C9orf78 Gene
protein-coding GIFtS: 48
GCID: GC09M132590
|
|
chromosome 9 open reading frame 78
| |
Aliases
for C9orf78 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 9 Open Reading Frame 781 2 | | HCA591 2 3 | | HSPC2201 2 | | Hepatocellular Carcinoma-Associated Antigen 592 3 | | BA409K20.31 | | Uncharacterized Protein C9orf782 |
Export aliases for C9orf78 gene to outside databasesPrevious GC identifers: GC09M127965 GC09M127946 GC09M129669 GC09M131629 GC09M102188 |
Summaries
for C9orf78 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for C9orf78
|
Genomic Views
for C9orf78 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C9orf78 gene promoter:
p53 Lmo2 AP-2gamma E47 Arnt Roaz AREB6 MEF-2A aMEF-2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for C9orf78
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C9orf78 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.2C9orf78 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M132590: view genomic region
(about GC identifiers)
Start:
|
132,589,564 bp from pter |
End:
|
132,598,142 bp from pter |
Size:
|
8,579 bases |
Orientation:
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minus strand |
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Proteins
for C9orf78 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CI078_HUMAN, Q9NZ63 (See
protein sequence)Recommended Name: Uncharacterized protein C9orf78 Size: 289 amino acids; 33688 Da
Secondary accessions: B3KPX8 Q8WVU6 Q9NT39Explore the universe of human proteins at neXtProt for C9orf78: NX_Q9NZ63
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZ63
C9orf78 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057604.1
ENSEMBL proteins: ENSP00000361524
Human Recombinant Protein Products for C9orf78:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
C9orf78 for ontologies About GeneDecksing
C9orf78 Antibody Products:
Assay Products for C9orf78: |
Protein
Domains /
Families
for C9orf78 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C9orf78 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NZ63ProtoNet protein and cluster: Q9NZ63 |
Function
for C9orf78 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf78 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf78 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C9orf78 (NM_016520) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C9orf78 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C9orf78 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf78 |
|
Pathways & Interactions
for C9orf78 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C9orf78
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/8 Interacting proteins for C9orf78 (Q9NZ632, 3 ENSP000003615244) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for C9orf78 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C9orf78
Search CenterWatch for drugs/clinical trials and news about C9orf78 / CI078
|
Transcripts
for C9orf78 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C9orf78 gene: NM_016520.2 Unigene Cluster for C9orf78: Chromosome 9 open reading frame 78 Hs.278429 [show with all ESTs]Unigene Representative Sequence: AK0975777 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372447(uc004byo.3 uc004byp.3) ENST00000461349 ENST00000461762(uc004byq.1)
ENST00000480023 ENST00000461539 ENST00000492991 ENST00000495934
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf78 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf78 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C9orf78 (NM_016520) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C9orf78 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C9orf78 |
Additional cDNA sequence: AF151054.1 AF218421.1 AK057004.1 AK096971.1 AK097577.1 AL137549.1 AY632862.1 BC007664.2 BC017570.1 BC037173.1 15 DOTS entries: DT.211137 DT.91736827 DT.100793221 DT.102829125 DT.99931222 DT.75103935 DT.121191309 DT.99930468 DT.100793222 DT.92461424 DT.100768186 DT.100793215 DT.91998860 DT.95233211 DT.101954476 24/251 AceView cDNA sequences (see all 251): AK096971 BG942838 AI685712 BM809560 AL547621 BX090077 CR606901 AI376077 BG575519 CD516422 BE049455 AA317976 AI863150 BM466383 CA771161 CA424433 AI812016 W69639 AI686336 CA867873 CA395609 BG104824 CR604621 BQ649162
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C9orf78 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C9orf78
|
Expression
for C9orf78 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C9orf78 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTCTGCTT
About this image
See C9orf78 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C9orf78
SOURCE GeneReport for Unigene cluster: Hs.278429
SABiosciences Custom PCR Arrays for C9orf78
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C9orf78
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C9orf78 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C9orf78 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C9orf78 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf78 |
Orthologs
for C9orf78 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C9orf78 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for C9orf78 (if available)
TreeFam Gene Tree for C9orf78 (if available) |
Paralogs
for C9orf78 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C9orf78 gene
C9orf78 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for C9orf78
PGOHUM00000245251 PGOHUM00000237843 PGOHUM00000250762
|
Genomic Variants
for C9orf78 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C9orf78 (132589564 - 132598142 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C9orf78: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C9orf78 |
|
Disorders
/ Diseases
for C9orf78 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C9orf78 for disorders About GeneDecksing
7  diseases for C9orf78: About MalaCardshepatocellular carcinoma carcinoma intrahepatic cholangiocarcinoma cholangiocarcinoma
medulloblastoma pancreatic cancer pancreatitis
Export disorders for C9orf78 gene to outside databases
|
Publications
for C9orf78 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C9orf78 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with C9orf78) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2, 3 Wang Y....Chen W.-F. (2002)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (2000)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
|
External Searches for C9orf78 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C9orf78 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C9orf78 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C9orf78 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for C9orf78 gene:
Search GeneIP for patents involving C9orf78
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C9orf78 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for C9orf78 | | OriGene shRNA RFP for C9orf78 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C9orf78 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C9orf78 | | | OriGene Protein Over-expression Lysate for C9orf78 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C9orf78 | | OriGene 3'-UTR Clone for C9orf78 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf78 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf78 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C9orf78 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C9orf78 | | OriGene Custom Protein Services for C9orf78 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C9orf78 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C9orf78 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C9orf78 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C9orf78 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C9orf78 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C9orf78 |
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| | | | Search Tocris compounds for C9orf78 |
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 | | | C9orf78 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf78 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C9orf78 |
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