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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C9orf156 Gene

protein-coding GIFtS: 47
GCID: GC09M100666

chromosome 9 open reading frame 156

Explore 7 diseases affiliated with
C9orf156 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 9 Open Reading Frame 156¹ ²		Nef (Lentivirus Myristoylated Factor) Associated Protein 1²
NAP1¹ ² ³		Nef Associated Protein 1²
HSPC219¹ ²		Nef-Associated Protein 1²
Thioesterase NAP1² ³		EC 3.1.2.-³

External Ids:	HGNC: 30967¹	Entrez Gene: 51531²	Ensembl: ENSG00000136932⁷	UniProtKB: Q9BU70³

Export aliases for C9orf156 gene to outside databases

Previous GC identifers: GC09M096047 GC09M097746 GC09M099706 GC09M070267

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NAP1_HUMAN, Q9BU70

Function: Hydrolyzes acyl-CoA thioesters (in vitro). Has a preference for substrates with medium chain length

(C10-C14). Inactive towards substrates with C18 or C20 aliphatic chains. Its physiological substrate is not known

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C9orf156 gene promoter:
RFX1 AML1a AREB6 N-Myc E2F E2F-1 IRF-7A Pax-4a ATF6
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C9orf156

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C9orf156

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q31.1

C9orf156 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C9orf156 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M100666: view genomic region (about GC identifiers)

Start:	100,666,771 bp from pter	End:	100,684,852 bp from pter
Size:	18,082 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NAP1_HUMAN, Q9BU70 (See protein sequence)

Recommended Name: Nef-associated protein 1

Size: 441 amino acids; 48587 Da

Subunit: Interacts with Nef from human immunodeficiency virus (HIV-1)

Sequence caution: Sequence=AAF36139.1; Type=Frameshift; Positions=Several; Sequence=AAF36139.1; Type=Miscellaneous

discrepancy; Note=Contaminating sequence;

Secondary accessions: Q5T113 Q86SK0 Q9NXJ7 Q9P0Q7

Explore the universe of human proteins at neXtProt for C9orf156: NX_Q9BU70

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BU70

C9orf156 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057565.3

ENSEMBL proteins:

ENSP00000364260 ENSP00000364259 ENSP00000364258 ENSP00000408473

Human Recombinant Protein Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C9orf156 for domains About GeneDecksing

3 InterPro domains/families:

IPR023370 UPF0066_YaeB

IPR023368 UPF0066_cons_site

IPR001378 UPF0066

Graphical View of Domain Structure for InterPro Entry Q9BU70

ProtoNet protein and cluster: Q9BU70

1 Blocks protein family: IPB001378 Protein of unknown function

UniProtKB/Swiss-Prot: NAP1_HUMAN, Q9BU70

Similarity: Contains 1 TsaA-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NAP1_HUMAN, Q9BU70

Function: Hydrolyzes acyl-CoA thioesters (in vitro). Has a preference for substrates with medium chain length

(C10-C14). Inactive towards substrates with C18 or C20 aliphatic chains. Its physiological substrate is not known

Biophysicochemical properties: Kinetic parameters: KM=10.1 uM for decanoyl-CoA; Vmax=7.1 umol/min/mg enzyme;

Enzyme Number (IUBMB): EC 3.1.2.-¹

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf156

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--

C9orf156 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for C9orf156:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C9orf156

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for C9orf156 (Q9BU70³ ENSP00000364260⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STAC	Q99469³, ENSP00000273183⁴	I2D: score=1 STRING: ENSP00000273183
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
SIRT5	ENSP00000368552⁴	STRING: ENSP00000368552
SIRT1	ENSP00000212015⁴	STRING: ENSP00000212015

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019048	virus-host interaction	IEA	--
GO:0044419	interspecies interaction between organisms	--	--

C9orf156 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C9orf156

10/32 HMDB Compounds for C9orf156 (see all 32) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

Search CenterWatch for drugs/clinical trials and news about C9orf156 / NAP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C9orf156 gene:

NM_016481.3

Unigene Cluster for C9orf156:

Chromosome 9 open reading frame 156

Hs.9196 [show with all ESTs]

Unigene Representative Sequence: AY189280

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375119(uc004axv.1 uc010msq.1) ENST00000375118(uc004axw.1)

ENST00000478126 ENST00000375117(uc022bku.1) ENST00000471580 ENST00000455506

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		hsa-miR-3671 hsa-miR-607
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Additional cDNA sequence:

AF151053.1 AK000213.1 AK023069.1 AK302701.1 AK309270.1 AY189280.1 BC002863.2 X86033.1

7 DOTS entries:

DT.452161 DT.100799655 DT.100023177 DT.100799657 DT.100799661 DT.92422060 DT.95164968

24/109 AceView cDNA sequences (see all 109):

