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CA14 Gene

protein-coding   GIFtS: 64
GCID: GC01P150230

Carbonic Anhydrase XIV

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbonic Anhydrase XIV1 2 3     Carbonic Anhydrase 142
Carbonate Dehydratase XIV2 3     Carbonic Dehydratase2
CA-XIV2 3     EC 4.2.1.13
CAXiV2     

External Ids:    HGNC: 13721   Entrez Gene: 236322   Ensembl: ENSG000001182987   OMIM: 6048325   UniProtKB: Q9ULX73   

Export aliases for CA14 gene to outside databases

Previous GC identifers: GC01P147881 GC01P145972 GC01P147005 GC01P147446 GC01P147043 GC01P148488 GC01P121608


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CA14 Gene:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of
carbon dioxide. They participate in a variety of biological processes, including respiration, calcification,
acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric
acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is
predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA
isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different
physiologic roles. (provided by RefSeq, Jul 2008)

GeneCards Summary for CA14 Gene:
CA14 (carbonic anhydrase XIV) is a protein-coding gene. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CA14 gene promoter:
         AhR   C/EBPbeta   RREB-1   Bach2   GATA-2   Arnt   AREB6   RORalpha1   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA14 promoter sequence
   Search Chromatin IP Primers for CA14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CA14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

CA14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA14 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150230:  view genomic region     (about GC identifiers)

Start:
150,229,554 bp from pter      End:
150,237,478 bp from pter
Size:
7,925 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7 (See protein sequence)
Recommended Name: Carbonic anhydrase 14 precursor  
Size: 337 amino acids; 37668 Da
Cofactor: Zinc (By similarity)
1 PDB 3D structure from and Proteopedia for CA14:
4LU3 (3D)    
Secondary accessions: Q5TB24 Q8NCF4

Explore the universe of human proteins at neXtProt for CA14: NX_Q9ULX7

Explore proteomics data for CA14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn213
  • Modification sites at PhosphoSitePlus

  • See CA14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036245.1  
    ENSEMBL proteins: 
     ENSP00000358107   ENSP00000475869   ENSP00000475238  
    Reactome Protein details: Q9ULX7

    CA14 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CA14
    Sino Biological Cell Lysate for CA14
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    Cloud-Clone Corp. Proteins for CA14

     
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    antibodies-online proteins for CA14 (8 products) 

     
    antibodies-online peptides for CA14

    CA14 Antibody Products:

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    antibodies-online antibodies for CA14 (22 products) 

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    Cloud-Clone Corp. ELISAs for CA14
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    antibodies-online kits for CA14 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CA: Carbonic anhydrases

    3 InterPro protein domains:
     IPR001148 Carbonic_anhydrase_a
     IPR018429 CA9/14
     IPR023561 Carbonic_anhydrase_a-class

    Graphical View of Domain Structure for InterPro Entry Q9ULX7

    ProtoNet protein and cluster: Q9ULX7

    1 Blocks protein domain: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
    Similarity: Belongs to the alpha-carbonic anhydrase family


    Find genes that share domains with CA14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH14_HUMAN, Q9ULX7
    Function: Reversible hydration of carbon dioxide
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited
    by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate
    trisodium salt)
    Biophysicochemical properties: Kinetic parameters: KM=7.9 mM for CO(2);

         Genatlas biochemistry entry for CA14:
    carbonic anhydrase XIV,expressed in adult heart,brain,kidney,liver and skeletal muscle,highly homolog to CA12

         Enzyme Number (IUBMB): EC 4.2.1.11

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with CA14           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CA14:
     Decreased cell number and incr  Increased G1 DNA content  Increased cell number in G1, s 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Car14):
     growth/size/body  homeostasis/metabolism  mortality/aging  normal  reproductive system 

    Find genes that share phenotypes with CA14           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Car14tm1Sly for CA14

       genOway: Develop your customized and physiologically relevant rodent model for CA14

    miRNA
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    miRTarBase miRNAs that target CA14:
    hsa-mir-335-5p (MIRT017187)

    Block miRNA regulation of human, mouse, rat CA14 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CA14:
    hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidCA14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CA14

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    GenScript: all cDNA clones in your preferred vector: CA14 (NM_012113)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA14

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAH14_HUMAN, Q9ULX7: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    chloroplast2
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CA14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CA14 About    
    See pathways by source

    SuperPathContained pathways About
    1Nitrogen metabolism
    Reversible Hydration of Carbon Dioxide0.00
    Nitrogen metabolism
    2Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with CA14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CA14
        Reversible hydration of carbon dioxide


    1 Kegg Pathway  (Kegg details for CA14):
        Nitrogen metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CA14
    Interactions:

        GeneGlobe Interaction Network for CA14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA14 (ENSP000003581074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF273ENSP000004187194STRING: ENSP00000418719
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with CA14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CA14 (CAH14)

    4 HMDB Compounds for CA14    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    4 DrugBank Compounds for CA14    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    Beta-D-Mannose-- 7322-31-8target--17139284 17016423 10592235
    AcetazolamideAcetamidothiadiazolesulfonamide (see all 7)59-66-5targetinhibitor10592235
    Ellagic Acid-- 476-66-4targetinhibitor20185318

    2 Novoseek inferred chemical compound relationships for CA14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfonamide 71.4 1 10512682 (1)
    bicarbonate 49.4 4 11140614 (1), 12028451 (1), 19692653 (1)



    Find genes that share compounds with CA14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CA14 gene: 
    NM_012113.1  

