigene Cluster for CA14:

    Carbonic anhydrase XIV
    Hs.528988  [show with all ESTs]
    Unigene Representative Sequence: AK074765
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369111(uc009wln.3 uc001etx.3) ENST00000607751 ENST00000607652
    ENST00000483993 ENST00000607082
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA14
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CA14:
    hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidCA14 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CA14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA14
    Clone
    Products:
         
    OriGene clones in human, mouse for CA14 (see all 6)
    OriGene ORF clones in mouse, rat for CA14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CA14 (NM_012113)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA14
    Sirion Biotech Customized lentivirus for stable overexpression of CA14 
                         Customized lentivirus expression plasmids for stable overexpression of CA14 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CA14
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA14

    Additional mRNA sequence: 

    AB025904.1 AK074765.1 AK290609.1 AK295341.1 AK308964.1 AK315469.1 AY358689.1 BC034412.1 
    BT020054.1 

    4 DOTS entries:

    DT.87015226  DT.415663  DT.40109292  DT.40257102 

    24/67 AceView cDNA sequences (see all 67):

    BQ070550 AA620395 BI820831 BM670068 AY358689 AA322820 BC034412 AI582759 
    AA418208 N36146 AW027850 AA640177 R07653 BM707998 AI015805 H60753 
    BP361793 AA418073 N67776 N26551 BX952561 AK074765 BI756209 BM545283 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CA14    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                              
    SP2:              -                                                               
    SP3:                                      -                                       


    ECgene alternative splicing isoforms for CA14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CA14 expression in normal human tissues (normalized intensities)      CA14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAGGAAA
    CA14 Expression
    About this image


    CA14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Melanocytes (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Eye (Sensory Organs)
             Retina
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod

    See CA14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CA14

    SOURCE GeneReport for Unigene cluster: Hs.528988

    UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
    Tissue specificity: High expression in all parts of the central nervous system and lower expression in adult
    liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle

        SABiosciences Custom PCR Arrays for CA14
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CA14
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CA14 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car141 , 5 carbonic anhydrase 141, 5 84.77(n)1
    83.98(a)1
      3 (41.48 cM)5
    238311  NM_011797.21  NP_035927.11 
     958977685 
    chicken
    (Gallus gallus)
    Aves LOC4314761 carbonic anhydrase 14-like 58.19(n)
    52.92(a)
      431476  XM_003642665.1  XP_003642713.1 
    lizard
    (Anolis carolinensis)
    Reptilia CA146
    Uncharacterized protein
    47(a)
    1 ↔ 1
    GL343697.1(5075-34228)
    zebrafish
    (Danio rerio)
    Actinopterygii ca141 carbonic anhydrase XIV 56.47(n)
    54.79(a)
      567897  NM_001037693.1  NP_001032782.1 


    ENSEMBL Gene Tree for CA14 (if available)
    TreeFam Gene Tree for CA14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CA14 gene
    CA22  CA122  CA72  CA32  CA62  CA112  CA5B2  CA5A2  
    CA82  CA42  CA12  CA92  CA132  CA102  
    14 SIMAP similar genes for CA14 using alignment to 2 protein entries:     CAH14_HUMAN (see all proteins):
    CA12    CA6    CA2    CA7    CA8    CA13
    CA5A    CA9    PTPRG    CA1    CA3    CA5B
    PTPRZ1    CA4

    CA14 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CA14
    PGOHUM00000245060


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/220 SNPs in CA14 are shown (see all 220)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853743981,2
    C--150228244(+) CCTCTC/GTCCTA 1 -- int10--------
    rs1866854741,2
    --150228461(+) TAGACA/GAGCCA 1 -- int10--------
    rs1912432751,2
    --150228476(+) GTGGCA/GCCTGG 1 -- int10--------
    rs1459930681,2
    --150228542(+) CTCTGC/TTCCGG 1 -- int10--------
    rs1841513451,2
    --150228546(+) GTTCCA/GGCAGA 1 -- int10--------
    rs1884842741,2
    --150229027(+) TGCCTC/GTGGTG 1 -- int10--------
    rs1399379061,2
    --150229159(+) AACATC/TAGTTC 1 -- int10--------
    rs741266301,2
    C,F--150229191(+) TCCATG/CCTCCA 1 -- int12Minor allele frequency- C:0.13WA 120
    rs1811549101,2
    --150229359(+) ATGGTA/GGTAGT 1 -- int10--------
    rs1432606481,2
    --150229411(+) TCTGCC/TGGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CA14 (150229554 - 150237478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CA14:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872415CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604832    OMIM disorders: --

    8 diseases for CA14:    About MalaCards
    anterograde amnesia    renal tubular acidosis    hypoxia    glaucoma
    renal cell carcinoma    dementia    retinitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CA14:
    Glaucoma

    CA14 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CA14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11140614 (1)

    Genetic Association Database (GAD): CA14
    Human Genome Epidemiology (HuGE) Navigator: CA14 (4 documents)

    Export disorders for CA14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CA14 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CA14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. (PubMed id 10512682)1, 2, 3, 9 Fujikawa-Adachi K.... Onishi S. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. (PubMed id 12028451)1, 9 Kaunisto K....Sly W.S. (2002)
    8. Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. (PubMed id 11172051)1, 9 Parkkila S....Sly W.S. (2001)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23632 HGNC: 1372 AceView: CA14 Ensembl:ENSG00000118298 euGenes: HUgn23632
    ECgene: CA14 Kegg: 23632 H-InvDB: CA14

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CA14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CA14 gene:
    Search GeneIP for patents involving CA14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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