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Aliases for CA10 Gene

Aliases for CA10 Gene

  • Carbonic Anhydrase 10 2 3
  • Carbonic Anhydrase X 2 3 5
  • Carbonic Anhydrase-Related Protein X 3 4
  • Cerebral Protein 15 3 4
  • CA-RP X 3 4
  • CARP X 3 4
  • Cerebral Protein-15 3
  • HUCEP-15 3
  • CA-RPX 3
  • CARPX 3

External Ids for CA10 Gene

Previous GeneCards Identifiers for CA10 Gene

  • GC17U990008
  • GC17M052189
  • GC17M050049
  • GC17M050182
  • GC17M047062
  • GC17M049707
  • GC17M045077

Summaries for CA10 Gene

Entrez Gene Summary for CA10 Gene

  • This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA10 Gene

CA10 (Carbonic Anhydrase 10) is a Protein Coding gene. Diseases associated with CA10 include Chondroblastoma and Herpangina. An important paralog of this gene is CA11.

UniProtKB/Swiss-Prot for CA10 Gene

  • Does not have a catalytic activity.

Gene Wiki entry for CA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA10 Gene

Genomics for CA10 Gene

Regulatory Elements for CA10 Gene

Enhancers for CA10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CA10 Gene

51,630,313 bp from pter
52,160,017 bp from pter
529,705 bases
Minus strand

Genomic View for CA10 Gene

Genes around CA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA10 Gene

Proteins for CA10 Gene

  • Protein details for CA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase-related protein 10
    Protein Accession:
    Secondary Accessions:
    • B2R7J0
    • B4DGL6

    Protein attributes for CA10 Gene

    328 amino acids
    Molecular mass:
    37563 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CA10 Gene


neXtProt entry for CA10 Gene

Proteomics data for CA10 Gene at MOPED

Post-translational modifications for CA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CA10 Gene

Domains & Families for CA10 Gene

Gene Families for CA10 Gene

Protein Domains for CA10 Gene

Suggested Antigen Peptide Sequences for CA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA10: view

Function for CA10 Gene

Molecular function for CA10 Gene

UniProtKB/Swiss-Prot Function:
Does not have a catalytic activity.
genes like me logo Genes that share phenotypes with CA10: view

Animal Model Products

CRISPR Products

miRNA for CA10 Gene

miRTarBase miRNAs that target CA10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA10 Gene

Localization for CA10 Gene

Subcellular locations from

Jensen Localization Image for CA10 Gene COMPARTMENTS Subcellular localization image for CA10 gene
Compartment Confidence
cytosol 2
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CA10 Gene

Pathways & Interactions for CA10 Gene

SuperPathways for CA10 Gene

No Data Available

Interacting Proteins for CA10 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000285273 for CA10 Gene via STRING

Gene Ontology (GO) - Biological Process for CA10 Gene


No data available for Pathways by source and SIGNOR curated interactions for CA10 Gene

Drugs & Compounds for CA10 Gene

(3) Drugs for CA10 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 65
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0
Montelukast Approved Pharma Antagonist 265
genes like me logo Genes that share compounds with CA10: view

Transcripts for CA10 Gene

Unigene Clusters for CA10 Gene

Carbonic anhydrase X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CA10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP3: -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for CA10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA10 Gene

mRNA expression in normal human tissues for CA10 Gene

mRNA differential expression in normal tissues according to GTEx for CA10 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.2), Brain - Cerebellum (x9.2), Brain - Frontal Cortex (BA9) (x5.4), Brain - Anterior cingulate cortex (BA24) (x5.2), and Brain - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for CA10 Gene

This gene is overexpressed in Vitreous humor (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA10 Gene

SOURCE GeneReport for Unigene cluster for CA10 Gene Hs.463466

mRNA Expression by UniProt/SwissProt for CA10 Gene

Tissue specificity: Strong expression in brain and central nervous system.
genes like me logo Genes that share expression patterns with CA10: view

