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Aliases for CA10 Gene

Aliases for CA10 Gene

  • Carbonic Anhydrase 10 2 3 5
  • Carbonic Anhydrase-Related Protein X 3 4
  • Carbonic Anhydrase X 2 3
  • CA-RP X 3 4
  • CARP X 3 4
  • Carbonic Anhydrase-Related Protein 10 3
  • Cerebral Protein-15 3
  • Cerebral Protein 15 4
  • HUCEP-15 3
  • CA-RPX 3
  • CARPX 3

External Ids for CA10 Gene

Previous GeneCards Identifiers for CA10 Gene

  • GC17U990008
  • GC17M052189
  • GC17M050049
  • GC17M050182
  • GC17M047062
  • GC17M049707
  • GC17M045077

Summaries for CA10 Gene

Entrez Gene Summary for CA10 Gene

  • This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA10 Gene

CA10 (Carbonic Anhydrase 10) is a Protein Coding gene. Diseases associated with CA10 include Chondroblastoma and Non-Suppurative Otitis Media. An important paralog of this gene is CA11.

UniProtKB/Swiss-Prot for CA10 Gene

  • Does not have a catalytic activity.

Gene Wiki entry for CA10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA10 Gene

Genomics for CA10 Gene

Regulatory Elements for CA10 Gene

Enhancers for CA10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G052156 0.3 FANTOM5 11.6 +3.2 3206 0.2 CA10 ENSG00000279743
GH17G051904 0.3 FANTOM5 7.2 +255.8 255818 0.0 CA10 ENSG00000279743
GH17G051959 0.6 FANTOM5 2.9 +200.4 200362 0.4 SMARCA4 PRDM10 THRB CA10 ENSG00000279743
GH17G051696 0.4 FANTOM5 4 +463.0 463035 0.2 MAFK CA10 ENSG00000279743 GC17M051595
GH17G051933 0.2 ENCODE 6.4 +226.4 226352 1.3 CA10 ENSG00000279743
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CA10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CA10 Gene

Chromosome:
17
Start:
51,630,313 bp from pter
End:
52,160,017 bp from pter
Size:
529,705 bases
Orientation:
Minus strand

Genomic View for CA10 Gene

Genes around CA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA10 Gene

Proteins for CA10 Gene

  • Protein details for CA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS85-CAH10_HUMAN
    Recommended name:
    Carbonic anhydrase-related protein 10
    Protein Accession:
    Q9NS85
    Secondary Accessions:
    • B2R7J0
    • B4DGL6

    Protein attributes for CA10 Gene

    Size:
    328 amino acids
    Molecular mass:
    37563 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CA10 Gene

Post-translational modifications for CA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for CA10 (Carbonic Anhydrase X/CA10)

No data available for DME Specific Peptides for CA10 Gene

Domains & Families for CA10 Gene

Gene Families for CA10 Gene

Protein Domains for CA10 Gene

Suggested Antigen Peptide Sequences for CA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS85

UniProtKB/Swiss-Prot:

CAH10_HUMAN :
  • Belongs to the alpha-carbonic anhydrase family.
Family:
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA10: view

Function for CA10 Gene

Molecular function for CA10 Gene

UniProtKB/Swiss-Prot Function:
Does not have a catalytic activity.

Gene Ontology (GO) - Molecular Function for CA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CA10: view
genes like me logo Genes that share phenotypes with CA10: view

Animal Model Products

CRISPR Products

miRNA for CA10 Gene

miRTarBase miRNAs that target CA10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CA10 Gene

Localization for CA10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CA10 gene
Compartment Confidence
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CA10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CA10 Gene

Pathways & Interactions for CA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development NAS 11311946
genes like me logo Genes that share ontologies with CA10: view

No data available for Pathways by source and SIGNOR curated interactions for CA10 Gene

Drugs & Compounds for CA10 Gene

(3) Drugs for CA10 Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 68
Fluticasone propionate Approved Pharma Selective high affinity glucocorticoid receptor agonist 0
Montelukast Approved Pharma Antagonist 270
genes like me logo Genes that share compounds with CA10: view

Transcripts for CA10 Gene

Unigene Clusters for CA10 Gene

Carbonic anhydrase X:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CA10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2:
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7:

Relevant External Links for CA10 Gene

GeneLoc Exon Structure for
CA10
ECgene alternative splicing isoforms for
CA10

Expression for CA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA10 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.2), Brain - Cerebellum (x9.2), Brain - Frontal Cortex (BA9) (x5.4), Brain - Anterior cingulate cortex (BA24) (x5.2), and Brain - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for CA10 Gene

This gene is overexpressed in Vitreous humor (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CA10 Gene



Protein tissue co-expression partners for CA10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CA10 Gene:

CA10

SOURCE GeneReport for Unigene cluster for CA10 Gene:

Hs.463466

mRNA Expression by UniProt/SwissProt for CA10 Gene:

Q9NS85-CAH10_HUMAN
Tissue specificity: Strong expression in brain and central nervous system.

