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Aliases for CA11 Gene

Aliases for CA11 Gene

  • Carbonic Anhydrase 11 2 3
  • Carbonic Anhydrase-Related Protein 2 2 3 4
  • Carbonic Anhydrase XI 2 3 5
  • Carbonic Anhydrase-Related Protein XI 2 3
  • CA-RP XI 2 4
  • CA-RP II 3 4
  • CARP XI 3 4
  • CARP-2 3 4
  • CA-XI 3 4
  • CARPX1 3
  • CARP2 4

External Ids for CA11 Gene

Previous GeneCards Identifiers for CA11 Gene

  • GC19M049785
  • GC19M049509
  • GC19M053817
  • GC19M053833
  • GC19M049141
  • GC19M045520

Summaries for CA11 Gene

Entrez Gene Summary for CA11 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA11 Gene

CA11 (Carbonic Anhydrase 11) is a Protein Coding gene. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA10.

UniProtKB/Swiss-Prot for CA11 Gene

  • Does not have a catalytic activity.

Gene Wiki entry for CA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA11 Gene

Genomics for CA11 Gene

Regulatory Elements for CA11 Gene

Enhancers for CA11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CA11 on UCSC Golden Path with GeneCards custom track

Promoters for CA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for CA11 Gene

Chromosome:
19
Start:
48,637,942 bp from pter
End:
48,646,312 bp from pter
Size:
8,371 bases
Orientation:
Minus strand

Genomic View for CA11 Gene

Genes around CA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA11 Gene

Proteins for CA11 Gene

  • Protein details for CA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75493-CAH11_HUMAN
    Recommended name:
    Carbonic anhydrase-related protein 11
    Protein Accession:
    O75493
    Secondary Accessions:
    • O60596
    • Q6FHI1
    • Q9UEC4

    Protein attributes for CA11 Gene

    Size:
    328 amino acids
    Molecular mass:
    36238 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CA11 Gene

Proteomics data for CA11 Gene at MOPED

Post-translational modifications for CA11 Gene

  • Glycosylation at Asn 118, Asn 170, and Asn 260
  • Modification sites at PhosphoSitePlus

Other Protein References for CA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CA11 Gene

Domains & Families for CA11 Gene

Gene Families for CA11 Gene

Protein Domains for CA11 Gene

Suggested Antigen Peptide Sequences for CA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75493

UniProtKB/Swiss-Prot:

CAH11_HUMAN :
  • Belongs to the alpha-carbonic anhydrase family.
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA11: view

Function for CA11 Gene

Molecular function for CA11 Gene

GENATLAS Biochemistry:
acatalytic carbonic anhydrase related peptide XI,embedded between the secretor cluster and DBP,expressed abundantly in the brain (moderatly in spinal cord and thyroid,cerebral cortex,cerebellum putamen)
UniProtKB/Swiss-Prot Function:
Does not have a catalytic activity.
genes like me logo Genes that share phenotypes with CA11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CA11

miRNA for CA11 Gene

miRTarBase miRNAs that target CA11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA11 Gene

Localization for CA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CA11 Gene COMPARTMENTS Subcellular localization image for CA11 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
mitochondrion 2
plasma membrane 2
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CA11: view

Pathways & Interactions for CA11 Gene

SuperPathways for CA11 Gene

No Data Available

Interacting Proteins for CA11 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000084798%0d%0a9606.ENSP00000357904%0d%0a9606.ENSP00000375977%0d%0a9606.ENSP00000434614%0d%0a
Selected Interacting proteins: ENSP00000084798 O75493-CAH11_HUMAN for CA11 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CA11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CA11 Gene

Drugs & Compounds for CA11 Gene

(7) Drugs for CA11 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 65
Brinzolamide Approved Pharma CA II inhibitor 60
Methazolamide Approved Pharma Carbonic anhydrase inhibitor 7
Topiramate Approved Pharma GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 242
Dorzolamide HCl Pharma Carbonic anhydrase inhibitor 0

(5) ApexBio Compounds for CA11 Gene

Compound Action Cas Number
Brinzolamide CA II inhibitor 138890-62-7
Dorzolamide HCl Carbonic anhydrase inhibitor 130693-82-2
Methazolamide Carbonic anhydrase inhibitor 554-57-4
Topiramate GluR5 receptor antagonist,anticonvulsant 97240-79-4
U-104 CAIX inhibitor 178606-66-1
genes like me logo Genes that share compounds with CA11: view

Transcripts for CA11 Gene

Unigene Clusters for CA11 Gene

Carbonic anhydrase XI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CA11 Gene

No ASD Table

Relevant External Links for CA11 Gene

GeneLoc Exon Structure for
CA11
ECgene alternative splicing isoforms for
CA11

Expression for CA11 Gene

mRNA expression in normal human tissues for CA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA11 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Putamen (basal ganglia) (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for CA11 Gene

This gene is overexpressed in Vitreous humor (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA11 Gene



SOURCE GeneReport for Unigene cluster for CA11 Gene Hs.428446

mRNA Expression by UniProt/SwissProt for CA11 Gene

O75493-CAH11_HUMAN
Tissue specificity: Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.
genes like me logo Genes that share expression patterns with CA11: view

Protein tissue co-expression partners for CA11 Gene

Primer Products

In Situ Assay Products

Orthologs for CA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CA11 35
  • 92.07 (n)
  • 97.87 (a)
CA11 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CA11 35
  • 93.8 (n)
  • 98.48 (a)
CA11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Car11 35
  • 90.24 (n)
  • 96.95 (a)
Car11 16
Car11 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CA11 35
  • 99.8 (n)
  • 100 (a)
CA11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Car11 35
  • 90.75 (n)
  • 97.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CA11 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CA11 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493884 35
  • 61.87 (n)
  • 62.42 (a)
zebrafish
(Danio rerio)
Actinopterygii CA11 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1402 36
  • 32 (a)
ManyToMany
CG32698 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cah-2 37
  • 35 (a)
cah-1 36
  • 25 (a)
ManyToMany
cah-2 36
  • 26 (a)
ManyToMany
Species with no ortholog for CA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA11 Gene

ENSEMBL:
Gene Tree for CA11 (if available)
TreeFam:
Gene Tree for CA11 (if available)

Paralogs for CA11 Gene

Paralogs for CA11 Gene

(8) SIMAP similar genes for CA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA11: view

Variants for CA11 Gene

Structural Variations from Database of Genomic Variants (DGV) for CA11 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294

Variation tolerance for CA11 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA11 Gene

HapMap Linkage Disequilibrium report
CA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CA11 Gene

Disorders for CA11 Gene

Relevant External Links for CA11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CA11

No disorders were found for CA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CA11 Gene

Publications for CA11 Gene

  1. Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3. (PMID: 9878252) Lovejoy D.A. … Tashian R.E. (Genomics 1998) 2 3 4 23 67
  2. cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain. (PMID: 11311946) Okamoto N. … Onishi S. (Biochim. Biophys. Acta 2001) 3 23
  3. cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI. (PMID: 10350627) Fujikawa-Adachi K. … Onishi S. (Biochim. Biophys. Acta 1999) 3 23
  4. Sequence and tissue expression of a novel human carbonic anhydrase- related protein, CARP-2, mapping to chromosome 19q13.3. (PMID: 9878543) Bellingham J. … Gregory-Evans C.Y. (Biochem. Biophys. Res. Commun. 1998) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CA11 Gene

Sources for CA11 Gene

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