CA1 Gene
protein-coding GIFtS: 69
GCID: GC08M086315
|
|
carbonic anhydrase I
| |
Aliases
for CA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carbonic Anhydrase I1 2 3 | | CAB2 3 | | Car11 2 | | EC 4.2.1.13 8 | | Carbonate Dehydratase I2 3 | | Carbonic Anhydrase 12 | | Carbonic Anhydrase B2 3 | | Carbonic Dehydratase2 | | CA-I2 3 | | |
Export aliases for CA1 gene to outside databasesPrevious GC identifers: GC08M085064 GC08M086197 GC08M086020 GC08M086427 GC08M081734 |
Summaries
for CA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CA1:
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbondioxide. They participate in a variety of biological processes, including respiration, calcification, acid-basebalance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They showextensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes.Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding thesame protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been describedin literature. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: CAH1_HUMAN, P00915Function: Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea
Gene Wiki entry for CA1
|
Genomic Views
for CA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CA1 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B2 oct-B3 MyoD POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for CA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.2 Ensembl cytogenetic band: 8q21.2 HGNC cytogenetic band: 8q21.2CA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M086315: view genomic region
(about GC identifiers)
Start:
|
86,239,837 bp from pter |
End:
|
86,291,243 bp from pter |
Size:
|
51,407 bases |
Orientation:
|
minus strand |
|
Proteins
for CA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAH1_HUMAN, P00915 (See
protein sequence)Recommended Name: Carbonic anhydrase 1 Size: 261 amino acids; 28870 Da
Cofactor: Zinc
Subcellular location: Cytoplasm
6/17 PDB 3D structures from  and Proteopedia  for CA1 (see all 17):1AZM (3D)
1BZM (3D)
1CRM (3D)
1CZM (3D)
1HCB (3D)
1HUG (3D)
Explore the universe of human proteins at neXtProt for CA1: NX_P00915
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P00915
4/15 DME Specific Peptides for CA1 (P00915) (see all 15)
CA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001122301.1 NP_001122302.1 NP_001122303.1 NP_001158302.1 NP_001729.1
ENSEMBL proteins: ENSP00000430656 ENSP00000429798 ENSP00000427773 ENSP00000429300 ENSP00000428923 ENSP00000430861 ENSP00000430543 ENSP00000430571 ENSP00000429843 ENSP00000430710 ENSP00000430471 ENSP00000427852 ENSP00000430737 ENSP00000430372 ENSP00000430975 ENSP00000429688 ENSP00000256119 ENSP00000392338 ENSP00000443517 ENSP00000401551 Reactome Protein details: P00915
Human Recombinant Protein Products for CA1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CA1 for ontologies About GeneDecksing
CA1 Antibody Products:
Assay Products for CA1: |
Protein
Domains /
Families
for CA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CA1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P00915ProtoNet protein and cluster: P00915 1 Blocks protein family: IPB001148 Carbonic anhydrase
UniProtKB/Swiss-Prot: CAH1_HUMAN, P00915Similarity: Belongs to the alpha-carbonic anhydrase family |
Function
for CA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CAH1_HUMAN, P00915Function: Reversible hydration of carbon dioxide. Can hydrates cyanamide to ureaCatalytic activity: H(2)CO(3) = CO(2) + H(2)OEnzyme regulation: Activated by histamine, imidazole, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine.Inhibited by coumarins, sulfonamide derivatives such as acetazolamide, benzenesulfonamide and derivatives(4-carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester,4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide), and 'prong inhibitors' BR15, BR17, BR22and BR30. Activated by a short exposition to Foscarnet (phosphonoformate trisodium salt), but inhibited by a long one.Esterase activity weakly reduced by cyanamideBiophysicochemical properties: Kinetic parameters: KM=4.0 mM for CO(2); KM=15 mM for 4-nitrophenyl acetate; Genatlas biochemistry entry for CA1:carbonic anhydrase I,cytosolic,erythrocyte
Enzyme Number (IUBMB): EC 4.2.1.11 2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004089 | carbonate dehydratase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
