Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C9orf156 Gene

Aliases for C9orf156 Gene

  • Chromosome 9 Open Reading Frame 156 2 3
  • Nef (Lentivirus Myristoylated Factor) Associated Protein 1 2 3
  • Thioesterase NAP1 3 4
  • NAP1 3 4
  • Nef Associated Protein 1 3
  • Nef-Associated Protein 1 3
  • EC 3.1.2.- 4
  • HSPC219 3

External Ids for C9orf156 Gene

Previous GeneCards Identifiers for C9orf156 Gene

  • GC09M096047
  • GC09M097746
  • GC09M099706
  • GC09M100666
  • GC09M070267

Summaries for C9orf156 Gene

GeneCards Summary for C9orf156 Gene

C9orf156 (Chromosome 9 Open Reading Frame 156) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for C9orf156 Gene

  • Hydrolyzes acyl-CoA thioesters (in vitro). Has a preference for substrates with medium chain length (C10-C14). Inactive towards substrates with C18 or C20 aliphatic chains. Its physiological substrate is not known.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf156 Gene

Genomics for C9orf156 Gene

Regulatory Elements for C9orf156 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C9orf156 Gene

97,900,099 bp from pter
97,922,570 bp from pter
22,472 bases
Minus strand

Genomic View for C9orf156 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf156 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf156 Gene

Proteins for C9orf156 Gene

  • Protein details for C9orf156 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nef-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5T113
    • Q86SK0
    • Q9NXJ7
    • Q9P0Q7

    Protein attributes for C9orf156 Gene

    441 amino acids
    Molecular mass:
    48587 Da
    Quaternary structure:
    • Interacts with Nef from human immunodeficiency virus (HIV-1).
    • Sequence=AAF36139.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF36139.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

neXtProt entry for C9orf156 Gene

Proteomics data for C9orf156 Gene at MOPED

Post-translational modifications for C9orf156 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C9orf156 Gene

Antibody Products

No data available for DME Specific Peptides for C9orf156 Gene

Domains for C9orf156 Gene

Protein Domains for C9orf156 Gene

Suggested Antigen Peptide Sequences for C9orf156 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BU70
  • Contains 1 TsaA-like domain.
genes like me logo Genes that share domains with C9orf156: view

No data available for Gene Families for C9orf156 Gene

Function for C9orf156 Gene

Molecular function for C9orf156 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=10.1 uM for decanoyl-CoA {ECO:0000269 PubMed:9153233}; Vmax=7.1 umol/min/mg enzyme {ECO:0000269 PubMed:9153233};
UniProtKB/Swiss-Prot Function: Hydrolyzes acyl-CoA thioesters (in vitro). Has a preference for substrates with medium chain length (C10-C14). Inactive towards substrates with C18 or C20 aliphatic chains. Its physiological substrate is not known.

Enzyme Numbers (IUBMB) for C9orf156 Gene

Gene Ontology (GO) - Molecular Function for C9orf156 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with C9orf156: view

Phenotypes for C9orf156 Gene

GenomeRNAi human phenotypes for C9orf156:
genes like me logo Genes that share phenotypes with C9orf156: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C9orf156 Gene

Localization for C9orf156 Gene

Subcellular locations from

Jensen Localization Image for C9orf156 Gene COMPARTMENTS Subcellular localization image for C9orf156 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C9orf156 Gene

Pathways for C9orf156 Gene

SuperPathways for C9orf156 Gene

No Data Available

Interacting Proteins for C9orf156 Gene

Gene Ontology (GO) - Biological Process for C9orf156 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with C9orf156: view

No data available for Pathways by source for C9orf156 Gene

Compounds for C9orf156 Gene

(32) HMDB Compounds for C9orf156 Gene

Compound Synonyms Cas Number PubMed IDs
  • (E)-S-2-decenoate Coenzyme A
  • 2-trans-Dodecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
  • (2E)-Tetradecenoyl-Coenzyme A
genes like me logo Genes that share compounds with C9orf156: view

Transcripts for C9orf156 Gene

Unigene Clusters for C9orf156 Gene

Chromosome 9 open reading frame 156:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf156

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C9orf156

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf156 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -

Relevant External Links for C9orf156 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C9orf156 Gene

mRNA expression in normal human tissues for C9orf156 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C9orf156 Gene

SOURCE GeneReport for Unigene cluster for C9orf156 Gene Hs.9196

mRNA Expression by UniProt/SwissProt for C9orf156 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with C9orf156: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for C9orf156 Gene

Orthologs for C9orf156 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf156 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C9H9orf156 35
  • 99.09 (n)
  • 98.18 (a)
C9orf156 36
  • 98 (a)
(Bos Taurus)
Mammalia C8H9orf156 35
  • 81.49 (n)
  • 76.5 (a)
C8H9ORF156 36
  • 75 (a)
(Canis familiaris)
Mammalia C11H9orf156 35
  • 84.77 (n)
  • 79.32 (a)
C9orf156 36
  • 79 (a)
(Mus musculus)
Mammalia 5830415F09Rik 35
  • 78.23 (n)
  • 72.21 (a)
5830415F09Rik 16
5830415F09Rik 36
  • 62 (a)
(Monodelphis domestica)
Mammalia C9orf156 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia C9orf156 36
  • 57 (a)
(Rattus norvegicus)
Mammalia RGD1305420 35
  • 79.04 (n)
  • 74.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14287 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf156 35
  • 59.64 (n)
  • 57.33 (a)
(Danio rerio)
Actinopterygii C1H9orf156 36
  • 38 (a)
zgc:123172 35
  • 61.52 (n)
  • 60.11 (a)
Species with no ortholog for C9orf156:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C9orf156 Gene

Gene Tree for C9orf156 (if available)
Gene Tree for C9orf156 (if available)

Paralogs for C9orf156 Gene

No data available for Paralogs for C9orf156 Gene

Variants for C9orf156 Gene

Sequence variations from dbSNP and Humsavar for C9orf156 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6586 -- 97,904,649(-) GTGTC(A/G)AGAAG utr-variant-3-prime, intron-variant
rs723227 -- 97,906,791(+) GAGCC(A/G)AGATC intron-variant
rs1127703 -- 97,913,534(-) AAAAA(C/T)GGTCA synonymous-codon, reference, utr-variant-5-prime
rs1561957 -- 97,907,990(-) TTGCA(A/G)TTTTA intron-variant
rs1561958 -- 97,907,517(-) TTACA(A/C)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf156 Gene

Variant ID Type Subtype PubMed ID
nsv893611 CNV Gain 21882294
nsv525113 CNV Loss 19592680
esv271218 CNV Insertion 20981092
esv272293 CNV Insertion 20981092
nsv524282 CNV Loss 19592680

Relevant External Links for C9orf156 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf156 Gene

Disorders for C9orf156 Gene

(1) University of Copenhagen DISEASES for C9orf156 Gene

Relevant External Links for C9orf156

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with C9orf156: view

No data available for UniProtKB/Swiss-Prot for C9orf156 Gene

Publications for C9orf156 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. (PMID: 9153233) Liu L.X. … Benichou S. (J. Biol. Chem. 1997) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PMID: 18654987) Thalappilly S. … Dusetti N.J. (Proteomics 2008) 3

Products for C9orf156 Gene

Sources for C9orf156 Gene

Back to Top