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Aliases for C9orf84 Gene

Aliases for C9orf84 Gene

  • Chromosome 9 Open Reading Frame 84 2 3

External Ids for C9orf84 Gene

Previous GeneCards Identifiers for C9orf84 Gene

  • GC09M109828
  • GC09M109880
  • GC09M111528
  • GC09M113488
  • GC09M114448
  • GC09M084047

Summaries for C9orf84 Gene

GeneCards Summary for C9orf84 Gene

C9orf84 (Chromosome 9 Open Reading Frame 84) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf84 Gene

Genomics for C9orf84 Gene

Regulatory Elements for C9orf84 Gene

Genomic Location for C9orf84 Gene

111,686,173 bp from pter
111,795,008 bp from pter
108,836 bases
Minus strand

Genomic View for C9orf84 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf84 Gene

Proteins for C9orf84 Gene

  • Protein details for C9orf84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C9orf84
    Protein Accession:
    Secondary Accessions:
    • A2A2V3
    • Q2M1H8
    • Q96M73

    Protein attributes for C9orf84 Gene

    1444 amino acids
    Molecular mass:
    165202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C9orf84 Gene


neXtProt entry for C9orf84 Gene

Proteomics data for C9orf84 Gene at MOPED

Post-translational modifications for C9orf84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf84 Gene

No data available for DME Specific Peptides for C9orf84 Gene

Domains & Families for C9orf84 Gene

Protein Domains for C9orf84 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf84: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf84 Gene

Function for C9orf84 Gene

Phenotypes for C9orf84 Gene

GenomeRNAi human phenotypes for C9orf84:
genes like me logo Genes that share phenotypes with C9orf84: view

miRNA for C9orf84 Gene

miRTarBase miRNAs that target C9orf84

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf84

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf84 Gene

Localization for C9orf84 Gene

Subcellular locations from

Jensen Localization Image for C9orf84 Gene COMPARTMENTS Subcellular localization image for C9orf84 gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf84 Gene

Pathways & Interactions for C9orf84 Gene

SuperPathways for C9orf84 Gene

No Data Available

Interacting Proteins for C9orf84 Gene

Gene Ontology (GO) - Biological Process for C9orf84 Gene


No data available for Pathways by source and SIGNOR curated interactions for C9orf84 Gene

Drugs & Compounds for C9orf84 Gene

No Compound Related Data Available

Transcripts for C9orf84 Gene

Unigene Clusters for C9orf84 Gene

Chromosome 9 open reading frame 84:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf84

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf84 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32

Relevant External Links for C9orf84 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C9orf84 Gene

mRNA expression in normal human tissues for C9orf84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C9orf84 Gene

This gene is overexpressed in Testis (x28.4) and Kidney - Cortex (x5.2).

SOURCE GeneReport for Unigene cluster for C9orf84 Gene Hs.428209

genes like me logo Genes that share expression patterns with C9orf84: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C9orf84 Gene

Orthologs for C9orf84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf84 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC617568 35
  • 84.96 (n)
  • 74.72 (a)
C9orf84 36
  • 74 (a)
(Canis familiaris)
Mammalia C11H9orf84 35
  • 85.53 (n)
  • 75.78 (a)
C9orf84 36
  • 74 (a)
(Mus musculus)
Mammalia AI481877 35
  • 74.51 (n)
  • 61.13 (a)
AI481877 16
AI481877 36
  • 58 (a)
(Pan troglodytes)
Mammalia C9H9orf84 35
  • 99.4 (n)
  • 98.48 (a)
C9orf84 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC686050 35
  • 72.97 (n)
  • 60.56 (a)
(Monodelphis domestica)
Mammalia C9orf84 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia C9orf84 36
  • 27 (a)
(Gallus gallus)
Aves CZH9orf84 35
  • 59.1 (n)
  • 45.15 (a)
C9orf84 36
  • 43 (a)
(Anolis carolinensis)
Reptilia C9orf84 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487050 35
  • 51.82 (n)
  • 37.36 (a)
Species with no ortholog for C9orf84:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf84 Gene

Gene Tree for C9orf84 (if available)
Gene Tree for C9orf84 (if available)

Paralogs for C9orf84 Gene

No data available for Paralogs for C9orf84 Gene

Variants for C9orf84 Gene

Sequence variations from dbSNP and Humsavar for C9orf84 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs167566 -- 111,788,452(-) tcatg(A/T)gaatt intron-variant
rs315699 -- 111,777,581(-) aaaaa(A/G)atgtc intron-variant, upstream-variant-2KB
rs315700 -- 111,775,019(-) GACTG(A/C)ATCTC intron-variant
rs315704 -- 111,790,195(-) acttc(A/G)tgagg intron-variant
rs315705 -- 111,789,745(-) CCACG(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf84 Gene

Variant ID Type Subtype PubMed ID
nsv893724 CNV Gain 21882294
nsv893726 CNV Gain 21882294
nsv466486 CNV Gain 19166990
nsv893727 CNV Loss 21882294
nsv893728 CNV Gain 21882294
nsv831690 CNV Loss 17160897
nsv6667 CNV Insertion 18451855

Variation tolerance for C9orf84 Gene

Residual Variation Intolerance Score: 92.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.37; 98.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf84 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf84 Gene

Disorders for C9orf84 Gene

Relevant External Links for C9orf84

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C9orf84: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf84 Gene

Publications for C9orf84 Gene

  1. SHOC1 and PTD form an XPF-ERCC1-like complex that is required for formation of class I crossovers. (PMID: 21771883) Macaisne N. … Mercier R. (J. Cell. Sci. 2011) 67
  2. SHOC1, an XPF endonuclease-related protein, is essential for the formation of class I meiotic crossovers. (PMID: 18812090) Macaisne N. … Mercier R. (Curr. Biol. 2008) 67
  3. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 67
  4. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell C.J. … Demissie S. (BMC Med. Genet. 2007) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for C9orf84 Gene

Sources for C9orf84 Gene

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