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Aliases for C8orf59 Gene

Aliases for C8orf59 Gene

  • Chromosome 8 Open Reading Frame 59 2 3 5

External Ids for C8orf59 Gene

Previous GeneCards Identifiers for C8orf59 Gene

  • GC08M086314
  • GC08M086126
  • GC08M081620

Summaries for C8orf59 Gene

GeneCards Summary for C8orf59 Gene

C8orf59 (Chromosome 8 Open Reading Frame 59) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf59 Gene

Genomics for C8orf59 Gene

Regulatory Elements for C8orf59 Gene

Enhancers for C8orf59 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C8orf59 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C8orf59 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf59 Gene

Chromosome:
8
Start:
85,214,053 bp from pter
End:
85,220,422 bp from pter
Size:
6,370 bases
Orientation:
Minus strand

Genomic View for C8orf59 Gene

Genes around C8orf59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf59 Gene

Proteins for C8orf59 Gene

  • Protein details for C8orf59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0T1-CH059_HUMAN
    Recommended name:
    Uncharacterized protein C8orf59
    Protein Accession:
    Q8N0T1
    Secondary Accessions:
    • B2RXE7
    • E5RFW5

    Protein attributes for C8orf59 Gene

    Size:
    100 amino acids
    Molecular mass:
    11456 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf59 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf59 Gene

Proteomics data for C8orf59 Gene at MOPED

Post-translational modifications for C8orf59 Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C8orf59 Gene

Domains & Families for C8orf59 Gene

Protein Domains for C8orf59 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf59: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf59 Gene

Function for C8orf59 Gene

genes like me logo Genes that share phenotypes with C8orf59: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf59 Gene

Localization for C8orf59 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf59 Gene COMPARTMENTS Subcellular localization image for C8orf59 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf59 Gene

Pathways & Interactions for C8orf59 Gene

SuperPathways for C8orf59 Gene

No Data Available

Interacting Proteins for C8orf59 Gene

Gene Ontology (GO) - Biological Process for C8orf59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with C8orf59: view

No data available for Pathways by source and SIGNOR curated interactions for C8orf59 Gene

Drugs & Compounds for C8orf59 Gene

No Compound Related Data Available

Transcripts for C8orf59 Gene

Unigene Clusters for C8orf59 Gene

Chromosome 8 open reading frame 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf59 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for C8orf59 Gene

GeneLoc Exon Structure for
C8orf59
ECgene alternative splicing isoforms for
C8orf59

Expression for C8orf59 Gene

mRNA expression in normal human tissues for C8orf59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C8orf59 Gene

This gene is overexpressed in Breast (42.7) and Bone (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C8orf59 Gene



SOURCE GeneReport for Unigene cluster for C8orf59 Gene Hs.443072

genes like me logo Genes that share expression patterns with C8orf59: view

Protein tissue co-expression partners for C8orf59 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C8orf59 Gene

Orthologs for C8orf59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf59 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C14H8orf59 35
  • 90.33 (n)
  • 83 (a)
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia C29H8orf59 35
  • 91.67 (n)
  • 84 (a)
mouse
(Mus musculus)
Mammalia 1810022K09Rik 35
  • 85.91 (n)
  • 79.38 (a)
1810022K09Rik 16
1810022K09Rik 36
  • 53 (a)
ManyToMany
Gm4540 36
  • 76 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf59 35
  • 100 (n)
  • 100 (a)
C8orf59 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565641 35
  • 84.54 (n)
  • 78.35 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii C24H8orf59 36
  • 36 (a)
OneToMany
Species with no ortholog for C8orf59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf59 Gene

ENSEMBL:
Gene Tree for C8orf59 (if available)
TreeFam:
Gene Tree for C8orf59 (if available)

Paralogs for C8orf59 Gene

Pseudogenes.org Pseudogenes for C8orf59 Gene

genes like me logo Genes that share paralogs with C8orf59: view

No data available for Paralogs for C8orf59 Gene

Variants for C8orf59 Gene

Sequence variations from dbSNP and Humsavar for C8orf59 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4150973 -- 85,215,079(+) ATAAC(C/G)ATTAA intron-variant
rs4150974 -- 85,215,235(+) TGTGG(A/C)TATGC intron-variant
rs4150975 -- 85,215,300(+) ATAAG(-/AT)ATATA intron-variant
rs4150976 -- 85,215,322(+) GGTCT(C/T)TGTCC intron-variant
rs4150977 -- 85,215,369(+) taaga(A/G)ggata intron-variant

Variation tolerance for C8orf59 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf59 Gene

HapMap Linkage Disequilibrium report
C8orf59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C8orf59 Gene

Disorders for C8orf59 Gene

Relevant External Links for C8orf59

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf59

No disorders were found for C8orf59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf59 Gene

Publications for C8orf59 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for C8orf59 Gene

Sources for C8orf59 Gene

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