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C8orf44-SGK3 Gene

protein-coding   GIFtS: 24
GCID: GC08P067579

C8orf44-SGK3 Readthrough

  Search for C8orf44-SGK3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
C8orf44-SGK3 Readthrough1 2
Cytokine-Independent Survival Kinase2
Serine/Threonine-Protein Kinase Sgk32
Serum/Glucocorticoid-Regulated Kinase 32

External Ids:    HGNC: 483541   Entrez Gene: 1005331052   Ensembl: ENSG000002700247   UniProtKB: E5RJV74   UniProtKB: Q6FHV74   
UniProtKB: E5RK284   UniProtKB: E5RHR84   

Export aliases for C8orf44-SGK3 gene to outside databases

Previous GC identifer: GC08U901547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C8orf44-SGK3 Gene:
This locus represents naturally occurring read-through transcription between the neighboring putative
uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on
chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream
gene product. (provided by RefSeq, Feb 2011)

GeneCards Summary for C8orf44-SGK3 Gene:
C8orf44-SGK3 (C8orf44-SGK3 readthrough) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatidylinositol binding. An important paralog of this gene is AKT1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for C8orf44-SGK3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C8orf44-SGK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C8orf44-SGK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.1

C8orf44-SGK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8orf44-SGK3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P067579:  view genomic region     (about GC identifiers)

Start:
67,579,787 bp from pter      End:
67,774,257 bp from pter
Size:
194,471 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: E5RJV7 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Sgk3  
Size: 109 amino acids; 12383 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: Q6FHV7 (See protein sequence)

Recommended Name: SGKL protein  
Size: 429 amino acids; 49004 Da

UniProtKB/TrEMBL: E5RK28 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase Sgk3  
Size: 128 amino acids; 15305 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: E5RHR8 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase Sgk3  
Size: 126 amino acids; 14407 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for C8orf44-SGK3 at MOPED


See C8orf44-SGK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001191102.1  
ENSEMBL proteins: 
 ENSP00000429022  

C8orf44-SGK3 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 8):
 IPR017441 Protein_kinase_ATP_BS
 IPR002290 Ser/Thr_dual-sp_kinase_dom
 IPR001683 Phox
 IPR011009 Kinase-like_dom
 IPR017892 Pkinase_C

Graphical View of Domain Structure for InterPro Entry E5RJV7
Graphical View of Domain Structure for InterPro Entry Q6FHV7
Graphical View of Domain Structure for InterPro Entry E5RK28
Graphical View of Domain Structure for InterPro Entry E5RHR8

ProtoNet protein and cluster: E5RJV7

UniProtKB/TrEMBL: Q6FHV7
Similarity: Contains 1 AGC-kinase C-terminal domain
Similarity: Contains AGC-kinase C-terminal domain


Find genes that share domains with C8orf44-SGK3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/TrEMBL Summary: Q6FHV7
Catalytic activity: ATP + a protein = ADP + a phosphoprotein

     Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004672protein kinase activity TAS10548550
GO:0004674protein serine/threonine kinase activity IEA--
GO:0004713protein tyrosine kinase activity ----
GO:0005246calcium channel regulator activity TAS16460280
GO:0005515protein binding IPI16888620
     
Find genes that share ontologies with C8orf44-SGK3           About GenesLikeMe


Animal Models:
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hsa-miR-100* hsa-miR-300 hsa-miR-199a-3p hsa-miR-30d hsa-miR-550a* hsa-miR-3916 hsa-miR-3122 hsa-miR-30a
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005769early endosome IEA--
GO:0005829cytosol TAS--
GO:0016023cytoplasmic membrane-bounded vesicle IEA--
GO:0055037recycling endosome IEA--

Find genes that share ontologies with C8orf44-SGK3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for C8orf44-SGK3 About    
See pathways by source

SuperPathContained pathways About
1PI3K-Akt signaling pathway
PI3K-Akt signaling pathway
2Insulin Signaling
Insulin Signaling
3FoxO signaling pathway
FoxO signaling pathway


Find genes that share SuperPaths with C8orf44-SGK3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for C8orf44-SGK3
    Insulin Signaling


2 Kegg Pathways  (Kegg details for C8orf44-SGK3):
    FoxO signaling pathway
PI3K-Akt signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C8orf44-SGK3
Interactions:

    Search GeneGlobe Interaction Network for C8orf44-SGK3

Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001558regulation of cell growth TAS--
GO:0006468protein phosphorylation TAS10548550
GO:0006950response to stress TAS10548550
GO:0007154cell communication ----
GO:0030334regulation of cell migration TAS--

Find genes that share ontologies with C8orf44-SGK3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C8orf44-SGK3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C8orf44-SGK3 gene: 
NM_001204173.1  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000520044 ENST00000519289
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate C8orf44-SGK3 (see all 81):
hsa-miR-100* hsa-miR-300 hsa-miR-199a-3p hsa-miR-30d hsa-miR-550a* hsa-miR-3916 hsa-miR-3122 hsa-miR-30a
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GenScript: all cDNA clones in your preferred vector: C8orf44-SGK3 (NM_001204173)
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Primer
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  Search QuantiFast Probe-based Assays in human, mouse, rat C8orf44-SGK3

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C8orf44-SGK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
C8orf44-SGK3 Expression
About this image

