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Aliases for C8orf4 Gene

Aliases for C8orf4 Gene

  • Chromosome 8 Open Reading Frame 4 2 3 5
  • Thyroid Cancer Protein 1 3 4
  • Human Thyroid Cancer 1 2 3
  • TC-1 3 4
  • TC1 3 4

External Ids for C8orf4 Gene

Previous GeneCards Identifiers for C8orf4 Gene

  • GC08P039461
  • GC08P040040
  • GC08P039751
  • GC08P040028
  • GC08P038544
  • GC08P040010

Summaries for C8orf4 Gene

Entrez Gene Summary for C8orf4 Gene

  • This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

GeneCards Summary for C8orf4 Gene

C8orf4 (Chromosome 8 Open Reading Frame 4) is a Protein Coding gene. Diseases associated with C8orf4 include thyroid cancer.

UniProtKB/Swiss-Prot for C8orf4 Gene

  • Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).

Gene Wiki entry for C8orf4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf4 Gene

Genomics for C8orf4 Gene

Regulatory Elements for C8orf4 Gene

Promoters for C8orf4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C8orf4 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf4 Gene

Chromosome:
8
Start:
40,153,455 bp from pter
End:
40,155,308 bp from pter
Size:
1,854 bases
Orientation:
Plus strand

Genomic View for C8orf4 Gene

Genes around C8orf4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf4 Gene

Proteins for C8orf4 Gene

  • Protein details for C8orf4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR00-CH004_HUMAN
    Recommended name:
    Protein C8orf4
    Protein Accession:
    Q9NR00

    Protein attributes for C8orf4 Gene

    Size:
    106 amino acids
    Molecular mass:
    12337 Da
    Quaternary structure:
    • Monomer. Interacts with NOTCH2 (via ANK repeats), the interaction inhibits the nuclear translocation of NOTCH2 N2ICD (PubMed:25985737). Interacts (C-terminus) with CBY1 (C-terminus), C8orf4 competes with CTNNB1 for the interaction with CBY1 (PubMed:16424001).

neXtProt entry for C8orf4 Gene

Proteomics data for C8orf4 Gene at MOPED

Post-translational modifications for C8orf4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for C8orf4

No data available for DME Specific Peptides for C8orf4 Gene

Domains & Families for C8orf4 Gene

Protein Domains for C8orf4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf4 Gene

Function for C8orf4 Gene

Molecular function for C8orf4 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737).
UniProtKB/Swiss-Prot Induction:
Induced by proinflammatory cytokines such as TNF and IL1B, via NF-kappaB signaling (PubMed:16730711, PubMed:19684084). Induced by cellular stresses such as heat shock, TPA, lipopolysaccahride and UV (PubMed:17603013). Induced by mitogens such as thrombin (PubMed:18959821).

Gene Ontology (GO) - Molecular Function for C8orf4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 25985737
genes like me logo Genes that share ontologies with C8orf4: view
genes like me logo Genes that share phenotypes with C8orf4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf4 Gene

Localization for C8orf4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C8orf4 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus speckle. Nucleus. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). {ECO:0000269 PubMed:16424001, ECO:0000269 PubMed:17603013}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf4 Gene COMPARTMENTS Subcellular localization image for C8orf4 gene
Compartment Confidence
nucleus 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for C8orf4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 16424001
GO:0016607 nuclear speck IDA 16424001
genes like me logo Genes that share ontologies with C8orf4: view

Pathways & Interactions for C8orf4 Gene

SuperPathways for C8orf4 Gene

No Data Available

Interacting Proteins for C8orf4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000319914%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000319914 for C8orf4 Gene via STRING

Gene Ontology (GO) - Biological Process for C8orf4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002264 endothelial cell activation involved in immune response IDA 19684084
GO:0006915 apoptotic process IEA --
GO:0042346 positive regulation of NF-kappaB import into nucleus IDA 19684084
GO:0043620 regulation of DNA-templated transcription in response to stress IDA 17603013
GO:1902806 regulation of cell cycle G1/S phase transition IDA 18959821
genes like me logo Genes that share ontologies with C8orf4: view