CA1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for CA1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA1 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CA1 (NM_005502) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA1 |
|
Pathways & Interactions
for CA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | O2/CO2 exchange in erythrocytes | | | 2 | Reversible Hydration of Carbon Dioxide | | | 3 | C-MYB transcription factor network | | | 4 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CA1
5 
Reactome Pathways for CA1
1 
Kegg Pathway (Kegg details for CA1):
CA1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CA1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for CA1 (P009152, 3 ENSP000002561194) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006730 | one-carbon metabolic process |
IEA | -- | | GO:0015701 | bicarbonate transport |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
CA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CA1 for compounds About GeneDecksing
 Browse Tocris compounds for CA1
7 HMDB Compounds for CA1 About this table
10/23 DrugBank Compounds for CA1 (see all 23) About this table
10/23 Novoseek chemical compound relationships for CA1 gene (see all 23) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| benzenesulfonamide |
86 |
1 |
15736932 (1) |
| p-nitrophenyl acetate |
80.3 |
1 |
16999776 (1) |
| sulfonamide |
79.6 |
7 |
12164389 (1), 15499997 (1), 15751944 (1), 18475761 (1) (see all 7) |
| dansylamide |
78.4 |
3 |
15751944 (2) |
| sulfamide |
73.3 |
2 |
16999776 (1), 17627576 (1) |
| dichlorphenamide |
70.4 |
1 |
16634001 (1) |
| acetazolamide |
69 |
7 |
8667211 (2), 10768298 (1), 8494570 (1), 11430635 (1) (see all 5) |
| methazolamide |
66.2 |
1 |
16634001 (1) |
| metaproterenol |
56 |
1 |
11262584 (1) |
| zinc |
53.3 |
29 |
8804152 (2), 12009884 (1), 2125094 (1), 1943730 (1) (see all 11) |
Search CenterWatch for drugs/clinical trials and news about CA1 / CAH1
|
Transcripts
for CA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CA1 gene (5 alternative transcripts): NM_001128829.2 NM_001128830.2 NM_001128831.2 NM_001164830.1 NM_001738.3 Unigene Cluster for CA1: Carbonic anhydrase I Hs.23118 [show with all ESTs]Unigene Representative Sequence: M3398718/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26): ENST00000523953(uc003ydh.3 uc003ydi.3) ENST00000523022 ENST00000522389
ENST00000521679 ENST00000524324 ENST00000517618 ENST00000519991 ENST00000523712
ENST00000520663 ENST00000517590 ENST00000518233 ENST00000517429 ENST00000521846
ENST00000522579 ENST00000518341 ENST00000522814 ENST00000522662 ENST00000523858
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CA1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CA1 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CA1 (NM_005502) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CA1 |
Additional cDNA sequence: BC027890.1 M33987.1 X05014.1 24/25 DOTS entries (see all 25): DT.121482872 DT.100031767 DT.100031745 DT.121482841 DT.100031757 DT.100031744 DT.121482834 DT.100794821 DT.100031763 DT.121482894 DT.100031768 DT.100794820 DT.100031746 DT.100794823 DT.100031742 DT.100031749 DT.100031758 DT.100031760 DT.100031761 DT.100031762 DT.100031766 DT.100794822 DT.95361469 DT.99969459 24/1202 AceView cDNA sequences (see all 1202): BU661378 BU661646 BU659856 AW848548 BU656564 BU663781 BU659445 BU660960 BU662290 BU657032 BU657438 BU657677 BU661688 BU660938 BU665399 BU661909 BU662069 BU657453 BU656616 BU656892 BU656890 BU656053 BU664791 BU664202
GeneLoc Exon Structure
5/20 Alternative Splicing Database (ASD) splice patterns (SP) for CA1 (see all 20) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16b | · | 16c | · | 16d | · | 16e |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for CA1
|
Expression
for CA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTCAAATC
About this image
See CA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CA1
SOURCE GeneReport for Unigene cluster: Hs.23118
SABiosciences Custom PCR Arrays for CA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CA1 |
Orthologs
for CA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CA1 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.156302 |
Transcribed sequence with weak similarity to protein more |
70.5(n) |
|
BX735639.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ca26cahz6 |
carbonic anhydrase |
62(a)61(a) |
many ↔ manymany ↔ many |
24(33852211-33870040) 2(29192215-29200240) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CAH13 |
carbonate dehydratase |
47(a) |
|
