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Aliases for C8orf44-SGK3 Gene

Aliases for C8orf44-SGK3 Gene

  • C8orf44-SGK3 Readthrough 2 3 5

External Ids for C8orf44-SGK3 Gene

Previous GeneCards Identifiers for C8orf44-SGK3 Gene

  • GC08U901547
  • GC08P067579

Summaries for C8orf44-SGK3 Gene

Entrez Gene Summary for C8orf44-SGK3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for C8orf44-SGK3 Gene

C8orf44-SGK3 (C8orf44-SGK3 Readthrough) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway and PI3K-Akt signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SGK3.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf44-SGK3 Gene

Genomics for C8orf44-SGK3 Gene

Regulatory Elements for C8orf44-SGK3 Gene

Enhancers for C8orf44-SGK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G066669 0.9 Ensembl dbSUPER 0.7 +2.3 2349 1.0 SMARCE1 NR2F1 NR4A1 HLF ZBTB40 IKZF1 NR2C1 KDM1A C8orf44 C8orf44-SGK3 SGK3
GH08G066678 1.2 Ensembl ENCODE dbSUPER 0.4 +12.3 12328 2.6 JUN FOSL1 ZNF316 POLR2A FOS NFE2 MAFK NFE2L2 CEBPB MAFG CSPP1 COPS5 C8orf44 C8orf44-SGK3 SGK3
GH08G066674 0.7 ENCODE 0.4 +7.3 7269 0.2 PKNOX1 MAX FOSL1 CBX5 FOS CREM ZNF10 BHLHE40 JUNB ZNF398 ADHFE1 RRS1 RRS1-AS1 C8orf44 C8orf44-SGK3 SGK3
GH08G066689 0.8 Ensembl 0.3 +21.7 21749 0.2 ELF3 HDGF CTCF ZBTB40 RAD21 ZNF121 ZFHX2 POLR3A CBX5 ZNF143 PPP1R42 CSPP1 COPS5 C8orf44 SGK3 C8orf44-SGK3
GH08G066690 0.8 ENCODE 0.3 +21.5 21539 0.2 ELF3 HDGF CTCF ZBTB40 RAD21 ZFHX2 CBX5 ZNF143 SMC3 FOS PPP1R42 CSPP1 COPS5 C8orf44 C8orf44-SGK3 SGK3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C8orf44-SGK3 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf44-SGK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C8orf44-SGK3 Gene

66,667,552 bp from pter
66,862,022 bp from pter
194,471 bases
Plus strand

Genomic View for C8orf44-SGK3 Gene

Genes around C8orf44-SGK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf44-SGK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf44-SGK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf44-SGK3 Gene

Proteins for C8orf44-SGK3 Gene

  • Protein details for C8orf44-SGK3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
    Protein Accession:

    Protein attributes for C8orf44-SGK3 Gene

    496 amino acids
    Molecular mass:
    57108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C8orf44-SGK3 Gene

Post-translational modifications for C8orf44-SGK3 Gene

No Post-translational modifications

Other Protein References for C8orf44-SGK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf44-SGK3 Gene

Domains & Families for C8orf44-SGK3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf44-SGK3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Function for C8orf44-SGK3 Gene

Gene Ontology (GO) - Molecular Function for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 10548550
GO:0004674 protein serine/threonine kinase activity IEA,IBA --
GO:0005246 calcium channel regulator activity TAS 16460280
GO:0005515 protein binding IPI 16888620
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

Phenotypes for C8orf44-SGK3 Gene

genes like me logo Genes that share phenotypes with C8orf44-SGK3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf44-SGK3 Gene

Localization for C8orf44-SGK3 Gene

Gene Ontology (GO) - Cellular Components for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IBA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C8orf44-SGK3 Gene

Pathways & Interactions for C8orf44-SGK3 Gene

genes like me logo Genes that share pathways with C8orf44-SGK3: view

Pathways by source for C8orf44-SGK3 Gene

2 KEGG pathways for C8orf44-SGK3 Gene

Interacting Proteins for C8orf44-SGK3 Gene

Gene Ontology (GO) - Biological Process for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation TAS,IEA 10548550
GO:0006950 response to stress TAS 10548550
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

