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Aliases for CA13 Gene

Aliases for CA13 Gene

  • Carbonic Anhydrase 13 2 3 5
  • Carbonic Anhydrase XIII 2 3 4
  • Carbonate Dehydratase XIII 3 4
  • EC 4 58
  • CA-XIII 3 4
  • CAXIII 3

External Ids for CA13 Gene

Previous GeneCards Identifiers for CA13 Gene

  • GC08P086207
  • GC08P086232
  • GC08P086345
  • GC08P081651

Summaries for CA13 Gene

Entrez Gene Summary for CA13 Gene

  • Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]

GeneCards Summary for CA13 Gene

CA13 (Carbonic Anhydrase 13) is a Protein Coding gene. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA2.

UniProtKB/Swiss-Prot for CA13 Gene

  • Reversible hydration of carbon dioxide.

Additional gene information for CA13 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA13 Gene

Genomics for CA13 Gene

Regulatory Elements for CA13 Gene

Enhancers for CA13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H085127 0.9 ENCODE 11.1 -92.4 -92391 1.5 HDAC1 PKNOX1 ATF1 CHAMP1 GATA2 ATF7 CREM CEBPB TFDP1 MTA1 LRRCC1 CA13 LOC105375933 E2F5
GH08H085147 0.7 ENCODE 12.1 -73.0 -72957 0.2 CTCF TFAP4 ZNF654 TAL1 TRIM22 RAD21 CC2D1A TCF12 GATA3 NCOR1 E2F5 ENSG00000254208 CA13 LOC105375933
GH08H085265 0.7 ENCODE 11.9 +46.8 46849 4 SOX5 SOX13 LEF1 HLF CEBPB CEBPG HNF1A CEBPA CREB1 TCF7 LRRCC1 CA13 CA1 LOC105375935 GC08M085277
GH08H085153 0.6 Ensembl ENCODE 10.4 -66.7 -66678 0.6 NFYC ENSG00000254208 E2F5 LRRCC1 CA13 LOC105375933
GH08H085459 0.8 FANTOM5 Ensembl ENCODE 6.2 +239.0 239007 0.9 CA13 CA3 CA2 GC08P085382
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CA13 on UCSC Golden Path with GeneCards custom track

Promoters for CA13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226516 213 2400 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Locations for CA13 Gene

Genomic Locations for CA13 Gene
63,487 bases
Plus strand

Genomic View for CA13 Gene

Genes around CA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA13 Gene

Proteins for CA13 Gene

  • Protein details for CA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 13
    Protein Accession:

    Protein attributes for CA13 Gene

    262 amino acids
    Molecular mass:
    29443 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA13 Gene

neXtProt entry for CA13 Gene

Selected DME Specific Peptides for CA13 Gene


Post-translational modifications for CA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CA13 (Carbonic Anhydrase XIII/CA13)
  • Abcam antibodies for CA13

Domains & Families for CA13 Gene

Gene Families for CA13 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA13: view

Function for CA13 Gene

Molecular function for CA13 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.8 mM for CO(2) {ECO:0000269 PubMed:18618712};
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by acetazolamide.
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide.

Enzyme Numbers (IUBMB) for CA13 Gene

Phenotypes From GWAS Catalog for CA13 Gene

Gene Ontology (GO) - Molecular Function for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CA13: view
genes like me logo Genes that share phenotypes with CA13: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA13 Gene

Localization for CA13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA13 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (1)
  • Nucleus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS,IEA --
GO:0043209 myelin sheath IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CA13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CA13 Gene

Pathways & Interactions for CA13 Gene

genes like me logo Genes that share pathways with CA13: view

Pathways by source for CA13 Gene

2 Reactome pathways for CA13 Gene
1 KEGG pathway for CA13 Gene

Interacting Proteins for CA13 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)
Selected Interacting proteins: Q8N1Q1-CAH13_HUMAN ENSP00000318912 for CA13 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with CA13: view

