Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CA13 Gene

protein-coding   GIFtS: 57
GCID: GC08P086232

Carbonic Anhydrase XIII

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carbonic Anhydrase XIII1 2 3
Carbonate Dehydratase XIII2 3
CA-XIII2 3
EC 4.2.1.13 8
CAXIII2
Carbonic Anhydrase 132

External Ids:    HGNC: 149141   Entrez Gene: 3776772   Ensembl: ENSG000001850157   OMIM: 6114365   UniProtKB: Q8N1Q13   

Export aliases for CA13 gene to outside databases

Previous GC identifers: GC08P086207 GC08P086345 GC08P081651


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CA13 Gene:
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see
MIM 114800.(supplied by OMIM, Mar 2008)

GeneCards Summary for CA13 Gene: 
CA13 (carbonic anhydrase XIII) is a protein-coding gene. Diseases associated with CA13 include suppurative otitis media, and otitis media, and among its related super-pathways are Nitrogen metabolism and Metabolic pathways. GO annotations related to this gene include carbonate dehydratase activity and zinc ion binding. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1
Function: Reversible hydration of carbon dioxide




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CA13 gene promoter:
         HFH-3   STAT5B   STAT5A   GATA-1   PPAR-alpha   FOXI1   HOXA5   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA13 promoter sequence
   Search SABiosciences Chromatin IP Primers for CA13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.2   Ensembl cytogenetic band:  8q21.2   HGNC cytogenetic band: 8q21

CA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA13 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P086232:  view genomic region     (about GC identifiers)

Start:
86,132,816 bp from pter      End:
86,196,302 bp from pter
Size:
63,487 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1 (See protein sequence)
Recommended Name: Carbonic anhydrase 13  
Size: 262 amino acids; 29443 Da
Cofactor: Zinc (By similarity)
4 PDB 3D structures from and Proteopedia for CA13:
3CZV (3D)        3D0N (3D)        3DA2 (3D)        4HU1 (3D)    

Explore the universe of human proteins at neXtProt for CA13: NX_Q8N1Q1

Explore proteomics data for CA13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1Q1

  • 3 DME Specific Peptides for CA13 (Q8N1Q1)
     TYPGSLT  RPPQPLK  PPLLESVTW 

    CA13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CA13 Protein Expression
    REFSEQ proteins: NP_940986.1  
    ENSEMBL proteins: 
     ENSP00000318912  
    Reactome Protein details: Q8N1Q1
    Human Recombinant Protein Products for CA13: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CA13 (Carbonic Anhydrase XIII/CA13)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CA13
    OriGene Protein Over-expression Lysate for CA13
    OriGene MassSpec for CA13 
    OriGene Custom Protein Services for CA13
    GenScript Custom Purified and Recombinant Proteins Services for CA13
    Novus Biologicals CA13 Protein
    Sino Biological Recombinant Protein for CA13
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CA13 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    CA13 for ontologies           About GeneDecksing



    CA13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CA13 (Carbonic Anhydrase XIII/CA13)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CA13
    GenScript Custom Superior Antibodies Services for CA13
    Novus Biologicals CA13 Antibodies
    Abcam antibodies for CA13
    Cloud-Clone Corp. Antibodies for CA13 
    ThermoFisher Antibodies for CA13
    LSBio Antibodies in human, mouse, rat for CA13 

    Assay Products for CA13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CA13
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CA13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CA13 
    Cloud-Clone Corp. CLIAs for CA13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CA: Carbonic anhydrases

    4 InterPro protein domains:
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class
     IPR018443 Carbonic_anhydrase_CA13

    Graphical View of Domain Structure for InterPro Entry Q8N1Q1

    ProtoNet protein and cluster: Q8N1Q1

    1 Blocks protein domain: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1
    Similarity: Belongs to the alpha-carbonic anhydrase family


    CA13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH13_HUMAN, Q8N1Q1
    Function: Reversible hydration of carbon dioxide
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Inhibited by acetazolamide
    Biophysicochemical properties: Kinetic parameters: KM=13.8 mM for CO(2);

         Enzyme Number (IUBMB): EC 4.2.1.11 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CA13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CA13:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CA13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CA13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA13 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA13
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CA13 (see all 11):
    hsa-miR-205 hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-548aa hsa-miR-29b-1* hsa-miR-570 hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidCA13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CA13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CA13
    Sirion Biotech Customized adenovirus for overexpression of CA13

