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Aliases for C8orf46 Gene

Aliases for C8orf46 Gene

  • Chromosome 8 Open Reading Frame 46 2 3 5

External Ids for C8orf46 Gene

Previous GeneCards Identifiers for C8orf46 Gene

  • GC08P067569
  • GC08P067372
  • GC08P062895

Summaries for C8orf46 Gene

GeneCards Summary for C8orf46 Gene

C8orf46 (Chromosome 8 Open Reading Frame 46) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf46 Gene

Genomics for C8orf46 Gene

Regulatory Elements for C8orf46 Gene

Enhancers for C8orf46 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C8orf46 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf46 Gene

66,460,003 bp from pter
66,518,524 bp from pter
58,522 bases
Plus strand

Genomic View for C8orf46 Gene

Genes around C8orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf46 Gene

Proteins for C8orf46 Gene

  • Protein details for C8orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf46
    Protein Accession:
    Secondary Accessions:
    • B2RDC3
    • B4DFU4
    • C9J814
    • C9JCS3

    Protein attributes for C8orf46 Gene

    207 amino acids
    Molecular mass:
    22584 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH28400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf46 Gene


neXtProt entry for C8orf46 Gene

Proteomics data for C8orf46 Gene at MOPED

Post-translational modifications for C8orf46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf46 Gene

No data available for DME Specific Peptides for C8orf46 Gene

Domains & Families for C8orf46 Gene

Protein Domains for C8orf46 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf46: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf46 Gene

Function for C8orf46 Gene

genes like me logo Genes that share phenotypes with C8orf46: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf46 Gene

Localization for C8orf46 Gene

Subcellular locations from

Jensen Localization Image for C8orf46 Gene COMPARTMENTS Subcellular localization image for C8orf46 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf46 Gene

Pathways & Interactions for C8orf46 Gene

SuperPathways for C8orf46 Gene

No Data Available

Interacting Proteins for C8orf46 Gene

Gene Ontology (GO) - Biological Process for C8orf46 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf46 Gene

Drugs & Compounds for C8orf46 Gene

No Compound Related Data Available

Transcripts for C8orf46 Gene

Unigene Clusters for C8orf46 Gene

Chromosome 8 open reading frame 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf46 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - -

Relevant External Links for C8orf46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf46 Gene

mRNA expression in normal human tissues for C8orf46 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf46 Gene

This gene is overexpressed in Brain - Hippocampus (x7.3), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.2), Brain - Spinal cord (cervical c-1) (x5.1), and Brain - Cortex (x5.0).

SOURCE GeneReport for Unigene cluster for C8orf46 Gene Hs.268869

genes like me logo Genes that share expression patterns with C8orf46: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C8orf46 Gene

Orthologs for C8orf46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf46 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C14H8orf46 35
  • 83.09 (n)
  • 79.8 (a)
C14H8orf46 36
  • 79 (a)
(Canis familiaris)
Mammalia C29H8orf46 35
  • 87.03 (n)
  • 84.73 (a)
C8orf46 36
  • 84 (a)
(Mus musculus)
Mammalia 3110035E14Rik 35
  • 84.48 (n)
  • 84.31 (a)
3110035E14Rik 16
3110035E14Rik 36
  • 83 (a)
(Pan troglodytes)
Mammalia C8H8orf46 35
  • 99.52 (n)
  • 100 (a)
C8H8orf46 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1561849 35
  • 83.66 (n)
  • 85.29 (a)
(Monodelphis domestica)
Mammalia C8orf46 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia C8orf46 36
  • 58 (a)
(Gallus gallus)
Aves C2H8orf46 35
  • 60.13 (n)
  • 48.74 (a)
C8orf46 36
  • 47 (a)
(Anolis carolinensis)
Reptilia C8orf46 36
  • 41 (a)
Species with no ortholog for C8orf46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf46 Gene

Gene Tree for C8orf46 (if available)
Gene Tree for C8orf46 (if available)

Paralogs for C8orf46 Gene Pseudogenes for C8orf46 Gene

genes like me logo Genes that share paralogs with C8orf46: view

No data available for Paralogs for C8orf46 Gene

Variants for C8orf46 Gene

Sequence variations from dbSNP and Humsavar for C8orf46 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2251827 -- 66,498,784(+) taaaa(C/T)ctatg intron-variant
rs7832611 -- 66,517,187(+) TATCA(A/G)TGAAA utr-variant-3-prime
rs2555583 -- 66,493,587(+) CCTCG(A/C)GACTA utr-variant-5-prime
rs2555584 -- 66,493,631(+) CACTT(C/T)GGGAA utr-variant-5-prime
rs2555585 -- 66,493,757(+) GTGGC(A/G)TCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf46 Gene

Variant ID Type Subtype PubMed ID
nsv516599 CNV Loss 19592680

Variation tolerance for C8orf46 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C8orf46 Gene

Disorders for C8orf46 Gene

Relevant External Links for C8orf46

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C8orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf46 Gene

Publications for C8orf46 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for C8orf46 Gene

Sources for C8orf46 Gene