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Aliases for C8orf58 Gene

Aliases for C8orf58 Gene

  • Chromosome 8 Open Reading Frame 58 2 3 5

External Ids for C8orf58 Gene

Previous GeneCards Identifiers for C8orf58 Gene

  • GC08U900616
  • GC08P022513
  • GC08P022446
  • GC08P022457
  • GC08P020999

Summaries for C8orf58 Gene

GeneCards Summary for C8orf58 Gene

C8orf58 (Chromosome 8 Open Reading Frame 58) is a Protein Coding gene. An important paralog of this gene is ENSG00000248235.

Additional gene information for C8orf58 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf58 Gene

Genomics for C8orf58 Gene

Regulatory Elements for C8orf58 Gene

Enhancers for C8orf58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H022603 1.2 ENCODE 65 +5.4 5408 3 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 C8orf58 ENSG00000253200 CCAR2 SORBS3 FAM160B2 LOC107986927 BMP1 POLR3D XPO7 LOC100507156
GH08H022593 1.6 Ensembl ENCODE dbSUPER 45.2 -3.0 -2990 5 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS C8orf58 ENSG00000248235
GH08H022578 1.8 FANTOM5 Ensembl ENCODE dbSUPER 38.4 -14.9 -14893 13 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ZNF143 FOS RUNX3 C8orf58 CCAR2 ENSG00000253200 PDLIM2 BIN3 FGF17 ENSG00000248235
GH08H022439 2 FANTOM5 Ensembl ENCODE dbSUPER 33.1 -154.9 -154936 10 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 CCAR2 ENSG00000253200 C8orf58 ENSG00000251034 XPO7 PPP3CC SORBS3 FAM160B2 POLR3D BIN3
GH08H022621 1.4 Ensembl ENCODE dbSUPER 46.3 +22.8 22832 2 ATF1 RB1 NFIB ZNF493 ZSCAN4 ARID4B KLF17 SIN3A ZNF2 RAD21 C8orf58 ENSG00000253200 PIR52534 GC08P022638
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C8orf58 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000222085 99 1801 INSM2 KLF17 SIN3A ZBTB40 GLIS2 EGR1 FOS IKZF2 EGR2 SP3

Genomic Location for C8orf58 Gene

Chromosome:
8
Start:
22,599,601 bp from pter
End:
22,604,150 bp from pter
Size:
4,550 bases
Orientation:
Plus strand

Genomic View for C8orf58 Gene

Genes around C8orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf58 Gene

Proteins for C8orf58 Gene

  • Protein details for C8orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAV2-CH058_HUMAN
    Recommended name:
    Uncharacterized protein C8orf58
    Protein Accession:
    Q8NAV2
    Secondary Accessions:
    • B4DI44

    Protein attributes for C8orf58 Gene

    Size:
    365 amino acids
    Molecular mass:
    39661 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03795.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf58 Gene

Post-translational modifications for C8orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf58 Gene

No data available for DME Specific Peptides for C8orf58 Gene

Domains & Families for C8orf58 Gene

Gene Families for C8orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf58: view

No data available for UniProtKB/Swiss-Prot for C8orf58 Gene

Function for C8orf58 Gene

Phenotypes From GWAS Catalog for C8orf58 Gene

genes like me logo Genes that share phenotypes with C8orf58: view

Animal Models for C8orf58 Gene

MGI Knock Outs for C8orf58:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C8orf58
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C8orf58 Gene

Localization for C8orf58 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C8orf58 Gene

Pathways & Interactions for C8orf58 Gene

SuperPathways for C8orf58 Gene

No Data Available

Interacting Proteins for C8orf58 Gene

Gene Ontology (GO) - Biological Process for C8orf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf58 Gene

Drugs & Compounds for C8orf58 Gene

No Compound Related Data Available

Transcripts for C8orf58 Gene

mRNA/cDNA for C8orf58 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf58 Gene

Chromosome 8 open reading frame 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C8orf58
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf58 Gene

No ASD Table

Relevant External Links for C8orf58 Gene

GeneLoc Exon Structure for
C8orf58
ECgene alternative splicing isoforms for
C8orf58

Expression for C8orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf58 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf58 Gene



Protein tissue co-expression partners for C8orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C8orf58 Gene:

C8orf58

SOURCE GeneReport for Unigene cluster for C8orf58 Gene:

Hs.743508
genes like me logo Genes that share expression patterns with C8orf58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf58 Gene

Orthologs for C8orf58 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C8orf58 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C25H8orf58 33
  • 78.66 (n)
-- 34
  • 63 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C8H8orf58 33
  • 75.72 (n)
-- 34
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1308117 33
  • 74.14 (n)
mouse
(Mus musculus)
Mammalia 9930012K11Rik 33 16 34
  • 74.12 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
OneToMany
Species where no ortholog for C8orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf58 Gene

ENSEMBL:
Gene Tree for C8orf58 (if available)
TreeFam:
Gene Tree for C8orf58 (if available)

Paralogs for C8orf58 Gene

Paralogs for C8orf58 Gene

genes like me logo Genes that share paralogs with C8orf58: view

Variants for C8orf58 Gene

Sequence variations from dbSNP and Humsavar for C8orf58 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000000258 -- 22,600,185(+) CCTAG(A/C)CTGTT intron-variant
rs1000502330 -- 22,599,997(+) CACTT(C/T)CTCCG intron-variant
rs1001423549 -- 22,600,611(+) GGCCG(C/G/T)CTAAG intron-variant
rs1002575859 -- 22,598,206(+) TGCAC(A/G/T)TCCTC downstream-variant-500B, upstream-variant-2KB
rs1002628381 -- 22,598,405(+) CAAAG(G/T)CAGGG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C8orf58 Gene

Variant ID Type Subtype PubMed ID
esv2759604 CNV loss 17122850
nsv1077027 CNV deletion 25765185

Variation tolerance for C8orf58 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf58 Gene

Disorders for C8orf58 Gene

Relevant External Links for C8orf58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf58

No disorders were found for C8orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf58 Gene

Publications for C8orf58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C8orf58 Gene

Sources for C8orf58 Gene

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