CA13 Gene
protein-coding GIFtS: 55
GCID: GC08P086232
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|
carbonic anhydrase XIII
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Aliases
for CA13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carbonic Anhydrase XIII1 2 3 | | EC 4.2.1.13 8 | | CAXIII1 2 | | FLJ379951 | | Carbonate Dehydratase XIII2 3 | | MGC598681 | | CA-XIII2 3 | | Carbonic Anhydrase 132 |
Export aliases for CA13 gene to outside databasesPrevious GC identifers: GC08P086207 GC08P086345 GC08P081651 |
Summaries
for CA13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CA13:
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM114800.(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1Function: Reversible hydration of carbon dioxide
|
Genomic Views
for CA13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CA13 gene promoter:
HFH-3 STAT5B STAT5A GATA-1 PPAR-alpha FOXI1 HOXA5 FOXJ2 (long isoform) c-Jun FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CA13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.2 Ensembl cytogenetic band: 8q21.2 HGNC cytogenetic band: 8q21CA13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P086232: view genomic region
(about GC identifiers)
Start:
|
86,132,816 bp from pter |
End:
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86,196,302 bp from pter |
Size:
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63,487 bases |
Orientation:
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plus strand |
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Proteins
for CA13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1 (See
protein sequence)Recommended Name: Carbonic anhydrase 13 Size: 262 amino acids; 29443 Da
Cofactor: Zinc (By similarity)
3 PDB 3D structures from  and Proteopedia  for CA13:3CZV (3D)
3D0N (3D)
3DA2 (3D)
Explore the universe of human proteins at neXtProt for CA13: NX_Q8N1Q1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N1Q1
3 DME Specific Peptides for CA13 (Q8N1Q1)
CA13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940986.1
ENSEMBL proteins: ENSP00000318912 Reactome Protein details: Q8N1Q1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
CA13 for ontologies About GeneDecksing
CA13 Antibody Products:
Assay Products for CA13: |
Protein
Domains /
Families
for CA13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CA13 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N1Q1ProtoNet protein and cluster: Q8N1Q1 1 Blocks protein family: IPB001148 Carbonic anhydrase
UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1Similarity: Belongs to the alpha-carbonic anhydrase family |
Function
for CA13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1Function: Reversible hydration of carbon dioxideCatalytic activity: H(2)CO(3) = CO(2) + H(2)OEnzyme regulation: Inhibited by acetazolamideBiophysicochemical properties: Kinetic parameters: KM=13.8 mM for CO(2);Enzyme Number (IUBMB): EC 4.2.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CA13 (NM_152701) | |  | Sino Biological Human cDNA Clone for CA13 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CA13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004089 | carbonate dehydratase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
CA13 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CA13:
|
Pathways & Interactions
for CA13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Reversible Hydration of Carbon Dioxide | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for CA13
1 
Kegg Pathway (Kegg details for CA13):
CA13 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA13
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006730 | one-carbon metabolic process |
IEA | -- | | GO:0015701 | bicarbonate transport |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
CA13 for ontologies About GeneDecksing
|
Drugs & Compounds
for CA13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CA13
4 HMDB Compounds for CA13 About this table
2 DrugBank Compounds for CA13 About this table
Search CenterWatch for drugs/clinical trials and news about CA13 / CAH13
|
Transcripts
for CA13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CA13 gene: NM_198584.2 Unigene Cluster for CA13: Carbonic anhydrase XIII Hs.127189 [show with all ESTs]Unigene Representative Sequence: NM_1985845 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000517831 ENST00000517298(uc003ydf.1) ENST00000522631 ENST00000518392
ENST00000321764(uc003ydg.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CA13 (NM_152701) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CA13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13 |
Additional cDNA sequence: AK095314.1 BC052602.1 3 DOTS entries: DT.97813946 DT.106891 DT.105927 24/234 AceView cDNA sequences (see all 234): AI807047 BX093441 AI057175 AA327952 BI831159 AA906098 BC052602 BF576371 BX956196 AW952139 AA305658 AW301200 H91582 BM720604 BE552131 BU169155 CF551842 AW950045 AA464972 BI830861 T27858 BX108206 BF790332 AK095314
GeneLoc Exon Structure
|
Expression
for CA13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CA13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGACAGGG
About this image
See CA13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CA13
SOURCE GeneReport for Unigene cluster: Hs.127189
UniProtKB/Swiss-Prot: CAH13_HUMAN, Q8N1Q1Tissue specificity: Expressed in thymus, small intestine, spleen, prostate, ovary, colon and testis
SABiosciences Custom PCR Arrays for CA13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13 |
Orthologs
for CA13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CA13 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for CA13 (if available)
TreeFam Gene Tree for CA13 (if available) |
Paralogs
for CA13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CA13 gene
- CA22 CA122 CA72 CA62 CA32 CA112 CA5B2 CA142
- CA5A2 CA82 CA42 CA12 CA92 CA102
15 SIMAP similar genes for CA13 using alignment to 1 protein entry: CAH13_HUMAN:CA1 CA2 CA3 CA7 CA5B CA5A
CA10 DKFZp686I20267 CA8 CA12 CA14 CA6
PTPRZ1 CA11 PTPRG
CA13 for paralogs About GeneDecksing
|
Genomic Variants
for CA13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CA13 (86132816 - 86196302 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CA13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA13 |
|
Disorders
/ Diseases
for CA13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CA13 for disorders About GeneDecksing
OMIM gene information: 611436
OMIM disorders: --
5  diseases for CA13: About MalaCardssuppurative otitis media otitis media glaucoma prostatitis
neuronitis
2 diseases from the University of Copenhagen DISEASES database for CA13:Glaucoma Suppurative otitis media Export disorders for CA13 gene to outside databases
|
Publications
for CA13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CA13 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with CA13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. (PubMed id 14600151)1, 2, 3, 9 Lehtonen J.... Parkkila S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV. (PubMed id 18336313)1, 9 Hilvo M....Parkkila S. (2008)
- Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. (PubMed id 15836783)1, 9 Kummola L....Parkkila S. (2005)
- Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. (PubMed id 18618712)2, 9 Di Fiore A.... De Simone G. (2009)
- Which carbonic anhydrases are targeted by the antiepi leptic sulfonamides and sulfamates? (PubMed id 19703035)7 De Simone G....Supuran C.T. (2009)
- Carbonic anhydrase inhibitors as emerging drugs for t he treatment of obesity. (PubMed id 18537527)7 Supuran C.T....De Simone G. (2008)
- Therapeutic role of zonisamide in neuropsychiatric disorders. (PubMed id 18782051)7 Farooq M.U....Kassab M.Y. (2008)
- Clinical pharmacology and mechanism of action of zoni samide. (PubMed id 17762320)7 Biton V. (2007)
|
External Searches for CA13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CA13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CA13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CA13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CA13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CA13 gene:
Search GeneIP for patents involving CA13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CA13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CA13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CA13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA13 | | | OriGene Protein Over-expression Lysate for CA13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CA13 | | OriGene 3'-UTR Clone for CA13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CA13 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CA13 | | OriGene Custom Protein Services for CA13 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CA13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CA13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA13 |
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 |  |  |  | |
| | | | Search Tocris compounds for CA13 |
| |  |  |  |  | | | | |
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 | | | CA13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA13 |
|  |  |  | | | | ThermoFisher Antibodies for CA13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA13 |
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