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Aliases for C8orf74 Gene

Aliases for C8orf74 Gene

  • Chromosome 8 Open Reading Frame 74 2 3

External Ids for C8orf74 Gene

Previous GeneCards Identifiers for C8orf74 Gene

  • GC08P010568
  • GC08P010569
  • GC08P010530
  • GC08P009460

Summaries for C8orf74 Gene

GeneCards Summary for C8orf74 Gene

C8orf74 (Chromosome 8 Open Reading Frame 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf74 Gene

Genomics for C8orf74 Gene

Regulatory Elements for C8orf74 Gene

Genomic Location for C8orf74 Gene

Start:
10,672,637 bp from pter
End:
10,700,593 bp from pter
Size:
27,957 bases
Orientation:
Plus strand

Genomic View for C8orf74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C8orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf74 Gene

Proteins for C8orf74 Gene

  • Protein details for C8orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P047-CH074_HUMAN
    Recommended name:
    Uncharacterized protein C8orf74
    Protein Accession:
    Q6P047
    Secondary Accessions:
    • A2RUD6

    Protein attributes for C8orf74 Gene

    Size:
    294 amino acids
    Molecular mass:
    33735 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH65837.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for C8orf74 Gene

Proteomics data for C8orf74 Gene at MOPED

Post-translational modifications for C8orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf74 Gene

No data available for DME Specific Peptides for C8orf74 Gene

Domains for C8orf74 Gene

Protein Domains for C8orf74 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf74: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf74 Gene

Function for C8orf74 Gene

Gene Ontology (GO) - Molecular Function for C8orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with C8orf74: view

Phenotypes for C8orf74 Gene

GenomeRNAi human phenotypes for C8orf74:
genes like me logo Genes that share phenotypes with C8orf74: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C8orf74 Gene

Localization for C8orf74 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf74 Gene COMPARTMENTS Subcellular localization image for C8orf74 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf74 Gene

Pathways for C8orf74 Gene

SuperPathways for C8orf74 Gene

No Data Available

Interacting Proteins for C8orf74 Gene

Selected Interacting proteins: Q6P047-CH074_HUMAN for C8orf74 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for C8orf74 Gene

None

No data available for Pathways by source for C8orf74 Gene

Transcripts for C8orf74 Gene

mRNA/cDNA for C8orf74 Gene

(12) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf74 Gene

Chromosome 8 open reading frame 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf74 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - -
SP3:
SP4: - -

Relevant External Links for C8orf74 Gene

GeneLoc Exon Structure for
C8orf74
ECgene alternative splicing isoforms for
C8orf74

Expression for C8orf74 Gene

mRNA expression in normal human tissues for C8orf74 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf74 Gene

This gene is overexpressed in Testis (47.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C8orf74 Gene

SOURCE GeneReport for Unigene cluster for C8orf74 Gene Hs.371776

genes like me logo Genes that share expressions with C8orf74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C8orf74 Gene

Orthologs for C8orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf74 35
  • 97.72 (n)
  • 96.58 (a)
C8orf74 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8H8orf74 35
  • 81.48 (n)
  • 75.63 (a)
C8orf74 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C25H8orf74 35
  • 81.48 (n)
  • 76.7 (a)
C8orf74 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930578I06Rik 35
  • 74.94 (n)
  • 69.39 (a)
4930578I06Rik 16
4930578I06Rik 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf74 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565212 35
  • 76.64 (n)
  • 70.75 (a)
lizard
(Anolis carolinensis)
Reptilia C8orf74 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C17H8orf74 36
  • 25 (a)
OneToOne
LOC100330335 35
  • 45.18 (n)
  • 28.93 (a)
Species with no ortholog for C8orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf74 Gene

ENSEMBL:
Gene Tree for C8orf74 (if available)
TreeFam:
Gene Tree for C8orf74 (if available)

Paralogs for C8orf74 Gene

No data available for Paralogs for C8orf74 Gene

Variants for C8orf74 Gene

Sequence variations from dbSNP and Humsavar for C8orf74 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4129653 -- 10,676,995(+) GGCGC(C/T)CTGGA intron-variant
rs4240665 -- 10,679,775(+) TGATG(A/T)CTGCG intron-variant
rs4311629 -- 10,680,910(+) AGCCC(A/G)GGCAG intron-variant
rs4367494 -- 10,671,375(+) GACAC(A/C)CCTAG upstream-variant-2KB
rs4427133 -- 10,685,581(+) ggaac(A/C)cagag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf74 Gene

Variant ID Type Subtype PubMed ID
nsv515898 CNV Loss 19592680
nsv527184 CNV Loss 19592680
nsv398183 CNV Loss 16902084
esv990685 CNV Deletion 20482838
esv2736591 CNV Deletion 23290073
dgv865n27 CNV Loss 19166990
esv2736592 CNV Deletion 23290073
nsv519236 CNV Loss 19592680

Relevant External Links for C8orf74 Gene

HapMap Linkage Disequilibrium report
C8orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf74 Gene

Disorders for C8orf74 Gene

No disorders were found for C8orf74 Gene.

No data available for UniProtKB/Swiss-Prot for C8orf74 Gene

Publications for C8orf74 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C8orf74 Gene

Sources for C8orf74 Gene

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