Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C8orf44-SGK3 Gene

Aliases for C8orf44-SGK3 Gene

  • C8orf44-SGK3 Readthrough 2 3 5
  • EC 63
  • EC 2.7.11 63

External Ids for C8orf44-SGK3 Gene

Previous GeneCards Identifiers for C8orf44-SGK3 Gene

  • GC08U901547
  • GC08P067579

Summaries for C8orf44-SGK3 Gene

Entrez Gene Summary for C8orf44-SGK3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for C8orf44-SGK3 Gene

C8orf44-SGK3 (C8orf44-SGK3 Readthrough) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and FoxO signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf44-SGK3 Gene

Genomics for C8orf44-SGK3 Gene

Regulatory Elements for C8orf44-SGK3 Gene

Enhancers for C8orf44-SGK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C8orf44-SGK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf44-SGK3 Gene

66,667,552 bp from pter
66,862,022 bp from pter
194,471 bases
Plus strand

Genomic View for C8orf44-SGK3 Gene

Genes around C8orf44-SGK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf44-SGK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf44-SGK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf44-SGK3 Gene

Proteins for C8orf44-SGK3 Gene

  • Protein details for C8orf44-SGK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase Sgk3
    Protein Accession:
    Secondary Accessions:
    • A8K5W3
    • B3KQC2
    • Q9P1Q7
    • Q9UKG5

    Protein attributes for C8orf44-SGK3 Gene

    496 amino acids
    Molecular mass:
    57108 Da
    Quaternary structure:
    • Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner.
    • Sequence=AAF12758.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf44-SGK3 Gene

  • Protein details for C8orf44-SGK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
    Protein Accession:

    Protein attributes for C8orf44-SGK3 Gene

    496 amino acids
    Molecular mass:
    57108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C8orf44-SGK3 Gene

Proteomics data for C8orf44-SGK3 Gene at MOPED

Post-translational modifications for C8orf44-SGK3 Gene

  • Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf44-SGK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for C8orf44-SGK3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf44-SGK3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Function for C8orf44-SGK3 Gene

Enzyme Numbers (IUBMB) for C8orf44-SGK3 Gene

Gene Ontology (GO) - Molecular Function for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16888620
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

Phenotypes for C8orf44-SGK3 Gene

genes like me logo Genes that share phenotypes with C8orf44-SGK3: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf44-SGK3 Gene

Localization for C8orf44-SGK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C8orf44-SGK3 Gene

Cytoplasmic vesicle. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C8orf44-SGK3 Gene

Pathways & Interactions for C8orf44-SGK3 Gene

genes like me logo Genes that share pathways with C8orf44-SGK3: view

Pathways by source for C8orf44-SGK3 Gene

1 BioSystems pathway for C8orf44-SGK3 Gene
2 KEGG pathways for C8orf44-SGK3 Gene

Interacting Proteins for C8orf44-SGK3 Gene

Gene Ontology (GO) - Biological Process for C8orf44-SGK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation IEA,TAS 10548550
GO:0006883 cellular sodium ion homeostasis IBA --
GO:0006950 response to stress TAS 10548550
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with C8orf44-SGK3: view

No data available for SIGNOR curated interactions for C8orf44-SGK3 Gene

Drugs & Compounds for C8orf44-SGK3 Gene

No Compound Related Data Available

Transcripts for C8orf44-SGK3 Gene

mRNA/cDNA for C8orf44-SGK3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf44-SGK3 Gene

No ASD Table

Relevant External Links for C8orf44-SGK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf44-SGK3 Gene

mRNA expression in normal human tissues for C8orf44-SGK3 Gene

Protein differential expression in normal tissues from HIPED for C8orf44-SGK3 Gene

This gene is overexpressed in Tlymphocyte (36.7) and Monocytes (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf44-SGK3 Gene

genes like me logo Genes that share expression patterns with C8orf44-SGK3: view

Protein tissue co-expression partners for C8orf44-SGK3 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C8orf44-SGK3 Gene

Orthologs for C8orf44-SGK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C8orf44-SGK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SGK3 35
  • 93.27 (n)
  • 97.96 (a)
-- 36
  • 98 (a)
(Canis familiaris)
Mammalia SGK3 35
  • 94.83 (n)
  • 98.78 (a)
SGK3 36
  • 99 (a)
(Mus musculus)
Mammalia Sgk3 35
  • 90.39 (n)
  • 96.77 (a)
Sgk3 36
  • 97 (a)
(Pan troglodytes)
Mammalia SGK3 35
  • 99.8 (n)
  • 99.8 (a)
SGK3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sgk3 35
  • 88.1 (n)
  • 94.35 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
(Gallus gallus)
Aves SGK3 35
  • 84.19 (n)
  • 93.87 (a)
SGK3 36
  • 94 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk3 35
  • 75.35 (n)
  • 76.81 (a)
(Danio rerio)
Actinopterygii sgk3 35
  • 72.22 (n)
  • 79.01 (a)
C24H8orf44 36
  • 79 (a)
(Caenorhabditis elegans)
Secernentea sgk-1 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 36
  • 28 (a)
YPK2 36
  • 28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sck2 35
  • 51.37 (n)
  • 45.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9294 36
  • 64 (a)
Species with no ortholog for C8orf44-SGK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C8orf44-SGK3 Gene

Gene Tree for C8orf44-SGK3 (if available)
Gene Tree for C8orf44-SGK3 (if available)

Paralogs for C8orf44-SGK3 Gene

genes like me logo Genes that share paralogs with C8orf44-SGK3: view

Variants for C8orf44-SGK3 Gene

Sequence variations from dbSNP and Humsavar for C8orf44-SGK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2291891 -- 66,686,074(-) ACTAC(A/G)TCAAG intron-variant
rs2291892 -- 66,686,034(-) TCCAG(C/T)CTGGT intron-variant
rs2291893 -- 66,685,836(-) AATTT(G/T)TAATC intron-variant
rs7842774 -- 66,686,203(+) TTGTA(C/T)ACAAA intron-variant
rs9643583 -- 66,689,081(+) TGCCA(A/C)TATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf44-SGK3 Gene

Variant ID Type Subtype PubMed ID
nsv831346 CNV Loss 17160897
esv2671255 CNV Deletion 23128226
esv2675141 CNV Deletion 23128226
nsv6238 CNV Insertion 18451855
esv2466698 CNV Insertion 19546169
esv1319586 CNV Insertion 17803354
esv2062022 CNV Deletion 18987734
nsv6239 CNV Insertion 18451855

Variation tolerance for C8orf44-SGK3 Gene

Gene Damage Index Score: 0.61; 13.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for C8orf44-SGK3 Gene

Disorders for C8orf44-SGK3 Gene

Relevant External Links for C8orf44-SGK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C8orf44-SGK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf44-SGK3 Gene

Publications for C8orf44-SGK3 Gene

  1. Second AKT: the rise of SGK in cancer signalling. (PMID: 20919962) Bruhn M.A. … Sheppard K.E. (Growth Factors 2010) 3 67
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  3. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C. … Stratton M.R. (Nature 2007) 3
  4. Sgk kinases and their role in epithelial transport. (PMID: 16460280) Loffing J. … Staub O. (Annu. Rev. Physiol. 2006) 3
  5. Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. (PMID: 16790420) Tessier M. … Woodgett J.R. (J. Biol. Chem. 2006) 3

Products for C8orf44-SGK3 Gene

Sources for C8orf44-SGK3 Gene