Protein tissue co-expression partners for CA10 Gene

- Elite partner

Primer Products

Orthologs for CA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CA10 35
  • 95.53 (n)
  • 99.39 (a)
CA10 36
  • 99 (a)
(Canis familiaris)
Mammalia CA10 35
  • 96.85 (n)
  • 100 (a)
CA10 36
  • 100 (a)
(Mus musculus)
Mammalia Car10 35
  • 94.51 (n)
  • 100 (a)
Car10 16
Car10 36
  • 100 (a)
(Pan troglodytes)
Mammalia CA10 35
  • 99.8 (n)
  • 100 (a)
CA10 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Ca10 35
  • 94 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia CA10 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia CA10 36
  • 96 (a)
(Gallus gallus)
Aves CA10 35
  • 86.79 (n)
  • 99.39 (a)
CA10 36
  • 99 (a)
(Anolis carolinensis)
Reptilia CA10 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca10 35
  • 80.89 (n)
  • 94.21 (a)
(Danio rerio)
Actinopterygii ca10a 35
  • 79.37 (n)
  • 90.24 (a)
wufd54f06 35
ca10a 36
  • 90 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000688 35
  • 52.77 (n)
  • 45.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32698 35
  • 52.91 (n)
  • 43.36 (a)
CG10899 36
  • 24 (a)
CG11284 36
  • 26 (a)
CG12309 36
  • 13 (a)
CG1402 36
  • 37 (a)
CG15227 36
  • 19 (a)
CG18672 36
  • 26 (a)
CG18673 36
  • 22 (a)
CG32698 36
  • 38 (a)
CG3669 36
  • 23 (a)
CG3940 36
  • 24 (a)
CG5379 36
  • 23 (a)
CG6074 36
  • 24 (a)
CG9235 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea cah-2 35
  • 47.37 (n)
  • 38.83 (a)
cah-1 36
  • 27 (a)
cah-2 36
  • 27 (a)
cah-4 36
  • 23 (a)
cah-6 36
  • 23 (a)
Species with no ortholog for CA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA10 Gene

Gene Tree for CA10 (if available)
Gene Tree for CA10 (if available)

Paralogs for CA10 Gene

Paralogs for CA10 Gene

(11) SIMAP similar genes for CA10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CA10: view

Variants for CA10 Gene

Sequence variations from dbSNP and Humsavar for CA10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs13293 -- 51,631,178(+) ACAAA(A/G)GCTGA nc-transcript-variant, utr-variant-3-prime
rs25597 -- 51,646,992(+) GGATC(-/TCTT)CTCTT intron-variant
rs64636 -- 51,906,845(-) gcaag(A/C)aggac intron-variant
rs69178 -- 51,934,937(+) CTGTG(A/G)AAACA intron-variant
rs123526 -- 51,935,198(+) AATGC(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA10 Gene

Variant ID Type Subtype PubMed ID
esv34090 CNV Loss 18971310
nsv908611 CNV Loss 21882294
nsv2086 CNV Insertion 18451855
esv2673970 CNV Deletion 23128226
esv24039 CNV Loss 19812545
nsv828040 CNV Gain 20364138
nsv833482 CNV Gain 17160897
nsv507844 CNV Insertion 20534489
esv2567906 CNV Insertion 19546169
nsv828041 CNV Loss 20364138
nsv2087 CNV Insertion 18451855
esv273536 CNV Insertion 20981092
esv270984 CNV Insertion 20981092
dgv554e199 CNV Deletion 23128226
nsv828043 CNV Loss 20364138
esv9578 CNV Loss 19470904
esv2716046 CNV Deletion 23290073
esv4530 CNV Deletion 18987735
esv2716047 CNV Deletion 23290073
esv2670652 CNV Deletion 23128226

Variation tolerance for CA10 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA10 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA10 Gene

Disorders for CA10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CA10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • chondroblastoma of bone
  • vesicular pharyngitis
retrograde amnesia
  • amnesia, retrograde
hand, foot and mouth disease
  • vesicular stomatitis and exanthem
- elite association - COSMIC cancer census association via MalaCards
Search CA10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CA10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA10 Gene

Publications for CA10 Gene

  1. CCG repeats in cDNAs from human brain. (PMID: 9921901) Kleiderlein J.J. … Margolis R.L. (Hum. Genet. 1998) 2 3 4 67
  2. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PMID: 19703035) De Simone G. … Supuran C.T. (Chem Biol Drug Des 2009) 25 26
  3. Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. (PMID: 18537527) Supuran C.T. … De Simone G. (Expert Opin Emerg Drugs 2008) 25 26
  4. Therapeutic role of zonisamide in neuropsychiatric disorders. (PMID: 18782051) Farooq M.U. … Kassab M.Y. (Mini Rev Med Chem 2008) 25 26
  5. Zonisamide: new drug. No advantage in refractory partial epilepsy. (PMID: 17582922) (Prescrire Int 2007) 25 26

Products for CA10 Gene

Sources for CA10 Gene