No data available for Pathways by source and SIGNOR curated interactions for C8orf4 Gene

Drugs & Compounds for C8orf4 Gene

No Compound Related Data Available

Transcripts for C8orf4 Gene

mRNA/cDNA for C8orf4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(205) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf4 Gene

Chromosome 8 open reading frame 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf4 Gene

No ASD Table

Relevant External Links for C8orf4 Gene

GeneLoc Exon Structure for
C8orf4
ECgene alternative splicing isoforms for
C8orf4

Expression for C8orf4 Gene

mRNA expression in normal human tissues for C8orf4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C8orf4 Gene

This gene is overexpressed in Liver (x6.0) and Lung (x4.4).

Protein differential expression in normal tissues from HIPED for C8orf4 Gene

This gene is overexpressed in Salivary gland (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf4 Gene



SOURCE GeneReport for Unigene cluster for C8orf4 Gene Hs.591849

mRNA Expression by UniProt/SwissProt for C8orf4 Gene

Q9NR00-CH004_HUMAN
Tissue specificity: Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347).
genes like me logo Genes that share expression patterns with C8orf4: view

Protein tissue co-expression partners for C8orf4 Gene

Primer Products

In Situ Assay Products

Orthologs for C8orf4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf4 35
  • 99.69 (n)
  • 99.06 (a)
C8orf4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C27H8orf4 36
  • 92 (a)
OneToOne
C27H8orf4 35
  • 89.62 (n)
  • 92.45 (a)
dog
(Canis familiaris)
Mammalia C16H8orf4 35
  • 89.94 (n)
  • 90.57 (a)
C8orf4 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1810011O10Rik 36
  • 92 (a)
OneToOne
1810011O10Rik 16
1810011O10Rik 35
  • 87.74 (n)
  • 91.51 (a)
oppossum
(Monodelphis domestica)
Mammalia C8orf4 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf4 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910163 35
  • 86.79 (n)
  • 91.51 (a)
chicken
(Gallus gallus)
Aves C8orf4 36
  • 76 (a)
OneToOne
C8ORF4 35
  • 75.47 (n)
  • 76.42 (a)
lizard
(Anolis carolinensis)
Reptilia C8orf4 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15208 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c8orf4 35
  • 69.15 (n)
  • 72.34 (a)
Str.10371 35
zebrafish
(Danio rerio)
Actinopterygii C5H8orf4 (2 of 2) 36
  • 51 (a)
OneToMany
C8orf4 (1 of 2) 36
  • 43 (a)
OneToMany
zgc:110340 35
  • 64.79 (n)
  • 60.67 (a)
Species with no ortholog for C8orf4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf4 Gene

ENSEMBL:
Gene Tree for C8orf4 (if available)
TreeFam:
Gene Tree for C8orf4 (if available)

Paralogs for C8orf4 Gene

No data available for Paralogs for C8orf4 Gene

Variants for C8orf4 Gene

Sequence variations from dbSNP and Humsavar for C8orf4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_050819 -

Variation tolerance for C8orf4 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf4 Gene

HapMap Linkage Disequilibrium report
C8orf4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C8orf4 Gene

Disorders for C8orf4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C8orf4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thyroid cancer
  • malignant neoplasm of thyroid gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C8orf4

Genetic Association Database (GAD)
C8orf4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf4
genes like me logo Genes that share disorders with C8orf4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C8orf4 Gene

Publications for C8orf4 Gene

  1. Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer. (PMID: 11056052) Chua E.L. … Dong Q. (Genomics 2000) 2 3 4 67
  2. TC1(C8orf4) regulates hematopoietic stem/progenitor cells and hematopoiesis. (PMID: 24937306) Jung Y. … Lee I. (PLoS ONE 2014) 2 3
  3. TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition. (PMID: 18959821) Wang Y.D. … Zhou Q. (BMB Rep 2008) 3 23
  4. TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response. (PMID: 17603013) Park J. … Lee I. (Biochem. Biophys. Res. Commun. 2007) 3 23
  5. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling. (PMID: 25985737) Zhu P. … Fan Z. (Nat. Commun. 2015) 3

Products for C8orf4 Gene

Sources for C8orf4 Gene

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