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C8orf4 Gene

protein-coding   GIFtS: 48
GCID: GC08P040010

Chromosome 8 Open Reading Frame 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 8 Open Reading Frame 41 2
TC12 3 5
Human Thyroid Cancer 11 2
Thyroid Cancer Protein 12 3
TC-12 3
Uncharacterized Protein C8orf42

External Ids:    HGNC: 13571   Entrez Gene: 568922   Ensembl: ENSG000001769077   OMIM: 6077025   UniProtKB: Q9NR003   

Export aliases for C8orf4 gene to outside databases

Previous GC identifers: GC08P039461 GC08P040040 GC08P039751 GC08P040028 GC08P040130 GC08P038544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C8orf4 Gene:
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of
the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated
transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with
beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role
in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of
several types of cancer including thyroid cancer, breast cancer and hematological malignancies. (provided by
RefSeq, Nov 2011)

GeneCards Summary for C8orf4 Gene:
C8orf4 (chromosome 8 open reading frame 4) is a protein-coding gene. Diseases associated with C8orf4 include thyroid cancer, and thyroiditis.

UniProtKB/Swiss-Prot: CH004_HUMAN, Q9NR00
Function: May decrease apoptosis

Gene Wiki entry for C8orf4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for C8orf4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C8orf4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C8orf4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.2

C8orf4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8orf4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P040010:  view genomic region     (about GC identifiers)

Start:
40,010,989 bp from pter      End:
40,012,821 bp from pter
Size:
1,833 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CH004_HUMAN, Q9NR00 (See protein sequence)
Recommended Name: Uncharacterized protein C8orf4  
Size: 106 amino acids; 12337 Da
Subunit: Monomer

Explore the universe of human proteins at neXtProt for C8orf4: NX_Q9NR00

Explore proteomics data for C8orf4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C8orf4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064515.1  
    ENSEMBL proteins: 
     ENSP00000319914  

    C8orf4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for C8orf4

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    LSBio Antibodies in human, mouse, rat for C8orf4

    C8orf4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for C8orf4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR020282 Arg_vasopressin-induced_prot_1

    Graphical View of Domain Structure for InterPro Entry Q9NR00

    ProtoNet protein and cluster: Q9NR00


    C8orf4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CH004_HUMAN, Q9NR00
    Function: May decrease apoptosis

    Phenotypes:
         1 GenomeRNAi human phenotype for C8orf4:

     Increased 8N DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C8orf4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C8orf4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C8orf4

    miRNA
    Products:
        
    miRTarBase miRNAs that target C8orf4:
    hsa-mir-128-3p (MIRT021971), hsa-mir-335-5p (MIRT017893), hsa-mir-98-5p (MIRT027641)

    Block miRNA regulation of human, mouse, rat C8orf4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C8orf4 (see all 20):
    hsa-miR-30c hsa-miR-513a-5p hsa-miR-128 hsa-miR-30d hsa-miR-3680 hsa-miR-30a hsa-miR-4325 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidC8orf4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C8orf4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: C8orf4 (NM_019607)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C8orf4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf4

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    Browse ESI BIO Cell Lines and PureStem Progenitors for C8orf4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    nucleus2
    cytosol1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C8orf4
    Interactions:

        GeneGlobe Interaction Network for C8orf4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for C8orf4 (ENSP000003199144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    C8orf4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C8orf4 (CH004)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C8orf4 gene: 
    NM_020130.4  

    Unigene Cluster for C8orf4:

    Chromosome 8 open reading frame 4
    Hs.591849  [show with all ESTs]
    Unigene Representative Sequence: NM_020130
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000315792(uc003xnq.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C8orf4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate C8orf4 (see all 20):
    hsa-miR-30c hsa-miR-513a-5p hsa-miR-128 hsa-miR-30d hsa-miR-3680 hsa-miR-30a hsa-miR-4325 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidC8orf4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C8orf4
    Predesigned siRNA for gene silencing in human, mouse, rat C8orf4
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    OriGene ORF clones in mouse, rat for C8orf4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C8orf4 (NM_019607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C8orf4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf4
    Primer
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    OriGene qPCR primer pairs and template standards for C8orf4
    OriGene qSTAR qPCR primer pairs in human, mouse for C8orf4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C8orf4
      QuantiTect SYBR Green Assays in human, mouse, rat C8orf4
      QuantiFast Probe-based Assays in human, mouse, rat C8orf4

    Additional mRNA sequence: 

    AF268037.1 AK026240.1 BC020623.1 BC021672.1 

    4 DOTS entries:

    DT.116347  DT.95373385  DT.100811453  DT.95373384 

    Selected AceView cDNA sequences (see all 205):

    AI476388 AI624570 AA707181 AI861861 CR619771 CR616793 AI078326 AA985263 
    CR607025 CR622918 CB241667 AA515889 AA630199 AW591118 AW472823 AI640475 
    AW192551 BX366761 BM976768 CR600720 AA370319 AI245398 AA862493 AI589312 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C8orf4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACAATAAT
    C8orf4 Expression
    About this image