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CA13 (see all 7)
    OriGene ORF clones in mouse, rat for CA13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CA13 (NM_152701)
    Sino Biological Human cDNA Clone for CA13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13
    Sirion Biotech Customized lentivirus for stable overexpression of CA13 
                         Customized lentivirus expression plasmids for stable overexpression of CA13 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CA13
    Search LifeMap BioReagents cell lines for CA13
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CA13 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Reversible Hydration of Carbon Dioxide
    Reversible Hydration of Carbon Dioxide0.67
    Nitrogen metabolism0.67
    2Metabolism
    Metabolism0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for CA13
        Reversible Hydration of Carbon Dioxide
    Metabolism


    1         Kegg Pathway  (Kegg details for CA13):
        Nitrogen metabolism


    CA13 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA13

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    CA13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CA13 (CAH13)

    4 HMDB Compounds for CA13    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for CA13    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CA13 / CAH13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CA13 gene: 
    NM_198584.2  

    Unigene Cluster for CA13:

    Carbonic anhydrase XIII
    Hs.127189  [show with all ESTs]
    Unigene Representative Sequence: NM_198584
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517831 ENST00000517298(uc003ydf.1) ENST00000522631 ENST00000518392
    ENST00000321764(uc003ydg.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CA13
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CA13 (see all 11):
    hsa-miR-205 hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-548aa hsa-miR-29b-1* hsa-miR-570 hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidCA13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CA13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA13
    Clone
    Products:
         
    OriGene clones in human, mouse for CA13 (see all 7)
    OriGene ORF clones in mouse, rat for CA13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CA13 (NM_152701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13
    Sirion Biotech Customized lentivirus for stable overexpression of CA13 
                         Customized lentivirus expression plasmids for stable overexpression of CA13 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CA13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA13

    Additional mRNA sequence: 

    AK095314.1 BC052602.1 

    3 DOTS entries:

    DT.97813946  DT.106891  DT.105927 

    24/234 AceView cDNA sequences (see all 234):

    AK095314 BX093441 BM720604 AA906098 AW102768 AA702404 AW301200 BI495173 
    BI830861 BE044345 NM_198584 BF670357 AW950045 BU169155 H91582 AI057175 
    AI417190 BC052602 BQ924401 AA464972 AW952139 AI807047 AA327952 AA305658 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CA13 expression in normal human tissues (normalized intensities)      CA13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGACAGGG
    CA13 Expression
    About this image


    CA13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)
             limb/forelimb   
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Tooth
             mouse/organ system/integumental system   
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer

    See CA13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CA13

    SOURCE GeneReport for Unigene cluster: Hs.127189

    UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1
    Tissue specificity: Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis

        SABiosciences Custom PCR Arrays for CA13
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CA13
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CA13 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car131 , 5 carbonic anhydrase 131, 5 87.02(n)1
    91.22(a)1
      3 (3.12 cM)5
    719341  NM_024495.51  NP_078771.11 
     146417275 
    chicken
    (Gallus gallus)
    Aves LOC1008589891 carbonic anhydrase 13-like 72.55(n)
    71.37(a)
      100858989  XM_003640811.1  XP_003640859.1 
    lizard
    (Anolis carolinensis)
    Reptilia CA136
    carbonic anhydrase XIII
    64(a)
    1 ↔ 1
    4(23195161-23219138)
    zebrafish
    (Danio rerio)
    Actinopterygii BC057412.12   -- 73.31(n)   387526  BC057412.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CAH16
    Carbonic anhydrase 1
    44(a)
    1 → many
    2L(13803626-13809994)


    ENSEMBL Gene Tree for CA13 (if available)
    TreeFam Gene Tree for CA13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CA13 gene
    CA22  CA122  CA72  CA32  CA62  CA112  CA5B2  CA5A2  
    CA142  CA82  CA42  CA12  CA92  CA102  
    14 SIMAP similar genes for CA13 using alignment to 1 protein entry:     CAH13_HUMAN:
    CA1    CA2    CA3    CA7    CA5B    CA5A
    CA10    DKFZp686I20267    CA8    CA12    CA14    PTPRZ1
    CA6    CA11

