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Aliases for C8orf44-SGK3 Gene

Aliases for C8orf44-SGK3 Gene

  • C8orf44-SGK3 Readthrough 2 3

External Ids for C8orf44-SGK3 Gene

Previous GeneCards Identifiers for C8orf44-SGK3 Gene

  • GC08U901547
  • GC08P067579

Summaries for C8orf44-SGK3 Gene

Entrez Gene Summary for C8orf44-SGK3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for C8orf44-SGK3 Gene

C8orf44-SGK3 (C8orf44-SGK3 Readthrough) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Insulin Signaling. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol binding. An important paralog of this gene is AKT1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf44-SGK3 Gene

Genomics for C8orf44-SGK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C8orf44-SGK3 Gene

Start:
66,667,552 bp from pter
End:
66,862,022 bp from pter
Size:
194,471 bases
Orientation:
Plus strand

Genomic View for C8orf44-SGK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C8orf44-SGK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf44-SGK3 Gene

No data available for Regulatory Elements for C8orf44-SGK3 Gene

Proteins for C8orf44-SGK3 Gene

  • Protein details for C8orf44-SGK3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R807
    Recommended name:
    Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
    Protein Accession:
    A0A024R807
    Secondary Accessions:

    Protein attributes for C8orf44-SGK3 Gene

    Size:
    496 amino acids
    Molecular mass:
    57108 Da
    Quaternary structure:
    No Data Available
  • Protein details for C8orf44-SGK3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E5RHR8
    Recommended name:
    Serine/threonine-protein kinase Sgk3
    Protein Accession:
    E5RHR8
    Secondary Accessions:

    Protein attributes for C8orf44-SGK3 Gene

    Size:
    126 amino acids
    Molecular mass:
    14407 Da
    Quaternary structure:
    No Data Available
  • Protein details for C8orf44-SGK3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E5RJV7
    Recommended name:
    Serine/threonine-protein kinase Sgk3
    Protein Accession:
    E5RJV7
    Secondary Accessions:

    Protein attributes for C8orf44-SGK3 Gene

    Size:
    108 amino acids
    Molecular mass:
    12284 Da
    Quaternary structure:
    No Data Available
  • Protein details for C8orf44-SGK3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E5RK28
    Recommended name:
    Serine/threonine-protein kinase Sgk3
    Protein Accession:
    E5RK28
    Secondary Accessions:

    Protein attributes for C8orf44-SGK3 Gene

    Size:
    128 amino acids
    Molecular mass:
    15305 Da
    Quaternary structure:
    No Data Available
  • Protein details for C8orf44-SGK3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q6FHV7
    Recommended name:
    SGKL protein
    Protein Accession:
    Q6FHV7
    Secondary Accessions:

    Protein attributes for C8orf44-SGK3 Gene

    Size:
    429 amino acids
    Molecular mass:
    49004 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C8orf44-SGK3 Gene

Proteomics data for C8orf44-SGK3 Gene at MOPED

Post-translational modifications for C8orf44-SGK3 Gene

No Post-translational modifications

Other Protein References for C8orf44-SGK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf44-SGK3 Gene

Domains for C8orf44-SGK3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf44-SGK3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Function for C8orf44-SGK3 Gene

Gene Ontology (GO) - Molecular Function for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10548550
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005246 calcium channel regulator activity TAS 16460280
GO:0005515 protein binding IPI 16888620
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

Animal Model Products

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C8orf44-SGK3 Gene

Localization for C8orf44-SGK3 Gene

Gene Ontology (GO) - Cellular Components for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C8orf44-SGK3 Gene

Pathways for C8orf44-SGK3 Gene

genes like me logo Genes that share pathways with C8orf44-SGK3: view

Pathways by source for C8orf44-SGK3 Gene

1 BioSystems pathway for C8orf44-SGK3 Gene
2 KEGG pathways for C8orf44-SGK3 Gene

Interacting Proteins for C8orf44-SGK3 Gene

Gene Ontology (GO) - Biological Process for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation IEA --
GO:0006950 response to stress TAS 10548550
GO:0030334 regulation of cell migration TAS 20919962
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

