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CA13 Gene

protein-coding   GIFtS: 58
GCID: GC08P086232

Carbonic Anhydrase XIII

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carbonic Anhydrase XIII1 2 3
Carbonate Dehydratase XIII2 3
CA-XIII2 3
EC 4.2.1.13 8
CAXIII2
Carbonic Anhydrase 132

External Ids:    HGNC: 149141   Entrez Gene: 3776772   Ensembl: ENSG000001850157   OMIM: 6114365   UniProtKB: Q8N1Q13   

Export aliases for CA13 gene to outside databases

Previous GC identifers: GC08P086207 GC08P086345 GC08P081651


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CA13 Gene:
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see
MIM 114800.(supplied by OMIM, Mar 2008)

GeneCards Summary for CA13 Gene:
CA13 (carbonic anhydrase XIII) is a protein-coding gene. Diseases associated with CA13 include suppurative otitis media, and otitis media. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1
Function: Reversible hydration of carbon dioxide




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CA13 gene promoter:
         HFH-3   STAT5B   STAT5A   GATA-1   PPAR-alpha   FOXI1   HOXA5   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCA13 promoter sequence
   Search Chromatin IP Primers for CA13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CA13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.2   Ensembl cytogenetic band:  8q21.2   HGNC cytogenetic band: 8q21

CA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CA13 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P086232:  view genomic region     (about GC identifiers)

Start:
86,132,816 bp from pter      End:
86,196,302 bp from pter
Size:
63,487 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1 (See protein sequence)
Recommended Name: Carbonic anhydrase 13  
Size: 262 amino acids; 29443 Da
Cofactor: Zinc (By similarity)
6 PDB 3D structures from and Proteopedia for CA13:
3CZV (3D)        3D0N (3D)        3DA2 (3D)        4HU1 (3D)        4KNM (3D)        4KNN (3D)    

Explore the universe of human proteins at neXtProt for CA13: NX_Q8N1Q1

Explore proteomics data for CA13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for CA13 (Q8N1Q1)
     TYPGSLT  RPPQPLK  PPLLESVTW 


    See CA13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940986.1  
    ENSEMBL proteins: 
     ENSP00000318912  
    Reactome Protein details: Q8N1Q1

    CA13 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CA13 (Carbonic Anhydrase XIII/CA13)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CA13
    OriGene Protein Over-expression Lysate for CA13
    OriGene MassSpec for CA13
    OriGene Custom Protein Services for CA13
    GenScript Custom Purified and Recombinant Proteins Services for CA13
    Novus Biologicals CA13 Protein
    Sino Biological Recombinant Protein for CA13
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CA13

    CA13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CA13 (Carbonic Anhydrase XIII/CA13)
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    Novus Biologicals CA13 Antibodies
    Abcam antibodies for CA13
    Cloud-Clone Corp. Antibodies for CA13
    ThermoFisher Antibodies for CA13
    LSBio Antibodies in human, mouse, rat for CA13

    CA13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CA13
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CA13
    Cloud-Clone Corp. CLIAs for CA13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CA: Carbonic anhydrases

    4 InterPro protein domains:
     IPR001148 Carbonic_anhydrase_a
     IPR018338 Carbonic_anhydrase_a-class_CS
     IPR023561 Carbonic_anhydrase_a-class
     IPR018443 CA2/13

    Graphical View of Domain Structure for InterPro Entry Q8N1Q1

    ProtoNet protein and cluster: Q8N1Q1

    1 Blocks protein domain: IPB001148 Carbonic anhydrase

    UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1
    Similarity: Belongs to the alpha-carbonic anhydrase family


    CA13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAH13_HUMAN, Q8N1Q1
    Function: Reversible hydration of carbon dioxide
    Catalytic activity: H(2)CO(3) = CO(2) + H(2)O
    Enzyme regulation: Inhibited by acetazolamide
    Biophysicochemical properties: Kinetic parameters: KM=13.8 mM for CO(2);

