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Aliases for C9orf84 Gene

Aliases for C9orf84 Gene

  • Chromosome 9 Open Reading Frame 84 2 3 5

External Ids for C9orf84 Gene

Previous GeneCards Identifiers for C9orf84 Gene

  • GC09M109828
  • GC09M109880
  • GC09M111528
  • GC09M113488
  • GC09M114448
  • GC09M084047

Summaries for C9orf84 Gene

GeneCards Summary for C9orf84 Gene

C9orf84 (Chromosome 9 Open Reading Frame 84) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf84 Gene

Genomics for C9orf84 Gene

Regulatory Elements for C9orf84 Gene

Genomic Location for C9orf84 Gene

Chromosome:
9
Start:
111,686,173 bp from pter
End:
111,795,008 bp from pter
Size:
108,836 bases
Orientation:
Minus strand

Genomic View for C9orf84 Gene

Genes around C9orf84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf84 Gene

Proteins for C9orf84 Gene

  • Protein details for C9orf84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXU9-CI084_HUMAN
    Recommended name:
    Uncharacterized protein C9orf84
    Protein Accession:
    Q5VXU9
    Secondary Accessions:
    • A2A2V3
    • Q2M1H8
    • Q96M73

    Protein attributes for C9orf84 Gene

    Size:
    1444 amino acids
    Molecular mass:
    165202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C9orf84 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf84 Gene

Proteomics data for C9orf84 Gene at MOPED

Post-translational modifications for C9orf84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf84 Gene

No data available for DME Specific Peptides for C9orf84 Gene

Domains & Families for C9orf84 Gene

Protein Domains for C9orf84 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf84: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf84 Gene

Function for C9orf84 Gene

genes like me logo Genes that share phenotypes with C9orf84: view

Animal Model Products

miRNA for C9orf84 Gene

miRTarBase miRNAs that target C9orf84

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf84 Gene

Localization for C9orf84 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf84 Gene COMPARTMENTS Subcellular localization image for C9orf84 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf84 Gene

Pathways & Interactions for C9orf84 Gene

SuperPathways for C9orf84 Gene

No Data Available

Interacting Proteins for C9orf84 Gene

Gene Ontology (GO) - Biological Process for C9orf84 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf84 Gene

Drugs & Compounds for C9orf84 Gene

No Compound Related Data Available

Transcripts for C9orf84 Gene

Unigene Clusters for C9orf84 Gene

Chromosome 9 open reading frame 84:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf84 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for C9orf84 Gene

GeneLoc Exon Structure for
C9orf84
ECgene alternative splicing isoforms for
C9orf84

Expression for C9orf84 Gene

mRNA expression in normal human tissues for C9orf84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C9orf84 Gene

This gene is overexpressed in Testis (x28.4) and Kidney - Cortex (x5.2).

SOURCE GeneReport for Unigene cluster for C9orf84 Gene Hs.428209

genes like me logo Genes that share expression patterns with C9orf84: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C9orf84 Gene

Orthologs for C9orf84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf84 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC617568 35
  • 84.96 (n)
  • 74.72 (a)
C9orf84 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H9orf84 35
  • 85.53 (n)
  • 75.78 (a)
C9orf84 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI481877 35
  • 74.51 (n)
  • 61.13 (a)
AI481877 16
AI481877 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf84 35
  • 99.4 (n)
  • 98.48 (a)
C9orf84 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC686050 35
  • 72.97 (n)
  • 60.56 (a)
oppossum
(Monodelphis domestica)
Mammalia C9orf84 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf84 36
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9orf84 35
  • 59.1 (n)
  • 45.15 (a)
C9orf84 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf84 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487050 35
  • 51.82 (n)
  • 37.36 (a)
Species with no ortholog for C9orf84:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf84 Gene

ENSEMBL:
Gene Tree for C9orf84 (if available)
TreeFam:
Gene Tree for C9orf84 (if available)

Paralogs for C9orf84 Gene

No data available for Paralogs for C9orf84 Gene

Variants for C9orf84 Gene

Sequence variations from dbSNP and Humsavar for C9orf84 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10981047 - 111,748,193(+) TGTTA(C/G)TAAGA nc-transcript-variant, reference, missense
rs7470491 - 111,728,028(+) AAGAA(C/T)GACTT nc-transcript-variant, reference, missense
rs1322257 - 111,718,282(+) CATCA(A/G)TTGTA intron-variant, nc-transcript-variant, reference, missense
rs11791445 - 111,714,468(+) TTGCA(A/T)CCAAC nc-transcript-variant, reference, missense
rs7868266 - 111,707,858(+) ACCCC(C/T)TTAAA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for C9orf84 Gene

Variant ID Type Subtype PubMed ID
nsv893724 CNV Gain 21882294
nsv893726 CNV Gain 21882294
nsv466486 CNV Gain 19166990
nsv893727 CNV Loss 21882294
nsv893728 CNV Gain 21882294
nsv831690 CNV Loss 17160897
nsv6667 CNV Insertion 18451855

Variation tolerance for C9orf84 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.37; 98.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf84 Gene

HapMap Linkage Disequilibrium report
C9orf84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf84 Gene

Disorders for C9orf84 Gene

Relevant External Links for C9orf84

Genetic Association Database (GAD)
C9orf84
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf84

No disorders were found for C9orf84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf84 Gene

Publications for C9orf84 Gene

  1. SHOC1 and PTD form an XPF-ERCC1-like complex that is required for formation of class I crossovers. (PMID: 21771883) Macaisne N. … Mercier R. (J. Cell. Sci. 2011) 2 3 67
  2. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  3. SHOC1, an XPF endonuclease-related protein, is essential for the formation of class I meiotic crossovers. (PMID: 18812090) Macaisne N. … Mercier R. (Curr. Biol. 2008) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for C9orf84 Gene

Sources for C9orf84 Gene

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