Transcripts for C8orf44-SGK3 Gene

mRNA/cDNA for C8orf44-SGK3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf44-SGK3 Gene

No ASD Table

Relevant External Links for C8orf44-SGK3 Gene

GeneLoc Exon Structure for
C8orf44-SGK3
ECgene alternative splicing isoforms for
C8orf44-SGK3

Expression for C8orf44-SGK3 Gene

mRNA expression in normal human tissues for C8orf44-SGK3 Gene

Integrated Proteomics: protein expression from MaxQB for C8orf44-SGK3 Gene

genes like me logo Genes that share expressions with C8orf44-SGK3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C8orf44-SGK3 Gene

Orthologs for C8orf44-SGK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C8orf44-SGK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGK3 35
  • 99.8 (n)
  • 99.8 (a)
SGK3 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
OneToMany
SGK3 35
  • 93.27 (n)
  • 97.96 (a)
dog
(Canis familiaris)
Mammalia SGK3 35
  • 94.83 (n)
  • 98.78 (a)
SGK3 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sgk3 35
  • 90.39 (n)
  • 96.77 (a)
Sgk3 36
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sgk3 35
  • 88.1 (n)
  • 94.35 (a)
chicken
(Gallus gallus)
Aves SGK3 35
  • 84.19 (n)
  • 93.87 (a)
SGK3 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk3 35
  • 75.35 (n)
  • 76.81 (a)
zebrafish
(Danio rerio)
Actinopterygii C24H8orf44 36
  • 79 (a)
OneToMany
sgk3 35
  • 72.22 (n)
  • 79.01 (a)
worm
(Caenorhabditis elegans)
Secernentea sgk-1 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 36
  • 28 (a)
ManyToMany
YPK2 36
  • 28 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sck2 35
  • 51.37 (n)
  • 45.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9294 36
  • 64 (a)
OneToMany
Species with no ortholog for C8orf44-SGK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C8orf44-SGK3 Gene

ENSEMBL:
Gene Tree for C8orf44-SGK3 (if available)
TreeFam:
Gene Tree for C8orf44-SGK3 (if available)

Paralogs for C8orf44-SGK3 Gene

Paralogs for C8orf44-SGK3 Gene

genes like me logo Genes that share paralogs with C8orf44-SGK3: view

Variants for C8orf44-SGK3 Gene

Sequence variations from dbSNP and Humsavar for C8orf44-SGK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2291891 -- 66,686,074(-) ACTAC(A/G)TCAAG intron-variant
rs2291892 -- 66,686,034(-) TCCAG(C/T)CTGGT intron-variant
rs2291893 -- 66,685,836(-) AATTT(G/T)TAATC intron-variant
rs6472282 -- 66,697,131(+) TAAAA(C/T)GCCTG intron-variant
rs6985442 -- 66,687,409(+) TTAAT(A/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf44-SGK3 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV Loss 17160897
esv2671255 CNV Deletion 23128226
esv2675141 CNV Deletion 23128226
nsv6238 CNV Insertion 18451855
esv2466698 CNV Insertion 19546169
esv1319586 CNV Insertion 17803354
esv2062022 CNV Deletion 18987734
nsv6239 CNV Insertion 18451855

Relevant External Links for C8orf44-SGK3 Gene

HapMap Linkage Disequilibrium report
C8orf44-SGK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Disorders for C8orf44-SGK3 Gene

No disorders were found for C8orf44-SGK3 Gene.

No data available for UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Publications for C8orf44-SGK3 Gene

  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T. … Cohen P. (Biochem. J. 1999) 3
  2. Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. (PMID: 10585774) Dai F. … Zhao S. (Genomics 1999) 3
  3. K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PMID: 12397388) Gamper N. … Lang F. (Pflugers Arch. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for C8orf44-SGK3 Gene

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