    Unigene Cluster for CA14:

    Carbonic anhydrase XIV
    Hs.528988  [show with all ESTs]
    Unigene Representative Sequence: AK074765
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369111(uc009wln.3 uc001etx.3) ENST00000607751 ENST00000607652
    ENST00000483993 ENST00000607082
    miRNA
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    Block miRNA regulation of human, mouse, rat CA14 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CA14:
    hsa-miR-3173-3p
    SwitchGear 3'UTR luciferase reporter plasmidCA14 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CA14
    Predesigned siRNA for gene silencing in human, mouse, rat CA14
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CA14
      QuantiTect SYBR Green Assays in human, mouse, rat CA14
      QuantiFast Probe-based Assays in human, mouse, rat CA14

    Additional mRNA sequence: 

    AB025904.1 AK074765.1 AK290609.1 AK295341.1 AK308964.1 AK315469.1 AY358689.1 BC034412.1 
    BT020054.1 

    4 DOTS entries:

    DT.87015226  DT.415663  DT.40109292  DT.40257102 

    Selected AceView cDNA sequences (see all 67):

    AA418208 BC034412 BM670068 AI015805 AA640177 BI820831 BP361793 BQ070550 
    AA322820 AY358689 AI582759 AA620395 H60753 AW027850 R07653 N36146 
    BM707998 AA418073 H83666 CB154932 AA401879 BI819281 N35665 AB025904 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CA14    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                              
    SP2:              -                                                               
    SP3:                                      -                                       


    ECgene alternative splicing isoforms for CA14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CA14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAGGAAA
    CA14 Expression
    About this image


    CA14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    CA14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CA14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528988

    UniProtKB/Swiss-Prot: CAH14_HUMAN, Q9ULX7
    Tissue specificity: High expression in all parts of the central nervous system and lower expression in adult
    liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CA14 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car141 , 5 carbonic anhydrase 141, 5 84.77(n)1
    83.98(a)1
      3 (41.48 cM)5
    238311  NM_011797.21  NP_035927.11 
     958977685 
    chicken
    (Gallus gallus)
    Aves CA141 carbonic anhydrase XIV 59.04(n)
    53.41(a)
      431476  XM_003642665.2  XP_003642713.2 
    lizard
    (Anolis carolinensis)
    Reptilia CA146
    carbonic anhydrase XIV
    49(a)
    1 ↔ 1
    GL343697.1(5075-34228)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ca141 carbonic anhydrase 14 58.12(n)
    52.85(a)
      100126213  NM_001110051.1  NP_001103521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ca141 carbonic anhydrase XIV 56.47(n)
    54.79(a)
      567897  NM_001037693.1  NP_001032782.1 


    ENSEMBL Gene Tree for CA14 (if available)
    TreeFam Gene Tree for CA14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CA14 gene
    CA22  CA122  CA72  CA32  CA62  CA5B2  CA5A2  CA82  
    CA42  CA12  CA92  CA132  
    14 SIMAP similar genes for CA14 using alignment to 4 protein entries:     CAH14_HUMAN (see all proteins):
    CA12    CA6    CA2    CA7    CA8    CA13
    CA5A    CA9    PTPRG    CA1    CA3    CA5B
    CA4    PTPRZ1

    Find genes that share paralogs with CA14           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CA14
    PGOHUM00000245060


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CA14 (see all 220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853743981,2
    C--150228244(+) CCTCTC/GTCCTA 1 -- int10--------
    rs1866854741,2
    --150228461(+) TAGACA/GAGCCA 1 -- int10--------
    rs1912432751,2
    --150228476(+) GTGGCA/GCCTGG 1 -- int10--------
    rs1459930681,2
    --150228542(+) CTCTGC/TTCCGG 1 -- int10--------
    rs1841513451,2
    --150228546(+) GTTCCA/GGCAGA 1 -- int10--------
    rs1884842741,2
    --150229027(+) TGCCTC/GTGGTG 1 -- int10--------
    rs1399379061,2
    --150229159(+) AACATC/TAGTTC 1 -- int10--------
    rs741266301,2
    C,F--150229191(+) TCCATG/CCTCCA 1 -- int12Minor allele frequency- C:0.13WA 120
    rs1811549101,2
    --150229359(+) ATGGTA/GGTAGT 1 -- int10--------
    rs1432606481,2
    --150229411(+) TCTGCC/TGGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CA14 (150229554 - 150237478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CA14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872415CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CA14
    DNA2.0 Custom Variant and Variant Library Synthesis for CA14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604832    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CA14:
    Glaucoma

    Find genes that share disorders with CA14           About GenesLikeMe

    1 Novoseek inferred disease relationship for CA14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 11140614 (1)

    Genetic Association Database (GAD): CA14
    Human Genome Epidemiology (HuGE) Navigator: CA14 (4 documents)

    Export disorders for CA14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CA14 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with CA14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. (PubMed id 10512682)1, 2, 3, 9 Fujikawa-Adachi K.... Onishi S. (Genomics 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. (PubMed id 12028451)1, 9 Kaunisto K....Sly W.S. (Kidney Int. 2002)
    8. Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. (PubMed id 11172051)1, 9 Parkkila S....Sly W.S. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23632 HGNC: 1372 AceView: CA14 Ensembl:ENSG00000118298 euGenes: HUgn23632
    ECgene: CA14 Kegg: 23632 H-InvDB: CA14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CA14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CA14 gene:
    Search GeneIP for patents involving CA14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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