         Enzyme Number (IUBMB): EC 4.2.1.11 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004089carbonate dehydratase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CA13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CA13:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CA13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CA13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CA13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CA13

    miRNA
    Products:
        
    miRTarBase miRNAs that target CA13:
    hsa-mir-19b-3p (MIRT031162), hsa-mir-18a-5p (MIRT031357), hsa-mir-374b-5p (MIRT016071), hsa-mir-192-5p (MIRT026474), hsa-mir-9-5p (MIRT021360)

    Block miRNA regulation of human, mouse, rat CA13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CA13 (see all 11):
    hsa-miR-205 hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-548aa hsa-miR-29b-1* hsa-miR-570 hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidCA13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CA13
    Predesigned siRNA for gene silencing in human, mouse, rat CA13

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CA13

    Clone
    Products:
         
    OriGene clones in human, mouse for CA13 (see all 6)
    OriGene ORF clones in mouse, rat for CA13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CA13 (NM_152701)
    Sino Biological Human cDNA Clone for CA13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CA13
    Browse ESI BIO Cell Lines and PureStem Progenitors for CA13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    chloroplast2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    CA13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CA13 About    
    See pathways by source

    SuperPathContained pathways About
    1Nitrogen metabolism
    Reversible Hydration of Carbon Dioxide0.00
    Nitrogen metabolism
    2Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CA13
        Reversible hydration of carbon dioxide


    1 Kegg Pathway  (Kegg details for CA13):
        Nitrogen metabolism


    CA13 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CA13
    Interactions:

        Search GeneGlobe Interaction Network for CA13

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CA13 (ENSP000003189124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000003295284STRING: ENSP00000329528
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0015701bicarbonate transport TAS--
    GO:0044281small molecule metabolic process TAS--

    CA13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CA13 (CAH13)

    4 HMDB Compounds for CA13    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Carbonic acidacid of air (see all 24)463-79-6--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZincZinc (see all 2)7440-66-6--

    2 DrugBank Compounds for CA13    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor18537527 17762320 19703035 18782051 17582922
    N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CA13 gene: 
    NM_198584.2  

    Unigene Cluster for CA13:

    Carbonic anhydrase XIII
    Hs.127189  [show with all ESTs]
    Unigene Representative Sequence: NM_198584
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517831 ENST00000517298(uc003ydf.1) ENST00000522631 ENST00000518392
    ENST00000321764(uc003ydg.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CA13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CA13 (see all 11):
    hsa-miR-205 hsa-miR-520d-5p hsa-miR-7-2* hsa-miR-548aa hsa-miR-29b-1* hsa-miR-570 hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidCA13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CA13
    Predesigned siRNA for gene silencing in human, mouse, rat CA13
    Clone
    Products:
         
    OriGene clones in human, mouse for CA13 (see all 6)
    OriGene ORF clones in mouse, rat for CA13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CA13 (NM_152701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CA13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CA13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CA13
      QuantiTect SYBR Green Assays in human, mouse, rat CA13
      QuantiFast Probe-based Assays in human, mouse, rat CA13

    Additional mRNA sequence: 

    AK095314.1 BC052602.1 

    3 DOTS entries:

    DT.97813946  DT.106891  DT.105927 

    Selected AceView cDNA sequences (see all 234):

    BI830861 H91582 AW950045 AI417190 BQ924401 AA702404 BE044345 BC052602 
    BM720604 AA906098 BU169155 BF670357 BI831159 BF790332 CF551842 AI057175 
    BX956196 BF576371 BX093441 AW301200 AA464972 AK095314 AW952139 BE552131 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CA13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGACAGGG
    CA13 Expression
    About this image


    CA13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Epidermis (Integumentary System)
    CA13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CA13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127189

    UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1
    Tissue specificity: Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis

