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Aliases for C8orf74 Gene

Aliases for C8orf74 Gene

  • Chromosome 8 Open Reading Frame 74 2 3

External Ids for C8orf74 Gene

Previous GeneCards Identifiers for C8orf74 Gene

  • GC08P010568
  • GC08P010569
  • GC08P010530
  • GC08P009460

Summaries for C8orf74 Gene

GeneCards Summary for C8orf74 Gene

C8orf74 (Chromosome 8 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf74 Gene

Genomics for C8orf74 Gene

Regulatory Elements for C8orf74 Gene

Genomic Location for C8orf74 Gene

10,672,592 bp from pter
10,700,613 bp from pter
28,022 bases
Plus strand

Genomic View for C8orf74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C8orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf74 Gene

Proteins for C8orf74 Gene

  • Protein details for C8orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf74
    Protein Accession:
    Secondary Accessions:
    • A2RUD6

    Protein attributes for C8orf74 Gene

    294 amino acids
    Molecular mass:
    33735 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH65837.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C8orf74 Gene

Proteomics data for C8orf74 Gene at MOPED

Post-translational modifications for C8orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf74 Gene

No data available for DME Specific Peptides for C8orf74 Gene

Domains & Families for C8orf74 Gene

Protein Domains for C8orf74 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf74: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf74 Gene

Function for C8orf74 Gene

Gene Ontology (GO) - Molecular Function for C8orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with C8orf74: view
genes like me logo Genes that share phenotypes with C8orf74: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C8orf74

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf74 Gene

Localization for C8orf74 Gene

Subcellular locations from

Jensen Localization Image for C8orf74 Gene COMPARTMENTS Subcellular localization image for C8orf74 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf74 Gene

Pathways & Interactions for C8orf74 Gene

SuperPathways for C8orf74 Gene

No Data Available

Interacting Proteins for C8orf74 Gene

Selected Interacting proteins: Q6P047-CH074_HUMAN for C8orf74 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for C8orf74 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf74 Gene

Drugs & Compounds for C8orf74 Gene

No Compound Related Data Available

Transcripts for C8orf74 Gene

mRNA/cDNA for C8orf74 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf74 Gene

Chromosome 8 open reading frame 74:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C8orf74

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf74 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - -
SP4: - -

Relevant External Links for C8orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf74 Gene

mRNA expression in normal human tissues for C8orf74 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf74 Gene

This gene is overexpressed in Testis (x47.1).

Protein differential expression in normal tissues from HIPED for C8orf74 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf74 Gene

SOURCE GeneReport for Unigene cluster for C8orf74 Gene Hs.371776

genes like me logo Genes that share expression patterns with C8orf74: view

Protein tissue co-expression partners for C8orf74 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C8orf74 Gene

Orthologs for C8orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C8H8orf74 35
  • 81.48 (n)
  • 75.63 (a)
C8orf74 36
  • 74 (a)
(Canis familiaris)
Mammalia C25H8orf74 35
  • 81.48 (n)
  • 76.7 (a)
C8orf74 36
  • 76 (a)
(Mus musculus)
Mammalia 4930578I06Rik 35
  • 74.94 (n)
  • 69.39 (a)
4930578I06Rik 16
4930578I06Rik 36
  • 68 (a)
(Pan troglodytes)
Mammalia C8H8orf74 35
  • 97.72 (n)
  • 96.58 (a)
C8orf74 36
  • 96 (a)
(Rattus norvegicus)
Mammalia RGD1565212 35
  • 76.64 (n)
  • 70.75 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
-- 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia C8orf74 36
  • 44 (a)
(Anolis carolinensis)
Reptilia C8orf74 36
  • 40 (a)
(Danio rerio)
Actinopterygii LOC100330335 35
  • 45.18 (n)
  • 28.93 (a)
C17H8orf74 36
  • 25 (a)
Species with no ortholog for C8orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf74 Gene

Gene Tree for C8orf74 (if available)
Gene Tree for C8orf74 (if available)

Paralogs for C8orf74 Gene

No data available for Paralogs for C8orf74 Gene

Variants for C8orf74 Gene

Sequence variations from dbSNP and Humsavar for C8orf74 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4129653 -- 10,676,995(+) GGCGC(C/T)CTGGA intron-variant
rs4240665 -- 10,679,775(+) TGATG(A/T)CTGCG intron-variant
rs4311629 -- 10,680,910(+) AGCCC(A/G)GGCAG intron-variant
rs4427133 -- 10,685,581(+) ggaac(A/C)cagag intron-variant
rs4531009 -- 10,680,804(+) CGTAG(C/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf74 Gene

Variant ID Type Subtype PubMed ID
nsv515898 CNV Loss 19592680
nsv527184 CNV Loss 19592680
nsv398183 CNV Loss 16902084
esv990685 CNV Deletion 20482838
esv2736591 CNV Deletion 23290073
dgv865n27 CNV Loss 19166990
esv2736592 CNV Deletion 23290073
nsv519236 CNV Loss 19592680

Variation tolerance for C8orf74 Gene

Residual Variation Intolerance Score: 90.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf74 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf74 Gene

Disorders for C8orf74 Gene

Relevant External Links for C8orf74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C8orf74: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf74 Gene

Publications for C8orf74 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for C8orf74 Gene

Sources for C8orf74 Gene

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