No data available for SIGNOR curated interactions for C8orf44-SGK3 Gene

Drugs & Compounds for C8orf44-SGK3 Gene

No Compound Related Data Available

Transcripts for C8orf44-SGK3 Gene

mRNA/cDNA for C8orf44-SGK3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf44-SGK3 Gene

No ASD Table

Relevant External Links for C8orf44-SGK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf44-SGK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf44-SGK3 Gene

Protein differential expression in normal tissues from HIPED for C8orf44-SGK3 Gene

This gene is overexpressed in Tlymphocyte (36.7) and Monocytes (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for C8orf44-SGK3 Gene

Protein tissue co-expression partners for C8orf44-SGK3 Gene

genes like me logo Genes that share expression patterns with C8orf44-SGK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf44-SGK3 Gene

Orthologs for C8orf44-SGK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C8orf44-SGK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SGK3 35 34
  • 99.8 (n)
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
SGK3 34
  • 93.27 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
(Canis familiaris)
Mammalia SGK3 34 35
  • 94.83 (n)
(Mus musculus)
Mammalia Sgk3 34 35
  • 90.39 (n)
(Rattus norvegicus)
Mammalia Sgk3 34
  • 88.1 (n)
(Gallus gallus)
Aves SGK3 34 35
  • 84.19 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk3 34
  • 75.35 (n)
(Danio rerio)
Actinopterygii C24H8orf44 35
  • 79 (a)
sgk3 34
  • 72.22 (n)
(Caenorhabditis elegans)
Secernentea sgk-1 35
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 35
  • 28 (a)
YPK2 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9294 35
  • 64 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sck2 34
  • 51.37 (n)
Species where no ortholog for C8orf44-SGK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C8orf44-SGK3 Gene

Gene Tree for C8orf44-SGK3 (if available)
Gene Tree for C8orf44-SGK3 (if available)

Paralogs for C8orf44-SGK3 Gene

Paralogs for C8orf44-SGK3 Gene

genes like me logo Genes that share paralogs with C8orf44-SGK3: view

Variants for C8orf44-SGK3 Gene

Sequence variations from dbSNP and Humsavar for C8orf44-SGK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs193920898 Uncertain significance 66,840,043(+) TGAGC(A/G)CAGAG reference, missense
rs1000003612 -- 66,716,463(+) AAGGA(C/T)TTGAG intron-variant
rs1000011288 -- 66,719,295(+) CAATT(C/T)GTTGT intron-variant
rs1000027959 -- 66,690,139(+) ACTCA(C/T)GTGGC intron-variant
rs1000053923 -- 66,826,866(+) TCTCG(A/T)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf44-SGK3 Gene

Variant ID Type Subtype PubMed ID
esv1319586 CNV insertion 17803354
esv2062022 CNV deletion 18987734
esv2466698 CNV insertion 19546169
esv2671255 CNV deletion 23128226
esv2675141 CNV deletion 23128226
esv3543607 CNV deletion 23714750
esv3617490 CNV loss 21293372
esv3617491 CNV loss 21293372
nsv1026746 CNV gain 25217958
nsv1115100 CNV deletion 24896259
nsv1117832 CNV deletion 24896259
nsv6238 CNV insertion 18451855
nsv6239 CNV insertion 18451855
nsv831346 CNV loss 17160897
nsv971317 CNV duplication 23825009

Variation tolerance for C8orf44-SGK3 Gene

Gene Damage Index Score: 0.61; 13.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf44-SGK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Disorders for C8orf44-SGK3 Gene

Relevant External Links for C8orf44-SGK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C8orf44-SGK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf44-SGK3 Gene

Publications for C8orf44-SGK3 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  2. Second AKT: the rise of SGK in cancer signalling. (PMID: 20919962) Bruhn M.A. … Sheppard K.E. (Growth Factors 2010) 3 64
  3. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 3 64
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 3 64
  5. Sgk kinases and their role in epithelial transport. (PMID: 16460280) Loffing J. … Staub O. (Annu. Rev. Physiol. 2006) 3 64

Products for C8orf44-SGK3 Gene

Sources for C8orf44-SGK3 Gene

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