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Aliases for C9orf91 Gene

Aliases for C9orf91 Gene

  • Chromosome 9 Open Reading Frame 91 2 3 5

External Ids for C9orf91 Gene

Previous GeneCards Identifiers for C9orf91 Gene

  • GC09P112750
  • GC09P114453
  • GC09P116413
  • GC09P117373
  • GC09P086978

Summaries for C9orf91 Gene

GeneCards Summary for C9orf91 Gene

C9orf91 (Chromosome 9 Open Reading Frame 91) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf91 Gene

Genomics for C9orf91 Gene

Regulatory Elements for C9orf91 Gene

Genomic Location for C9orf91 Gene

Chromosome:
9
Start:
114,603,942 bp from pter
End:
114,646,423 bp from pter
Size:
42,482 bases
Orientation:
Plus strand

Genomic View for C9orf91 Gene

Genes around C9orf91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf91 Gene

Proteins for C9orf91 Gene

  • Protein details for C9orf91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZI3-CI091_HUMAN
    Recommended name:
    Transmembrane protein C9orf91
    Protein Accession:
    Q5VZI3
    Secondary Accessions:
    • A0PJA3
    • Q3KNS4
    • Q5VZI2
    • Q6P5Z7
    • Q8N1P3
    • Q8ND43

    Protein attributes for C9orf91 Gene

    Size:
    342 amino acids
    Molecular mass:
    37569 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04537.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C9orf91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf91 Gene

Proteomics data for C9orf91 Gene at MOPED

Post-translational modifications for C9orf91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf91 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C9orf91 Gene

Domains & Families for C9orf91 Gene

Protein Domains for C9orf91 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C9orf91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf91: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C9orf91 Gene

Function for C9orf91 Gene

genes like me logo Genes that share phenotypes with C9orf91: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C9orf91 Gene

Localization for C9orf91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C9orf91 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf91 Gene COMPARTMENTS Subcellular localization image for C9orf91 gene
Compartment Confidence
plasma membrane 3
cytosol 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for C9orf91 Gene

Pathways & Interactions for C9orf91 Gene

SuperPathways for C9orf91 Gene

No Data Available

Interacting Proteins for C9orf91 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000288502%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000295025%0d%0a
Selected Interacting proteins: ENSP00000288502 for C9orf91 Gene via STRING

Gene Ontology (GO) - Biological Process for C9orf91 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf91 Gene

Drugs & Compounds for C9orf91 Gene

No Compound Related Data Available

Transcripts for C9orf91 Gene

Unigene Clusters for C9orf91 Gene

Chromosome 9 open reading frame 91:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf91 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: -

Relevant External Links for C9orf91 Gene

GeneLoc Exon Structure for
C9orf91
ECgene alternative splicing isoforms for
C9orf91

Expression for C9orf91 Gene

mRNA expression in normal human tissues for C9orf91 Gene

Protein differential expression in normal tissues from HIPED for C9orf91 Gene

This gene is overexpressed in Testis (55.1) and Brain (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C9orf91 Gene



SOURCE GeneReport for Unigene cluster for C9orf91 Gene Hs.522357

genes like me logo Genes that share expression patterns with C9orf91: view

Protein tissue co-expression partners for C9orf91 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C9orf91 Gene

Orthologs for C9orf91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf91 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C8H9orf91 35
  • 87.33 (n)
  • 89.18 (a)
C9orf91 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H9orf91 35
  • 87.82 (n)
  • 90.94 (a)
C9orf91 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 6330416G13Rik 35
  • 85.92 (n)
  • 87.68 (a)
6330416G13Rik 16
6330416G13Rik 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf91 35
  • 99.22 (n)
  • 99.71 (a)
C9ORF91 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304595 35
  • 85.04 (n)
  • 87.39 (a)
oppossum
(Monodelphis domestica)
Mammalia C9orf91 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf91 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF91 35
  • 61.37 (n)
  • 48.34 (a)
C9orf91 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485830 35
  • 52.26 (n)
  • 42.86 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559789 35
  • 46.21 (n)
  • 33.9 (a)
C19H9orf91 36
  • 28 (a)
OneToOne
Species with no ortholog for C9orf91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf91 Gene

ENSEMBL:
Gene Tree for C9orf91 (if available)
TreeFam:
Gene Tree for C9orf91 (if available)

Paralogs for C9orf91 Gene

No data available for Paralogs for C9orf91 Gene

Variants for C9orf91 Gene

Sequence variations from dbSNP and Humsavar for C9orf91 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs728407 -- 114,605,790(-) CCACC(A/G)TATCC intron-variant
rs751780 -- 114,633,601(-) GGCAG(G/T)CACAG intron-variant
rs756015 -- 114,632,923(+) GCAGA(A/G)CTGGG intron-variant
rs756016 -- 114,632,947(+) CTGTC(C/T)GACAC intron-variant
rs999009 -- 114,628,397(-) AATTT(G/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf91 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv948n27 CNV Gain 19166990
nsv831694 CNV Gain 17160897
nsv7433 OTHER Inversion 18451855
esv1008480 CNV Deletion 20482838
nsv893766 CNV Gain 21882294
nsv520757 CNV Gain 19592680
nsv6679 CNV Insertion 18451855

Variation tolerance for C9orf91 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf91 Gene

HapMap Linkage Disequilibrium report
C9orf91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf91 Gene

Disorders for C9orf91 Gene

Relevant External Links for C9orf91

Genetic Association Database (GAD)
C9orf91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf91

No disorders were found for C9orf91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf91 Gene

Publications for C9orf91 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for C9orf91 Gene

Sources for C9orf91 Gene

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