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Aliases for C9orf85 Gene

Aliases for C9orf85 Gene

  • Chromosome 9 Open Reading Frame 85 2 3 5

External Ids for C9orf85 Gene

Previous GeneCards Identifiers for C9orf85 Gene

  • GC09P069983
  • GC09P071755
  • GC09P073716
  • GC09P074526
  • GC09P044349

Summaries for C9orf85 Gene

GeneCards Summary for C9orf85 Gene

C9orf85 (Chromosome 9 Open Reading Frame 85) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf85 Gene

Genomics for C9orf85 Gene

Regulatory Elements for C9orf85 Gene

Enhancers for C9orf85 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G071791 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -116.4 -116441 6.1 PKNOX1 FOXA2 TBL1XR1 TEAD4 YY1 TEAD3 ZNF316 ARID3A ETV6 IKZF2 TMEM2 ABHD17B C9orf85 LOC100420790 GC09P071678
GH09G071806 1 Ensembl ENCODE 10.8 -104.3 -104258 0.3 ELF3 CTCF RAD21 RFX5 YY1 GATA3 ZNF143 SMC3 TCF7L2 MIXL1 ABHD17B C9orf85 LOC100420790 TMEM2
GH09G071961 0.6 ENCODE 16.6 +51.1 51115 1.6 CTCF ESRRA RFX1 CREB1 BMI1 FOXA1 C9orf85 ABHD17B TMEM2 GC09M071961 HSPB1P1
GH09G071944 0.6 ENCODE dbSUPER 16.6 +34.1 34060 2.3 STAT1 C9orf85 ABHD17B GC09M071961 PIR47528
GH09G071908 1.4 ENCODE dbSUPER 5.7 -0.4 -402 4.1 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 C9orf85 ABHD17B ENSG00000200922 GC09M071903
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C9orf85 on UCSC Golden Path with GeneCards custom track

Promoters for C9orf85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000235835 -521 3601 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1

Genomic Location for C9orf85 Gene

Chromosome:
9
Start:
71,911,321 bp from pter
End:
71,986,054 bp from pter
Size:
74,734 bases
Orientation:
Plus strand

Genomic View for C9orf85 Gene

Genes around C9orf85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf85 Gene

Proteins for C9orf85 Gene

  • Protein details for C9orf85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MD7-CI085_HUMAN
    Recommended name:
    Uncharacterized protein C9orf85
    Protein Accession:
    Q96MD7
    Secondary Accessions:
    • Q5W0N1
    • Q5W0N3
    • Q6PJW9
    • Q86U95

    Protein attributes for C9orf85 Gene

    Size:
    179 amino acids
    Molecular mass:
    20166 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH72769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C9orf85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf85 Gene

Post-translational modifications for C9orf85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf85 Gene

No data available for DME Specific Peptides for C9orf85 Gene

Domains & Families for C9orf85 Gene

Protein Domains for C9orf85 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf85: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf85 Gene

Function for C9orf85 Gene

genes like me logo Genes that share phenotypes with C9orf85: view

Animal Model Products

CRISPR Products

miRNA for C9orf85 Gene

miRTarBase miRNAs that target C9orf85

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf85 Gene

Localization for C9orf85 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf85 gene
Compartment Confidence
nucleus 3
golgi apparatus 2
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf85 Gene

Pathways & Interactions for C9orf85 Gene

SuperPathways for C9orf85 Gene

No Data Available

Interacting Proteins for C9orf85 Gene

Selected Interacting proteins: Q96MD7-CI085_HUMAN for C9orf85 Gene via IID

Symbol External ID(s) Details
IMP3
OSGEP

Gene Ontology (GO) - Biological Process for C9orf85 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf85 Gene

Transcripts for C9orf85 Gene

Unigene Clusters for C9orf85 Gene

Chromosome 9 open reading frame 85:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf85 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - -
SP7:
SP8: - - - - - - -

Relevant External Links for C9orf85 Gene

GeneLoc Exon Structure for
C9orf85
ECgene alternative splicing isoforms for
C9orf85

Expression for C9orf85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf85 Gene

Protein differential expression in normal tissues from HIPED for C9orf85 Gene

This gene is overexpressed in Lung (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C9orf85 Gene



Protein tissue co-expression partners for C9orf85 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C9orf85 Gene:

C9orf85

SOURCE GeneReport for Unigene cluster for C9orf85 Gene:

Hs.534190
genes like me logo Genes that share expression patterns with C9orf85: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf85 Gene

Orthologs for C9orf85 Gene

This gene was present in the common ancestor of animals.

Orthologs for C9orf85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9orf85 35
  • 100 (a)
OneToOne
C9H9orf85 34
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia C1H9orf85 34
  • 91.67 (n)
C9orf85 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8H9orf85 34
  • 91.36 (n)
-- 35
  • 89 (a)
OneToMany
C8H9ORF85 35
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1359158 34
  • 88.73 (n)
mouse
(Mus musculus)
Mammalia 1110059E24Rik 34 16 35
  • 84.52 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf85 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf85 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9orf85 34
  • 69.95 (n)
C9orf85 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf85 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf85 34
  • 69.95 (n)
Str.6988 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14278 34
zebrafish
(Danio rerio)
Actinopterygii zgc:101016 34
  • 65.93 (n)
C5H9orf85 35
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4222 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003732 34
  • 54.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8675 34 35
  • 52.48 (n)
Species where no ortholog for C9orf85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf85 Gene

ENSEMBL:
Gene Tree for C9orf85 (if available)
TreeFam:
Gene Tree for C9orf85 (if available)

Paralogs for C9orf85 Gene

Pseudogenes.org Pseudogenes for C9orf85 Gene

genes like me logo Genes that share paralogs with C9orf85: view

No data available for Paralogs for C9orf85 Gene

Variants for C9orf85 Gene

Sequence variations from dbSNP and Humsavar for C9orf85 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000000863 -- 71,925,504(+) GAAGA(A/C)GGTTC intron-variant
rs1000079004 -- 71,977,992(+) GGTAC(A/G)GTATT intron-variant
rs1000116613 -- 71,925,212(+) ACTGA(A/G)CATGT intron-variant
rs1000153171 -- 71,971,133(+) TGTTT(C/T)GTAAT intron-variant
rs1000180607 -- 71,972,668(+) TAAAT(A/G)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf85 Gene

Variant ID Type Subtype PubMed ID
esv2761535 CNV gain 21179565
esv3620617 CNV loss 21293372
esv3620620 CNV loss 21293372
nsv1050324 CNV gain 25217958
nsv521672 CNV loss 19592680
nsv614609 CNV loss 21841781
nsv831618 CNV loss 17160897

Variation tolerance for C9orf85 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C9orf85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf85 Gene

Disorders for C9orf85 Gene

Relevant External Links for C9orf85

Genetic Association Database (GAD)
C9orf85
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf85

No disorders were found for C9orf85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf85 Gene

Publications for C9orf85 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for C9orf85 Gene

Sources for C9orf85 Gene

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