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Aliases for C9orf89 Gene

Aliases for C9orf89 Gene

  • Chromosome 9 Open Reading Frame 89 2 3
  • Bcl10-Interacting Protein With CARD 2 3
  • BinCARD 3 4
  • BA370F5.1 3
  • CARD19 3

External Ids for C9orf89 Gene

Previous GeneCards Identifiers for C9orf89 Gene

  • GC09P091200
  • GC09P092938
  • GC09P094898
  • GC09P095858
  • GC09P065535

Summaries for C9orf89 Gene

GeneCards Summary for C9orf89 Gene

C9orf89 (Chromosome 9 Open Reading Frame 89) is a Protein Coding gene. GO annotations related to this gene include CARD domain binding.

UniProtKB/Swiss-Prot for C9orf89 Gene

  • Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf89 Gene

Genomics for C9orf89 Gene

Regulatory Elements for C9orf89 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C9orf89 Gene

Chromosome:
9
Start:
93,096,129 bp from pter
End:
93,113,283 bp from pter
Size:
17,155 bases
Orientation:
Plus strand

Genomic View for C9orf89 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf89 Gene

Proteins for C9orf89 Gene

  • Protein details for C9orf89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW7-BINCA_HUMAN
    Recommended name:
    Bcl10-interacting CARD protein
    Protein Accession:
    Q96LW7
    Secondary Accessions:
    • Q5BJH8
    • Q9BSY2

    Protein attributes for C9orf89 Gene

    Size:
    228 amino acids
    Molecular mass:
    25589 Da
    Quaternary structure:
    • Associates with BCL10 by CARD-CARD interaction

    Three dimensional structures from OCA and Proteopedia for C9orf89 Gene

    Alternative splice isoforms for C9orf89 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf89 Gene

Proteomics data for C9orf89 Gene at MOPED

Post-translational modifications for C9orf89 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf89 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C9orf89 Gene

Domains & Families for C9orf89 Gene

Protein Domains for C9orf89 Gene

Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for C9orf89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LW7

UniProtKB/Swiss-Prot:

BINCA_HUMAN :
  • Contains 1 CARD domain.
Domain:
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with C9orf89: view

No data available for Gene Families for C9orf89 Gene

Function for C9orf89 Gene

Molecular function for C9orf89 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Gene Ontology (GO) - Molecular Function for C9orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050700 CARD domain binding NAS 15637807
genes like me logo Genes that share ontologies with C9orf89: view

Phenotypes for C9orf89 Gene

GenomeRNAi human phenotypes for C9orf89:
genes like me logo Genes that share phenotypes with C9orf89: view

Animal Model Products

CRISPR Products

miRNA for C9orf89 Gene

miRTarBase miRNAs that target C9orf89

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf89

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf89 Gene

Localization for C9orf89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C9orf89 Gene

Isoform 1: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.
Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf89 Gene COMPARTMENTS Subcellular localization image for C9orf89 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 3
mitochondrion 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for C9orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15637807
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol NAS 15637807
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with C9orf89: view

Pathways & Interactions for C9orf89 Gene

SuperPathways for C9orf89 Gene

No Data Available

Interacting Proteins for C9orf89 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364613%0d%0a9606.ENSP00000271015%0d%0a
Selected Interacting proteins: Q96LW7-BINCA_HUMAN ENSP00000364613 for C9orf89 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for C9orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling NAS 15637807
genes like me logo Genes that share ontologies with C9orf89: view

No data available for Pathways by source and SIGNOR curated interactions for C9orf89 Gene

Drugs & Compounds for C9orf89 Gene

No Compound Related Data Available

Transcripts for C9orf89 Gene

Unigene Clusters for C9orf89 Gene

Chromosome 9 open reading frame 89:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf89

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf89 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9: - - -
SP10: -
SP11:

Relevant External Links for C9orf89 Gene

GeneLoc Exon Structure for
C9orf89
ECgene alternative splicing isoforms for
C9orf89

Expression for C9orf89 Gene

mRNA expression in normal human tissues for C9orf89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C9orf89 Gene

This gene is overexpressed in Whole Blood (x8.8).

Protein differential expression in normal tissues from HIPED for C9orf89 Gene

This gene is overexpressed in Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C9orf89 Gene



SOURCE GeneReport for Unigene cluster for C9orf89 Gene Hs.434213

mRNA Expression by UniProt/SwissProt for C9orf89 Gene

Q96LW7-BINCA_HUMAN
Tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.
genes like me logo Genes that share expression patterns with C9orf89: view

Protein tissue co-expression partners for C9orf89 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for C9orf89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf89 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C8H9orf89 35
  • 84.34 (n)
  • 87.43 (a)
C9orf89 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110007C09Rik 35
  • 87.43 (n)
  • 90.16 (a)
1110007C09Rik 16
1110007C09Rik 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf89 35
  • 86.7 (n)
  • 82.51 (a)
C9orf89 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306058 35
  • 85.82 (n)
  • 86.74 (a)
dog
(Canis familiaris)
Mammalia C9orf89 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C9orf89 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf89 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12H9ORF89 35
  • 61.42 (n)
  • 56.74 (a)
C9orf89 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf89 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11132 35
zebrafish
(Danio rerio)
Actinopterygii LOC557314 35
  • 52.79 (n)
  • 38.73 (a)
C11H9orf89 36
  • 37 (a)
OneToOne
Species with no ortholog for C9orf89:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf89 Gene

ENSEMBL:
Gene Tree for C9orf89 (if available)
TreeFam:
Gene Tree for C9orf89 (if available)

Paralogs for C9orf89 Gene

No data available for Paralogs for C9orf89 Gene

Variants for C9orf89 Gene

Sequence variations from dbSNP and Humsavar for C9orf89 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs15026 -- 93,113,171(-) GTCCC(A/C)TTGGC utr-variant-3-prime
rs1970623 -- 93,109,467(+) TACTT(C/T)TGTCT intron-variant
rs2027585 -- 93,111,788(+) CAGGA(C/G/T)GCAGC intron-variant, utr-variant-3-prime
rs2275849 -- 93,107,661(+) CTGTG(C/T)TATCT intron-variant
rs2298242 -- 93,113,274(+) GTTCA(A/G)GTTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C9orf89 Gene

Variant ID Type Subtype PubMed ID
nsv526296 CNV Loss 19592680
nsv893576 CNV Gain 21882294
dgv8260n71 CNV Loss 21882294
dgv8261n71 CNV Loss 21882294
nsv893580 CNV Loss 21882294

Variation tolerance for C9orf89 Gene

Residual Variation Intolerance Score: 77.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.43; 63.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf89 Gene

HapMap Linkage Disequilibrium report
C9orf89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf89 Gene

Disorders for C9orf89 Gene

Relevant External Links for C9orf89

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf89
genes like me logo Genes that share disorders with C9orf89: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf89 Gene

Publications for C9orf89 Gene

  1. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. (PMID: 15637807) Woo H.-N. … Jung Y.-K. (FEBS Lett. 2004) 2 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. (PMID: 23633586) Chen K.E. … Martin J. (Acta Crystallogr. D 2013) 67
  5. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S. … Elledge S.J. (Science 2007) 67

Products for C9orf89 Gene

Sources for C9orf89 Gene

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