Evidence on tissue expression from TISSUES for CA10 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with CA10: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CA10 Gene

Orthologs for CA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA10 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia CA10 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CA10 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia CA10 34 35
  • 96.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CA10 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CA10 34 35
  • 95.53 (n)
mouse
(Mus musculus)
Mammalia Car10 34 16 35
  • 94.51 (n)
rat
(Rattus norvegicus)
Mammalia Ca10 34
  • 94 (n)
chicken
(Gallus gallus)
Aves CA10 34 35
  • 86.79 (n)
lizard
(Anolis carolinensis)
Reptilia CA10 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ca10 34
  • 80.89 (n)
zebrafish
(Danio rerio)
Actinopterygii ca10a 34 35
  • 79.37 (n)
wufd54f06 34
fruit fly
(Drosophila melanogaster)
Insecta CG32698 34 35
  • 52.91 (n)
CG1402 35
  • 37 (a)
ManyToMany
CG11284 35
  • 26 (a)
ManyToMany
CG18672 35
  • 26 (a)
ManyToMany
CG10899 35
  • 24 (a)
ManyToMany
CG3940 35
  • 24 (a)
ManyToMany
CG6074 35
  • 24 (a)
ManyToMany
CG3669 35
  • 23 (a)
ManyToMany
CG5379 35
  • 23 (a)
ManyToMany
CG18673 35
  • 22 (a)
ManyToMany
CG9235 35
  • 20 (a)
ManyToMany
CG15227 35
  • 19 (a)
ManyToMany
CG12309 35
  • 13 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000688 34
  • 52.77 (n)
worm
(Caenorhabditis elegans)
Secernentea cah-2 34 35
  • 47.37 (n)
cah-1 35
  • 27 (a)
ManyToMany
cah-4 35
  • 23 (a)
ManyToMany
cah-6 35
  • 23 (a)
ManyToMany
Species where no ortholog for CA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CA10 Gene

ENSEMBL:
Gene Tree for CA10 (if available)
TreeFam:
Gene Tree for CA10 (if available)

Paralogs for CA10 Gene

Paralogs for CA10 Gene

(11) SIMAP similar genes for CA10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CA10: view

Variants for CA10 Gene

Sequence variations from dbSNP and Humsavar for CA10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000000005 -- 51,974,498(+) AACTA(-/AAAC)AAAAC intron-variant
rs1000000243 -- 51,813,198(+) TGGTA(C/T)CTGGC intron-variant
rs1000007518 -- 51,972,550(+) AGGAG(G/T)TCCAT intron-variant
rs1000010830 -- 51,725,676(+) AGACC(C/T)TTTTT intron-variant
rs1000015708 -- 52,082,799(+) GAAGC(A/C)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CA10 Gene

Variant ID Type Subtype PubMed ID
dgv554e199 CNV deletion 23128226
dgv5690n54 CNV loss 21841781
dgv952e212 CNV loss 25503493
esv24039 CNV loss 19812545
esv2567906 CNV insertion 19546169
esv2670652 CNV deletion 23128226
esv2673970 CNV deletion 23128226
esv2716046 CNV deletion 23290073
esv2716047 CNV deletion 23290073
esv2760447 CNV gain 21179565
esv3306708 CNV mobile element insertion 20981092
esv3309263 CNV mobile element insertion 20981092
esv3364542 CNV insertion 20981092
esv3396689 CNV insertion 20981092
esv3396976 CNV insertion 20981092
esv34090 CNV loss 18971310
esv3554547 CNV deletion 23714750
esv3582814 CNV loss 25503493
esv3640771 CNV loss 21293372
esv3640772 CNV loss 21293372
esv3640773 CNV loss 21293372
esv3640774 CNV loss 21293372
esv3640776 CNV loss 21293372
esv3640777 CNV loss 21293372
esv3893028 CNV gain 25118596
esv4530 CNV loss 18987735
esv9578 CNV loss 19470904
nsv1110712 CNV insertion 24896259
nsv1119458 CNV insertion 24896259
nsv1129594 CNV tandem duplication 24896259
nsv1138556 CNV deletion 24896259
nsv2086 CNV insertion 18451855
nsv2087 CNV insertion 18451855
nsv472231 CNV novel sequence insertion 20440878
nsv507844 OTHER sequence alteration 20534489
nsv575551 CNV loss 21841781
nsv575552 CNV loss 21841781
nsv828040 CNV gain 20364138
nsv828041 CNV loss 20364138
nsv828043 CNV loss 20364138
nsv833482 CNV gain 17160897
nsv962341 CNV duplication 23825009

Variation tolerance for CA10 Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CA10 Gene

Human Gene Mutation Database (HGMD)
CA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA10 Gene

Disorders for CA10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CA10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chondroblastoma
  • chondroblastoma of bone
non-suppurative otitis media
  • nonsuppurative otitis media
herpangina
  • vesicular pharyngitis
periarthritis
retrograde amnesia
  • amnesia, retrograde
- elite association - COSMIC cancer census association via MalaCards
Search CA10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CA10

Genetic Association Database (GAD)
CA10
Human Genome Epidemiology (HuGE) Navigator
CA10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CA10
genes like me logo Genes that share disorders with CA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA10 Gene

Publications for CA10 Gene

  1. cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain. (PMID: 11311946) Okamoto N. … Onishi S. (Biochim. Biophys. Acta 2001) 3 4 22 64
  2. CCG repeats in cDNAs from human brain. (PMID: 9921901) Kleiderlein J.J. … Margolis R.L. (Hum. Genet. 1998) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for CA10 Gene

Sources for CA10 Gene

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