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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C8orf59 Gene

protein-coding   GIFtS: 37
GCID: GC08M086126

Chromosome 8 Open Reading Frame 59

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 8 Open Reading Frame 591 2
Uncharacterized Protein C8orf592

External Ids:    HGNC: 322351   Entrez Gene: 4014662   Ensembl: ENSG000001767317   UniProtKB: Q8N0T13   

Export aliases for C8orf59 gene to outside databases

Previous GC identifers: GC08M086314 GC08M081620


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C8orf59 Gene: 
C8orf59 (chromosome 8 open reading frame 59) is a protein-coding gene. Diseases associated with C8orf59 include gastric cancer. An important paralog of this gene is ENSG00000226209.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C8orf59 gene promoter:
         STAT5B   E2F-3a   E2F-4   E2F-5   LUN-1   E2F-2   FOXL1   E2F-1   E2F   FOXO4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C8orf59

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8orf59


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.2   Ensembl cytogenetic band:  8q21.2   HGNC cytogenetic band: 8q21.2

C8orf59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8orf59 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M086126:  view genomic region     (about GC identifiers)

Start:
86,126,288 bp from pter      End:
86,132,650 bp from pter
Size:
6,363 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CH059_HUMAN, Q8N0T1 (See protein sequence)
Recommended Name: Uncharacterized protein C8orf59  
Size: 98 amino acids; 11243 Da
Secondary accessions: B2RXE7 E5RFW5
Alternative splicing: 2 isoforms:  Q8N0T1-1   Q8N0T1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C8orf59: NX_Q8N0T1

Explore proteomics data for C8orf59 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N0T1

  • C8orf59 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C8orf59 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001093140.1  NP_001093141.1  NP_001093142.1  NP_001093143.1  

    ENSEMBL proteins: 
     ENSP00000416245   ENSP00000389669   ENSP00000404132   ENSP00000427911   ENSP00000430658  
     ENSP00000429521   ENSP00000407200   ENSP00000428722   ENSP00000319020   ENSP00000444092  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N0T1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf59

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C8orf59 (CH059)

    Search CenterWatch for drugs/clinical trials and news about C8orf59 / CH059

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C8orf59 gene (4 alternative transcripts): 
    NM_001099670.1  NM_001099671.1  NM_001099672.1  NM_001099673.1  

    Unigene Cluster for C8orf59:

    Chromosome 8 open reading frame 59
    Hs.443072  [show with all ESTs]
    Unigene Representative Sequence: NM_001099670
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417663(uc022awy.1 uc022awz.1 uc022axa.1 uc022axb.1)
    ENST00000431163 ENST00000421308 ENST00000520236 ENST00000524353 ENST00000518562(uc011lfu.2)
    ENST00000518091 ENST00000458398 ENST00000523281 ENST00000523245 ENST00000321777
    ENST00000518786 ENST00000521286 ENST00000545322
    miRNA
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    hsa-miR-455-5p hsa-miR-3611 hsa-miR-1237 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-519e hsa-miR-493* hsa-miR-573
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C8orf59
    Clone
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    Additional mRNA sequence: 

    BC032347.1 BC055092.1 BC062221.1 BC146983.1 BC146988.1 BC157825.1 BC171873.1 

    15 DOTS entries:

    DT.100029031  DT.91767884  DT.101983550  DT.95257961  DT.91767898  DT.435186  DT.95165118  DT.95165119 
    DT.100029032  DT.100813249  DT.95165117  DT.121478011  DT.40124506  DT.95165120  DT.95165122 

    24/171 AceView cDNA sequences (see all 171):

    AA878770 AA932658 AW511955 AA934407 AI693348 AI680707 AA361904 BC032347 
    BX404720 AW408357 BQ188446 BC055092 CB144985 BI760915 CB159889 CA428785 
    BM840176 AI281928 CD356614 AA044296 AA315106 AA551303 CN481353 N69244 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for C8orf59    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3
    SP1:                                -         
    SP2:                          -     -         
    SP3:                                -         
    SP4:                                          


    ECgene alternative splicing isoforms for C8orf59

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C8orf59 expression in normal human tissues (normalized intensities)      C8orf59 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCAAACC
    C8orf59 Expression
    About this image


    C8orf59 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Limb (Muscoskeletal System)

     -- (Gastrointestinal Tract)
             pharynx   

    See C8orf59 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C8orf59

    SOURCE GeneReport for Unigene cluster: Hs.443072
        SABiosciences Custom PCR Arrays for C8orf59
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf59

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for C8orf59 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1810022K09Rik1 , 5 RIKEN cDNA 1810022K09 gene1, 5 85.91(n)1
    79.38(a)1
      3 (3.11 cM)5
    691261  NM_001099674.11  NP_001093144.11 
     146063205 


    ENSEMBL Gene Tree for C8orf59 (if available)
    TreeFam Gene Tree for C8orf59 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C8orf59 gene
    ENSG000002262092  

    C8orf59 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for C8orf59
    PGOHUM00000256699 PGOHUM00000243234 PGOHUM00000243739 PGOHUM00000241723


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 SNPs in C8orf59 are shown (see all 99)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs775779111,2
    F--81619843(+) AAAAAG/AAAAAA 4 -- ds50011Minor allele frequency- A:0.50NA 4
    rs1509082231,2
    --81619920(+) TCAAAA/CTACAC 4 -- ds50010--------
    rs2021384851,2
    C--81620029(+) TTGTTC/TGCAGT 4 -- ds50011Minor allele frequency- T:0.00EU 593
    rs1998454551,2
    C--81620030(+) TGTTCG/ACAGTG 4 -- ds50011Minor allele frequency- A:0.00EU 593
    rs1394271341,2
    C--81620098(+) GATAAC/TGAAGG 4 -- ds50010--------
    rs1905988561,2
    C--81620144(+) ATTAGA/CTTCCA 4 -- ds50010--------
    rs1500299911,2
    C--81620388(+) ATATTC/TTGGAT 4 -- ut310--------
    rs1444024681,2
    --81620514(+) TTTTA-/CCCCTGCC 4 -- cds10--------
    rs2019581411,2
    C--81620514(-) GGCAGG/TAAAAA 4 -- ut310--------
    rs1461371581,2
    --81620523(+) CCACTA/CAACTG 4 -- ut310--------

    HapMap Linkage Disequilibrium report for C8orf59 (86126288 - 86132650 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C8orf59: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C8orf59
    DNA2.0 Custom Variant and Variant Library Synthesis for C8orf59

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for C8orf59:    About MalaCards
    gastric cancer    


    C8orf59 for disorders           About GeneDecksing


    Export disorders for C8orf59 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C8orf59 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with C8orf59)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    6. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401466 HGNC: 32235 AceView: LOC401466 Ensembl:ENSG00000176731 euGenes: HUgn401466
    ECgene: C8orf59 H-InvDB: C8orf59

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C8orf59 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C8orf59 gene:
    Search GeneIP for patents involving C8orf59

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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