C8orf44-SGK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C8orf44-SGK3 Protein Expression
    Custom PCR Arrays for C8orf44-SGK3
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for C8orf44-SGK3 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sgk31 serum/glucocorticoid regulated kinase 3 90.39(n)
96.77(a)
  170755  NM_001037759.1  NP_001032848.1 
chicken
(Gallus gallus)
Aves SGK31 serum/glucocorticoid regulated kinase family, member more 84.19(n)
93.87(a)
  420167  NM_001030940.1  NP_001026111.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
92(a)
1 → many
4(30940678-31007924)
tropical clawed frog
(Xenopus tropicalis)
Amphibia sgk31 serum/glucocorticoid regulated kinase family, member more 75.35(n)
76.81(a)
  100491891  XM_002935321.2  XP_002935367.2 
zebrafish
(Danio rerio)
Actinopterygii sgk31 serum/glucocorticoid regulated kinase family, member more 72.22(n)
79.01(a)
  564523  NM_001110467.1  NP_001103937.1 
worm
(Caenorhabditis elegans)
Secernentea sgk-16
Protein SGK-1, isoform a (sgk-1) mRNA, complete cd...
44(a)
1 → many
X(16254840-16262129) WBGene00004789
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK26
YPK16
Protein kinase with similarity to serine/threonine...
Serine/threonine protein kinase that phosphorylate...
28(a)
28(a)
many ↔ many
many ↔ many
XIII(473420-475453) YMR104C
XI(205707-207749) YKL126W


ENSEMBL Gene Tree for C8orf44-SGK3 (if available)
TreeFam Gene Tree for C8orf44-SGK3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for C8orf44-SGK3 gene
SGK31 2  AKT12  GRK72  RPS6KB12  GRK12  GRK42  GRK62  SGK22  
ADRBK22  AKT32  SGK12  RPS6KB22  GRK52  ADRBK12  AKT22  

Find genes that share paralogs with C8orf44-SGK3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C8orf44-SGK3 (see all 505)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1913174001,2
--67593955(+) CCCCAA/GTTCAA 1 -- int10--------
rs752416721,2
C--67594004(+) ACAGGC/TGCCTG 1 -- int10--------
rs767073681,2
C--67594005(+) CAGGTC/GCCTGA 1 -- int10--------
rs1138905461,2
C,F--67594623(+) TGCCTG/ATTTCA 1 -- int13Minor allele frequency- A:0.04CSA WA 120
rs1824563651,2
--67594629(+) TTTCAC/TCATGA 1 -- int10--------
rs1868229371,2
--67594675(+) TGAACA/GTACAG 1 -- int10--------
rs772243631,2
C,F--67594725(+) TGTTCA/GTGTTT 1 -- int11Minor allele frequency- G:0.02NA 120
rs78186331,2
C,F,A,H--67594777(+) CCTCCT/CTGTGA 1 -- int113Minor allele frequency- C:0.07NS EA NA WA 1348
rs1435013021,2
--67594779(+) TCCTTC/GTGATT 1 -- int10--------
rs1896788081,2
--67595068(+) CACTTA/GCTGCC 1 -- int10--------

HapMap Linkage Disequilibrium report for C8orf44-SGK3 (67579787 - 67774257 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for C8orf44-SGK3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2671255CNV Deletion23128226
esv2675141CNV Deletion23128226
esv2062022CNV Deletion18987734
nsv6239CNV Insertion18451855
esv2466698CNV Insertion19546169
esv1319586CNV Insertion17803354
nsv6238CNV Insertion18451855
nsv831346CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C8orf44-SGK3 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with C8orf44-SGK3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  2. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)1 Greenman C.... Stratton M.R. (Nature 2007)
  3. Sgk kinases and their role in epithelial transport. (PubMed id 16460280)1 Loffing J.... Staub O. (Annu. Rev. Physiol. 2006)
  4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)1 Sjoeblom T.... Velculescu V.E. (Science 2006)
  5. CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. (PubMed id 16888620)1 Slagsvold T.... Stenmark H. (EMBO J. 2006)
  6. Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. (PubMed id 16790420)1 Tessier M. and Woodgett J.R. (J. Biol. Chem. 2006)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. (PubMed id 12397388)1 Gamper N.... Lang F. (Pflugers Arch. 2002)
  10. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PubMed id 10548550)1 Kobayashi T.... Cohen P. (Biochem. J. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100533105 HGNC: 48354 Ensembl:ENSG00000270024 euGenes: HUgn100533105 ECgene: C8orf44-SGK3 Kegg: 100533105
H-InvDB: C8orf44-SGK3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C8orf44-SGK3 gene:
Search GeneIP for patents involving C8orf44-SGK3

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 OriGene Custom Antibody Services for C8orf44-SGK3   OriGene Custom Protein Services for C8orf44-SGK3  

 
 
 Block miRNA regulation of human, mouse, rat C8orf44-SGK3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C8orf44-SGK3
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 GenScript Custom Purified and Recombinant Proteins Services for C8orf44-SGK3 GenScript cDNA clones with any tag delivered in your preferred vector for C8orf44-SGK3
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 Browse ESI BIO Cell Lines and PureStem Progenitors for C8orf44-SGK3
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C8orf44-SGK3
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 Search LSBio for Antibodies for C8orf44-SGK3
Customized transgenic rodents for:
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 Search Addgene for plasmids for C8orf44-SGK3
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