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CA1 Gene

protein-coding GIFtS: 65

GC08M086427

carbonic anhydrase I
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CA-I ^³
CAB ^³
Car1 ^¹, ²
EC 4.2.1.1 ^³

Descriptions
Carbonate dehydratase I ^³
Carbonic anhydrase B ^³
carbonic anhydrase I ^², ³
carbonic dehydratase ^²

External Ids
HGNC: 1368¹
Entrez Gene: 759²
UniProtKB: P00915³
Ensembl: ENSG00000133742⁷

Search outside databases for aliases for CA1 gene

Previous GC identifers: GC08M085064 GC08M086197 GC08M086020 GC08M086315

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CA1:

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible

hydration of carbon dioxide. They participate in a variety of biological processes, including

respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous

humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue

distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on

chromosome 8, and it encodes a cytosolic protein which is found at the highest level in

erythrocytes. Transcript variants of CA1 utilizing alternative polyA_sites have been described in

literature. [provided by RefSeq]

UniProtKB/Swiss-Prot: CAH1_HUMAN, P00915

Function: Reversible hydration of carbon dioxide

Gene Wiki entry for CA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CA1 gene

Entrez Gene cytogenetic band: 8q13-q22.1 Ensembl cytogenetic band: 8q21.2 HGNC cytogenetic band: 8q21.2

CA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M086427: (about GC identifiers)

Start:	86,427,709 bp from pter
End:	86,477,594 bp from pter
Size:	49,886 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CAH1_HUMAN, P00915 (See protein sequence)

Recommended Name: Carbonic anhydrase 1

Size: 261 amino acids; 28870 Da

Cofactor: Zinc

Subcellular location: Cytoplasm

PDB structures from and Proteopedia :

1AZM (3D)

1BZM (3D)

1CRM (3D)

1CZM (3D)

1HCB (3D)

1HUG (3D)

1HUH (3D)

1J9W (3D)

1JV0 (3D)

2CAB (3D)

2FOY (3D)

2FW4 (3D)

2IT4 (3D)

2NMX (3D)

2NN1 (3D)

2NN7 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001122301.1 NP_001122302.1 NP_001122303.1 NP_001729.1

ENSEMBL proteins:

ENSP00000256119

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and CompoZr ZFN for CA1
	R&D Systems Recombinant & Natural Proteins for CA1 (Carbonic Anhydrase I)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Carbonic Anhydrase I)
	Human Recombinant Proteins from Abnova (CA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005794	Golgi apparatus	IDA	18029348

About this table

Antibodies for CA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CA1
	Sigma-Aldrich Antibodies for CA1
	R&D Systems Antibodies for CA1 (Carbonic Anhydrase I)
	Antibodies from Abcam (Carbonic Anhydrase I), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CA1)
	Novus Biologicals Antibodies for CA1

Assays for CA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00915

ProtoNet protein and cluster: P00915

1 Blocks protein family: IPB001148 Carbonic anhydrase

UniProtKB/Swiss-Prot: CAH1_HUMAN, P00915

Similarity: Belongs to the alpha-carbonic anhydrase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001738

Applied Biosystems Silencer® siRNAs for CA1

Sigma-Aldrich siRNA and siRNA Panels for CA1

Sigma-Aldrich shRNA Panels and shRNA for CA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001128829
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001128829
untagged cDNA clones in CMV expression vector (see all 4): NM_001128829

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001128830

UniProtKB/Swiss-Prot: CAH1_HUMAN, P00915

Function: Reversible hydration of carbon dioxide

Catalytic activity: H(2)CO(3) = CO(2) + H(2)O

Enzyme Number (IUBMB): EC 4.2.1.1

Genatlas biochemistry entry for CA1:

carbonic anhydrase I,cytosolic,erythrocyte

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004089	carbonate dehydratase activity	TAS	2121614
GO:0008270	zinc ion binding	IEA	--
GO:0016829	lyase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CA1 (Your Favorite Gene powered by Ingenuity)

Nitrogen Metabolism
Methionine Metabolism

GeneDecks CA1 for the pathways selected above

About GeneDecksing

2 Interacting proteins for CA1 (ENSP00000256119³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDX2	ENSP00000370408³	STRING (score=.927)
ENSG00000166278	ENSP00000299367³	STRING (score=.753)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006730	one-carbon compound metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for CA1:

Activator Inhibitor

Browse Tocris compounds for CA1
10 Novoseek chemical compound relationships for CA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
p-nitrophenyl acetate	80.76	1	16999776 (1)
dansylamide	79.12	3	15751944 (2)
sulfamide	73.99	2	16999776 (1), 17627576 (1)
zinc	53.44	28	8804152 (2), 12009884 (1), 2125094 (1), 1943730 (1) (see all 10)
cyanate	51.92	1	9629531 (1)
bicarbonate	36.41	2	8057362 (1), 1554744 (1)
hydrogen	10.01	3	1312606 (2), 9390408 (1)
histidine	5.60	1	2114290 (1)
calcium	3.40	2	11061585 (2)
urea	0.00	1	9629531 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001738

