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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C8orf82 Gene

protein-coding   GIFtS: 37
GCID: GC08M145751          (predicted)

chromosome 8 open reading frame 82
  Search for C8orf82
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C8orf82    

Aliases
for C8orf82 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 8 Open Reading Frame 821 2
MGC708571
UPF0598 Protein C8orf822

External Ids:    HGNC: 338261   Entrez Gene: 4149192   Ensembl: ENSG000002135637   UniProtKB: Q6P1X63   

Export aliases for C8orf82 gene to outside databases

Previous GC identifers: GC08M145723 GC08M140865


Summaries
for C8orf82 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C8orf82 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_037704.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C8orf82 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: C8orf82 promoter sequence
   Search SABiosciences Chromatin IP Primers for C8orf82

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8orf82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

C8orf82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8orf82 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145751:  view genomic region     (about GC identifiers)

Start:
 145,751,117 bp from pter      End:
 145,754,516 bp from pter
Size:
 3,400 bases      Orientation:
 minus strand

Proteins
for C8orf82 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CH082_HUMAN, Q6P1X6 (See protein sequence)
Recommended Name: UPF0598 protein C8orf82  
Size: 216 amino acids; 23889 Da
Secondary accessions: Q6GMR2 Q6P2Q7
Alternative splicing: 2 isoforms:  Q6P1X6-1   Q6P1X6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C8orf82: NX_Q6P1X6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6P1X6

    • C8orf82 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001001795.1  
    ENSEMBL proteins: 
     ENSP00000436621   ENSP00000316262   ENSP00000434593   ENSP00000437092   ENSP00000436060  

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    Uscn Proteins for C8orf82

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--


    C8orf82 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for C8orf82 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6P1X6

    UniProtKB/Swiss-Prot: CH082_HUMAN, Q6P1X6
    Similarity: Belongs to the UPF0598 family


    Function
    for C8orf82 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for C8orf82 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf82

    Drugs & Compounds
    for C8orf82 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for C8orf82
    Search CenterWatch for drugs/clinical trials and news about C8orf82 / CH082 

    Transcripts
    for C8orf82 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for C8orf82 gene: 
    NM_001001795.1  

    Unigene Cluster for C8orf82:

    Chromosome 8 open reading frame 82
    Hs.105685  [show with all ESTs]
    Unigene Representative Sequence: BC073936
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524821(uc003zdp.1) ENST00000313465(uc003zdq.1) ENST00000534680
    ENST00000532827 ENST00000527462

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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    BC064373.1 BC064829.1 BC073936.1 

    6 DOTS entries:

    DT.99956074  DT.92418609  DT.121469462  DT.207407  DT.102843664  DT.95164501 

    24/138 AceView cDNA sequences (see all 138):

    CR619484 BQ070255 CR614853 CA944658 BC064373 BI789071 CR607461 AA931913 
    AI611836 BE465287 BI962510 BF348140 BU683306 BQ876813 BU622744 BM666720 
    BM924513 BF530541 BM982982 BQ188918 AI734995 BQ345019 BI823121 CR617155 

    GeneLoc Exon Structure


    Expression
    for C8orf82 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C8orf82 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCTGGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C8orf82 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C8orf82 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C8orf82

    SOURCE GeneReport for Unigene cluster: Hs.105685
        SABiosciences Custom PCR Arrays for C8orf82
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    In Situ
    Assay Products:     
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    Orthologs
    for C8orf82 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for C8orf82 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia C030006K11Rik1 , 5 RIKEN cDNA C030006K11 gene1, 5 84.1(n)1
    86.57(a)1    		   15 (36.28 cM)5
    2236651  NM_145472.21  NP_663447.11 
     767214665 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch1073-287p18.16
    		 si:ch1073-287p18.1
    		 56(a)
    		 1 ↔ 1
    		 20(52672610-52678448)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG300101 CG30010 56.31(n)
    56.08(a)    		   246389  NM_165715.1  NP_724847.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F59C6.121 Protein F59C6.12 50(n)
    48.61(a)    		   3565901  NM_001026351.1  NP_001021522.1 


    ENSEMBL Gene Tree for C8orf82 (if available)
    TreeFam Gene Tree for C8orf82 (if available) 

    Paralogs
    for C8orf82 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for C8orf82 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/37 NCBI SNPs in C8orf82 are shown (see all 37)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1824828661,2
    		--145751540(+) TGGCCG/TTGGTG 2 -- int10--------
    rs1847822221,2
    		--145751682(+) TGTGAA/TCCCCA 2 -- int1 ut310--------
    rs1382618571,2
    		--145751746(+) TGTTGA/GTACGT 2 -- ut31 int10--------
    rs1891208481,2
    		--145751883(+) GGCCTA/GCCAGG 2 -- ut31 int10--------
    rs1814364341,2
    		--145751889(+) CCAGGA/GCAGGG 2 -- int1 ut310--------
    rs1169056431,2
    		--145752130(+) CAGCGC/TTGCGA 2 -- int1 ut311Minor allele frequency- T:0.01EA 120
    rs602640481,2
    		C,F,--145752155(+) CCCCCA/CCGGCC 2 -- int1 ut311Minor allele frequency- C:0.20WA 118
    rs1167931221,2
    		F,--145752287(+) GGATGG/ATCCCC 2 -- ut31 int11Minor allele frequency- A:0.06WA 118
    rs27211421,2
    		C,--145752467(+) CCGCCA/TGTGCC 2 -- us2k1 ut313Minor allele frequency- T:0.45NA 124
    rs1860715341,2
    		--145752527(+) GGGGGA/GCGCGC 2 -- us2k1 ut310--------

    HapMap Linkage Disequilibrium report for C8orf82 (145751117 - 145754516 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for C8orf82
         1 CNV: 4613

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    Disorders / Diseases
    for C8orf82 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C8orf82 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C8orf82 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C8orf82)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for C8orf82 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C8orf82 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 414919 HGNC: 33826 AceView: MGC70857 Ensembl:ENSG00000213563 euGenes: HUgn414919
    ECgene: C8orf82 H-InvDB: C8orf82

    Other Databases showing C8orf82 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C8orf82 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C8orf82 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C8orf82 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C8orf82 gene:
    Search GeneIP for patents involving C8orf82

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C8orf82 gene

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    About This Section

     
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