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Aliases for C9orf89 Gene

Aliases for C9orf89 Gene

  • Chromosome 9 Open Reading Frame 89 2 3
  • Bcl10-Interacting Protein With CARD 2 3
  • BinCARD 3 4
  • Bcl10-Interacting CARD Protein 3
  • BA370F5.1 3

External Ids for C9orf89 Gene

Summaries for C9orf89 Gene

GeneCards Summary for C9orf89 Gene

C9orf89 (Chromosome 9 Open Reading Frame 89) is a Protein Coding gene. GO annotations related to this gene include CARD domain binding.

UniProtKB/Swiss-Prot for C9orf89 Gene

  • Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf89 Gene

Genomics for C9orf89 Gene

Genomic Location for C9orf89 Gene

Start:
93,096,168 bp from pter
End:
93,113,283 bp from pter
Size:
17,116 bases
Orientation:
Plus strand

Genomic View for C9orf89 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf89 Gene

Regulatory Elements for C9orf89 Gene

Proteins for C9orf89 Gene

  • Protein details for C9orf89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LW7-BINCA_HUMAN
    Recommended name:
    Bcl10-interacting CARD protein
    Protein Accession:
    Q96LW7
    Secondary Accessions:
    • Q5BJH8
    • Q9BSY2

    Protein attributes for C9orf89 Gene

    Size:
    228 amino acids
    Molecular mass:
    25589 Da
    Quaternary structure:
    • Associates with BCL10 by CARD-CARD interaction

    Three dimensional structures from OCA and Proteopedia for C9orf89 Gene

    Alternative splice isoforms for C9orf89 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf89 Gene

Proteomics data for C9orf89 Gene at MOPED

Post-translational modifications for C9orf89 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf89 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C9orf89 Gene

Domains for C9orf89 Gene

Protein Domains for C9orf89 Gene

Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BINCA_HUMAN
Domain:
  • Contains 1 CARD domain.:
    • Q96LW7
genes like me logo Genes that share domains with C9orf89: view

No data available for Gene Families for C9orf89 Gene

Function for C9orf89 Gene

Molecular function for C9orf89 Gene

UniProtKB/Swiss-Prot Function: Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.

Gene Ontology (GO) - Molecular Function for C9orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050700 CARD domain binding NAS 15637807
genes like me logo Genes that share ontologies with C9orf89: view

miRNA for C9orf89 Gene

miRTarBase miRNAs that target C9orf89

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C9orf89 Gene

Localization for C9orf89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C9orf89 Gene

Isoform 1: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.
Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf89 Gene COMPARTMENTS Subcellular localization image for C9orf89 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C9orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15637807
GO:0005739 mitochondrion --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with C9orf89: view

Pathways for C9orf89 Gene

SuperPathways for C9orf89 Gene

No Data Available

Interacting Proteins for C9orf89 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364613%0d%0a9606.ENSP00000271015%0d%0a
Selected Interacting proteins: Q96LW7-BINCA_HUMAN ENSP00000364613 for C9orf89 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for C9orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling NAS 15637807
genes like me logo Genes that share ontologies with C9orf89: view

No data available for Pathways by source for C9orf89 Gene

Transcripts for C9orf89 Gene

Unigene Clusters for C9orf89 Gene

Chromosome 9 open reading frame 89:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf89 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8: - -
SP9: - - -
SP10: -
SP11:

Relevant External Links for C9orf89 Gene

GeneLoc Exon Structure for
C9orf89
ECgene alternative splicing isoforms for
C9orf89

Expression for C9orf89 Gene

mRNA expression in normal human tissues for C9orf89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C9orf89 Gene

This gene is overexpressed in Whole Blood (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for C9orf89 Gene

SOURCE GeneReport for Unigene cluster for C9orf89 Gene Hs.434213

mRNA Expression by UniProt/SwissProt for C9orf89 Gene

Q96LW7-BINCA_HUMAN
Tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.
genes like me logo Genes that share expressions with C9orf89: view

Orthologs for C9orf89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf89 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf89 36
  • 86.7 (n)
  • 82.51 (a)
C9orf89 37
  • 43 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8H9orf89 36
  • 84.34 (n)
  • 87.43 (a)
C9orf89 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9orf89 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110007C09Rik 36
  • 87.43 (n)
  • 90.16 (a)
1110007C09Rik 16
1110007C09Rik 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C9orf89 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf89 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306058 36
  • 85.82 (n)
  • 86.74 (a)
chicken
(Gallus gallus)
Aves C12H9ORF89 36
  • 61.42 (n)
  • 56.74 (a)
C9orf89 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf89 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11132 36
zebrafish
(Danio rerio)
Actinopterygii C11H9orf89 37
  • 37 (a)
OneToOne
LOC557314 36
  • 52.79 (n)
  • 38.73 (a)
Species with no ortholog for C9orf89:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf89 Gene

ENSEMBL:
Gene Tree for C9orf89 (if available)
TreeFam:
Gene Tree for C9orf89 (if available)

Paralogs for C9orf89 Gene

No data available for Paralogs for C9orf89 Gene

Variants for C9orf89 Gene

Sequence variations from dbSNP and Humsavar for C9orf89 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs15026 -- 93,113,171(-) GTCCC(A/C)TTGGC utr-variant-3-prime, nc-transcript-variant
rs1970623 -- 93,109,467(+) TACTT(C/T)TGTCT intron-variant
rs2027585 -- 93,111,788(+) CAGGA(C/G/T)GCAGC intron-variant, nc-transcript-variant
rs2275849 -- 93,107,661(+) CTGTG(C/T)TATCT intron-variant
rs2298242 -- 93,113,274(+) GTTCA(A/G)GTTCT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf89 Gene

Variant ID Type Subtype PubMed ID
nsv526296 CNV Loss 19592680
nsv893576 CNV Gain 21882294
dgv8260n71 CNV Loss 21882294
dgv8261n71 CNV Loss 21882294
nsv893580 CNV Loss 21882294

Relevant External Links for C9orf89 Gene

HapMap Linkage Disequilibrium report
C9orf89

Disorders for C9orf89 Gene

No disorders were found for C9orf89 Gene.

No data available for UniProtKB/Swiss-Prot for C9orf89 Gene

Publications for C9orf89 Gene

  1. Inhibition of Bcl10-mediated activation of NF-kappa B by BinCARD, a Bcl10-interacting CARD protein. (PMID: 15637807) Woo H.-N. … Jung Y.-K. (FEBS Lett. 2004) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for C9orf89 Gene

Sources for C9orf89 Gene

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