C8orf42 Gene
protein-coding GIFtS: 38
GCID: GC08M000439
|
|
chromosome 8 open reading frame 42
| |
Aliases
for C8orf42 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 8 Open Reading Frame 421 2 | | INM011 | | Inm012 | | Tdrp2 | | Testis Development-Related Protein2 | | Protein INM013 |
Export aliases for C8orf42 gene to outside databasesPrevious GC identifers: GC08M000432 GC08M000285 |
Summaries
for C8orf42 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C8orf42 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_023736.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C8orf42 gene promoter:
RORalpha1 Bach1 FOXC1 Olf-1 RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for C8orf42
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8orf42 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p23.3 Ensembl cytogenetic band: 8p23.3 HGNC cytogenetic band: 8p23.3C8orf42 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M000439: view genomic region
(about GC identifiers)
Start:
|
439,803 bp from pter |
End:
|
495,781 bp from pter |
Size:
|
55,979 bases |
Orientation:
|
minus strand |
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Proteins
for C8orf42 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TDRP_HUMAN, Q86YL5 (See
protein sequence)Recommended Name: Testis development-related protein Size: 185 amino acids; 20403 Da
Subcellular location: Nucleus. Cytoplasm
Secondary accessions: B6VF03 B9EG53Alternative splicing: 2 isoforms: Q86YL5-1 Q86YL5-2 Explore the universe of human proteins at neXtProt for C8orf42: NX_Q86YL5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86YL5
C8orf42 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243042.1 NP_778250.2
ENSEMBL proteins: ENSP00000315111 ENSP00000430325 ENSP00000408126
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
C8orf42 for ontologies About GeneDecksing
C8orf42 Antibody Products:
Assay Products for C8orf42: |
Protein
Domains /
Families
for C8orf42 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86YL5 |
Function
for C8orf42 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf42 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf42
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C8orf42 (NM_175075) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C8orf42 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf42 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf42 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C8orf42 for ontologies About GeneDecksing
|
Pathways & Interactions
for C8orf42 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf42
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C8orf42 for ontologies About GeneDecksing
|
Drugs & Compounds
for C8orf42 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C8orf42
Search CenterWatch for drugs/clinical trials and news about C8orf42 / TDRP
|
Transcripts
for C8orf42 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C8orf42 gene (2 alternative transcripts): NM_001256113.1 NM_175075.4 Unigene Cluster for C8orf42: Chromosome 8 open reading frame 42 Hs.289293 [show with all ESTs]Unigene Representative Sequence: NM_1750754 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324079(uc011kwg.1 uc003wpd.3) ENST00000523656 ENST00000524229
ENST00000427263
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf42 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf42
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C8orf42 (NM_175075) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C8orf42 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf42 |
Additional cDNA sequence: AK126209.1 AY194292.2 BC033779.1 BC136248.1 BC136249.1 BX648606.1 FJ381685.1 3 DOTS entries: DT.92418637 DT.100752308 DT.100722955 24/124 AceView cDNA sequences (see all 124): AA236185 BQ030381 AA902144 AA234990 Z45653 BM129746 CB110976 AA366166 AI610818 BM680744 CK906328 F06260 Z41324 F02533 AI669762 AI632224 CK429755 AV660883 AI129637 AI971253 AI077315 BF990565 AI332448 N57671
GeneLoc Exon Structure
|
Expression
for C8orf42 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C8orf42 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C8orf42 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C8orf42
SOURCE GeneReport for Unigene cluster: Hs.289293
UniProtKB/Swiss-Prot: TDRP_HUMAN, Q86YL5Tissue specificity: Expressed in spermatogenic cells, especially in spermatocytes (at protein level)
SABiosciences Custom PCR Arrays for C8orf42
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C8orf42
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C8orf42 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C8orf42 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C8orf42 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf42 |
Orthologs
for C8orf42 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C8orf42 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
2610019F03Rik1 , 5 |
RIKEN cDNA 2610019F03 gene1, 5 |
79.37(n)1
77.9(a)1 |
|
8 (6.44 cM)5
721481 NM_173744.41 NP_776105.11
139520095 |
chicken
(Gallus gallus) |
Aves |
C3H8orf421 |
chromosome 3 open reading frame, human C8orf42 |
70.02(n)
67.92(a) |
|
421905 XM_419923.3 XP_419923.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C8orf426 |
-- |
69(a) |
1 ↔ 1 |
1(159702506-159703657) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.29362 |
Xenopus laevis transcribed sequences |
78.04(n) |
|
BU914254.1 |
ENSEMBL Gene Tree for C8orf42 (if available)
TreeFam Gene Tree for C8orf42 (if available) |
Paralogs
for C8orf42 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C8orf42 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: TDRP_HUMAN, Q86YL5Polymorphism: The poly-Ala region seems to be polymorphic and the number of Ala varies between 4 and 6
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C8orf42 (439803 - 495781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C8orf42
1 CNV: 3716
1 Indel: 62762 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C8orf42 |
|
Disorders
/ Diseases
for C8orf42 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C8orf42 for disorders About GeneDecksing
1  disease for C8orf42: About MalaCardsinsulinoma
Human Genome Epidemiology (HuGE) Navigator: C8orf42 (2 documents)
Export disorders for C8orf42 gene to outside databases
|
Publications
for C8orf42 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C8orf42 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C8orf42) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a novel nuclear factor, TDRP1, i n spermatogenic cells of testis and its relationship with spermatogenesis. (PubMed id 20170638)1, 2 Wang X....Hu R. (2010)
- Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circ ulating bilirubin levels. (PubMed id 21646302)1 Bielinski S.J....Chute C.G. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Gene expression profiling in human insulinoma tissue: genes involved in the insulin secretion pathway and cloning of novel full-length cDNAs. (PubMed id 15163304)2 Wang X.-C....Hu R.-M. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for C8orf42 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C8orf42 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C8orf42 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C8orf42 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C8orf42 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C8orf42 gene:
Search GeneIP for patents involving C8orf42
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C8orf42 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C8orf42 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C8orf42 | | | OriGene Protein Over-expression Lysate for C8orf42 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C8orf42 | | OriGene 3'-UTR Clone for C8orf42 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf42 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf42 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C8orf42 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for C8orf42 |
| |  |  |  |  | | | | |
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 |
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 | | | C8orf42 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf42 |
|  |  |  | | | | Search ThermoFisher Antibodies for C8orf42 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf42 |
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