Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C9orf84 Gene

Aliases for C9orf84 Gene

  • Chromosome 9 Open Reading Frame 84 2 3 5

External Ids for C9orf84 Gene

Previous GeneCards Identifiers for C9orf84 Gene

  • GC09M109828
  • GC09M109880
  • GC09M111528
  • GC09M113488
  • GC09M114448
  • GC09M084047

Summaries for C9orf84 Gene

GeneCards Summary for C9orf84 Gene

C9orf84 (Chromosome 9 Open Reading Frame 84) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf84 Gene

Genomics for C9orf84 Gene

Regulatory Elements for C9orf84 Gene

Enhancers for C9orf84 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G111759 1 Ensembl ENCODE 23.1 +34.8 34804 1.2 CTCF PKNOX1 HINFP ARNT RAD21 RFX5 YY1 ZNF766 GATA2 FOXK2 C9orf84 ENSG00000224067 GNG10 GC09P111683
GH09G111957 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -165.2 -165238 5.8 PKNOX1 FOXA2 ARNT MLX SIN3A ARID4B DMAP1 FEZF1 YY1 SLC30A9 RNU6-710P ENSG00000224067 C9orf84 RNU6-1013P GNG10 UGCG MIR4668
GH09G112072 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 -279.2 -279188 4.0 HDGF PKNOX1 ATF1 ARNT WRNIP1 TCF12 ZNF766 GATA2 ZNF143 FOS C9orf84 ENSG00000224067 RNU6-1013P SUSD1 UGCG GNG10 PTGR1 ENSG00000259953 RNU6-855P
GH09G111742 1.6 FANTOM5 Ensembl ENCODE 11.6 +51.4 51357 3.1 ATF1 AGO1 ARID4B SIN3A GATA2 FOS ZNF202 SP3 REST ZNF518A C9orf84 GNG10 GC09P111683
GH09G112020 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -226.4 -226366 2.6 ELF3 HDGF PKNOX1 BMI1 RAD21 YY1 CBX5 FOS RELB ETV6 ENSG00000224067 C9orf84 ENSG00000259953 LOC105376220 RNU6-710P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C9orf84 on UCSC Golden Path with GeneCards custom track

Genomic Location for C9orf84 Gene

Chromosome:
9
Start:
111,686,173 bp from pter
End:
111,795,008 bp from pter
Size:
108,836 bases
Orientation:
Minus strand

Genomic View for C9orf84 Gene

Genes around C9orf84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf84 Gene

Proteins for C9orf84 Gene

  • Protein details for C9orf84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXU9-CI084_HUMAN
    Recommended name:
    Uncharacterized protein C9orf84
    Protein Accession:
    Q5VXU9
    Secondary Accessions:
    • A2A2V3
    • Q2M1H8
    • Q96M73

    Protein attributes for C9orf84 Gene

    Size:
    1444 amino acids
    Molecular mass:
    165202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C9orf84 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf84 Gene

Post-translational modifications for C9orf84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C9orf84 Gene

Domains & Families for C9orf84 Gene

Protein Domains for C9orf84 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf84: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf84 Gene

Function for C9orf84 Gene

genes like me logo Genes that share phenotypes with C9orf84: view

Animal Model Products

miRNA for C9orf84 Gene

miRTarBase miRNAs that target C9orf84

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf84 Gene

Localization for C9orf84 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C9orf84 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf84 Gene

Pathways & Interactions for C9orf84 Gene

SuperPathways for C9orf84 Gene

No Data Available

Interacting Proteins for C9orf84 Gene

Gene Ontology (GO) - Biological Process for C9orf84 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf84 Gene

Drugs & Compounds for C9orf84 Gene

No Compound Related Data Available

Transcripts for C9orf84 Gene

Unigene Clusters for C9orf84 Gene

Chromosome 9 open reading frame 84:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf84 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -
SP6: - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for C9orf84 Gene

GeneLoc Exon Structure for
C9orf84
ECgene alternative splicing isoforms for
C9orf84

Expression for C9orf84 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C9orf84 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C9orf84 Gene

This gene is overexpressed in Testis (x28.4) and Kidney - Cortex (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of C9orf84 Gene:

C9orf84

SOURCE GeneReport for Unigene cluster for C9orf84 Gene:

Hs.428209
genes like me logo Genes that share expression patterns with C9orf84: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C9orf84 Gene

Orthologs for C9orf84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf84 34
  • 99.4 (n)
C9orf84 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H9orf84 34
  • 85.53 (n)
C9orf84 35
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC617568 34
  • 84.96 (n)
C9orf84 35
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI481877 34 16 35
  • 74.51 (n)
rat
(Rattus norvegicus)
Mammalia LOC686050 34
  • 72.97 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf84 35
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf84 35
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9orf84 34
  • 59.1 (n)
C9orf84 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf84 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487050 34
  • 51.82 (n)
Species where no ortholog for C9orf84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf84 Gene

ENSEMBL:
Gene Tree for C9orf84 (if available)
TreeFam:
Gene Tree for C9orf84 (if available)

Paralogs for C9orf84 Gene

No data available for Paralogs for C9orf84 Gene

Variants for C9orf84 Gene

Sequence variations from dbSNP and Humsavar for C9orf84 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000040329 -- 111,697,093(+) AATAT(A/C)CCCAT intron-variant
rs1000081497 -- 111,729,886(+) TTGGT(C/T)TCAAA intron-variant
rs1000106755 -- 111,740,785(+) CAGAC(G/T)GGTCT intron-variant
rs1000137704 -- 111,739,875(+) CTTTG(A/T)AGCAC intron-variant
rs1000191927 -- 111,739,542(+) TTTAT(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf84 Gene

Variant ID Type Subtype PubMed ID
dgv7700n100 CNV gain 25217958
esv1003380 CNV deletion 20482838
esv1650763 CNV deletion 17803354
esv2420162 CNV deletion 18987734
esv2738937 CNV deletion 23290073
esv2738938 CNV deletion 23290073
esv2761550 CNV gain 21179565
nsv1110050 CNV deletion 24896259
nsv466486 CNV gain 19166990
nsv615193 CNV gain 21841781
nsv615194 CNV loss 21841781
nsv6667 CNV insertion 18451855
nsv831690 CNV loss 17160897

Variation tolerance for C9orf84 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.37; 98.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C9orf84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf84 Gene

Disorders for C9orf84 Gene

Relevant External Links for C9orf84

Genetic Association Database (GAD)
C9orf84
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf84

No disorders were found for C9orf84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf84 Gene

Publications for C9orf84 Gene

  1. SHOC1 and PTD form an XPF-ERCC1-like complex that is required for formation of class I crossovers. (PMID: 21771883) Macaisne N. … Mercier R. (J. Cell. Sci. 2011) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3 64
  5. SHOC1, an XPF endonuclease-related protein, is essential for the formation of class I meiotic crossovers. (PMID: 18812090) Macaisne N. … Mercier R. (Curr. Biol. 2008) 3 64

Products for C9orf84 Gene

Sources for C9orf84 Gene

Content
Loading form....