No data available for SIGNOR curated interactions for CA13 Gene

Drugs & Compounds for CA13 Gene

(5) Drugs for CA13 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 68
Carbon dioxide Approved, Vet_approved Pharma 0
Water Approved Pharma 0
Zinc Approved Pharma 2359
N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide Experimental Pharma Target 0

(1) Additional Compounds for CA13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carbonic acid
  • Acid of air
  • Aerial acid
  • Bisodium carbonate
  • Calcined
  • Carbonic acid sodium salt
genes like me logo Genes that share compounds with CA13: view

Transcripts for CA13 Gene

Unigene Clusters for CA13 Gene

Carbonic anhydrase XIII:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA13 Gene

No ASD Table

Relevant External Links for CA13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CA13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.2), Platelet (15.7), Salivary gland (10.4), and Skin (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CA13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CA13 Gene:


SOURCE GeneReport for Unigene cluster for CA13 Gene:


mRNA Expression by UniProt/SwissProt for CA13 Gene:

Tissue specificity: Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis.

Evidence on tissue expression from TISSUES for CA13 Gene

  • Pancreas(4.2)
  • Nervous system(2.8)
  • Gall bladder(2.4)
  • Intestine(2.4)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with CA13: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CA13 Gene

Orthologs for CA13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CA13 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia CA13 33 34
  • 89.69 (n)
(Bos Taurus)
Mammalia CA13 33 34
  • 87.87 (n)
(Rattus norvegicus)
Mammalia Car13 33
  • 87.4 (n)
(Mus musculus)
Mammalia Car13 33 16 34
  • 87.02 (n)
(Monodelphis domestica)
Mammalia CA13 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia CA13 34
  • 84 (a)
(Gallus gallus)
Aves LOC100858989 33
  • 72.55 (n)
CA13 34
  • 70 (a)
(Anolis carolinensis)
Reptilia CA13 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca13 33
  • 70.07 (n)
(Danio rerio)
Actinopterygii ca2 33 34
  • 63.27 (n)
cahz 34
  • 62 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CAH1 34
  • 44 (a)
Species where no ortholog for CA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA13 Gene

Gene Tree for CA13 (if available)
Gene Tree for CA13 (if available)

Paralogs for CA13 Gene

Paralogs for CA13 Gene

(14) SIMAP similar genes for CA13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CA13: view

Variants for CA13 Gene

Sequence variations from dbSNP and Humsavar for CA13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000033976 -- 85,244,770(+) GGTTT(A/G)CTAGG intron-variant, upstream-variant-2KB
rs1000041156 -- 85,257,293(+) GAATT(G/T)GTATC intron-variant, upstream-variant-2KB
rs1000104442 -- 85,259,348(+) TCAGG(G/T)AGATG intron-variant
rs1000141425 -- 85,250,023(+) AAATT(C/G)AAATG intron-variant, nc-transcript-variant
rs1000142024 -- 85,277,598(+) GACAG(G/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA13 Gene

Variant ID Type Subtype PubMed ID
nsv1129440 OTHER inversion 24896259
nsv483126 CNV gain+loss 15286789
nsv981959 CNV duplication 23825009
nsv1125268 CNV insertion 24896259
nsv1116573 OTHER inversion 24896259
esv3408198 CNV insertion 20981092
esv2761441 CNV loss 21179565

Variation tolerance for CA13 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA13 Gene

Disorders for CA13 Gene

Relevant External Links for CA13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CA13 Gene

Publications for CA13 Gene

  1. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. (PMID: 14600151) Lehtonen J … Parkkila S (The Journal of biological chemistry 2004) 2 3 4 22 60
  2. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. (PMID: 18618712) Di Fiore A … De Simone G (Proteins 2009) 4 22 60
  3. Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV. (PMID: 18336313) Hilvo M … Parkkila S (Current pharmaceutical design 2008) 3 22 60
  4. Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. (PMID: 15836783) Kummola L … Parkkila S (BMC cancer 2005) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for CA13 Gene

Sources for CA13 Gene

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