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Aliases for C8orf44-SGK3 Gene

Aliases for C8orf44-SGK3 Gene

  • C8orf44-SGK3 Readthrough 2 3

External Ids for C8orf44-SGK3 Gene

Previous GeneCards Identifiers for C8orf44-SGK3 Gene

  • GC08U901547
  • GC08P067579

Summaries for C8orf44-SGK3 Gene

Entrez Gene Summary for C8orf44-SGK3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for C8orf44-SGK3 Gene

C8orf44-SGK3 (C8orf44-SGK3 Readthrough) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Insulin Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf44-SGK3 Gene

Genomics for C8orf44-SGK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C8orf44-SGK3 Gene

Chromosome:
8
Start:
66,667,552 bp from pter
End:
66,862,022 bp from pter
Size:
194,471 bases
Orientation:
Plus strand

Genomic View for C8orf44-SGK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for C8orf44-SGK3 Gene

No data available for Regulatory Elements for C8orf44-SGK3 Gene

Proteins for C8orf44-SGK3 Gene

  • Protein details for C8orf44-SGK3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R807
    Recommended name:
    Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
    Protein Accession:
    A0A024R807

    Protein attributes for C8orf44-SGK3 Gene

    Size:
    496 amino acids
    Molecular mass:
    57108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C8orf44-SGK3 Gene

Proteomics data for C8orf44-SGK3 Gene at MOPED

Post-translational modifications for C8orf44-SGK3 Gene

No Post-translational modifications

Other Protein References for C8orf44-SGK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf44-SGK3 Gene

Domains & Families for C8orf44-SGK3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf44-SGK3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Function for C8orf44-SGK3 Gene

Gene Ontology (GO) - Molecular Function for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10548550
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005246 calcium channel regulator activity TAS 16460280
GO:0005515 protein binding IPI 16888620
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf44-SGK3 Gene

Localization for C8orf44-SGK3 Gene

Gene Ontology (GO) - Cellular Components for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IBA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C8orf44-SGK3 Gene

Pathways & Interactions for C8orf44-SGK3 Gene

genes like me logo Genes that share pathways with C8orf44-SGK3: view

Pathways by source for C8orf44-SGK3 Gene

1 BioSystems pathway for C8orf44-SGK3 Gene
2 KEGG pathways for C8orf44-SGK3 Gene

Interacting Proteins for C8orf44-SGK3 Gene

Gene Ontology (GO) - Biological Process for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation TAS 10548550
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0006950 response to stress TAS 10548550
GO:0010765 positive regulation of sodium ion transport IBA --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

No data available for SIGNOR curated interactions for C8orf44-SGK3 Gene

Drugs & Compounds for C8orf44-SGK3 Gene

No Compound Related Data Available

Transcripts for C8orf44-SGK3 Gene

mRNA/cDNA for C8orf44-SGK3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf44-SGK3 Gene

No ASD Table

Relevant External Links for C8orf44-SGK3 Gene

GeneLoc Exon Structure for
C8orf44-SGK3
ECgene alternative splicing isoforms for
C8orf44-SGK3

Expression for C8orf44-SGK3 Gene

mRNA expression in normal human tissues for C8orf44-SGK3 Gene

Protein differential expression in normal tissues from HIPED for C8orf44-SGK3 Gene

This gene is overexpressed in Tlymphocyte (36.7) and Monocytes (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB for C8orf44-SGK3 Gene



genes like me logo Genes that share expression patterns with C8orf44-SGK3: view

Protein tissue co-expression partners for C8orf44-SGK3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C8orf44-SGK3 Gene

Orthologs for C8orf44-SGK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C8orf44-SGK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SGK3 35
  • 93.27 (n)
  • 97.96 (a)
-- 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SGK3 35
  • 94.83 (n)
  • 98.78 (a)
SGK3 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sgk3 35
  • 90.39 (n)
  • 96.77 (a)
Sgk3 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SGK3 35
  • 99.8 (n)
  • 99.8 (a)
SGK3 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sgk3 35
  • 88.1 (n)
  • 94.35 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves SGK3 35
  • 84.19 (n)
  • 93.87 (a)
SGK3 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk3 35
  • 75.35 (n)
  • 76.81 (a)
zebrafish
(Danio rerio)
Actinopterygii sgk3 35
  • 72.22 (n)
  • 79.01 (a)
C24H8orf44 36
  • 79 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sgk-1 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 36
  • 28 (a)
ManyToMany
YPK2 36
  • 28 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sck2 35
  • 51.37 (n)
  • 45.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9294 36
  • 64 (a)
OneToMany
Species with no ortholog for C8orf44-SGK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C8orf44-SGK3 Gene

ENSEMBL:
Gene Tree for C8orf44-SGK3 (if available)
TreeFam:
Gene Tree for C8orf44-SGK3 (if available)

Paralogs for C8orf44-SGK3 Gene

Paralogs for C8orf44-SGK3 Gene

genes like me logo Genes that share paralogs with C8orf44-SGK3: view

Variants for C8orf44-SGK3 Gene

Sequence variations from dbSNP and Humsavar for C8orf44-SGK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2291891 -- 66,686,074(-) ACTAC(A/G)TCAAG intron-variant
rs2291892 -- 66,686,034(-) TCCAG(C/T)CTGGT intron-variant
rs2291893 -- 66,685,836(-) AATTT(G/T)TAATC intron-variant
rs6472282 -- 66,697,131(+) TAAAA(C/T)GCCTG intron-variant
rs6985442 -- 66,687,409(+) TTAAT(A/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf44-SGK3 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV Loss 17160897
esv2671255 CNV Deletion 23128226
esv2675141 CNV Deletion 23128226
nsv6238 CNV Insertion 18451855
esv2466698 CNV Insertion 19546169
esv1319586 CNV Insertion 17803354
esv2062022 CNV Deletion 18987734
nsv6239 CNV Insertion 18451855

Variation tolerance for C8orf44-SGK3 Gene

Gene Damage Index Score: 0.61; 13.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf44-SGK3 Gene

HapMap Linkage Disequilibrium report
C8orf44-SGK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Disorders for C8orf44-SGK3 Gene

Relevant External Links for C8orf44-SGK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf44-SGK3
genes like me logo Genes that share disorders with C8orf44-SGK3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf44-SGK3 Gene

Publications for C8orf44-SGK3 Gene

  1. Second AKT: the rise of SGK in cancer signalling. (PMID: 20919962) Bruhn M.A. … Sheppard K.E. (Growth Factors 2010) 67
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 67
  3. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 67
  4. Sgk kinases and their role in epithelial transport. (PMID: 16460280) Loffing J. … Staub O. (Annu. Rev. Physiol. 2006) 67
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 67

Products for C8orf44-SGK3 Gene

Sources for C8orf44-SGK3 Gene

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