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Aliases for C8orf76 Gene

Aliases for C8orf76 Gene

  • Chromosome 8 Open Reading Frame 76 2 3 5

External Ids for C8orf76 Gene

Previous GeneCards Identifiers for C8orf76 Gene

  • GC08M124302
  • GC08M124232
  • GC08M119557

Summaries for C8orf76 Gene

GeneCards Summary for C8orf76 Gene

C8orf76 (Chromosome 8 Open Reading Frame 76) is a Protein Coding gene. An important paralog of this gene is ZHX1-C8orf76.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf76 Gene

Genomics for C8orf76 Gene

Regulatory Elements for C8orf76 Gene

Enhancers for C8orf76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F122916 1.1 Ensembl ENCODE 5.5 +323.1 323066 3.2 HDGF HDAC1 PKNOX1 SIN3A ZBTB40 ZNF23 CREM JUNB TBX21 ZNF592 C8orf76 PIR45357 GC08P122905
GH08F123232 0.6 ENCODE 5.8 +8.8 8794 1.7 JUND SMARCA4 SIN3A REST MNT C8orf76 FAM83A UBA52P5 GC08P123216
GH08F123394 1.5 FANTOM5 ENCODE 2.3 -154.5 -154452 3.0 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3 NFYC DERL1 LOC105375738 ARF1P3 ENSG00000254249 FER1L6-AS1 ENSG00000254000 LOC392268 WDYHV1 FAM91A1 C8orf76
GH08F122796 1.5 FANTOM5 Ensembl ENCODE 1.5 +442.5 442498 4.2 HDGF ELF3 ARID4B RAD21 RARA CREM SP5 KAT8 RAD51 MAFF ZHX2 C8orf76 PIR52073 ENSG00000253372
GH08F122779 1.5 FANTOM5 ENCODE 1.4 +459.5 459466 4.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZHX2 TBC1D31 DERL1 C8orf76 PIR52073
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C8orf76 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001445004 498 2200 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for C8orf76 Gene

Chromosome:
8
Start:
123,219,956 bp from pter
End:
123,241,398 bp from pter
Size:
21,443 bases
Orientation:
Minus strand

Genomic View for C8orf76 Gene

Genes around C8orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf76 Gene

Proteins for C8orf76 Gene

  • Protein details for C8orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K31-CH076_HUMAN
    Recommended name:
    Uncharacterized protein C8orf76
    Protein Accession:
    Q96K31
    Secondary Accessions:
    • Q53HC1

    Protein attributes for C8orf76 Gene

    Size:
    380 amino acids
    Molecular mass:
    43273 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf76 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf76 Gene

Post-translational modifications for C8orf76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf76 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf76 Gene

Domains & Families for C8orf76 Gene

Protein Domains for C8orf76 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf76: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf76 Gene

Function for C8orf76 Gene

Phenotypes for C8orf76 Gene

genes like me logo Genes that share phenotypes with C8orf76: view

Animal Model Products

miRNA for C8orf76 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf76 Gene

Localization for C8orf76 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf76 gene
Compartment Confidence
cytosol 2
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf76 Gene

Pathways & Interactions for C8orf76 Gene

SuperPathways for C8orf76 Gene

No Data Available

Interacting Proteins for C8orf76 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000276704%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000276704 Q96K31-CH076_HUMAN for C8orf76 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C8orf76 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf76 Gene

Transcripts for C8orf76 Gene

Unigene Clusters for C8orf76 Gene

Chromosome 8 open reading frame 76:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf76 Gene

No ASD Table

Relevant External Links for C8orf76 Gene

GeneLoc Exon Structure for
C8orf76
ECgene alternative splicing isoforms for
C8orf76

Expression for C8orf76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C8orf76 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf76 Gene:

C8orf76

SOURCE GeneReport for Unigene cluster for C8orf76 Gene:

Hs.707401
genes like me logo Genes that share expression patterns with C8orf76: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C8orf76 Gene

Orthologs for C8orf76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf76 34
  • 99.47 (n)
C8orf76 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C13H8orf76 34
  • 91.23 (n)
-- 35
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C14H8orf76 34
  • 89.01 (n)
-- 35
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1310852 34
  • 78.37 (n)
mouse
(Mus musculus)
Mammalia 9130401M01Rik 34 16 35
  • 77.99 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves C2H8ORF76 34
  • 59.91 (n)
-- 35
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c8orf76 34
  • 54.55 (n)
Str.11515 34
zebrafish
(Danio rerio)
Actinopterygii zgc:101716 34
  • 52.36 (n)
C16H8orf76 35
  • 35 (a)
OneToMany
Species where no ortholog for C8orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf76 Gene

ENSEMBL:
Gene Tree for C8orf76 (if available)
TreeFam:
Gene Tree for C8orf76 (if available)

Paralogs for C8orf76 Gene

Paralogs for C8orf76 Gene

(1) SIMAP similar genes for C8orf76 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C8orf76: view

Variants for C8orf76 Gene

Sequence variations from dbSNP and Humsavar for C8orf76 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs111248288 -- 123,237,802(+) CCAAG(C/T)TTGCA reference, missense
rs111443637 -- 123,225,924(+) GTCTC(-/A)AAAAA intron-variant
rs111474404 -- 123,240,185(+) AGTGG(G/T)TAAAG intron-variant
rs111493779 -- 123,224,163(+) AGAAT(A/T)AAAAA intron-variant
rs111508752 -- 123,226,739(+) CTGCA(A/G)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf76 Gene

Variant ID Type Subtype PubMed ID
nsv1032827 CNV gain 25217958
nsv981978 CNV duplication 23825009

Variation tolerance for C8orf76 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf76 Gene

Disorders for C8orf76 Gene

Relevant External Links for C8orf76

Human Genome Epidemiology (HuGE) Navigator
C8orf76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf76

No disorders were found for C8orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf76 Gene

Publications for C8orf76 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. (PMID: 25356737) Jung J.G. … Wang T.L. (PLoS Genet. 2014) 3 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  5. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. (PMID: 19416867) Kim Y.C. … Wang S.M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 64

Products for C8orf76 Gene

Sources for C8orf76 Gene

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