Sigma-Aldrich siRNA and siRNA Panels for CA1

Sigma-Aldrich shRNA Panels and shRNA for CA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001128829 NM_001128830 NM_001128831 NM_001738

REFSEQ mRNAs for CA1 gene (4 alternative transcripts):

NM_001128829.1 NM_001128830.1 NM_001128831.1 NM_001738.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001128829 NM_001128830 NM_001128831 NM_001738

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001128829
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001128829
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001128829

Additional cDNA sequence:

BC027890.1 M33987.1 X05014.1

24/25 DOTS entries (see all 25 ):

DT.121482872 DT.100031767 DT.100031745 DT.121482841 DT.100031757 DT.100031744 DT.121482834 DT.100794821

DT.100031763 DT.121482894 DT.100031768 DT.100794820 DT.100031746 DT.100794823 DT.91971847 DT.100031742

DT.100031749 DT.100031758 DT.100031760 DT.100031761 DT.100031762 DT.100031766 DT.100794822 DT.95361469

24/1202 AceView cDNA sequences (see all 1202 ):

BU656674 BU665399 BU660932 BU664664 AW083254 BU656096 BU656564 BU657648

BU659740 BU664735 BU664226 BU660481 BU658937 BU658447 BU656876 BU660938

BU657631 BU656486 BU664611 BU665447 AW135107 BU656862 BU657296 BU663769

highest scoring ESTs for CA1:

M33987 BC027890 BI838466 BU655732 BU655746 BU655749 BU655754 BU655755 BU655766 BU655767

Unigene Cluster for CA1:

Carbonic anhydrase I

Hs.23118 [show with all ESTs]

Unigene Representative Sequence: M33987

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for CA1 (see all 20 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	·	11d	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14	^	15	^	16a	·
SP1:			-		-		-		-		-		-				-				-		-		-		-
SP2:																	-				-		-		-		-																-		-		-
SP3:											-		-				-				-		-		-		-
SP4:																	-				-		-		-		-
SP5:																	-						-		-		-

ExUns:	16b	·	16c	·	16d	·	16e
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CA1

1 Ensembl transcript including schematic representation:

ENST00000256119

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CA1

¹ / ² / ³

5 probe-sets matching CA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39241_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M33987	1.00	1.00	1.00	1
205950_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001738	0.60	1.00	0.82	1
205949_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M33987	1.00	1.00	1.00	1
205950_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205949_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTTCAAATC

SOURCE GeneReport for Unigene cluster: Hs.23118
Expression variation in blood from EXPOLDB for CA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CA1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CA1¹	--	carbonic anhydrase I	87.1(n) 84.29(a)	487031 XM_544160.2 XP_544160.1
chimpanzee (Pan troglodytes)	CA1¹	--	carbonic anhydrase I	99.11(n) 99.23(a)	464264 XM_519839.2 XP_519839.1
cow (Bos taurus)	CA1¹	--	carbonic anhydrase I	83.01(n) 79.31(a)	510801 NM_001075466.1 NP_001068934.1
rat (Rattus norvegicus)	Car1¹	--	carbonic anhydrase 1	82.12(n) 81.23(a)	310218 XM_226922.4 XP_226922.3
mouse (Mus musculus)	Car1^{1, 5}	3 (10.50 cM)⁵	carbonic anhydrase 1^{1, 5}	81.74(n)¹ 78.16(a)¹	12346¹ NM_009799.3¹ NP_033929.2¹ AK003066⁵ AK033719⁵ (see all 27)

About this table Species with no ortholog for CA1

ENSEMBL Gene Tree for CA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CA1 gene

CA2² CA3² CA13²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/211 NCBI SNPs in CA1 are shown (see all 211 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3808539^1,2	A,C,F,H	86427437(+)	`GAAGCA/GTCATC`	1	--	ng5¹ ese³		11	NA EU EA WA	978
	rs7821248^1,2	C,F,H	86433028(+)	`TAACTG/ACCAAA`	4	V/A	mis¹		4	EU EA WA	420
	rs2432071^1,2	F,H	86479478(+)	`ACTTCG/AAGTTT`	1	--	ng3¹ tfbs³		4	EU EA WA	420
	rs1045899^1,2	F,H	86437881(-)	`AACCAG/ATCCCC`	4	Q/Q	syn¹ ese³		5	MN EU EA WA	596
	rs2725292^1,2	A,C,F,H,O	86465930(-)	`TTTCTA/CAACAG`	1	--	int¹		7	EU EA WA NA	548
	rs1532423^1,2	A,C,F,H,O	86455565(-)	`GGAGGC/TACAAA`	1	--	int¹		7	EU EA WA NA	552
	rs1496531^1,2	A,C,F,H,O	86441314(-)	`GTAGAA/TTTTTT`	1	--	int¹		7	NA EU EA WA	548
	rs1032551^1,2	A,C,F,H,O	86442331(-)	`AAATTC/GCTCCT`	1	--	int¹		12	EA NA EU WA	784
	rs1496530^1,2	A,C,F,H,O	86443150(-)	`ACATAA/GTCGTG`	1	--	int¹		4	EU EA WA	416
	rs1532424^1,2	A,C,F,H,O	86455444(-)	`CCACAA/CGTTGT`	1	--	int¹		7	EU EA WA NA	552