AA810738 BQ066736 CD364567 CB528791 BQ574340 BQ029434 BU176962 BX281012

CR605882 BP352177 AA281066 AI524537 BU152959 CB159044 BG396531 AU130223

BU621720 CR620447 AA452281 AA448626 AA748492 CR604210 BU682251 CF551965

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for C9orf156 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b
SP1:
SP2:			-		-		-				-												-		-		-
SP3:											-												-		-		-
SP4:											-										-		-
SP5:																					-		-		-		-

ECgene alternative splicing isoforms for C9orf156

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C9orf156 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See C9orf156 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C9orf156

SOURCE GeneReport for Unigene cluster: Hs.9196

UniProtKB/Swiss-Prot: NAP1_HUMAN, Q9BU70

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf156

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for C9orf156 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	5830415F09Rik^{1 , 5}	RIKEN cDNA 5830415F09 gene^{1, 5}	78.23(n)¹ 72.21(a)¹		4 (24.71 cM)⁵ 74753¹ NM_029086.2¹ NP_083362.1¹ 46376505⁵
African clawed frog (Xenopus laevis)	Amphibia	Xl.14287²	Xenopus laevis transcribed sequence with moderate similarity more	77.42(n)		BX853513.1
zebrafish (Danio rerio)	Actinopterygii	zgc:123172¹	zgc:123172	53.1(n) 46.55(a)		567565 NM_001037692.1 NP_001032781.1
fruit fly (Drosophila melanogaster)	Insecta	CG12822⁶ CG18853⁶	--	26(a) 14(a)	many → 1 many → 1	2R(3719676-3721346) 2R(3716562-3717934)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G28020⁶	uncharacterized protein	26(a)	1 ↔ 1	4(13933232-13935315)
rice (Oryza sativa)	Liliopsida	--	regulator protein, putative, expressed	21(a)	1 ↔ 1	9(15582139-15585501)
E. coli (Escherichia coli)	Gamma proteobacteria	yaeB⁶	conserved protein, UPF0066 family	33(a)	1 ↔ 1	Chromosome(218887-219594)

ENSEMBL Gene Tree for C9orf156 (if available)
TreeFam Gene Tree for C9orf156 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190036208^1,2		--	100666539(+)	`TGAAAC/TACATA`	1	--	ds500¹		0	--	--	--	--
rs9299258^1,2	C,F,A,H,	--	100666543(+)	`ACACAG/TAAGTT`	1	--	ds500¹		33		NS EA NA WA CSA	2587
rs75886452^1,2	C,F,	--	100666713(+)	`AACTTT/CGTCTA`	1	--	ds500¹		1		EA	120
rs182370126^1,2		--	100666715(+)	`CTTTGA/TCTAAT`	1	--	ds500¹		0	--	--	--	--
rs185747371^1,2		--	100666726(+)	`TTTATC/GAAGTG`	1	--	ds500¹		0	--	--	--	--
rs189377300^1,2		--	100666774(+)	`CATCAC/TCTTTT`	1	--	ut3¹		0	--	--	--	--
rs2282190^1,2	C,F,H,	--	100666843(+)	`CTTTGT/CTAAGT`	1	--	ut3¹		5		NS EA	490
rs180971587^1,2		--	100666891(+)	`CAGCCC/TAAATC`	1	--	ut3¹		0	--	--	--	--
rs6586^1,2	C,F,O,A,H,	--	100666931(-)	`GTGTCA/GAGAAG`	1	--	ut3¹ ese³		36		EA MN NA NS WA CSA	4621
rs75475064^1,2	C,	--	100666951(+)	`TTGTTA/CAGAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C9orf156 (100666771 - 100684852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C9orf156: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C9orf156

DNA2.0 Custom Variant and Variant Library Synthesis for C9orf156

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C9orf156 for disorders About GeneDecksing

7 diseases for C9orf156: About MalaCards

cleft lip/palate cleft palate, isolated cleft lip cleft palate

immunodeficiency pancreatic cancer pancreatitis

1 disease from the University of Copenhagen DISEASES database for C9orf156:

Cleft lip

Human Genome Epidemiology (HuGE) Navigator: C9orf156 (2 documents)

Export disorders for C9orf156 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C9orf156 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C9orf156)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. (PubMed id 9153233)^{1, 2} Liu L.X.... Benichou S. (1997)
Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)¹ Eriksson N....Do C.B. (2012)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)¹ Letra A....Vieira A.R. (2010)
FOXE1 association with both isolated cleft lip with o r without cleft palate, and isolated cleft palate. (PubMed id 19779022)¹ Moreno L.M....Lidral A.C. (2009)
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)¹ Thalappilly S....Dusetti N.J. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51531	HGNC: 30967	AceView: C9orf156	Ensembl:ENSG00000136932	euGenes: HUgn51531
ECgene: C9orf156	H-InvDB: C9orf156

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C9orf156	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C9orf156 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for C9orf156 gene:
Search GeneIP for patents involving C9orf156

GeneCards and IP:
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C9orf156 Gene

chromosome 9 open reading frame 156

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C9orf156 Gene

chromosome 9 open reading frame 156

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