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Aliases for C9orf114 Gene

Aliases for C9orf114 Gene

  • Chromosome 9 Open Reading Frame 114 2 3
  • Centromere Protein 32 2 3
  • CENP-32 3 4
  • Putative Methyltransferase C9orf114 3
  • EC 2.1.1.- 4
  • HSPC109 3

External Ids for C9orf114 Gene

Summaries for C9orf114 Gene

GeneCards Summary for C9orf114 Gene

C9orf114 (Chromosome 9 Open Reading Frame 114) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C9orf114 Gene

  • Required both for chromosome alignment and for association of the centrosomes with the poles of the bipolar spindle during metaphase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C9orf114 Gene

Genomics for C9orf114 Gene

Genomic Location for C9orf114 Gene

Start:
128,819,651 bp from pter
End:
128,830,016 bp from pter
Size:
10,366 bases
Orientation:
Minus strand

Genomic View for C9orf114 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C9orf114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C9orf114 Gene

Regulatory Elements for C9orf114 Gene

Proteins for C9orf114 Gene

  • Protein details for C9orf114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T280-CI114_HUMAN
    Recommended name:
    Putative methyltransferase C9orf114
    Protein Accession:
    Q5T280
    Secondary Accessions:
    • Q0D2P6
    • Q6P469
    • Q6PGP9
    • Q6PIJ1
    • Q6PJV9

    Protein attributes for C9orf114 Gene

    Size:
    376 amino acids
    Molecular mass:
    42009 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Depletion with RNAi causes a significant accumulation of cells in later prometaphase with misaligned chromosomes.

    Three dimensional structures from OCA and Proteopedia for C9orf114 Gene

neXtProt entry for C9orf114 Gene

Proteomics data for C9orf114 Gene at MOPED

Post-translational modifications for C9orf114 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys66

Other Protein References for C9orf114 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C9orf114 Gene

Domains for C9orf114 Gene

UniProtKB/Swiss-Prot:

CI114_HUMAN
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily.:
    • Q5T280
genes like me logo Genes that share domains with C9orf114: view

No data available for Gene Families for C9orf114 Gene

Function for C9orf114 Gene

Molecular function for C9orf114 Gene

UniProtKB/Swiss-Prot Function: Required both for chromosome alignment and for association of the centrosomes with the poles of the bipolar spindle during metaphase.

Enzyme Numbers (IUBMB) for C9orf114 Gene

Gene Ontology (GO) - Molecular Function for C9orf114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C9orf114: view

Phenotypes for C9orf114 Gene

MGI mutant phenotypes for C9orf114:
inferred from 1 alleles
GenomeRNAi human phenotypes for C9orf114:
genes like me logo Genes that share phenotypes with C9orf114: view

Animal Models for C9orf114 Gene

MGI Knock Outs for C9orf114:

miRNA for C9orf114 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for C9orf114 Gene

Localization for C9orf114 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C9orf114 Gene

Chromosome, centromere, kinetochore. Note=Associated with the outer kinetochore. {ECO:0000269 PubMed:20813266}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C9orf114 Gene COMPARTMENTS Subcellular localization image for C9orf114 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for C9orf114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C9orf114: view

Pathways for C9orf114 Gene

SuperPathways for C9orf114 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C9orf114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008150 biological_process ND --
GO:0032259 methylation IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with C9orf114: view

No data available for Pathways by source for C9orf114 Gene

Transcripts for C9orf114 Gene

Unigene Clusters for C9orf114 Gene

Chromosome 9 open reading frame 114:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C9orf114 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for C9orf114 Gene

GeneLoc Exon Structure for
C9orf114
ECgene alternative splicing isoforms for
C9orf114

Expression for C9orf114 Gene

mRNA expression in normal human tissues for C9orf114 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C9orf114 Gene

SOURCE GeneReport for Unigene cluster for C9orf114 Gene Hs.224137

genes like me logo Genes that share expressions with C9orf114: view

Orthologs for C9orf114 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C9orf114 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf114 36
  • 99.38 (n)
  • 99.2 (a)
C9orf114 37
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H9orf114 36
  • 88.59 (n)
  • 94.39 (a)
C9orf114 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf114 36
  • 88.92 (n)
  • 92.55 (a)
C9orf114 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D2Wsu81e 36
  • 85.65 (n)
  • 90.37 (a)
D2Wsu81e 16
D2Wsu81e 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C9orf114 37
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf114 37
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9orf114 36
  • 72.33 (n)
  • 73.7 (a)
C17H9ORF114 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf114 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26356 36
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf114 36
  • 67.78 (n)
  • 75.92 (a)
Str.1277 36
zebrafish
(Danio rerio)
Actinopterygii C21H9orf114 37
  • 65 (a)
OneToOne
sbcb90 36
zgc:101748 36
  • 69.25 (n)
  • 76.09 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007570 36
  • 58.99 (n)
  • 58.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12128 36
  • 56.12 (n)
  • 54.88 (a)
CG12128 37
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0361.6 36
  • 48.74 (n)
  • 44.48 (a)
B0361.6 37
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 21 (a)
OneToMany
-- 37
  • 22 (a)
OneToMany
-- 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19300 36
  • 51.01 (n)
  • 47.97 (a)
rice
(Oryza sativa)
Liliopsida Os.9692 36
Os04g0244500 36
  • 54.07 (n)
  • 52.58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00597 36
  • 50.63 (n)
  • 43.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5582 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToOne
Species with no ortholog for C9orf114:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C9orf114 Gene

ENSEMBL:
Gene Tree for C9orf114 (if available)
TreeFam:
Gene Tree for C9orf114 (if available)

Paralogs for C9orf114 Gene

No data available for Paralogs for C9orf114 Gene

Variants for C9orf114 Gene

Sequence variations from dbSNP and Humsavar for C9orf114 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2272673 -- 128,826,248(-) AGACG(C/T)AGGTC intron-variant
rs2280842 -- 128,823,529(-) ACTGG(C/G)TGACC intron-variant
rs2293964 -- 128,829,871(-) GGCGA(C/T)ATTGG upstream-variant-2KB, synonymous-codon, reference
rs2293965 -- 128,829,570(-) GCGCC(C/T)GTGTC intron-variant
rs2293966 -- 128,829,553(-) GGAAC(C/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C9orf114 Gene

Variant ID Type Subtype PubMed ID
nsv893901 CNV Loss 21882294
nsv893902 CNV Gain 21882294
dgv8296n71 CNV Loss 21882294
nsv521120 CNV Loss 19592680
dgv8297n71 CNV Loss 21882294
nsv6724 CNV Insertion 18451855

Relevant External Links for C9orf114 Gene

HapMap Linkage Disequilibrium report
C9orf114
Human Gene Mutation Database (HGMD)
C9orf114

Disorders for C9orf114 Gene

No disorders were found for C9orf114 Gene.

No data available for UniProtKB/Swiss-Prot for C9orf114 Gene

Publications for C9orf114 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3

Products for C9orf114 Gene

  • antibodies-online proteins for C9orf114
  • antibodies-online antibodies for C9orf114
  • antibodies-online kits for C9orf114

Sources for C9orf114 Gene

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