C9orf169 Gene
protein-coding GIFtS: 39
GCID: GC09P140120
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chromosome 9 open reading frame 169
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Aliases
for C9orf169 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 9 Open Reading Frame 1691 2 | | MGC599371 | | UPF0574 Protein C9orf1692 |
Export aliases for C9orf169 gene to outside databasesPrevious GC identifers: GC09M9S0004 GC09P109578 |
Summaries
for C9orf169 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C9orf169 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C9orf169 gene promoter:
AhR RP58 FOXF2 SREBP-1c E47 SREBP-1b Roaz SREBP-1a HOXA5 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for C9orf169
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C9orf169 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3C9orf169 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P140120: view genomic region
(about GC identifiers)
Start:
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140,119,087 bp from pter |
End:
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140,120,763 bp from pter |
Size:
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1,677 bases |
Orientation:
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plus strand |
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Proteins
for C9orf169 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CI169_HUMAN, A8MQ03 (See
protein sequence)Recommended Name: UPF0574 protein C9orf169 Size: 144 amino acids; 15313 Da
Secondary accessions: Q86UY7Explore the universe of human proteins at neXtProt for C9orf169: NX_A8MQ03
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MQ03
C9orf169 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_945352.2
ENSEMBL proteins: ENSP00000386453 ENSP00000351967
Human Recombinant Protein Products:
C9orf169 Antibody Products:
Assay Products for C9orf169: |
Protein
Domains /
Families
for C9orf169 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C9orf169 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A8MQ03ProtoNet protein and cluster: A8MQ03 UniProtKB/Swiss-Prot: CI169_HUMAN, A8MQ03Similarity: Belongs to the UPF0574 family |
Function
for C9orf169 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf169 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf169
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C9orf169 (NM_199001) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C9orf169 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C9orf169 |
1 GenomeRNAi human phenotype for C9orf169:
|
Pathways & Interactions
for C9orf169 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C9orf169
1 Interacting protein for C9orf169 (A8MQ033) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C9orf169 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C9orf169
Search CenterWatch for drugs/clinical trials and news about C9orf169 / CI169
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Transcripts
for C9orf169 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C9orf169 gene: NM_199001.2 Unigene Cluster for C9orf169: Chromosome 9 open reading frame 169 Hs.512469 [show with all ESTs]Unigene Representative Sequence: BC0187872 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409414(uc004cmb.3) ENST00000359069
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf169 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf169
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C9orf169 (NM_199001) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C9orf169 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C9orf169 |
Additional cDNA sequence: BC018787.1 BC052297.1 2 DOTS entries: DT.100687589 DT.101955483 6 AceView cDNA sequences: NM_199001 BC052297 AF282170 BQ646152 AI939523 AI362155
GeneLoc Exon Structure
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Expression
for C9orf169 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C9orf169 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGTCTGCC
About this image
See C9orf169 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C9orf169
SOURCE GeneReport for Unigene cluster: Hs.512469
SABiosciences Custom PCR Arrays for C9orf169
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C9orf169
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C9orf169 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C9orf169 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C9orf169 |
Orthologs
for C9orf169 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for C9orf169 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for C9orf169 (if available)
TreeFam Gene Tree for C9orf169 (if available) |
Paralogs
for C9orf169 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C9orf169 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for C9orf169 (140119087 - 140120763 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C9orf169
1 CNV: 5415 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C9orf169 |
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Disorders
/ Diseases
for C9orf169 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C9orf169 for disorders About GeneDecksing
2  diseases for C9orf169: About MalaCardsmacular degeneration ataxia
Export disorders for C9orf169 gene to outside databases
|
Publications
for C9orf169 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C9orf169 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C9orf169) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for C9orf169 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C9orf169 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C9orf169 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C9orf169 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C9orf169 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C9orf169 gene:
Search GeneIP for patents involving C9orf169
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C9orf169 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C9orf169 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C9orf169 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C9orf169 | | | OriGene Protein Over-expression Lysate for C9orf169 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C9orf169 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf169 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C9orf169 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C9orf169 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C9orf169 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C9orf169 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C9orf169 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C9orf169 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C9orf169 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C9orf169 |
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 | | | C9orf169 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for C9orf169 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C9orf169 |
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