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Aliases for CA13 Gene

Aliases for CA13 Gene

  • Carbonic Anhydrase XIII 2 3 4
  • Carbonate Dehydratase XIII 3 4
  • EC 4 63
  • CA-XIII 3 4
  • CAXIII 3

External Ids for CA13 Gene

Previous GeneCards Identifiers for CA13 Gene

  • GC08P086207
  • GC08P086232
  • GC08P086345
  • GC08P081651

Summaries for CA13 Gene

Entrez Gene Summary for CA13 Gene

  • Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]

GeneCards Summary for CA13 Gene

CA13 (Carbonic Anhydrase XIII) is a Protein Coding gene. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14.

UniProtKB/Swiss-Prot for CA13 Gene

  • Reversible hydration of carbon dioxide

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA13 Gene

Genomics for CA13 Gene

Regulatory Elements for CA13 Gene

Genomic Location for CA13 Gene

85,220,587 bp from pter
85,284,073 bp from pter
63,487 bases
Plus strand

Genomic View for CA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA13 Gene

Proteins for CA13 Gene

  • Protein details for CA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 13
    Protein Accession:

    Protein attributes for CA13 Gene

    262 amino acids
    Molecular mass:
    29443 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA13 Gene

neXtProt entry for CA13 Gene

Proteomics data for CA13 Gene at MOPED

Selected DME Specific Peptides for CA13 Gene

Post-translational modifications for CA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CA13 (Carbonic Anhydrase XIII/CA13)

Domains & Families for CA13 Gene

Gene Families for CA13 Gene

Suggested Antigen Peptide Sequences for CA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA13: view

Function for CA13 Gene

Molecular function for CA13 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=13.8 mM for CO(2) {ECO:0000269 PubMed:18618712};
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by acetazolamide.
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide

Enzyme Numbers (IUBMB) for CA13 Gene

Gene Ontology (GO) - Molecular Function for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CA13: view
genes like me logo Genes that share phenotypes with CA13: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CA13 Gene

Localization for CA13 Gene

Subcellular locations from

Jensen Localization Image for CA13 Gene COMPARTMENTS Subcellular localization image for CA13 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043209 myelin sheath IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CA13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CA13 Gene

Pathways & Interactions for CA13 Gene

genes like me logo Genes that share pathways with CA13: view

Pathways by source for CA13 Gene

2 Reactome pathways for CA13 Gene
1 KEGG pathway for CA13 Gene

Interacting Proteins for CA13 Gene

Gene Ontology (GO) - Biological Process for CA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006730 one-carbon metabolic process IEA --
GO:0015701 bicarbonate transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA13: view

No data available for SIGNOR curated interactions for CA13 Gene

Drugs & Compounds for CA13 Gene

(3) Drugs for CA13 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 63
Zinc Approved Pharma 1404
N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide Experimental Pharma Target 0

(3) Additional Compounds for CA13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Carbonic acid
  • Acid of air
  • Aerial acid
  • Bisodium carbonate
  • Calcined
  • Carbonic acid sodium salt
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with CA13: view

Transcripts for CA13 Gene

mRNA/cDNA for CA13 Gene

Unigene Clusters for CA13 Gene

Carbonic anhydrase XIII:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CA13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA13 Gene

No ASD Table

Relevant External Links for CA13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA13 Gene

mRNA expression in normal human tissues for CA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CA13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.2), Platelet (15.7), Salivary gland (10.4), and Skin (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CA13 Gene

SOURCE GeneReport for Unigene cluster for CA13 Gene Hs.127189

mRNA Expression by UniProt/SwissProt for CA13 Gene

Tissue specificity: Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis.
genes like me logo Genes that share expression patterns with CA13: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CA13 Gene

Orthologs for CA13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CA13 35
  • 87.87 (n)
  • 87.74 (a)
CA13 36
  • 87 (a)
(Canis familiaris)
Mammalia CA13 35
  • 89.69 (n)
  • 93.89 (a)
CA13 36
  • 94 (a)
(Mus musculus)
Mammalia Car13 35
  • 87.02 (n)
  • 91.22 (a)
Car13 16
Car13 36
  • 91 (a)
(Pan troglodytes)
Mammalia CA13 35
  • 99.36 (n)
  • 99.24 (a)
CA13 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Car13 35
  • 87.4 (n)
  • 91.6 (a)
(Monodelphis domestica)
Mammalia CA13 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia CA13 36
  • 84 (a)
(Gallus gallus)
Aves LOC100858989 35
  • 72.55 (n)
  • 71.37 (a)
CA13 36
  • 70 (a)
(Anolis carolinensis)
Reptilia CA13 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca13 35
  • 70.07 (n)
  • 67.45 (a)
(Danio rerio)
Actinopterygii -- 35
ca2 35
  • 63.27 (n)
  • 63.14 (a)
ca2 36
  • 63 (a)
cahz 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CAH1 36
  • 44 (a)
Species with no ortholog for CA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA13 Gene

Gene Tree for CA13 (if available)
Gene Tree for CA13 (if available)

Paralogs for CA13 Gene

Paralogs for CA13 Gene

(14) SIMAP similar genes for CA13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CA13: view

Variants for CA13 Gene

Sequence variations from dbSNP and Humsavar for CA13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7818163 -- 85,269,641(+) GGAGG(C/T)TCTTT intron-variant
rs7826075 -- 85,276,322(+) tgggc(C/T)cctgt intron-variant
rs7827242 -- 85,263,851(+) TTGGT(G/T)TCATG intron-variant
rs7827544 -- 85,262,105(+) CAAGg(G/T)tgggt intron-variant
rs7835882 -- 85,276,262(+) ccccc(A/C/G)gggca intron-variant

Variation tolerance for CA13 Gene

Residual Variation Intolerance Score: 53.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CA13 Gene

Disorders for CA13 Gene

Relevant External Links for CA13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CA13: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CA13 Gene

Publications for CA13 Gene

  1. Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. (PMID: 14600151) Lehtonen J. … Parkkila S. (J. Biol. Chem. 2004) 2 23 67
  2. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PMID: 19703035) De Simone G. … Supuran C.T. (Chem Biol Drug Des 2009) 25 26
  3. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. (PMID: 18618712) Di Fiore A. … De Simone G. (Proteins 2009) 23 67
  4. Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. (PMID: 18537527) Supuran C.T. … De Simone G. (Expert Opin Emerg Drugs 2008) 25 26
  5. Therapeutic role of zonisamide in neuropsychiatric disorders. (PMID: 18782051) Farooq M.U. … Kassab M.Y. (Mini Rev Med Chem 2008) 25 26

Products for CA13 Gene

Sources for CA13 Gene

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