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Aliases for C8orf46 Gene

Aliases for C8orf46 Gene

  • Chromosome 8 Open Reading Frame 46 2 3 5

External Ids for C8orf46 Gene

Previous GeneCards Identifiers for C8orf46 Gene

  • GC08P067569
  • GC08P067372
  • GC08P062895

Summaries for C8orf46 Gene

GeneCards Summary for C8orf46 Gene

C8orf46 (Chromosome 8 Open Reading Frame 46) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf46 Gene

Genomics for C8orf46 Gene

Regulatory Elements for C8orf46 Gene

Enhancers for C8orf46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F066466 1 ENCODE 48.2 +8.0 7964 2.9 CTCF SIN3A RAD21 CTBP1 MTA3 GATA3 SCRT2 FOSL2 RCOR1 ZNF687 C8orf46 ADHFE1 RNU6-1324P MYBL1 LOC100131770
GH08F066470 0.7 Ensembl ENCODE 36.4 +11.6 11597 2.2 JUN BRCA1 RFX5 GATA3 POLR2A PRDM10 RCOR1 FOSL2 FOS BHLHE40 C8orf46 LOC100131770
GH08F066348 0.2 ENCODE 31.4 -111.4 -111433 1.1 ZNF664 ZNF316 SMARCA4 C8orf46 PIR44367 PIR56052
GH08F066458 1.1 Ensembl ENCODE 31.1 +1.9 1868 6.5 PKNOX1 RAD21 RARA SCRT2 FOS MIXL1 ZNF654 CEBPB MIER2 REST C8orf46 ADHFE1 RNU6-1324P LOC100131770
GH08F066454 0.9 Ensembl ENCODE 30.3 -3.8 -3761 2.9 PKNOX1 KLF1 DDX20 GTF2E2 JUN MAX ZNF140 SIN3A FOSL1 ZNF316 C8orf46 ADHFE1 C8orf44 RRS1 RRS1-AS1 LOC102724687
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C8orf46 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf46 Gene

Chromosome:
8
Start:
66,460,003 bp from pter
End:
66,518,524 bp from pter
Size:
58,522 bases
Orientation:
Plus strand

Genomic View for C8orf46 Gene

Genes around C8orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf46 Gene

Proteins for C8orf46 Gene

  • Protein details for C8orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAG6-CH046_HUMAN
    Recommended name:
    Uncharacterized protein C8orf46
    Protein Accession:
    Q8TAG6
    Secondary Accessions:
    • B2RDC3
    • B4DFU4
    • C9J814
    • C9JCS3

    Protein attributes for C8orf46 Gene

    Size:
    207 amino acids
    Molecular mass:
    22584 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28400.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf46 Gene

Post-translational modifications for C8orf46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf46 Gene

No data available for DME Specific Peptides for C8orf46 Gene

Domains & Families for C8orf46 Gene

Protein Domains for C8orf46 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf46: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf46 Gene

Function for C8orf46 Gene

genes like me logo Genes that share phenotypes with C8orf46: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf46 Gene

Localization for C8orf46 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf46 Gene COMPARTMENTS Subcellular localization image for C8orf46 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf46 Gene

Pathways & Interactions for C8orf46 Gene

SuperPathways for C8orf46 Gene

No Data Available

Interacting Proteins for C8orf46 Gene

Gene Ontology (GO) - Biological Process for C8orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf46 Gene

Transcripts for C8orf46 Gene

Unigene Clusters for C8orf46 Gene

Chromosome 8 open reading frame 46:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf46 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12:

Relevant External Links for C8orf46 Gene

GeneLoc Exon Structure for
C8orf46
ECgene alternative splicing isoforms for
C8orf46

Expression for C8orf46 Gene

mRNA expression in normal human tissues for C8orf46 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf46 Gene

This gene is overexpressed in Brain - Hippocampus (x7.3), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.2), Brain - Spinal cord (cervical c-1) (x5.1), and Brain - Cortex (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of C8orf46 Gene:

C8orf46

SOURCE GeneReport for Unigene cluster for C8orf46 Gene:

Hs.268869
genes like me logo Genes that share expression patterns with C8orf46: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C8orf46 Gene

Orthologs for C8orf46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf46 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia C29H8orf46 34
  • 87.03 (n)
C8orf46 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110035E14Rik 34 16 35
  • 84.48 (n)
rat
(Rattus norvegicus)
Mammalia RGD1561849 34
  • 83.66 (n)
cow
(Bos Taurus)
Mammalia C14H8orf46 34 35
  • 83.09 (n)
oppossum
(Monodelphis domestica)
Mammalia C8orf46 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf46 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H8orf46 34
  • 60.13 (n)
C8orf46 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf46 35
  • 41 (a)
OneToOne
Species where no ortholog for C8orf46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf46 Gene

ENSEMBL:
Gene Tree for C8orf46 (if available)
TreeFam:
Gene Tree for C8orf46 (if available)

Paralogs for C8orf46 Gene

Pseudogenes.org Pseudogenes for C8orf46 Gene

genes like me logo Genes that share paralogs with C8orf46: view

No data available for Paralogs for C8orf46 Gene

Variants for C8orf46 Gene

Sequence variations from dbSNP and Humsavar for C8orf46 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10092120 -- 66,501,034(+) GGCCC(A/G)GCTAA intron-variant
rs10095700 -- 66,515,268(+) ATTTG(C/T)TCCTG intron-variant
rs10100008 -- 66,495,639(+) CATGG(C/T)CACTT intron-variant
rs111259195 -- 66,493,438(+) AATAG(G/T)ATTCA utr-variant-5-prime
rs111713317 -- 66,491,923(+) CATAC(A/G)TAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C8orf46 Gene

Variant ID Type Subtype PubMed ID
nsv1026137 CNV loss 25217958
nsv516599 CNV loss 19592680
nsv951440 CNV deletion 24416366

Variation tolerance for C8orf46 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf46 Gene

Disorders for C8orf46 Gene

Relevant External Links for C8orf46

Genetic Association Database (GAD)
C8orf46
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf46

No disorders were found for C8orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf46 Gene

Publications for C8orf46 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang S.J. … Fox C.S. (BMC Med. Genet. 2007) 46 64
  5. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 46 64

Products for C8orf46 Gene

Sources for C8orf46 Gene

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