34D4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
cah-33 |
carbonic anhydrase |
33(a) |
|
X(16518334-16519911) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ACA11 |
carbonic anhydrase |
46.88(n)
36.53(a) |
|
824438 NM_115132.2 NP_566971.2 |
rice
(Oryza sativa) |
Liliopsida |
Os02g05333001 |
hypothetical protein |
45.19(n)
36.89(a) |
|
4329556 NM_001053565.2 NP_001047030.1 |
ENSEMBL Gene Tree for CA1 (if available)
TreeFam Gene Tree for CA1 (if available) |
Paralogs
for CA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CA1 gene
- CA22 CA122 CA72 CA62 CA32 CA112 CA5B2 CA142
- CA5A2 CA82 CA42 CA92 CA132 CA102
14 SIMAP similar genes for CA1 using alignment to 14 protein entries: CAH1_HUMAN (see all proteins):CA13 CA3 CA2 CA7 CA5B CA5A
CA10 CA8 DKFZp686I20267 CA12 CA6 CA14
PTPRZ1 PTPRG
CA1 for paralogs About GeneDecksing
|
Genomic Variants
for CA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CA1 (86239837 - 86291243 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CA1
1 CNV: 4601
Human Gene Mutation Database (HGMD): CA1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CA1 |
|
Disorders
/ Diseases
for CA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CA1 for disorders About GeneDecksing
OMIM gene information: 114800
OMIM disorders: --
20/32  diseases for CA1 (see all 32): About MalaCardstransient global amnesia familial adenomatous polyposis temporal lobe epilepsy ankylosing spondylitis
labyrinthitis subacute thyroiditis thyrotoxicosis polyposis
ulcerative colitis spondylitis diabetic retinopathy colonic neoplasm
brain ischemia sjogren's syndrome graves' disease gastric cancer
endocarditis colorectal cancer kidney disease ischemia
2 diseases from the University of Copenhagen DISEASES database for CA1:Amnestic disorder Vascular disease 10/12 Novoseek disease relationships for CA1 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hyperthyroidism |
36.5 |
6 |
1899425 (1), 1943730 (1), 9669291 (1), 8612521 (1) (see all 5) |
| erythroleukemia |
32.6 |
2 |
1719810 (1) |
| thyroid diseases |
21.4 |
3 |
8804152 (1), 17657991 (1) |
| chronic pancreatitis |
17.3 |
4 |
8613065 (2), 12806141 (1), 10824693 (1) |
| familial adenomatous polyposis |
9.64 |
1 |
8359594 (1) |
| tumors |
0.621 |
6 |
12927591 (2), 15908201 (1), 17187689 (1) |
| gastric cancer |
0 |
1 |
16185290 (1) |
| adenocarcinoma |
0 |
1 |
1690978 (1) |
| metastasis |
0 |
4 |
11020863 (2), 12927591 (1) |
| adenoma |
0 |
3 |
1690978 (1), 18708730 (1), 8359594 (1) |
Human Genome Epidemiology (HuGE) Navigator: CA1 (6 documents)
Export disorders for CA1 gene to outside databases
|
Publications
for CA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CA1 gene, integrated from 9 sources (see all 220):
(articles sorted by number of sources associating them with CA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination. (PubMed id 12009884)1, 2, 9 Ferraroni M.... Scozzafava A. (2002)
- Structure and methylation patterns of the gene encoding human carbonic anhydrase I. (PubMed id 2121614)1, 2, 9 Lowe N....Butterworth P.H.W. (1990)
- Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X- ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. (PubMed id 17314045)1, 2, 9 Temperini C....Supuran C.T. (2007)
- Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action. (PubMed id 11392054)1, 7, 9 Puscas I....Hecht A. (2001)
- Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I. (PubMed id 7866410)1, 2, 9 Chegwidden W.R.... Tashian R.E. (1994)
- Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I. (PubMed id 16870440)1, 2 Temperini C.... Supuran C.T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8. (PubMed id 1916821)1, 3 Lowe N....Butterworth P.H. (1991)
- Human carbonic anhydrase I cDNA. (PubMed id 3104879)1, 2 Barlow J.H.... Butterworth P.H.W. (1987)
- Population genetic studies of the Philippine Negritos. III. Identification of the carbonic anhydrase-1 variant with CA1 Guam. (PubMed id 6781336)1, 2 Omoto K.... Pagaran I.G. (1981)
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External Searches for CA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CA1 gene
(According to HUGE)
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Specialized Databases showing CA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CA1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CA1 gene:
Search GeneIP for patents involving CA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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