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Aliases for C9orf69 Gene

Aliases for C9orf69 Gene

  • Chromosome 9 Open Reading Frame 69 2 3
  • Herpes Virus UL25-Binding Protein 3 4
  • Protein C9orf69 3
  • BA83N9.1 3

External Ids for C9orf69 Gene

Previous GeneCards Identifiers for C9orf69 Gene

  • GC09U900585
  • GC09M138147
  • GC09M139006
  • GC09M108469

Summaries for C9orf69 Gene

GeneCards Summary for C9orf69 Gene

C9orf69 (Chromosome 9 Open Reading Frame 69) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

UniProtKB/Swiss-Prot for C9orf69 Gene

  • Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf69 Gene

Genomics for C9orf69 Gene

Regulatory Elements for C9orf69 Gene

Genomic Location for C9orf69 Gene

Start:
136,114,581 bp from pter
End:
136,118,885 bp from pter
Size:
4,305 bases
Orientation:
Minus strand

Genomic View for C9orf69 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf69 Gene

Proteins for C9orf69 Gene

  • Protein details for C9orf69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H0YL14-CI069_HUMAN
    Recommended name:
    Protein C9orf69
    Protein Accession:
    H0YL14
    Secondary Accessions:

    Protein attributes for C9orf69 Gene

    Size:
    139 amino acids
    Molecular mass:
    16083 Da
    Quaternary structure:
    • Interacts with HHV-1 protein UL25; this interaction occurs in the course of a HHV-1 infection.

neXtProt entry for C9orf69 Gene

Proteomics data for C9orf69 Gene at MOPED

Post-translational modifications for C9orf69 Gene

No Post-translational modifications

Other Protein References for C9orf69 Gene

No data available for DME Specific Peptides for C9orf69 Gene

Domains for C9orf69 Gene

Protein Domains for C9orf69 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf69: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf69 Gene

Function for C9orf69 Gene

Molecular function for C9orf69 Gene

UniProtKB/Swiss-Prot Function: Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation.
UniProtKB/Swiss-Prot Induction: Up-regulated upon HHV-1 infection.

Gene Ontology (GO) - Molecular Function for C9orf69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21667337
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with C9orf69: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf69

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C9orf69 Gene

Localization for C9orf69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C9orf69 Gene

Membrane; Multi-pass membrane protein. Nucleus. Cytoplasm. Note=Upon HHV-1 infection, accumulates arround the nuclear membrane and translocates into the nucleus.

Gene Ontology (GO) - Cellular Components for C9orf69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21667337
GO:0005737 cytoplasm IDA 21667337
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C9orf69: view

No data available for Subcellular locations from COMPARTMENTS for C9orf69 Gene

Pathways for C9orf69 Gene

SuperPathways for C9orf69 Gene

No Data Available

Interacting Proteins for C9orf69 Gene

Gene Ontology (GO) - Biological Process for C9orf69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IDA 21667337
GO:0016032 viral process IEA --
GO:0048524 positive regulation of viral process IDA 21667337
genes like me logo Genes that share ontologies with C9orf69: view

No data available for Pathways by source for C9orf69 Gene

Transcripts for C9orf69 Gene

mRNA/cDNA for C9orf69 Gene

(10) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C9orf69 Gene

Chromosome 9 open reading frame 69:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf69

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf69 Gene

No ASD Table

Relevant External Links for C9orf69 Gene

GeneLoc Exon Structure for
C9orf69
ECgene alternative splicing isoforms for
C9orf69

Expression for C9orf69 Gene

mRNA expression in normal human tissues for C9orf69 Gene

SOURCE GeneReport for Unigene cluster for C9orf69 Gene Hs.287411

genes like me logo Genes that share expressions with C9orf69: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for C9orf69 Gene

Orthologs for C9orf69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf69 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H9orf69 35
  • 91.37 (n)
  • 93.53 (a)
C9orf69 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf69 35
  • 87.77 (n)
  • 91.37 (a)
C9orf69 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C330006A16Rik 35
  • 89.45 (n)
  • 95.68 (a)
C330006A16Rik 16
rat
(Rattus norvegicus)
Mammalia RGD1564379 35
  • 89.93 (n)
  • 95.68 (a)
chicken
(Gallus gallus)
Aves C17H9orf69 35
  • 76.02 (n)
  • 83.45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489629 35
  • 76.5 (n)
  • 83.45 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332331 35
  • 75.06 (n)
  • 69.78 (a)
Species with no ortholog for C9orf69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf69 Gene

ENSEMBL:
Gene Tree for C9orf69 (if available)
TreeFam:
Gene Tree for C9orf69 (if available)

Paralogs for C9orf69 Gene

Pseudogenes.org Pseudogenes for C9orf69 Gene

genes like me logo Genes that share paralogs with C9orf69: view

No data available for Paralogs for C9orf69 Gene

Variants for C9orf69 Gene

Sequence variations from dbSNP and Humsavar for C9orf69 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1044233 -- 136,114,675(-) GCCCT(C/T)TGAGC utr-variant-3-prime, nc-transcript-variant
rs1717426 -- 136,115,062(+) TCATG(A/G)CTCCT utr-variant-3-prime, intron-variant
rs1747837 -- 136,114,722(+) CACGA(A/G)CGGCA utr-variant-3-prime, nc-transcript-variant
rs7875075 -- 136,114,537(+) TATTA(C/T)GTCCT downstream-variant-500B
rs10121797 -- 136,114,155(+) gtggt(C/G)gtggg downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C9orf69 Gene

Variant ID Type Subtype PubMed ID
nsv831757 CNV Loss 17160897
nsv825173 CNV Gain 20364138
dgv8373n71 CNV Loss 21882294
nsv894294 CNV Loss 21882294
nsv894295 CNV Loss 21882294
dgv8379n71 CNV Loss 21882294
nsv894301 CNV Loss 21882294
nsv509332 CNV Insertion 20534489
dgv8380n71 CNV Loss 21882294
dgv8381n71 CNV Loss 21882294
dgv8382n71 CNV Loss 21882294
dgv8383n71 CNV Loss 21882294
dgv8384n71 CNV Loss 21882294
dgv8385n71 CNV Loss 21882294
nsv466670 CNV Gain 19166990
nsv894319 CNV Gain 21882294
nsv894320 CNV Loss 21882294
nsv6762 CNV Insertion 18451855
nsv894322 CNV Loss 21882294
esv24552 CNV Loss 19812545

Relevant External Links for C9orf69 Gene

HapMap Linkage Disequilibrium report
C9orf69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf69 Gene

Disorders for C9orf69 Gene

Relevant External Links for C9orf69

Genetic Association Database (GAD)
C9orf69
genes like me logo Genes that share disorders with C9orf69: view

No data available for UniProtKB/Swiss-Prot for C9orf69 Gene

Publications for C9orf69 Gene

  1. Host cell protein C9orf9 promotes viral proliferation via interaction with HSV-1 UL25 protein. (PMID: 21667337) Zhang Y. … Li Q.H. (Zhongguo Bing Du Xue 2011) 2 3 4
  2. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PMID: 19875614) Paterson A.D. … Bull S.B. (Diabetes 2010) 48
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C9orf69 Gene

Sources for C9orf69 Gene

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