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Aliases for C9orf16 Gene

Aliases for C9orf16 Gene

  • Chromosome 9 Open Reading Frame 16 2 3 5
  • UPF0184 Protein C9orf16 3
  • EST00098 3

External Ids for C9orf16 Gene

Previous GeneCards Identifiers for C9orf16 Gene

  • GC09P122037
  • GC09P122569
  • GC09P124376
  • GC09P126298
  • GC09P128002
  • GC09P129963
  • GC09P130922
  • GC09P100536

Summaries for C9orf16 Gene

GeneCards Summary for C9orf16 Gene

C9orf16 (Chromosome 9 Open Reading Frame 16) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf16 Gene

Genomics for C9orf16 Gene

Regulatory Elements for C9orf16 Gene

Enhancers for C9orf16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F128230 0.4 FANTOM5 11.7 +70.9 70903 0.1 ZIC2 ZNF623 DNM1 CIZ1 C9orf16 LCN2 SLC25A25 SH2D3C ST6GALNAC6 SPTAN1 MIR199B GC09M128212
GH09F128090 0.5 ENCODE 11.4 -66.2 -66188 5.3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A YY1 GATA2 FOS NFYC SLC25A25-AS1 PTGES2 PTGES2-AS1 NAIF1 SLC25A25 ENSG00000230848 LCN2 C9orf16 CIZ1 ENSG00000230536
GH09F128105 0.5 ENCODE 11.3 -53.0 -53039 1.6 ZNF263 CTCF POLR2A ZNF580 ZIC2 ZNF18 LCN2 C9orf16 CIZ1 DNM1 NAIF1 ENSG00000230536 SLC25A25-AS1
GH09F128096 1 Ensembl ENCODE 11.2 -58.6 -58552 9.0 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 NAIF1 PTGES2 CIZ1 ZNF79 PTGES2-AS1 SLC25A25-AS1 SLC25A25 LCN2 C9orf16 DNM1
GH09F128251 0.5 ENCODE 11.1 +92.4 92376 0.3 ATF1 CEBPB NR2F2 CIZ1 C9orf16 LCN2 GC09M128249 MIR3154
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C9orf16 on UCSC Golden Path with GeneCards custom track

Promoters for C9orf16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001315052 975 1601 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 KLF13 ZNF263

Genomic Location for C9orf16 Gene

Chromosome:
9
Start:
128,159,425 bp from pter
End:
128,163,928 bp from pter
Size:
4,504 bases
Orientation:
Plus strand

Genomic View for C9orf16 Gene

Genes around C9orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C9orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C9orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf16 Gene

Proteins for C9orf16 Gene

  • Protein details for C9orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUW7-CI016_HUMAN
    Recommended name:
    UPF0184 protein C9orf16
    Protein Accession:
    Q9BUW7
    Secondary Accessions:
    • Q5SYV8
    • Q9Y3F7

    Protein attributes for C9orf16 Gene

    Size:
    83 amino acids
    Molecular mass:
    9054 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C9orf16 Gene

Post-translational modifications for C9orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C9orf16 Gene

Domains & Families for C9orf16 Gene

Protein Domains for C9orf16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C9orf16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUW7

UniProtKB/Swiss-Prot:

CI016_HUMAN :
  • Belongs to the UPF0184 (EST00098) family.
Family:
  • Belongs to the UPF0184 (EST00098) family.
genes like me logo Genes that share domains with C9orf16: view

No data available for Gene Families for C9orf16 Gene

Function for C9orf16 Gene

Gene Ontology (GO) - Molecular Function for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C9orf16: view
genes like me logo Genes that share phenotypes with C9orf16: view

Animal Model Products

miRNA for C9orf16 Gene

miRTarBase miRNAs that target C9orf16

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C9orf16 Gene

Localization for C9orf16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf16 Gene COMPARTMENTS Subcellular localization image for C9orf16 gene
Compartment Confidence
cytoskeleton 2
extracellular 2
nucleus 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C9orf16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C9orf16 Gene

Pathways & Interactions for C9orf16 Gene

SuperPathways for C9orf16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C9orf16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C9orf16: view

No data available for Pathways by source and SIGNOR curated interactions for C9orf16 Gene

Transcripts for C9orf16 Gene

Unigene Clusters for C9orf16 Gene

Chromosome 9 open reading frame 16:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for C9orf16 Gene

GeneLoc Exon Structure for
C9orf16
ECgene alternative splicing isoforms for
C9orf16

Expression for C9orf16 Gene

mRNA expression in normal human tissues for C9orf16 Gene

mRNA differential expression in normal tissues according to GTEx for C9orf16 Gene

This gene is overexpressed in Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for C9orf16 Gene

This gene is overexpressed in Fetal Brain (51.5) and Adrenal (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C9orf16 Gene



Protein tissue co-expression partners for C9orf16 Gene

NURSA nuclear receptor signaling pathways regulating expression of C9orf16 Gene:

C9orf16

SOURCE GeneReport for Unigene cluster for C9orf16 Gene:

Hs.522412
genes like me logo Genes that share expression patterns with C9orf16: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for C9orf16 Gene

Orthologs for C9orf16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9ORF16 35
  • 100 (a)
OneToOne
LOC740632 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia C11H9orf16 34 35
  • 93.57 (n)
dog
(Canis familiaris)
Mammalia C9H9orf16 34
  • 92.77 (n)
C9orf16 35
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1561113 34
  • 91.16 (n)
mouse
(Mus musculus)
Mammalia 1110008P14Rik 34 16 35
  • 90.36 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf16 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf16 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF16 34 35
  • 80.37 (n)
lizard
(Anolis carolinensis)
Reptilia C9orf16 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C5H9orf16 35
  • 60 (a)
OneToOne
Species where no ortholog for C9orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf16 Gene

ENSEMBL:
Gene Tree for C9orf16 (if available)
TreeFam:
Gene Tree for C9orf16 (if available)

Paralogs for C9orf16 Gene

Pseudogenes.org Pseudogenes for C9orf16 Gene

genes like me logo Genes that share paralogs with C9orf16: view

No data available for Paralogs for C9orf16 Gene

Variants for C9orf16 Gene

Sequence variations from dbSNP and Humsavar for C9orf16 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1052196 -- 128,163,487(+) CCTGT(C/T)TGGAC reference, synonymous-codon
rs1052203 -- 128,163,736(+) TGGGT(C/T)TGCCT utr-variant-3-prime
rs10524542 -- 128,161,087(+) AAAAA(-/AAAAA/AAAAAAAAAAA/AAAAAAAAAAAA/AAAAAAAAAAAAA)GGAAA intron-variant
rs10635315 -- 128,161,281(+) CCCAT(-/TTAA)ACTGT intron-variant
rs10987901 -- 128,157,661(+) TGAAA(C/T)TAAAA upstream-variant-2KB

Variation tolerance for C9orf16 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C9orf16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C9orf16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C9orf16 Gene

Disorders for C9orf16 Gene

Relevant External Links for C9orf16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C9orf16

No disorders were found for C9orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C9orf16 Gene

Publications for C9orf16 Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 2 3 4 64
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C9orf16 Gene

Sources for C9orf16 Gene

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