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Aliases for CA11 Gene

Aliases for CA11 Gene

  • Carbonic Anhydrase 11 2 3 5
  • Carbonic Anhydrase-Related Protein 2 2 3 4
  • Carbonic Anhydrase-Related Protein XI 2 3
  • Carbonic Anhydrase XI 2 3
  • CA-RP XI 2 4
  • CA-RP II 3 4
  • CARP XI 3 4
  • CARP-2 3 4
  • CA-XI 3 4
  • Carbonic Anhydrase-Related Protein 11 3
  • CARPX1 3
  • CARP2 4

External Ids for CA11 Gene

Previous GeneCards Identifiers for CA11 Gene

  • GC19M049785
  • GC19M049509
  • GC19M053817
  • GC19M053833
  • GC19M049141
  • GC19M045520

Summaries for CA11 Gene

Entrez Gene Summary for CA11 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA11 Gene

CA11 (Carbonic Anhydrase 11) is a Protein Coding gene. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA10.

UniProtKB/Swiss-Prot for CA11 Gene

  • Does not have a catalytic activity.

Gene Wiki entry for CA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA11 Gene

Genomics for CA11 Gene

Regulatory Elements for CA11 Gene

Enhancers for CA11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F048612 0.2 ENCODE 10.4 +29.6 29550 7.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 KDELR1 GRWD1 PRR12 SNORD35A ENSG00000269321 ALDH16A1 SNORD35B TEAD2 RPS11 RPL18
GH19F047741 0.4 ENCODE 10.2 +902.4 902391 5.0 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ZC3H4 GLTSCR1 ENSG00000269321 GRWD1 SELENOW KDELR1 CCDC9 EHD2 TPRX2P ELSPBP1
GH19F049154 0.6 ENCODE 10.2 -510.6 -510625 4.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF263 GRWD1 KDELR1 TEAD2 PLEKHA4 TRPM4 PRR12 ENSG00000268157 RPS11 ENSG00000197813 NTN5
GH19F049631 0.9 Ensembl 10.2 -985.0 -984989 0.6 ATF1 ZNF133 GLI4 ZNF2 ZNF155 ZEB1 ZNF23 GLIS2 ZNF302 SCRT2 PRR12 NUP62 POLD1 PTOV1-AS2 PNKP SNORD35A ALDH16A1 SNORD35B NTN5 RPS11
GH19F049117 0.2 ENCODE 10.2 -472.5 -472497 2.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF207 ENSG00000269321 PRR12 NTF6B NTF6A LOC105372430 NTN5 LIN7B PTH2 C19orf68 RUVBL2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CA11 on UCSC Golden Path with GeneCards custom track

Promoters for CA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CA11 Gene

48,637,942 bp from pter
48,646,312 bp from pter
8,371 bases
Minus strand

Genomic View for CA11 Gene

Genes around CA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA11 Gene

Proteins for CA11 Gene

  • Protein details for CA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase-related protein 11
    Protein Accession:
    Secondary Accessions:
    • O60596
    • Q6FHI1
    • Q9UEC4

    Protein attributes for CA11 Gene

    328 amino acids
    Molecular mass:
    36238 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CA11 Gene

Post-translational modifications for CA11 Gene

  • Glycosylation at Asn 118, Asn 170, and Asn 260
  • Modification sites at PhosphoSitePlus

Other Protein References for CA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CA11 Gene

Domains & Families for CA11 Gene

Gene Families for CA11 Gene

Protein Domains for CA11 Gene

Suggested Antigen Peptide Sequences for CA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 alpha-carbonic anhydrase domain.
  • Belongs to the alpha-carbonic anhydrase family.
  • Contains 1 alpha-carbonic anhydrase domain.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA11: view

Function for CA11 Gene

Molecular function for CA11 Gene

GENATLAS Biochemistry:
acatalytic carbonic anhydrase related peptide XI,embedded between the secretor cluster and DBP,expressed abundantly in the brain (moderatly in spinal cord and thyroid,cerebral cortex,cerebellum putamen)
UniProtKB/Swiss-Prot Function:
Does not have a catalytic activity.

