C9orf135 Gene
protein-coding GIFtS : 38
GCID: GC09 P072435
chromosome 9 open reading frame 135
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Aliasesfor C9orf135 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 9 Open Reading Frame 135 1 2 OTTHUMP000000214391 Uncharacterized Protein C9orf1352
Export aliases for C9orf135 gene to outside databases Previous GC identifers: GC09P071625 GC09P042280
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Summariesfor C9orf135 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor C9orf135 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C9orf135 gene promoter: Nkx3-1 Lmo2 HSF1 (long) Nkx3-1 v1 HNF-1A YY1 Nkx3-1 v2 HNF-1 Nkx3-1 v3 HSF1short Other transcription factors Search SABiosciences Chromatin IP Primers for C9orf135 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C9orf135
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q21.12 Ensembl cytogenetic band: 9q21.12 HGNC cytogenetic band: 9q21.11 C9orf135 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P072435: view genomic region
(about GC identifiers )
Start:
72,435,709 bp from pter
End:
72,521,148 bp from pter
Size:
85,440 bases
Orientation:
plus strand
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Proteinsfor C9orf135 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CI135_HUMAN, Q5VTT2 (See
protein sequence )Recommended Name: Uncharacterized protein C9orf135 Size : 229 amino acids; 26445 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)
Secondary accessions : B2RN61Explore the universe of human proteins at neXtProt for C9orf135: NX_Q5VTT2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5VTT2 C9orf135 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001010940.1 ENSEMBL proteins: ENSP00000366402 ENSP00000431855 ENSP00000434032 ENSP00000436701 ENSP00000433973 ENSP00000433123 Human Recombinant Protein Products for C9orf135: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
C9orf135 for ontologies About GeneDecksing C9orf135 Antibody Products: Assay Products for C9orf135:
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Protein
Domains / Familiesfor C9orf135 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q5VTT2
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Functionfor C9orf135 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C9orf135 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C9orf135OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C9orf135 (NM_001010940 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C9orf135 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C9orf135
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf135
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Pathways & Interactionsfor C9orf135 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C9orf135
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Drugs & Compoundsfor C9orf135 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C9orf135 Search CenterWatch for drugs/clinical trials and news about C9orf135 / CI135
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Transcriptsfor C9orf135 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for C9orf135 gene: NM_001010940.1 Unigene Cluster for C9orf135:
Chromosome 9 open reading frame 135 Hs.444459 [show with all ESTs ] Unigene Representative Sequence: NM_001010940 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000377197 (uc004ahl.3 uc010moq.3 uc010mop.3 ) ENST00000527647 ENST00000529446 ENST00000529131 (uc011lrw.2 ) ENST00000466872 (uc011lrx.2 )ENST00000495399 ENST00000480564 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C9orf135 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C9orf135OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C9orf135 (NM_001010940 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C9orf135 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C9orf135
Additional cDNA sequence: BC127686.1 BC127687.1 BC136709.1 BC144373.1 BC144374.1 BC144375.1 BC150564.1
4 DOTS entries : DT.99946013 DT.404735
DT.95301379 DT.92017153 22 AceView cDNA sequences :
AA948291 BI825449 BE502978 AW014133 AI216761 BX118754 CD684431 CK126031 AA416734 AA757101 AA894567 AI768674 AA416815 BG192998 AA431486 BF059207 BG193301 BG213996 BG198579 BG182005 CA502919 BG218975 GeneLoc Exon Structure
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Expression for C9orf135 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C9orf135 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGAGAGTGGAbout this image C9orf135 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See C9orf135 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C9orf135 SOURCE GeneReport for Unigene cluster: Hs.444459 SABiosciences Custom PCR Arrays for C9orf135 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C9orf135Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C9orf135 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C9orf135 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C9orf135 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf135
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Orthologsfor C9orf135 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for C9orf135 gene from 2/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for C9orf135 (if available)TreeFam Gene Tree for C9orf135 (if available)
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Paralogsfor C9orf135 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor C9orf135 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C9orf135 (72435709 - 72521148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for C9orf135 1 CNV : 52852 1 Indel : 11344
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C9orf135
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Disorders
/ Diseasesfor C9orf135 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section C9orf135 for disorders About MalaCards
C9orf135 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: C9orf135 (3 documents) Export disorders for C9orf135 gene to outside databases
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Publicationsfor C9orf135 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C9orf135 gene integrated from 9 sources : (articles sorted by number of sources associating them with C9orf135) Utopia : connect your pdf to the dynamic world of online information
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952) 1 , 2 Liu T.... Smith R.D. (2005) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) A Bayesian approach to genetic association studies wi th family-based designs. (PubMed id 20818722) 1 Naylor M.G....Lange C. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C9orf135 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C9orf135 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C9orf135 gene
(According to HUGE )
About This Section --
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Specialized Databases showing C9orf135 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C9orf135 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C9orf135 gene: Search GeneIP for patents involving C9orf135 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C9orf135 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C9orf135 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C9orf135 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C9orf135 OriGene Protein Over-expression Lysate for C9orf135 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C9orf135 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C9orf135 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C9orf135 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C9orf135 OriGene Custom Protein Services for C9orf135 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C9orf135 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C9orf135 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C9orf135 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C9orf135 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C9orf135 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C9orf135
C9orf135 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C9orf135
Search ThermoFisher Antibodies for C9orf135
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C9orf135
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