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Aliases for C8orf74 Gene

Aliases for C8orf74 Gene

  • Chromosome 8 Open Reading Frame 74 2 3 5

External Ids for C8orf74 Gene

Previous GeneCards Identifiers for C8orf74 Gene

  • GC08P010568
  • GC08P010569
  • GC08P010530
  • GC08P009460

Summaries for C8orf74 Gene

GeneCards Summary for C8orf74 Gene

C8orf74 (Chromosome 8 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf74 Gene

Genomics for C8orf74 Gene

Regulatory Elements for C8orf74 Gene

Enhancers for C8orf74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F010965 0.7 FANTOM5 26.3 +293.2 293165 0.2 POLR2A C8orf74 PRSS55 ENSG00000254936 GC08P010967 PIR55470 PIR49045
GH08F010652 0.7 ENCODE 12.5 -21.3 -21347 0.2 C8orf74 RP1L1 ENSG00000269954 MIR4286 LOC105379237
GH08F010698 0.2 ENCODE 12.4 +26.1 26145 1.1 ZNF589 MCM3 JUND ATF3 CEBPB ZNF584 NR2F2 C8orf74 ENSG00000269918 RNA5SP252 RP1L1
GH08F010728 0.5 ENCODE 11.7 +57.3 57256 2.6 ARNT ZNF2 RAD21 GLIS2 ZNF143 ZNF391 ZNF654 YY2 REST ZEB2 C8orf74 RP1L1 ENSG00000269918 GC08M010730 LOC102723313
GH08F010714 0.8 FANTOM5 Ensembl ENCODE 11.6 +43.6 43649 3.3 TBP HDAC1 KLF17 ETV6 REST NR2F2 TFDP1 ZFP69B ZNF589 SMARCA4 C8orf74 ENSG00000269918 SOX7 RP1L1 LOC102723313
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C8orf74 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf74 Gene

Chromosome:
8
Start:
10,672,592 bp from pter
End:
10,700,613 bp from pter
Size:
28,022 bases
Orientation:
Plus strand

Genomic View for C8orf74 Gene

Genes around C8orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf74 Gene

Proteins for C8orf74 Gene

  • Protein details for C8orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P047-CH074_HUMAN
    Recommended name:
    Uncharacterized protein C8orf74
    Protein Accession:
    Q6P047
    Secondary Accessions:
    • A2RUD6

    Protein attributes for C8orf74 Gene

    Size:
    294 amino acids
    Molecular mass:
    33735 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65837.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C8orf74 Gene

Post-translational modifications for C8orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf74 Gene

No data available for DME Specific Peptides for C8orf74 Gene

Domains & Families for C8orf74 Gene

Protein Domains for C8orf74 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf74: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf74 Gene

Function for C8orf74 Gene

Gene Ontology (GO) - Molecular Function for C8orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with C8orf74: view
genes like me logo Genes that share phenotypes with C8orf74: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf74 Gene

Localization for C8orf74 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf74 Gene COMPARTMENTS Subcellular localization image for C8orf74 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf74 Gene

Pathways & Interactions for C8orf74 Gene

SuperPathways for C8orf74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C8orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf74 Gene

Transcripts for C8orf74 Gene

mRNA/cDNA for C8orf74 Gene

Unigene Clusters for C8orf74 Gene

Chromosome 8 open reading frame 74:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf74 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for C8orf74 Gene

GeneLoc Exon Structure for
C8orf74
ECgene alternative splicing isoforms for
C8orf74

Expression for C8orf74 Gene

mRNA expression in normal human tissues for C8orf74 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf74 Gene

This gene is overexpressed in Testis (x47.1).

Protein differential expression in normal tissues from HIPED for C8orf74 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf74 Gene



Protein tissue co-expression partners for C8orf74 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C8orf74 Gene:

C8orf74

SOURCE GeneReport for Unigene cluster for C8orf74 Gene:

Hs.371776
genes like me logo Genes that share expression patterns with C8orf74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C8orf74 Gene

Orthologs for C8orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf74 34
  • 97.72 (n)
C8orf74 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8H8orf74 34
  • 81.48 (n)
C8orf74 35
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C25H8orf74 34
  • 81.48 (n)
C8orf74 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565212 34
  • 76.64 (n)
mouse
(Mus musculus)
Mammalia 4930578I06Rik 34 16 35
  • 74.94 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf74 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf74 35
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330335 34
  • 45.18 (n)
C17H8orf74 35
  • 25 (a)
OneToOne
Species where no ortholog for C8orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf74 Gene

ENSEMBL:
Gene Tree for C8orf74 (if available)
TreeFam:
Gene Tree for C8orf74 (if available)

Paralogs for C8orf74 Gene

No data available for Paralogs for C8orf74 Gene

Variants for C8orf74 Gene

Sequence variations from dbSNP and Humsavar for C8orf74 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086065 -- 10,695,996(+) GTACA(C/T)TTCCA intron-variant
rs10086875 -- 10,693,178(+) TCCCC(A/G)ACCTT intron-variant
rs10088259 -- 10,693,601(+) ATACA(A/C)AGGTG intron-variant
rs10094634 -- 10,670,746(+) caggc(G/T)tggtg upstream-variant-2KB
rs10094968 -- 10,691,645(+) CCTCA(A/G)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf74 Gene

Variant ID Type Subtype PubMed ID
dgv11953n54 CNV loss 21841781
dgv865n27 CNV loss 19166990
esv990685 CNV deletion 20482838
nsv1025557 CNV gain 25217958
nsv1030934 CNV gain 25217958
nsv398183 CNV deletion 16902084
nsv515898 CNV loss 19592680
nsv519236 CNV loss 19592680
nsv527184 CNV loss 19592680

Variation tolerance for C8orf74 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf74 Gene

Disorders for C8orf74 Gene

Relevant External Links for C8orf74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf74

No disorders were found for C8orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf74 Gene

Publications for C8orf74 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C8orf74 Gene

Sources for C8orf74 Gene

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