Gene Ontology (GO) - Molecular Function for CA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 NOT carbonate dehydratase activity TAS 9878252
genes like me logo Genes that share ontologies with CA11: view
genes like me logo Genes that share phenotypes with CA11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CA11

miRNA for CA11 Gene

miRTarBase miRNAs that target CA11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA11 Gene

Localization for CA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA11 Gene


Subcellular locations from

Jensen Localization Image for CA11 Gene COMPARTMENTS Subcellular localization image for CA11 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
mitochondrion 2
plasma membrane 2
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CA11: view

Pathways & Interactions for CA11 Gene

SuperPathways for CA11 Gene

No Data Available

Interacting Proteins for CA11 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: O75493-CAH11_HUMAN ENSP00000084798 for CA11 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CA11 Gene


No data available for Pathways by source and SIGNOR curated interactions for CA11 Gene

Drugs & Compounds for CA11 Gene

(7) Drugs for CA11 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 67
Brinzolamide Approved Pharma CA II inhibitor 60
Methazolamide Approved Pharma Carbonic anhydrase inhibitor 7
Topiramate Approved Pharma GluR5 receptor antagonist,anticonvulsant, GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV 247
Dorzolamide HCl Pharma Carbonic anhydrase inhibitor 0

(5) ApexBio Compounds for CA11 Gene

Compound Action Cas Number
Brinzolamide CA II inhibitor 138890-62-7
Dorzolamide HCl Carbonic anhydrase inhibitor 130693-82-2
Methazolamide Carbonic anhydrase inhibitor 554-57-4
Topiramate GluR5 receptor antagonist,anticonvulsant 97240-79-4
U-104 CAIX inhibitor 178606-66-1
genes like me logo Genes that share compounds with CA11: view

Transcripts for CA11 Gene

Unigene Clusters for CA11 Gene

Carbonic anhydrase XI:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA11 Gene

No ASD Table

Relevant External Links for CA11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA11 Gene

mRNA expression in normal human tissues for CA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA11 Gene

This gene is overexpressed in Brain - Cortex (x5.6), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Putamen (basal ganglia) (x4.5), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for CA11 Gene

This gene is overexpressed in Vitreous humor (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA11 Gene

Protein tissue co-expression partners for CA11 Gene

NURSA nuclear receptor signaling pathways regulating expression of CA11 Gene:


SOURCE GeneReport for Unigene cluster for CA11 Gene:


mRNA Expression by UniProt/SwissProt for CA11 Gene:

Tissue specificity: Expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid.
genes like me logo Genes that share expression patterns with CA11: view

Primer Products

Orthologs for CA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CA11 34 35
  • 99.8 (n)
(Canis familiaris)
Mammalia CA11 34 35
  • 93.8 (n)
(Bos Taurus)
Mammalia CA11 34 35
  • 92.07 (n)
(Rattus norvegicus)
Mammalia Car11 34
  • 90.75 (n)
(Mus musculus)
Mammalia Car11 34 16 35
  • 90.24 (n)
(Monodelphis domestica)
Mammalia CA11 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
-- 35
  • 25 (a)
-- 35
  • 20 (a)
(Anolis carolinensis)
Reptilia CA11 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493884 34
  • 61.87 (n)
(Danio rerio)
Actinopterygii CA11 35
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32698 35
  • 34 (a)
CG1402 35
  • 32 (a)
(Caenorhabditis elegans)
Secernentea cah-2 36 35
  • 35 (a)
cah-1 35
  • 25 (a)
Species where no ortholog for CA11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA11 Gene

Gene Tree for CA11 (if available)
Gene Tree for CA11 (if available)

Paralogs for CA11 Gene

Paralogs for CA11 Gene

(8) SIMAP similar genes for CA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CA11: view

Variants for CA11 Gene

Sequence variations from dbSNP and Humsavar for CA11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10426317 -- 48,645,524(+) ACCTC(C/T)ACCCT intron-variant
rs1045854 -- 48,644,489(-) TGGAG(C/G)TGAAG intron-variant, nc-transcript-variant, reference, missense
rs10561261 -- 48,638,387(+) TTCAT(-/G)GGGGG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111488261 -- 48,642,313(+) GGCCA(A/G)CATGG intron-variant
rs111772747 -- 48,641,090(+) TTCTC(C/T)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA11 Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
nsv9739 CNV gain+loss 18304495

Variation tolerance for CA11 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA11 Gene

Disorders for CA11 Gene

Relevant External Links for CA11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CA11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CA11 Gene

Publications for CA11 Gene

  1. Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3. (PMID: 9878252) Lovejoy D.A. … Tashian R.E. (Genomics 1998) 2 3 4 22 64
  2. cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI. (PMID: 10350627) Fujikawa-Adachi K. … Onishi S. (Biochim. Biophys. Acta 1999) 3 4 22 64
  3. Sequence and tissue expression of a novel human carbonic anhydrase- related protein, CARP-2, mapping to chromosome 19q13.3. (PMID: 9878543) Bellingham J. … Gregory-Evans C.Y. (Biochem. Biophys. Res. Commun. 1998) 3 4 22 64
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CA11 Gene

Sources for CA11 Gene

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