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Aliases for C9orf135 Gene

Aliases for C9orf135 Gene

  • Chromosome 9 Open Reading Frame 135 2 3

External Ids for C9orf135 Gene

Previous GeneCards Identifiers for C9orf135 Gene

  • GC09P071625
  • GC09P072435
  • GC09P042280

Summaries for C9orf135 Gene

GeneCards Summary for C9orf135 Gene

C9orf135 (Chromosome 9 Open Reading Frame 135) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf135 Gene

Genomics for C9orf135 Gene

Regulatory Elements for C9orf135 Gene

Genomic Location for C9orf135 Gene

Start:
69,820,793 bp from pter
End:
69,906,232 bp from pter
Size:
85,440 bases
Orientation:
Plus strand

Genomic View for C9orf135 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf135 Gene

Proteins for C9orf135 Gene

  • Protein details for C9orf135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTT2-CI135_HUMAN
    Recommended name:
    Uncharacterized protein C9orf135
    Protein Accession:
    Q5VTT2
    Secondary Accessions:
    • A7E2U4
    • B2RN61

    Protein attributes for C9orf135 Gene

    Size:
    229 amino acids
    Molecular mass:
    26445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C9orf135 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C9orf135 Gene

Proteomics data for C9orf135 Gene at MOPED

Post-translational modifications for C9orf135 Gene

  • Glycosylation at Asn75
  • Modification sites at PhosphoSitePlus

Other Protein References for C9orf135 Gene

No data available for DME Specific Peptides for C9orf135 Gene

Domains for C9orf135 Gene

Protein Domains for C9orf135 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C9orf135: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C9orf135 Gene

Function for C9orf135 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf135

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C9orf135 Gene

Localization for C9orf135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C9orf135 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf135 Gene COMPARTMENTS Subcellular localization image for C9orf135 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for C9orf135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C9orf135: view

Pathways for C9orf135 Gene

SuperPathways for C9orf135 Gene

No Data Available

Interacting Proteins for C9orf135 Gene

Gene Ontology (GO) - Biological Process for C9orf135 Gene

None

No data available for Pathways by source for C9orf135 Gene

Transcripts for C9orf135 Gene

Unigene Clusters for C9orf135 Gene

Chromosome 9 open reading frame 135:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C9orf135

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C9orf135

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf135 Gene

No ASD Table

Relevant External Links for C9orf135 Gene

GeneLoc Exon Structure for
C9orf135
ECgene alternative splicing isoforms for
C9orf135

Expression for C9orf135 Gene

mRNA expression in normal human tissues for C9orf135 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C9orf135 Gene

This gene is overexpressed in Pituitary (15.5) and Testis (12.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C9orf135 Gene

SOURCE GeneReport for Unigene cluster for C9orf135 Gene Hs.444459

genes like me logo Genes that share expressions with C9orf135: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for C9orf135 Gene

Orthologs for C9orf135 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C9orf135 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf135 35
  • 98.25 (n)
  • 96.51 (a)
C9orf135 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8H9orf135 35
  • 85.74 (n)
  • 78.6 (a)
C8H9orf135 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1H9orf135 35
  • 84.72 (n)
  • 75.98 (a)
C9orf135 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700028P14Rik 35
  • 74.85 (n)
  • 63.6 (a)
1700028P14Rik 16
1700028P14Rik 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C9orf135 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf135 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1560242 35
  • 73.25 (n)
  • 63.16 (a)
lizard
(Anolis carolinensis)
Reptilia C9orf135 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485682 35
  • 53.77 (n)
  • 46.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for C9orf135:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C9orf135 Gene

ENSEMBL:
Gene Tree for C9orf135 (if available)
TreeFam:
Gene Tree for C9orf135 (if available)

Paralogs for C9orf135 Gene

No data available for Paralogs for C9orf135 Gene

Variants for C9orf135 Gene

Sequence variations from dbSNP and Humsavar for C9orf135 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs766002 -- 69,865,754(+) ATACA(A/G)GCTGA intron-variant
rs766003 -- 69,865,524(+) TTATG(A/G)ATGGC intron-variant
rs990865 -- 69,878,394(+) GTGTT(C/T)CACCC intron-variant
rs1004487 -- 69,851,981(-) ACTGA(A/G)ACTCA intron-variant
rs1027285 -- 69,891,064(-) TTTTC(C/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf135 Gene

Variant ID Type Subtype PubMed ID
nsv831611 CNV Gain 17160897
nsv893438 CNV Gain 21882294
nsv6552 CNV Insertion 18451855
nsv831612 CNV Gain 17160897
nsv471310 CNV Gain 18288195
nsv466416 CNV Gain 19166990
nsv893439 CNV Loss 21882294
esv32574 CNV Loss 17666407
nsv524309 CNV Loss 19592680
nsv515734 CNV Loss 19592680

Relevant External Links for C9orf135 Gene

HapMap Linkage Disequilibrium report
C9orf135

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C9orf135 Gene

Disorders for C9orf135 Gene

Relevant External Links for C9orf135

Genetic Association Database (GAD)
C9orf135
Human Genome Epidemiology (HuGE) Navigator
C9orf135
genes like me logo Genes that share disorders with C9orf135: view

No data available for UniProtKB/Swiss-Prot for C9orf135 Gene

Publications for C9orf135 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. A Bayesian approach to genetic association studies with family-based designs. (PMID: 20818722) Naylor M.G. … Lange C. (Genet. Epidemiol. 2010) 3 48
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48

Products for C9orf135 Gene

Sources for C9orf135 Gene

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