Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CA13 Gene

Aliases for CA13 Gene

  • Carbonic Anhydrase XIII 2 3 4
  • Carbonate Dehydratase XIII 3 4
  • EC 4.2.1.1 4 63
  • CA-XIII 3 4
  • Carbonic Anhydrase 13 3
  • CAXIII 3

External Ids for CA13 Gene

Previous GeneCards Identifiers for CA13 Gene

  • GC08P086207
  • GC08P086232
  • GC08P086345
  • GC08P081651

Summaries for CA13 Gene

Entrez Gene Summary for CA13 Gene

  • Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]

GeneCards Summary for CA13 Gene

CA13 (Carbonic Anhydrase XIII) is a Protein Coding gene. Diseases associated with CA13 include suppurative otitis media. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA13 Gene

  • Reversible hydration of carbon dioxide

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA13 Gene

Genomics for CA13 Gene

Regulatory Elements for CA13 Gene

Genomic Location for CA13 Gene

Start:
85,220,587 bp from pter
End:
85,284,073 bp from pter
Size:
63,487 bases
Orientation:
Plus strand

Genomic View for CA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA13 Gene

Proteins for CA13 Gene

  • Protein details for CA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1Q1-CAH13_HUMAN
    Recommended name:
    Carbonic anhydrase 13
    Protein Accession:
    Q8N1Q1
    Secondary Accessions:

    Protein attributes for CA13 Gene

    Size:
    262 amino acids
    Molecular mass:
    29443 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA13 Gene

neXtProt entry for CA13 Gene

Proteomics data for CA13 Gene at MOPED

Selected DME Specific Peptides for CA13 Gene

Post-translational modifications for CA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CA13 (Carbonic Anhydrase XIII/CA13)

Domains for CA13 Gene

Gene Families for CA13 Gene

HGNC:
  • CA :Carbonic anhydrases

Suggested Antigen Peptide Sequences for CA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1Q1

UniProtKB/Swiss-Prot:

CAH13_HUMAN :
  • Q8N1Q1
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA13: view

Function for CA13 Gene

Molecular function for CA13 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=13.8 mM for CO(2) {ECO:0000269 PubMed:18618712};
UniProtKB/Swiss-Prot CatalyticActivity: H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by acetazolamide.
UniProtKB/Swiss-Prot Function: Reversible hydration of carbon dioxide

Enzyme Numbers (IUBMB) for CA13 Gene

Gene Ontology (GO) - Molecular Function for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA13: view

Phenotypes for CA13 Gene

GenomeRNAi human phenotypes for CA13:
genes like me logo Genes that share phenotypes with CA13: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CA13 Gene

Localization for CA13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CA13 Gene COMPARTMENTS Subcellular localization image for CA13 gene
Compartment Confidence
cytosol 4
chloroplast 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with CA13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CA13 Gene

Pathways for CA13 Gene

genes like me logo Genes that share pathways with CA13: view

Pathways by source for CA13 Gene

2 Reactome pathways for CA13 Gene
1 KEGG pathway for CA13 Gene

Interacting Proteins for CA13 Gene

Gene Ontology (GO) - Biological Process for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA13: view

Compounds for CA13 Gene

(4) HMDB Compounds for CA13 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
Carbonic acid
  • acid of air
463-79-6
Water
  • Dihydrogen oxide
7732-18-5
Zinc
  • Zinc
7440-66-6

(2) Drugbank Compounds for CA13 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide
target
Zonisamide
  • Zonisamida [Spanish]
68291-97-4 target inhibitor
genes like me logo Genes that share compounds with CA13: view

Transcripts for CA13 Gene

mRNA/cDNA for CA13 Gene

Unigene Clusters for CA13 Gene

Carbonic anhydrase XIII:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA13

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CA13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA13 Gene

No ASD Table

Relevant External Links for CA13 Gene

GeneLoc Exon Structure for
CA13
ECgene alternative splicing isoforms for
CA13

Expression for CA13 Gene

mRNA expression in normal human tissues for CA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CA13 Gene

SOURCE GeneReport for Unigene cluster for CA13 Gene Hs.127189

mRNA Expression by UniProt/SwissProt for CA13 Gene

Q8N1Q1-CAH13_HUMAN
Tissue specificity: Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis.
genes like me logo Genes that share expressions with CA13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CA13 Gene

Orthologs for CA13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA13 35
  • 99.36 (n)
  • 99.24 (a)
CA13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CA13 35
  • 87.87 (n)
  • 87.74 (a)
CA13 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CA13 35
  • 89.69 (n)
  • 93.89 (a)
CA13 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Car13 35
  • 87.02 (n)
  • 91.22 (a)
Car13 16
Car13 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CA13 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CA13 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Car13 35
  • 87.4 (n)
  • 91.6 (a)
chicken
(Gallus gallus)
Aves CA13 36
  • 70 (a)
OneToOne
LOC100858989 35
  • 72.55 (n)
  • 71.37 (a)
lizard
(Anolis carolinensis)
Reptilia CA13 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ca13 35
  • 70.07 (n)
  • 67.45 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ca2 35
  • 63.27 (n)
  • 63.14 (a)
ca2 36
  • 63 (a)
ManyToMany
cahz 36
  • 62 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CAH1 36
  • 44 (a)
OneToMany
Species with no ortholog for CA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA13 Gene

ENSEMBL:
Gene Tree for CA13 (if available)
TreeFam:
Gene Tree for CA13 (if available)

Paralogs for CA13 Gene

Paralogs for CA13 Gene

Selected SIMAP similar genes for CA13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CA13: view

Variants for CA13 Gene

Sequence variations from dbSNP and Humsavar for CA13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1812511 -- 85,258,863(+) accca(A/G)aagtt intron-variant
rs1845891 -- 85,284,097(-) AATGC(A/G)CATAC downstream-variant-500B
rs1845892 -- 85,260,388(-) CTGTC(C/T)TGCCT intron-variant
rs1845893 -- 85,260,372(-) ACTCA(A/G)AAACC intron-variant
rs1908762 -- 85,283,442(-) AAAAA(A/G)TTTTT utr-variant-3-prime

Relevant External Links for CA13 Gene

HapMap Linkage Disequilibrium report
CA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CA13 Gene

Disorders for CA13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CA13 Gene including...

Search for CA13 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CA13 Gene

genes like me logo Genes that share disorders with CA13: view

No data available for UniProtKB/Swiss-Prot for CA13 Gene

Publications for CA13 Gene

  1. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. (PMID: 14600151) Lehtonen J. … Parkkila S. (J. Biol. Chem. 2004) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. (PMID: 15836783) Kummola L. … Parkkila S. (BMC Cancer 2005) 3 23
  5. Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV. (PMID: 18336313) Hilvo M. … Parkkila S. (Curr. Pharm. Des. 2008) 3 23

Products for CA13 Gene

Sources for CA13 Gene

Back to Top

Content