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Aliases for C9orf85 Gene

Aliases for C9orf85 Gene

  • Chromosome 9 Open Reading Frame 85 2 3

External Ids for C9orf85 Gene

Previous GeneCards Identifiers for C9orf85 Gene

  • GC09P069983
  • GC09P071755
  • GC09P073716
  • GC09P074526
  • GC09P044349

Summaries for C9orf85 Gene

GeneCards Summary for C9orf85 Gene

C9orf85 (Chromosome 9 Open Reading Frame 85) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf85 Gene

Genomics for C9orf85 Gene

Regulatory Elements for C9orf85 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C9orf85 Gene

Chromosome:
9
Start:
71,911,321 bp from pter
End:
71,986,054 bp from pter
Size:
74,734 bases
Orientation:
Plus strand

Genomic View for C9orf85 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf85 Gene

Proteins for C9orf85 Gene

  • Protein details for C9orf85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MD7-CI085_HUMAN
    Recommended name:
    Uncharacterized protein C9orf85
    Protein Accession:
    Q96MD7
    Secondary Accessions:
    • Q5W0N1
    • Q5W0N3
    • Q6PJW9
    • Q86U95

    Protein attributes for C9orf85 Gene

    Size:
    179 amino acids
    Molecular mass:
    20166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH72769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C9orf85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf85 Gene

Proteomics data for C9orf85 Gene at MOPED

Post-translational modifications for C9orf85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf85 Gene

No data available for DME Specific Peptides for C9orf85 Gene

Domains & Families for C9orf85 Gene

Protein Domains for C9orf85 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf85: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf85 Gene

Function for C9orf85 Gene

Phenotypes for C9orf85 Gene

GenomeRNAi human phenotypes for C9orf85:
genes like me logo Genes that share phenotypes with C9orf85: view

Animal Model Products

CRISPR Products

miRNA for C9orf85 Gene

miRTarBase miRNAs that target C9orf85

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf85

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf85 Gene

Localization for C9orf85 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf85 Gene COMPARTMENTS Subcellular localization image for C9orf85 gene
Compartment Confidence
golgi apparatus 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf85 Gene

Pathways & Interactions for C9orf85 Gene

SuperPathways for C9orf85 Gene

No Data Available

Interacting Proteins for C9orf85 Gene

Gene Ontology (GO) - Biological Process for C9orf85 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf85 Gene

Drugs & Compounds for C9orf85 Gene

No Compound Related Data Available

Transcripts for C9orf85 Gene

Unigene Clusters for C9orf85 Gene

Chromosome 9 open reading frame 85:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf85

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf85 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - -
SP7:
SP8: - - - - - - -

Relevant External Links for C9orf85 Gene

GeneLoc Exon Structure for
C9orf85
ECgene alternative splicing isoforms for
C9orf85

Expression for C9orf85 Gene

mRNA expression in normal human tissues for C9orf85 Gene

Protein differential expression in normal tissues from HIPED for C9orf85 Gene

This gene is overexpressed in Lung (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C9orf85 Gene



SOURCE GeneReport for Unigene cluster for C9orf85 Gene Hs.534190

genes like me logo Genes that share expression patterns with C9orf85: view

Protein tissue co-expression partners for C9orf85 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C9orf85 Gene

Orthologs for C9orf85 Gene

This gene was present in the common ancestor of animals.

Orthologs for C9orf85 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C8H9orf85 35
  • 91.36 (n)
  • 92.59 (a)
-- 36
  • 89 (a)
OneToMany
C8H9ORF85 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C1H9orf85 35
  • 91.67 (n)
  • 91.18 (a)
C9orf85 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110059E24Rik 35
  • 84.52 (n)
  • 82.58 (a)
1110059E24Rik 16
1110059E24Rik 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf85 35
  • 99.36 (n)
  • 100 (a)
C9orf85 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1359158 35
  • 88.73 (n)
  • 88.24 (a)
oppossum
(Monodelphis domestica)
Mammalia C9orf85 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf85 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9orf85 35
  • 69.95 (n)
  • 69.7 (a)
C9orf85 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf85 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf85 35
  • 69.95 (n)
  • 71.21 (a)
Str.6988 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14278 35
zebrafish
(Danio rerio)
Actinopterygii zgc:101016 35
  • 65.93 (n)
  • 61.76 (a)
C5H9orf85 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4222 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003732 35
  • 54.31 (n)
  • 48.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8675 35
  • 52.48 (n)
  • 53.47 (a)
CG8675 36
  • 28 (a)
OneToOne
Species with no ortholog for C9orf85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf85 Gene

ENSEMBL:
Gene Tree for C9orf85 (if available)
TreeFam:
Gene Tree for C9orf85 (if available)

Paralogs for C9orf85 Gene

Pseudogenes.org Pseudogenes for C9orf85 Gene

genes like me logo Genes that share paralogs with C9orf85: view

No data available for Paralogs for C9orf85 Gene

Variants for C9orf85 Gene

Sequence variations from dbSNP and Humsavar for C9orf85 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs140856 -- 71,924,370(-) CGTTA(-/TTA)ACATT intron-variant
rs1137563 -- 71,930,669(+) gcatg(C/G)tggca intron-variant
rs1359254 -- 71,914,717(-) GTCCA(A/C)GTTTG intron-variant
rs1408322 -- 71,953,103(+) agaga(C/T)caggg intron-variant
rs1408323 -- 71,914,599(-) TATAT(A/T)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf85 Gene

Variant ID Type Subtype PubMed ID
nsv831618 CNV Loss 17160897
esv267786 CNV Insertion 20981092
esv273935 CNV Insertion 20981092
nsv521672 CNV Loss 19592680

Variation tolerance for C9orf85 Gene

Residual Variation Intolerance Score: 57.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf85 Gene

HapMap Linkage Disequilibrium report
C9orf85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf85 Gene

Disorders for C9orf85 Gene

Relevant External Links for C9orf85

Genetic Association Database (GAD)
C9orf85
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf85
genes like me logo Genes that share disorders with C9orf85: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf85 Gene

Publications for C9orf85 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  3. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 67
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 67
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D. … Mitchell G.F. (BMC Med. Genet. 2007) 67

Products for C9orf85 Gene

Sources for C9orf85 Gene

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