C8orf74 Gene
protein-coding GIFtS: 37
GCID: GC08P010530
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chromosome 8 open reading frame 74
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Aliases
for C8orf74 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 8 Open Reading Frame 741 2 | | Uncharacterized Protein C8orf742 |
Export aliases for C8orf74 gene to outside databasesPrevious GC identifers: GC08P010568 GC08P010569 GC08P009460 |
Summaries
for C8orf74 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C8orf74 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_077531.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C8orf74 gene promoter:
Tal-1 POU6F1 (c2) NF-kappaB Tal-1beta Cdc5 E47 Ik-2 NF-kappaB2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C8orf74
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8orf74 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1C8orf74 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P010530: view genomic region
(about GC identifiers)
Start:
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10,530,147 bp from pter |
End:
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10,558,103 bp from pter |
Size:
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27,957 bases |
Orientation:
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plus strand |
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Proteins
for C8orf74 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CH074_HUMAN, Q6P047 (See
protein sequence)Recommended Name: Uncharacterized protein C8orf74 Size: 294 amino acids; 33735 Da
Sequence caution: Sequence=AAH65837.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RUD6Explore the universe of human proteins at neXtProt for C8orf74: NX_Q6P047
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P047
C8orf74 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035121.1
ENSEMBL proteins: ENSP00000307129 ENSP00000432993 ENSP00000430613 ENSP00000429505
Human Recombinant Protein Products:
C8orf74 Antibody Products:
Assay Products for C8orf74: |
Protein
Domains /
Families
for C8orf74 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6P047 |
Function
for C8orf74 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf74 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf74
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C8orf74 (NM_001040032) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C8orf74 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf74 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf74 |
1 GenomeRNAi human phenotype for C8orf74:
|
Pathways & Interactions
for C8orf74 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf74
|
Drugs & Compounds
for C8orf74 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C8orf74
Search CenterWatch for drugs/clinical trials and news about C8orf74 / CH074
|
Transcripts
for C8orf74 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C8orf74 gene: NM_001040032.1 Unigene Cluster for C8orf74: Chromosome 8 open reading frame 74 Hs.371776 [show with all ESTs]Unigene Representative Sequence: AK1314437 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000304519(uc003wtd.1) ENST00000524025 ENST00000517414 ENST00000523723
ENST00000523289(uc003wte.1) ENST00000521818 ENST00000519925
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf74 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf74
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C8orf74 (NM_001040032) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C8orf74 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf74 |
Additional cDNA sequence: AK131443.1 BC038534.1 BC065837.1 BC132852.1 BC132854.1 3 DOTS entries: DT.100673544 DT.454169 DT.102820641 12 AceView cDNA sequences: BC065837 BC038534 CD251983 AI201239 AK131443 BI832125 AW593209 AA781848 AA609312 AI279969 AA609189 AA644405
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for C8orf74 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
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| SP1: | | | | | - | | | | - | | - | | - | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for C8orf74
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Expression
for C8orf74 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C8orf74 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTTGGTG
About this image
See C8orf74 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C8orf74
SOURCE GeneReport for Unigene cluster: Hs.371776
SABiosciences Custom PCR Arrays for C8orf74
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C8orf74
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C8orf74 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C8orf74 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C8orf74 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf74 |
Orthologs
for C8orf74 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C8orf74 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for C8orf74 (if available)
TreeFam Gene Tree for C8orf74 (if available) |
Paralogs
for C8orf74 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C8orf74 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C8orf74 (10530147 - 10558103 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 20 variations for C8orf74
2 CNVs: 53324 52326
2 Indels: 95242 82474
15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C8orf74 |
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Disorders
/ Diseases
for C8orf74 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C8orf74 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C8orf74 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C8orf74) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C8orf74 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C8orf74 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C8orf74 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C8orf74 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C8orf74 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C8orf74 gene:
Search GeneIP for patents involving C8orf74
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C8orf74 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C8orf74 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C8orf74 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C8orf74 | | | OriGene Protein Over-expression Lysate for C8orf74 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C8orf74 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf74 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf74 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C8orf74 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for C8orf74 |
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 | | | C8orf74 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf74 |
|  |  |  | | | | Search ThermoFisher Antibodies for C8orf74 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf74 |
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