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Aliases for C8orf49 Gene

Subcategory (RNA class) for C8orf49 Gene


Quality Score for this RNA gene is


Aliases for C8orf49 Gene

  • Chromosome 8 Open Reading Frame 49 2 3 5
  • GATA4 Downstream Membrane Protein 2 3
  • G4DM 3

External Ids for C8orf49 Gene

ORGUL Members for C8orf49 Gene

Previous GeneCards Identifiers for C8orf49 Gene

  • GC08U900584
  • GC08P011658
  • GC08P011618

Summaries for C8orf49 Gene

GeneCards Summary for C8orf49 Gene

C8orf49 (Chromosome 8 Open Reading Frame 49) is an RNA Gene, and is affiliated with the lncRNA class.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf49 Gene

Genomics for C8orf49 Gene

Regulatory Elements for C8orf49 Gene

Enhancers for C8orf49 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F011761 1.1 Ensembl ENCODE 12.6 +1.1 1126 1.1 PKNOX1 ATF1 ARNT ZBTB40 FOS ETV6 CREM EGR2 SMARCA5 MCM3 NEIL2 C8orf49
GH08F011795 0.2 ENCODE 11.8 +35.4 35395 2.6 CTCF HDAC1 PKNOX1 ZNF146 ESRRA HINFP ZNF384 ZNF316 GATA2 NFYB NEIL2 CTSB C8orf49 FDFT1 LOC105379243
GH08F011883 1.6 FANTOM5 Ensembl ENCODE 11.6 +126.6 126646 9.4 ATF1 MLX ZNF133 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF121 GLIS2 CTSB RPS3AP34 LOC101929290 NEIL2 C8orf49 DEFB136 DEFB135 FDFT1 ENSG00000254507 FAM66D
GH08F011768 0.5 ENCODE 10.8 +8.6 8640 2.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 NEIL2 FDFT1 LOC105379243 C8orf49 CTSB LOC105379241 BLK ENSG00000269918 PIR40911
GH08F011765 0.7 Ensembl ENCODE 10.4 +4.5 4509 1.3 CTCF SAP130 ARID4B MAX ZNF2 RAD21 YY1 ZFHX2 POLR2A SCRT2 NEIL2 C8orf49
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C8orf49 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf49 Gene

11,761,256 bp from pter
11,763,223 bp from pter
1,968 bases
Plus strand

Genomic View for C8orf49 Gene

Genes around C8orf49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf49 Gene

Proteins for C8orf49 Gene

  • Protein details for C8orf49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative uncharacterized protein C8orf49
    Protein Accession:

    Protein attributes for C8orf49 Gene

    230 amino acids
    Molecular mass:
    25558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C8orf49 Gene

Post-translational modifications for C8orf49 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C8orf49 Gene

Domains & Families for C8orf49 Gene

Protein Domains for C8orf49 Gene


Suggested Antigen Peptide Sequences for C8orf49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf49: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf49 Gene

Function for C8orf49 Gene

Phenotypes for C8orf49 Gene

genes like me logo Genes that share phenotypes with C8orf49: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C8orf49 Gene

Localization for C8orf49 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C8orf49 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for C8orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C8orf49: view

No data available for Subcellular locations from COMPARTMENTS for C8orf49 Gene

Pathways & Interactions for C8orf49 Gene

SuperPathways for C8orf49 Gene

No Data Available

Interacting Proteins for C8orf49 Gene

Gene Ontology (GO) - Biological Process for C8orf49 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf49 Gene

Transcripts for C8orf49 Gene

mRNA/cDNA for C8orf49 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf49 Gene

No ASD Table

Relevant External Links for C8orf49 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf49 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C8orf49 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf49 Gene

This gene is overexpressed in Ovary (x10.2), Heart - Left Ventricle (x8.7), Heart - Atrial Appendage (x7.6), Pancreas (x6.5), Artery - Coronary (x5.1), and Stomach (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of C8orf49 Gene:


SOURCE GeneReport for Unigene cluster for C8orf49 Gene:

genes like me logo Genes that share expression patterns with C8orf49: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C8orf49 Gene

Orthologs for C8orf49 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C8orf49 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C8orf49 35
  • 92 (a)
Species where no ortholog for C8orf49 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf49 Gene

Gene Tree for C8orf49 (if available)
Gene Tree for C8orf49 (if available)

Paralogs for C8orf49 Gene

No data available for Paralogs for C8orf49 Gene

Variants for C8orf49 Gene

Sequence variations from dbSNP and Humsavar for C8orf49 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10092853 -- 11,763,408(+) CGGGC(C/G)CTGCT downstream-variant-500B
rs10108052 -- 11,760,254(+) AAACA(A/G)AGTTC downstream-variant-500B, upstream-variant-2KB
rs10108876 -- 11,760,956(+) AGAGG(A/G)GGACT upstream-variant-2KB
rs1062270 -- 11,759,830(+) TGGCT(A/G)TAGCA upstream-variant-2KB, utr-variant-3-prime
rs111566513 -- 11,762,606(+) ATAAG(C/G)AGTTT nc-transcript-variant

Variation tolerance for C8orf49 Gene

Gene Damage Index Score: 5.77; 73.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf49 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C8orf49 Gene

Disorders for C8orf49 Gene

Relevant External Links for C8orf49

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C8orf49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf49 Gene

Publications for C8orf49 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genetic analysis of the promoter region of the GATA4 gene in patients with ventricular septal defects. (PMID: 22500510) Wu G. … Yan B. (Transl Res 2012) 3 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C8orf49 Gene

Sources for C8orf49 Gene

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