    C8orf4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
             Hepatocyte-like cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
    C8orf4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C8orf4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591849

    UniProtKB/Swiss-Prot: CH004_HUMAN, Q9NR00
    Tissue specificity: Ubiquitous. Expressed in thyroid papillary carcinoma

        Custom PCR Arrays for C8orf4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C8orf4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1810011O10Rik1 , 5 RIKEN cDNA 1810011O10 gene1, 5 87.74(n)1
    91.51(a)1
      8 (12.47 cM)5
    690681  NM_026931.21  NP_081207.11 
     244376165 
    chicken
    (Gallus gallus)
    Aves C8ORF41 chromosome 22 open reading frame, human C8orf4 75.47(n)
    76.42(a)
      771032  XM_001232954.2  XP_001232955.1 
    lizard
    (Anolis carolinensis)
    Reptilia C8orf46
    chromosome 8 open reading frame 4
    73(a)
    1 ↔ 1
    GL343418.1(758291-758602)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152082 Xenopus laevis transcribed sequence with weak similarity more 72.76(n)    BJ037054.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1103401 zgc:110340 64.79(n)
    60.67(a)
      541345  NM_001013472.2  NP_001013490.1 


    ENSEMBL Gene Tree for C8orf4 (if available)
    TreeFam Gene Tree for C8orf4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C8orf4 (see all 111)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340728341,2
    C--38546501(+) GTGTG-/G/T/TG
            
    CATTT
    1 -- ds50010--------
    rs1912879041,2
    --40009052(+) GCAATC/TGTCTT 1 -- us2k10--------
    rs1838785201,2
    --40009237(+) TAAGCC/TTTTAA 1 -- us2k10--------
    rs125462881,2
    C,F,H--40009304(+) ctcctA/Gacagt 1 -- us2k110Minor allele frequency- G:0.07NS EA NA CSA WA 814
    rs1899033011,2
    --40009308(+) TAACAC/GTGTAC 1 -- us2k10--------
    rs1450604771,2
    --40009325(+) AATCCA/GCAATC 1 -- us2k10--------
    rs1134663651,2
    F--40009462(+) ATACAC/TTCTTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs69806261,2
    C,F,H--40009501(+) ttgctC/Tctctg 1 -- us2k117Minor allele frequency- T:0.01NS EA NA WA CSA 779
    rs1441824641,2
    --40009537(+) TATAGC/GTGACT 1 -- us2k10--------
    rs1166064911,2
    C,F--40009617(+) AAAATC/TTCAAC 1 -- us2k11Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for C8orf4 (40010989 - 40012821 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C8orf4: --
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing C8orf4:
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing C8orf4
    DNA2.0 Custom Variant and Variant Library Synthesis for C8orf4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607702    OMIM disorders: --

    9 diseases for C8orf4:    
    About MalaCards
    thyroid cancer    thyroiditis    pulmonary function    goiter
    papillary carcinoma    breast cancer    attention deficit hyperactivity disorder    parkinson's disease
    endotheliitis


    C8orf4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C8orf4

    Export disorders for C8orf4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C8orf4 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with C8orf4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer. (PubMed id 11056052)1, 2, 3 Chua E.L.... Dong Q. (Genomics 2000)
    2. TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer. (PubMed id 15087392)1, 2 Sunde M.... Death A.K. (Cancer Res. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response. (PubMed id 17603013)1, 9 Park J....Lee I. (Biochem. Biophys. Res. Commun. 2007)
    5. TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to S-phase transition. (PubMed id 18959821)1, 9 Wang Y.D....Zhou Q. (BMB Rep 2008)
    6. TC-1 (c8orf4) enhances aggressive biologic behavior in lung cancer through the Wnt/I^-catenin pathway. (PubMed id 23880650)1 Su K....Wang Y. (J. Surg. Res. 2013)
    7. TC-1 (C8orf4) expression is correlated with differentiation in ovarian carcinomas and might distinguish metastatic ovarian from metastatic colorectal carcinomas. (PubMed id 23377761)1 Xu H.T....Wang E.H. (Virchows Arch. 2013)
    8. Genomic determinants of motor and cognitive outcomes in Parkinson's disease. (PubMed id 22658654)1 Chung S.J....Maraganore D.M. (amp 2012)
    9. Investigation of copy-number variations of C8orf4 in hematological malignancies. (PubMed id 20878554)1 Zhang J....Yu B. (Med. Oncol. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56892 HGNC: 1357 AceView: C8orf4 Ensembl:ENSG00000176907 euGenes: HUgn56892
    ECgene: C8orf4 H-InvDB: C8orf4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C8orf4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C8orf4 gene:
    Search GeneIP for patents involving C8orf4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat C8orf4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C8orf4
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