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Aliases for C9orf64 Gene

Aliases for C9orf64 Gene

  • Chromosome 9 Open Reading Frame 64 2 3 5

External Ids for C9orf64 Gene

Previous GeneCards Identifiers for C9orf64 Gene

  • GC09M082010
  • GC09M083782
  • GC09M085743
  • GC09M086553
  • GC09M056378

Summaries for C9orf64 Gene

GeneCards Summary for C9orf64 Gene

C9orf64 (Chromosome 9 Open Reading Frame 64) is a Protein Coding gene.

Gene Wiki entry for C9orf64 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf64 Gene

Genomics for C9orf64 Gene

Regulatory Elements for C9orf64 Gene

Enhancers for C9orf64 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C9orf64 on UCSC Golden Path with GeneCards custom track

Promoters for C9orf64 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C9orf64 on UCSC Golden Path with GeneCards custom track

Genomic Location for C9orf64 Gene

Chromosome:
9
Start:
83,938,307 bp from pter
End:
83,957,067 bp from pter
Size:
18,761 bases
Orientation:
Minus strand

Genomic View for C9orf64 Gene

Genes around C9orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf64 Gene

Proteins for C9orf64 Gene

  • Protein details for C9orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6V5-CI064_HUMAN
    Recommended name:
    UPF0553 protein C9orf64
    Protein Accession:
    Q5T6V5
    Secondary Accessions:
    • B2RPI6
    • Q8N2B1
    • Q9BT18

    Protein attributes for C9orf64 Gene

    Size:
    341 amino acids
    Molecular mass:
    39029 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C9orf64 Gene

Proteomics data for C9orf64 Gene at MOPED

Post-translational modifications for C9orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf64 Gene

No data available for DME Specific Peptides for C9orf64 Gene

Domains & Families for C9orf64 Gene

Protein Domains for C9orf64 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C9orf64 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T6V5

UniProtKB/Swiss-Prot:

CI064_HUMAN :
  • Belongs to the UPF0553 family.
Family:
  • Belongs to the UPF0553 family.
genes like me logo Genes that share domains with C9orf64: view

No data available for Gene Families for C9orf64 Gene

Function for C9orf64 Gene

Phenotypes for C9orf64 Gene

genes like me logo Genes that share phenotypes with C9orf64: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf64 Gene

Localization for C9orf64 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf64 Gene COMPARTMENTS Subcellular localization image for C9orf64 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf64 Gene

Pathways & Interactions for C9orf64 Gene

SuperPathways for C9orf64 Gene

No Data Available

Interacting Proteins for C9orf64 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365522%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000385083%0d%0a
Selected Interacting proteins: ENSP00000365522 Q5T6V5-CI064_HUMAN for C9orf64 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C9orf64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C9orf64 Gene

Drugs & Compounds for C9orf64 Gene

No Compound Related Data Available

Transcripts for C9orf64 Gene

Unigene Clusters for C9orf64 Gene

Chromosome 9 open reading frame 64:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf64 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1: - - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for C9orf64 Gene

GeneLoc Exon Structure for
C9orf64
ECgene alternative splicing isoforms for
C9orf64

Expression for C9orf64 Gene

mRNA expression in normal human tissues for C9orf64 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C9orf64 Gene

This gene is overexpressed in Testis (6.9) and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C9orf64 Gene



SOURCE GeneReport for Unigene cluster for C9orf64 Gene Hs.208914

genes like me logo Genes that share expression patterns with C9orf64: view

Protein tissue co-expression partners for C9orf64 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C9orf64 Gene

Orthologs for C9orf64 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C9orf64 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C8H9orf64 35
  • 88.17 (n)
  • 88.27 (a)
C8H9orf64 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1H9orf64 35
  • 86.12 (n)
  • 87.1 (a)
C9orf64 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2210016F16Rik 35
  • 79.09 (n)
  • 77.51 (a)
2210016F16Rik 16
2210016F16Rik 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf64 35
  • 99.87 (n)
  • 99.6 (a)
C9orf64 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311345 35
  • 79.4 (n)
  • 78.21 (a)
oppossum
(Monodelphis domestica)
Mammalia C9orf64 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf64 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF64 35
  • 71.16 (n)
  • 70.67 (a)
C9orf64 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf64 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf64 35
  • 64.52 (n)
  • 62.76 (a)
Str.5189 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15578 35
zebrafish
(Danio rerio)
Actinopterygii zgc:136564 35
  • 58.6 (n)
  • 51.62 (a)
C8H9orf64 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005844 35
  • 52.5 (n)
  • 46.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9752 35
  • 51.41 (n)
  • 44.58 (a)
CG9752 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C11D2.4 35
  • 52.61 (n)
  • 47.2 (a)
C11D2.4 36
  • 46 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os07g0588800 35
  • 46.14 (n)
  • 38.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03527 35
  • 51.12 (n)
  • 41.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC589.05c 35
  • 51.67 (n)
  • 45.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for C9orf64:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C9orf64 Gene

ENSEMBL:
Gene Tree for C9orf64 (if available)
TreeFam:
Gene Tree for C9orf64 (if available)

Paralogs for C9orf64 Gene

Pseudogenes.org Pseudogenes for C9orf64 Gene

genes like me logo Genes that share paralogs with C9orf64: view

No data available for Paralogs for C9orf64 Gene

Variants for C9orf64 Gene

Sequence variations from dbSNP and Humsavar for C9orf64 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7848149 -- 83,955,619(+) AGTAC(C/G)AGGCA reference, missense
rs1572030 -- 83,956,696(+) AAACC(A/G)GAGAG intron-variant, utr-variant-5-prime
rs1572031 -- 83,956,883(+) ATGTT(G/T)TGCCT intron-variant, upstream-variant-2KB
rs1795390 -- 83,948,203(+) GGCCG(C/T)GACCC intron-variant
rs113026016 -- 83,958,590(+) TTGAT(A/G/T)TAGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C9orf64 Gene

Variant ID Type Subtype PubMed ID
nsv469859 CNV Complex 16826518
dgv2394e1 CNV Complex 17122850
nsv8541 CNV Gain 18304495
nsv436717 OTHER Inversion 17901297
nsv831644 CNV Gain 17160897

Variation tolerance for C9orf64 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C9orf64 Gene

Disorders for C9orf64 Gene

Relevant External Links for C9orf64

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf64

No disorders were found for C9orf64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf64 Gene

Publications for C9orf64 Gene

  1. Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family. (PMID: 24911101) Zallot R. … de CrAccy-Lagard V. (ACS Chem. Biol. 2014) 2 3 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. (PMID: 20354154) Chen Y.C. … Garcia G.A. (RNA 2010) 3

Products for C9orf64 Gene

Sources for C9orf64 Gene

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