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Aliases for C9orf66 Gene

Aliases for C9orf66 Gene

  • Chromosome 9 Open Reading Frame 66 2 3 5

External Ids for C9orf66 Gene

Summaries for C9orf66 Gene

GeneCards Summary for C9orf66 Gene

C9orf66 (Chromosome 9 Open Reading Frame 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf66 Gene

Genomics for C9orf66 Gene

Regulatory Elements for C9orf66 Gene

Enhancers for C9orf66 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C9orf66 on UCSC Golden Path with GeneCards custom track

Promoters for C9orf66 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C9orf66 on UCSC Golden Path with GeneCards custom track

Genomic Location for C9orf66 Gene

Chromosome:
9
Start:
212,824 bp from pter
End:
215,893 bp from pter
Size:
3,070 bases
Orientation:
Minus strand

Genomic View for C9orf66 Gene

Genes around C9orf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf66 Gene

Proteins for C9orf66 Gene

  • Protein details for C9orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T8R8-CI066_HUMAN
    Recommended name:
    Uncharacterized protein C9orf66
    Protein Accession:
    Q5T8R8
    Secondary Accessions:
    • Q96NB0

    Protein attributes for C9orf66 Gene

    Size:
    295 amino acids
    Molecular mass:
    31184 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C9orf66 Gene

Proteomics data for C9orf66 Gene at MOPED

Post-translational modifications for C9orf66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C9orf66 Gene

Domains & Families for C9orf66 Gene

Protein Domains for C9orf66 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C9orf66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf66: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C9orf66 Gene

Function for C9orf66 Gene

genes like me logo Genes that share phenotypes with C9orf66: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf66 Gene

Localization for C9orf66 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf66 Gene COMPARTMENTS Subcellular localization image for C9orf66 gene
Compartment Confidence
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf66 Gene

Pathways & Interactions for C9orf66 Gene

SuperPathways for C9orf66 Gene

No Data Available

Interacting Proteins for C9orf66 Gene

Gene Ontology (GO) - Biological Process for C9orf66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf66 Gene

Drugs & Compounds for C9orf66 Gene

No Compound Related Data Available

Transcripts for C9orf66 Gene

mRNA/cDNA for C9orf66 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C9orf66 Gene

Chromosome 9 open reading frame 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf66 Gene

No ASD Table

Relevant External Links for C9orf66 Gene

GeneLoc Exon Structure for
C9orf66
ECgene alternative splicing isoforms for
C9orf66

Expression for C9orf66 Gene

Protein differential expression in normal tissues from HIPED for C9orf66 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C9orf66 Gene



SOURCE GeneReport for Unigene cluster for C9orf66 Gene Hs.190877

Protein tissue co-expression partners for C9orf66 Gene

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C9orf66 Gene

Orthologs for C9orf66 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C9orf66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf66 35
  • 93.79 (n)
  • 87.46 (a)
Species with no ortholog for C9orf66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf66 Gene

ENSEMBL:
Gene Tree for C9orf66 (if available)
TreeFam:
Gene Tree for C9orf66 (if available)

Paralogs for C9orf66 Gene

No data available for Paralogs for C9orf66 Gene

Variants for C9orf66 Gene

Sequence variations from dbSNP and Humsavar for C9orf66 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_050824 -
VAR_050825 -
VAR_050826 -
rs542876383 -- 212,812(+) TGCTG(-/A)AAATC downstream-variant-500B
rs12376752 -- 212,760(+) TGGAA(C/G)GTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C9orf66 Gene

Variant ID Type Subtype PubMed ID
dgv2266e1 CNV Complex 17122850
esv735 CNV CNV 17122850
dgv253e55 CNV Gain 17911159
dgv254e55 CNV Gain 17911159
nsv515505 CNV Gain+Loss 19592680
nsv8403 CNV Gain+Loss 18304495
nsv891942 CNV Gain 21882294
essv1889 CNV CNV 17122850
dgv2267e1 CNV Complex 17122850
nsv442127 CNV CNV 18776908
dgv7990n71 CNV Gain 21882294
dgv7991n71 CNV Gain 21882294
dgv7992n71 CNV Gain 21882294
nsv891954 CNV Loss 21882294
nsv466028 CNV Gain 19166990
nsv818668 CNV Gain 17921354
dgv908n27 CNV Gain 19166990
dgv909n27 CNV Gain 19166990
esv32541 CNV Gain 17666407
nsv891955 CNV Loss 21882294
dgv7993n71 CNV Gain 21882294

Variation tolerance for C9orf66 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.56; 95.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C9orf66 Gene

Disorders for C9orf66 Gene

Relevant External Links for C9orf66

Genetic Association Database (GAD)
C9orf66
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf66

No disorders were found for C9orf66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf66 Gene

Publications for C9orf66 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 67
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C9orf66 Gene

Sources for C9orf66 Gene

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