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Aliases for C8orf46 Gene

Aliases for C8orf46 Gene

  • Chromosome 8 Open Reading Frame 46 2 3

External Ids for C8orf46 Gene

Summaries for C8orf46 Gene

GeneCards Summary for C8orf46 Gene

C8orf46 (Chromosome 8 Open Reading Frame 46) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf46 Gene

Genomics for C8orf46 Gene

Genomic Location for C8orf46 Gene

Start:
66,460,003 bp from pter
End:
66,518,524 bp from pter
Size:
58,522 bases
Orientation:
Plus strand

Genomic View for C8orf46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C8orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf46 Gene

Regulatory Elements for C8orf46 Gene

Proteins for C8orf46 Gene

  • Protein details for C8orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAG6-CH046_HUMAN
    Recommended name:
    Uncharacterized protein C8orf46
    Protein Accession:
    Q8TAG6
    Secondary Accessions:
    • B2RDC3
    • B4DFU4
    • C9J814
    • C9JCS3

    Protein attributes for C8orf46 Gene

    Size:
    207 amino acids
    Molecular mass:
    22584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf46 Gene

Proteomics data for C8orf46 Gene at MOPED

Post-translational modifications for C8orf46 Gene

No Post-translational modifications

Other Protein References for C8orf46 Gene

No data available for DME Specific Peptides for C8orf46 Gene

Domains for C8orf46 Gene

Protein Domains for C8orf46 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C8orf46: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf46 Gene

Function for C8orf46 Gene

Phenotypes for C8orf46 Gene

GenomeRNAi human phenotypes for C8orf46:
genes like me logo Genes that share phenotypes with C8orf46: view

miRNA for C8orf46 Gene

miRTarBase miRNAs that target C8orf46

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for C8orf46 Gene

Localization for C8orf46 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf46 Gene COMPARTMENTS Subcellular localization image for C8orf46 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for C8orf46 Gene

Pathways for C8orf46 Gene

SuperPathways for C8orf46 Gene

No Data Available

Interacting Proteins for C8orf46 Gene

Gene Ontology (GO) - Biological Process for C8orf46 Gene

None

No data available for Pathways by source for C8orf46 Gene

Transcripts for C8orf46 Gene

mRNA/cDNA for C8orf46 Gene

Unigene Clusters for C8orf46 Gene

Chromosome 8 open reading frame 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf46 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12:

Relevant External Links for C8orf46 Gene

GeneLoc Exon Structure for
C8orf46
ECgene alternative splicing isoforms for
C8orf46

Expression for C8orf46 Gene

mRNA expression in normal human tissues for C8orf46 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf46 Gene

This gene is overexpressed in Brain - Hippocampus (7.3), Brain - Anterior cingulate cortex (BA24) (6.0), Brain - Frontal Cortex (BA9) (5.2), Brain - Spinal cord (cervical c-1) (5.1), and Brain - Cortex (5.0).

SOURCE GeneReport for Unigene cluster for C8orf46 Gene Hs.268869

genes like me logo Genes that share expressions with C8orf46: view

Orthologs for C8orf46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf46 36
  • 99.52 (n)
  • 100 (a)
C8H8orf46 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C14H8orf46 36
  • 83.09 (n)
  • 79.8 (a)
C14H8orf46 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C29H8orf46 36
  • 87.03 (n)
  • 84.73 (a)
C8orf46 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110035E14Rik 36
  • 84.48 (n)
  • 84.31 (a)
3110035E14Rik 16
3110035E14Rik 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C8orf46 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf46 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1561849 36
  • 83.66 (n)
  • 85.29 (a)
chicken
(Gallus gallus)
Aves C2H8orf46 36
  • 60.13 (n)
  • 48.74 (a)
C8orf46 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf46 37
  • 41 (a)
OneToOne
Species with no ortholog for C8orf46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf46 Gene

ENSEMBL:
Gene Tree for C8orf46 (if available)
TreeFam:
Gene Tree for C8orf46 (if available)

Paralogs for C8orf46 Gene

Pseudogenes.org Pseudogenes for C8orf46 Gene

genes like me logo Genes that share paralogs with C8orf46: view

No data available for Paralogs for C8orf46 Gene

Variants for C8orf46 Gene

Sequence variations from dbSNP and Humsavar for C8orf46 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs736458 -- 66,512,802(-) AGCAA(C/T)ATCTC intron-variant
rs746787 -- 66,512,443(-) TGCTG(C/G)AAATT intron-variant
rs746788 -- 66,512,442(-) GCTGG(A/G)AATTC intron-variant
rs746789 -- 66,512,434(-) TTCCC(A/G)GTCAA intron-variant
rs957655 -- 66,497,606(-) TAAAG(C/T)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf46 Gene

Variant ID Type Subtype PubMed ID
nsv516599 CNV Loss 19592680

Relevant External Links for C8orf46 Gene

HapMap Linkage Disequilibrium report
C8orf46

Disorders for C8orf46 Gene

Relevant External Links for C8orf46

Genetic Association Database (GAD)
C8orf46
genes like me logo Genes that share disorders with C8orf46: view

No data available for UniProtKB/Swiss-Prot for C8orf46 Gene

Publications for C8orf46 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 49
  5. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 49

Products for C8orf46 Gene

Sources for C8orf46 Gene

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