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Aliases for C8orf88 Gene

Aliases for C8orf88 Gene

  • Chromosome 8 Open Reading Frame 88 2 3 5

External Ids for C8orf88 Gene

Previous GeneCards Identifiers for C8orf88 Gene

  • GC08M091971

Summaries for C8orf88 Gene

GeneCards Summary for C8orf88 Gene

C8orf88 (Chromosome 8 Open Reading Frame 88) is a Protein Coding gene.

Additional gene information for C8orf88 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf88 Gene

Genomics for C8orf88 Gene

Regulatory Elements for C8orf88 Gene

Enhancers for C8orf88 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H089999 1.3 ENCODE dbSUPER 10.9 +983.7 983738 3 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 NBN C8orf88 LOC101929709 DECR1
GH08H090983 1 ENCODE 7.5 +0.2 175 2 HDGF PKNOX1 ATF1 ZNF2 ZNF766 GLIS2 ZNF143 ATF7 SP3 REST LOC102724670 OTUD6B-AS1 OTUD6B LOC105375634 C8orf88 TMEM64
GH08H090858 1.1 ENCODE dbSUPER 5.1 +125.6 125570 3 HDGF PKNOX1 NFIB SIN3A ZNF207 FOS RCOR1 ZNF843 ZNF592 ZNF217 LOC105375634 SLC26A7 C8orf88 LOC105375635
GH08H090883 0.6 ENCODE dbSUPER 4.2 +101.5 101548 0 HNF4A LOC105375634 C8orf88 LOC105375635
GH08H090942 0.2 Ensembl 6 +43.0 42957 0 C8orf88 LOC105375634 LOC105375635
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C8orf88 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf88 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226879 256 1600 HDGF PKNOX1 ATF1 ZNF2 ZNF766 GLIS2 ZNF143 ATF7 SP3 REST

Genomic Location for C8orf88 Gene

Chromosome:
8
Start:
90,958,478 bp from pter
End:
90,985,257 bp from pter
Size:
26,780 bases
Orientation:
Minus strand

Genomic View for C8orf88 Gene

Genes around C8orf88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf88 Gene

Proteins for C8orf88 Gene

  • Protein details for C8orf88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMB2-CH088_HUMAN
    Recommended name:
    Uncharacterized protein C8orf88
    Protein Accession:
    P0DMB2

    Protein attributes for C8orf88 Gene

    Size:
    117 amino acids
    Molecular mass:
    13372 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C8orf88 Gene

Post-translational modifications for C8orf88 Gene

No Post-translational modifications

Other Protein References for C8orf88 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf88 Gene

Domains & Families for C8orf88 Gene

Gene Families for C8orf88 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf88 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf88: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf88 Gene

Function for C8orf88 Gene

Gene Ontology (GO) - Molecular Function for C8orf88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008190 eukaryotic initiation factor 4E binding IBA --
genes like me logo Genes that share ontologies with C8orf88: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf88 Gene

Localization for C8orf88 Gene

Gene Ontology (GO) - Cellular Components for C8orf88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with C8orf88: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for C8orf88 Gene

Pathways & Interactions for C8orf88 Gene

SuperPathways for C8orf88 Gene

No Data Available

Interacting Proteins for C8orf88 Gene

Gene Ontology (GO) - Biological Process for C8orf88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045947 negative regulation of translational initiation IBA --
genes like me logo Genes that share ontologies with C8orf88: view

No data available for Pathways by source and SIGNOR curated interactions for C8orf88 Gene

Drugs & Compounds for C8orf88 Gene

No Compound Related Data Available

Transcripts for C8orf88 Gene

mRNA/cDNA for C8orf88 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf88 Gene

No ASD Table

Relevant External Links for C8orf88 Gene

GeneLoc Exon Structure for
C8orf88
ECgene alternative splicing isoforms for
C8orf88

Expression for C8orf88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf88 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf88 Gene

This gene is overexpressed in Testis (x7.0) and Heart - Left Ventricle (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of C8orf88 Gene:

C8orf88

Evidence on tissue expression from TISSUES for C8orf88 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with C8orf88: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf88 Gene

Orthologs for C8orf88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC464280 33
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia LOC100848919 33
  • 94.54 (n)
mouse
(Mus musculus)
Mammalia Gm11837 33 16
  • 94.02 (n)
chicken
(Gallus gallus)
Aves LOC420220 33
  • 65.2 (n)
C8orf88 34
  • 48 (a)
OneToOne
Species where no ortholog for C8orf88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf88 Gene

ENSEMBL:
Gene Tree for C8orf88 (if available)
TreeFam:
Gene Tree for C8orf88 (if available)

Paralogs for C8orf88 Gene

No data available for Paralogs for C8orf88 Gene

Variants for C8orf88 Gene

Sequence variations from dbSNP and Humsavar for C8orf88 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000022009 -- 90,984,922(+) GCTCC(C/T)ATCCC intron-variant
rs1000331627 -- 90,984,148(+) ATTCT(A/T)GTCTT intron-variant
rs1000350792 -- 90,972,564(+) TTAAA(A/T)TACTG intron-variant
rs1000695761 -- 90,974,009(+) AGCTC(C/T)CAGGA intron-variant
rs1000726474 -- 90,973,753(+) TGCTA(C/G)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf88 Gene

Variant ID Type Subtype PubMed ID
esv2759629 CNV loss 17122850
nsv1028201 CNV loss 25217958

Variation tolerance for C8orf88 Gene

Gene Damage Index Score: 0.32; 7.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf88 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf88 Gene

Disorders for C8orf88 Gene

Relevant External Links for C8orf88

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf88

No disorders were found for C8orf88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf88 Gene

Publications for C8orf88 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  3. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PMID: 16368877) Choy KW … Pang CP (Physiological genomics 2006) 4 60
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60

Products for C8orf88 Gene

Sources for C8orf88 Gene

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