About this table

HapMap Linkage Disequilibrium images for CA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114800

10/12 Novoseek disease relationships for CA1 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperthyroidism	37.51	6	1899425 (1), 1943730 (1), 9669291 (1), 8612521 (1) (see all 5)
erythroleukemia	33.20	2	1719810 (1)
thyroid diseases	22.79	3	8804152 (1), 17657991 (1)
chronic pancreatitis	18.56	4	8613065 (2), 12806141 (1), 10824693 (1)
familial adenomatous polyposis	10.73	1	8359594 (1)
cancer	0.00	4	16088401 (1), 1615938 (1), 11680594 (1)
tumors	0.00	6	12927591 (2), 15908201 (1), 17187689 (1)
gastric cancer	0.00	1	16185290 (1)
adenocarcinoma	0.00	1	1690978 (1)
metastasis	0.00	4	11020863 (2), 12927591 (1)

About this table

Human Gene Mutation Database: CA1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/146 PubMed articles for CA1 gene (see all 146 ):

Structure and methylation patterns of the gene encoding human carbonic anhydrase I. (PubMed id 2121614)^{1, 3, 4} Lowe N....Butterworth P.H.W. (1990)
Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I. (PubMed id 7866410)^{1, 3, 4} Chegwidden W.R.... Tashian R.E. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Physical mapping of the human carbonic anhydrase gene cluster on chromosome 8. (PubMed id 1916821)^{2, 3} Lowe N....Butterworth P.H. (1991)
Human carbonic anhydrase I cDNA. (PubMed id 3104879)^{3, 4} Barlow J.H.... Butterworth P.H.W. (1987)
Population genetic studies of the Philippine Negritos. III. Identification of the carbonic anhydrase-1 variant with CA1 Guam. (PubMed id 6781336)^{3, 4} Omoto K.... Pagaran I.G. (1981)
Crystal structure of human erythrocyte carbonic anhydrase B. Three- dimensional structure at a nominal 2.2-A resolution. (PubMed id 804171)^{3, 4} Kannan K.K....Petef M. (1975)
Human carbonic anhydrases. XII. The complete primary structure of the C isozyme. (PubMed id 4207120)^{3, 4} Lin K.-T.D. and Deutsch H.F. (1974)
Primary structure of human B erythrocyte carbonic anhydrase. 3. Sequence of CNBr fragment I and III (residues 149-260). (PubMed id 4217196)^{3, 4} Giraud N.... Laurent-Tabusse G. (1974)
Human carbonic anhydrases. XI. The complete primary structure of carbonic anhydrase B. (PubMed id 4632246)^{3, 4} Lin K.-T.D. and Deutsch H.F. (1973)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 759	HGNC: 1368	AceView: CA1	Ensembl:ENSG00000133742	euGenes: HUgn759
ECgene: CA1	H-InvDB: CA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CA1		Antibodies for CA1
	Explore super-pooled esiRNAs		Proteins for CA1
	Lentivirus-delivered shRNAs for CA1		Small molecules for CA1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CA1)
	Antibodies (CA1)
	Chimera RNAi (CA1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Carbonic Anhydrase I)
	Antibodies (Carbonic Anhydrase I)

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Search Tocris compounds for CA1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CA1

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CA1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CA1

Summaries
for CA1

Genomic Location
for CA1

Proteins
for CA1

Protein Domains/
Families
for CA1

Gene Function
for CA1

Pathways & Interactions
for CA1

Drugs & Compounds
for CA1

Transcripts
for CA1

Expression
for CA1

Orthologs
for CA1

Paralogs
for CA1

SNPs/Variants
for CA1

Disorders & Mutations
for CA1

Medical News
for CA1

Publications
for CA1

Search for CA1

Genome Databases showing CA1

Other Databases showing CA1

Specialized Databases showing CA1

Licensable Technologies
for CA1

Services
for CA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CA1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CA1

Summariesfor CA1

Genomic Locationfor CA1

Proteinsfor CA1

Protein Domains/Familiesfor CA1

Gene Functionfor CA1

Pathways & Interactionsfor CA1

Drugs & Compoundsfor CA1

Transcriptsfor CA1

Expression for CA1

Orthologsfor CA1

Paralogsfor CA1

SNPs/Variantsfor CA1

Disorders & Mutationsfor CA1

Medical Newsfor CA1

Publicationsfor CA1

Search for CA1

Genome Databases showing CA1

Other Databases showing CA1

Specialized Databases showing CA1

Licensable Technologiesfor CA1

Servicesfor CA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CA1

Summaries
for CA1

Genomic Location
for CA1

Proteins
for CA1

Protein Domains/
Families
for CA1

Gene Function
for CA1

Pathways & Interactions
for CA1

Drugs & Compounds
for CA1

Transcripts
for CA1

Expression
for CA1

Orthologs
for CA1

Paralogs
for CA1

SNPs/Variants
for CA1

Disorders & Mutations
for CA1

Medical News
for CA1

Publications
for CA1

Licensable Technologies
for CA1

Services
for CA1