        Custom PCR Arrays for CA13
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CA13 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Car131 , 5 carbonic anhydrase 131, 5 87.02(n)1
    91.22(a)1
      3 (3.12 cM)5
    719341  NM_024495.51  NP_078771.11 
     146417275 
    chicken
    (Gallus gallus)
    Aves LOC1008589891 carbonic anhydrase 13-like 72.55(n)
    71.37(a)
      100858989  XM_003640811.2  XP_003640859.1 
    lizard
    (Anolis carolinensis)
    Reptilia CA136
    carbonic anhydrase XIII
    65(a)
    1 ↔ 1
    4(23195161-23219138)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ca131 carbonic anhydrase XIII 70.07(n)
    67.45(a)
      779902  NM_001078980.1  NP_001072448.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC057412.12   -- 73.31(n)   387526  BC057412.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CAH16
    Carbonic anhydrase 1
    44(a)
    1 → many
    2L(13803626-13809994)


    ENSEMBL Gene Tree for CA13 (if available)
    TreeFam Gene Tree for CA13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CA13 gene
    CA22  CA122  CA72  CA32  CA62  CA5B2  CA5A2  CA142  
    CA82  CA42  CA12  CA92  
    14 SIMAP similar genes for CA13 using alignment to 1 protein entry:     CAH13_HUMAN:
    CA1    CA2    CA3    CA7    CA5B    CA5A
    CA10    DKFZp686I20267    CA8    CA12    CA14    PTPRZ1
    CA6    CA11

    CA13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CA13 (see all 810)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919576931,2
    --86155782(+) GCCACC/TAGTAA 1 -- us2k10--------
    rs1837822161,2
    --86155807(+) CCCAGA/CTACTC 1 -- us2k10--------
    rs1866924531,2
    --86155892(+) TCCAGC/TGTGGG 1 -- us2k10--------
    rs285236591,2
    C--86155908(+) AGAGCA/GAAATT 1 -- us2k10--------
    rs132594641,2
    C--86155928(+) aaaaaT/AaTATA 1 -- us2k1 tfbs36Minor allele frequency- A:0.45NA WA EA 364
    rs1914761411,2
    C--86156121(+) AGAGAC/G/TTGGAC 1 -- us2k10--------
    rs1476880351,2
    C--86156171(+) TTACTC/TATTCT 1 -- us2k10--------
    rs736886881,2
    C,F--86156176(+) CATTCT/CTAGGC 1 -- us2k13Minor allele frequency- C:0.08WA NA 124
    rs1824293861,2
    --86156282(+) TGGACC/GGCCTT 1 -- us2k10--------
    rs1866636521,2
    --86156283(+) GGACCA/GCCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CA13 (86132816 - 86196302 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CA13: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CA13
    DNA2.0 Custom Variant and Variant Library Synthesis for CA13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611436    OMIM disorders: --

    4 diseases for CA13:    
    About MalaCards
    suppurative otitis media    otitis media    glaucoma    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for CA13:
    Glaucoma     Suppurative otitis media

    CA13 for disorders           About GeneDecksing


    Export disorders for CA13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CA13 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CA13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. (PubMed id 14600151)1, 2, 3, 9 Lehtonen J.... Parkkila S. (J. Biol. Chem. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV. (PubMed id 18336313)1, 9 Hilvo M....Parkkila S. (Curr. Pharm. Des. 2008)
    5. Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. (PubMed id 15836783)1, 9 Kummola L....Parkkila S. (BMC Cancer 2005)
    6. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. (PubMed id 18618712)2, 9 Di Fiore A.... De Simone G. (Proteins 2009)
    7. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    8. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (amp 2009)
    9. Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. (PubMed id 18537527)7 Supuran C.T....De Simone G. (Expert Opin Emerg Drugs 2008)
    10. Therapeutic role of zonisamide in neuropsychiatric disorders. (PubMed id 18782051)7 Farooq M.U....Kassab M.Y. (Mini Rev Med Chem 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 377677 HGNC: 14914 AceView: CA3andCA13 Ensembl:ENSG00000185015 euGenes: HUgn377677
    ECgene: CA13 Kegg: 377677 H-InvDB: CA13

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CA13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CA13 gene:
    Search GeneIP for patents involving CA13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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