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C8orf82 Gene

protein-coding   GIFtS: 35
GCID: GC08M145751          (predicted)

Chromosome 8 Open Reading Frame 82

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 8 Open Reading Frame 821 2
UPF0598 Protein C8orf822

External Ids:    HGNC: 338261   Entrez Gene: 4149192   Ensembl: ENSG000002135637   UniProtKB: Q6P1X63   

Export aliases for C8orf82 gene to outside databases

Previous GC identifers: GC08M145723 GC08M140865


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C8orf82 Gene:
C8orf82 (chromosome 8 open reading frame 82) is a protein-coding gene. Diseases associated with C8orf82 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the C8orf82 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC8orf82 promoter sequence
   Search Chromatin IP Primers for C8orf82

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C8orf82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

C8orf82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8orf82 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145751:  view genomic region     (about GC identifiers)

Start:
145,751,117 bp from pter      End:
145,754,516 bp from pter
Size:
3,400 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CH082_HUMAN, Q6P1X6 (See protein sequence)
Recommended Name: UPF0598 protein C8orf82  
Size: 216 amino acids; 23889 Da
Secondary accessions: Q6GMR2 Q6P2Q7
Alternative splicing: 2 isoforms:  Q6P1X6-1   Q6P1X6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C8orf82: NX_Q6P1X6

Explore proteomics data for C8orf82 at MOPED


See C8orf82 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001001795.1  
ENSEMBL proteins: 
 ENSP00000436621   ENSP00000316262   ENSP00000434593   ENSP00000437092   ENSP00000436060  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR028108 DUF4505

Graphical View of Domain Structure for InterPro Entry Q6P1X6

ProtoNet protein and cluster: Q6P1X6

UniProtKB/Swiss-Prot: CH082_HUMAN, Q6P1X6
Similarity: Belongs to the UPF0598 family


C8orf82 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C8orf82
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SwitchGear 3'UTR luciferase reporter plasmidC8orf82 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion3
cytosol1
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IEA--

C8orf82 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C8orf82
Interactions:

    Search GeneGlobe Interaction Network for C8orf82

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C8orf82 (CH082)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for C8orf82 gene: 
NM_001001795.1  

Unigene Cluster for C8orf82:

Chromosome 8 open reading frame 82
Hs.105685  [show with all ESTs]
Unigene Representative Sequence: BC073936
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000524821(uc003zdp.1) ENST00000313465(uc003zdq.1) ENST00000534680
ENST00000532827 ENST00000527462
miRNA
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5 qRT-PCR Assays for microRNAs that regulate C8orf82:
hsa-miR-1178 hsa-miR-501-5p hsa-miR-3622b-3p hsa-miR-561 hsa-miR-3939
SwitchGear 3'UTR luciferase reporter plasmidC8orf82 3' UTR sequence
Inhib. RNA
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat C8orf82

Additional mRNA sequence: 

BC064373.1 BC064829.1 BC073936.1 

6 DOTS entries:

DT.99956074  DT.92418609  DT.207407  DT.121469462  DT.102843664  DT.95164501 

Selected AceView cDNA sequences (see all 138):

AI734995 BQ345019 BI962510 BX280596 AI611836 BU622744 BI823121 BQ876813 
BF530541 BM924513 NM_001001795 CR607461 CR614853 BQ188918 BQ070255 AA931913 
CR617155 BC064373 BM666720 AW342082 BU683306 CR620177 BI789071 BE465287 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C8orf82 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACCTGGCCC
C8orf82 Expression
About this image

C8orf82 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C8orf82 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.105685
    Custom PCR Arrays for C8orf82
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf82

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for C8orf82 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia C030006K11Rik1 , 5 RIKEN cDNA C030006K11 gene1, 5 84.1(n)1
86.57(a)1
  15 (36.28 cM)5
2236651  NM_145472.21  NP_663447.11 
 767214665 
zebrafish
(Danio rerio)
Actinopterygii C20H8orf826
chromosome 8 open reading frame 82
55(a)
1 ↔ 1
20(52672610-52678448) ENSDARG00000075765
fruit fly
(Drosophila melanogaster)
Insecta CG300101 CG30010 56.76(n)
56.08(a)
  246389  NM_165715.1  NP_724847.1 
worm
(Caenorhabditis elegans)
Secernentea CELE_F59C6.121 CELE_F59C6.12 50(n)
48(a)
  3565901  NM_001026351.1  NP_001021522.1 


ENSEMBL Gene Tree for C8orf82 (if available)
TreeFam Gene Tree for C8orf82 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) Selected variations for C8orf82 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
dgv7966n71CNV Loss21882294
nsv891897CNV Loss21882294
dgv7977n71CNV Loss21882294
dgv7976n71CNV Loss21882294
dgv7978n71CNV Loss21882294
dgv7984n71CNV Loss21882294
nsv522459CNV Loss19592680
nsv891846CNV Loss21882294
dgv7969n71CNV Loss21882294
nsv891807CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for C8orf82:    
About MalaCards
malaria


C8orf82 for disorders           About GeneDecksing


Export disorders for C8orf82 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C8orf82 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C8orf82)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 414919 HGNC: 33826 AceView: MGC70857 Ensembl:ENSG00000213563 euGenes: HUgn414919
ECgene: C8orf82 H-InvDB: C8orf82

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C8orf82 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C8orf82 gene:
Search GeneIP for patents involving C8orf82

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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