    CA13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/810 SNPs in CA13 are shown (see all 810)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919576931,2
    --86155782(+) GCCACC/TAGTAA 1 -- us2k10--------
    rs1837822161,2
    --86155807(+) CCCAGA/CTACTC 1 -- us2k10--------
    rs1866924531,2
    --86155892(+) TCCAGC/TGTGGG 1 -- us2k10--------
    rs285236591,2
    C--86155908(+) AGAGCA/GAAATT 1 -- us2k10--------
    rs132594641,2
    C--86155928(+) aaaaaT/AaTATA 1 -- us2k1 tfbs36Minor allele frequency- A:0.45NA WA EA 364
    rs1914761411,2
    C--86156121(+) AGAGAC/G/TTGGAC 1 -- us2k10--------
    rs1476880351,2
    C--86156171(+) TTACTC/TATTCT 1 -- us2k10--------
    rs736886881,2
    C,F--86156176(+) CATTCT/CTAGGC 1 -- us2k13Minor allele frequency- C:0.08WA NA 124
    rs1824293861,2
    --86156282(+) TGGACC/GGCCTT 1 -- us2k10--------
    rs1866636521,2
    --86156283(+) GGACCA/GCCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CA13 (86132816 - 86196302 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CA13: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CA13
    DNA2.0 Custom Variant and Variant Library Synthesis for CA13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611436    OMIM disorders: --

    4 diseases for CA13:    About MalaCards
    suppurative otitis media    otitis media    glaucoma    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for CA13:
    Glaucoma     Suppurative otitis media

    CA13 for disorders           About GeneDecksing


    Export disorders for CA13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CA13 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with CA13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. (PubMed id 14600151)1, 2, 3, 9 Lehtonen J.... Parkkila S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV. (PubMed id 18336313)1, 9 Hilvo M....Parkkila S. (2008)
    5. Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. (PubMed id 15836783)1, 9 Kummola L....Parkkila S. (2005)
    6. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. (PubMed id 18618712)2, 9 Di Fiore A.... De Simone G. (2009)
    7. Which carbonic anhydrases are targeted by the antiepi leptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (2009)
    8. Carbonic anhydrase inhibitors as emerging drugs for t he treatment of obesity. (PubMed id 18537527)7 Supuran C.T....De Simone G. (2008)
    9. Therapeutic role of zonisamide in neuropsychiatric disorders. (PubMed id 18782051)7 Farooq M.U....Kassab M.Y. (2008)
    10. Clinical pharmacology and mechanism of action of zoni samide. (PubMed id 17762320)7 Biton V. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 377677 HGNC: 14914 AceView: CA3andCA13 Ensembl:ENSG00000185015 euGenes: HUgn377677
    ECgene: CA13 Kegg: 377677 H-InvDB: CA13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CA13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CA13 gene:
    Search GeneIP for patents involving CA13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CA13 (Carbonic Anhydrase XIII/CA13)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CA13 (Carbonic Anhydrase XIII/CA13)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CA13  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CA13  
     OriGene MassSpec something-or-other for CA13   OriGene clones in human, mouse for CA13  
     OriGene qSTAR qPCR primer pairs in human, mouse for CA13   OriGene Purified Protein for CA13  
     OriGene ORF clones in mouse, rat for CA13   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CA13   OriGene Custom Protein Services for CA13  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CA13
     QIAGEN SeqTarget long-range PCR primers for resequencing CA13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA13
     GenScript Custom Purified and Recombinant Proteins Services for CA13 GenScript cDNA clones with any tag delivered in your preferred vector for CA13
     GenScript Custom Assay Services for CA13 GenScript Custom Superior Antibodies Services for CA13
     GenScript Custom overexpressing Cell Line Services for CA13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CA13 promoter
     Search Chromatin IP Primers for CA13
     RT2 qPCR Primer Assay in human, mouse, rat CA13
     Search GNC Networks for CA13
     SABiosciences Custom PCR Arrays for CA13
     Search Tocris compounds for CA13 (CAH13)
     Proteins and Antibodies for CA13
     Browse Sino Biological Cell Lysates
     cDNA Clones for CA13
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CA13 antibodies
     CA13 proteins
     Antibodies for CA13
     See all of Abcam's Antibodies, Kits and Proteins for CA13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CA13
     Antibodies for CA13
     ELISAs for CA13
     CLIAs for CA13
     Search LifeMap BioReagents cell lines for CA13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13
     SwitchGear 3'UTR luciferase reporter plasmids for CA13
     SwitchGear Promoter luciferase reporter plasmids for CA13
     ThermoFisher Antibodies for CA13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CA13
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CA13
    Customized:
     lentivirus for stable overexpression of CA13
     lentivirus expression plasmids for stable overexpression of CA13
     adenovirus for overexpression of CA13
     LSBio Antibodies in human, mouse, rat for CA13
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CA13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4