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C8orf37 Gene

protein-coding   GIFtS: 37

GC08M096327
chromosome 8 open reading frame 37
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
chromosome 8 open reading frame 371 2
FLJ306001 2
hypothetical protein LOC1576572

External Ids:    HGNC: 272321   Entrez Gene: 1576572   Ensembl: ENSG000001561727   UniProtKB: Q96NL83   

Search outside databases for aliases for C8orf37 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the C8orf37 gene upstream (promoter) region "":
GR-alpha   Meis-1   HOXA9B   Tal-1beta   ITF-2   POU2F1   Nkx2-2   AP-4   MEF-2A   STAT5A   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for C8orf37:  ""
MePH11752-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

C8orf37 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M096327:  view genomic region     (about GC identifiers)

Start:
96,257,148 bp from pter
End:
96,281,437 bp from pter
Size:
24,290 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: CH037_HUMAN, Q96NL8 (See protein sequence)
Recommended Name: Uncharacterized protein C8orf37  
Size: 207 amino acids; 23381 Da

REFSEQ proteins: NP_808880.1  

ENSEMBL proteins: 
ENSP00000286688 


Human Recombinant Proteins 
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""Browse recombinant and purified proteins available from Enzo Life Sciences
""HuPro® and/or Recombinant Proteins from Abnova for C8orf37 ""
""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
""Browse Sino Biological Recombinant Proteins  ""


Antibodies for C8orf37: 
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""Browse antibodies at Epitomics

Assays for C8orf37: 
""Browse Kits and Assays available from Millipore
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""Browse Enzo Life Sciences for kits & assays

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96NL8

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib.
RNA:
""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
"" Origene 29mer shRNA kits in GFP-retroviral vector: C8orf37
Origene shRNA RFP: C8orf37
Origene basic RS shRNA: C8orf37

""Applied Biosystems Silencer® siRNAs for C8orf37
""Sigma-Aldrich siRNA for C8orf37
Sigma-Aldrich shRNA for C8orf37
Explore Sigma-Aldrich super-pooled esiRNAs
Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
""Browse iPSC Reprogramming Factors at Sigma-Aldrich
"" Origene GFP tagged cDNA clones in CMV expression vector: C8orf37
Origene Myc/DDK tagged cDNA clones in CMV expression vector: C8orf37
Origene untagged cDNA clones in CMV expression vector: C8orf37
""Browse Sino Biological Human cDNA Clones  ""
(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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"" Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf37
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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"" Browse drugs & compounds from Enzo Life Sciences
""Browse Small Molecules at Sigma-Aldrich

"" Browse Tocris compounds for C8orf37

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib.
RNA:
""Browse for Gene Knock-down Tools from Millipore
""Browse Abnova for Chimera RNAi Products
""Applied Biosystems Silencer® siRNAs:  NM_177965  
"" Origene 29mer shRNA kits in GFP-retroviral vector: C8orf37
Origene shRNA RFP: C8orf37
Origene basic RS shRNA: C8orf37

""Sigma-Aldrich siRNA for C8orf37
Sigma-Aldrich shRNA for C8orf37
Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:""Search SABiosciences for microRNAs that regulate C8orf37: ""
Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
NM_177965  


Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: C8orf37
Origene Myc/DDK tagged cDNA clones in CMV expression vector: C8orf37
Origene untagged cDNA clones in CMV expression vector: C8orf37
Primers:"" Origene genome-wide validated SYBR primer pairs: C8orf37
""SABiosciences RT2 qPCR Primer Assay for C8orf37: PPH11881A ""

REFSEQ mRNAs for C8orf37 gene: 

NM_177965.2  

Additional cDNA sequence: 

AK055162.1 BC036855.2 BC150301.1 

4 DOTS entries:

DT.40127304  DT.100748146  DT.97809873  DT.102821088 

23 AceView cDNA sequences:

BX089757 BC036855 AA972183 AA018056 AI885321 AI911357 AA782091 N92755 
BU679782 AK055162 BX100102 BM543014 BE220870 BI088674 NM_177965 AA399492 
AL134492 AI142618 BE670614 AI473651 AA897574 AA018237 R93855 

"" highest scoring ESTs for C8orf37:

AA018237 AI885321 AK055162 BC036855 BM543014 R93855 AA972183 AI911357 BE220870 BE670614 

Unigene Cluster for C8orf37:

Chromosome 8 open reading frame 37
Hs.548157  [show with all ESTs]
Unigene Representative Sequence: BC150301


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000286688  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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C8orf37 expression in normal and diseased human tissues

"" Applied Biosystems TaqMan ® Gene Expression Assays for C8orf37

1""  / 2""  / 3""

4 probe-sets matching C8orf37 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
53299_r_at2, 3 U95-C 1 0.81 1.00 0.76 1.14 N92755 0.60 1.00 0.82 1
77322_at2, 3 U95-D 1 0.75 1.00 0.73 0.89 AI885321 0.80 1.00 0.91 1
244569_at2, 3 U133-B 1 0.82 1.00 -- -- N92755 0.60 1.00 0.82 1
244569_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
About this table

"" C8orf37 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTTATTGGCA

SOURCE GeneReport for Unigene cluster: Hs.548157
Primers:"" Origene genome-wide validated SYBR primer pairs: C8orf37 ""
""SABiosciences RT2 qPCR Primer Assay for C8orf37: PPH11881A ""
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for C8orf37 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6118151   -- hypothetical protein LOC611815 81.7(n)
75.72(a)
611815  XM_849528.1  XP_854621.1 
chimpanzee
(Pan troglodytes)
LOC7394601   -- hypothetical protein LOC739460 99.36(n)
99.52(a)
739460  XM_001144875.1  XP_001144875.1 
cow
(Bos taurus)
LOC6147441   -- similar to Uncharacterized protein C8orf37 homolog 87.76(n)
81.64(a)
614744  XM_866332.2  XP_871425.1 
rat
(Rattus norvegicus)
MGC941991   -- similar to RIKEN cDNA 2610301B20; EST AI428449 85.19(n)
80.19(a)
362483  NM_001007746.1  NP_001007747.1 
mouse
(Mus musculus)
2610301B20Rik1, 5 45
RIKEN cDNA 2610301B20 gene1, 5 85.02(n)1
78.26(a)1
671571  NM_026005.21  NP_080281.21 
 AI4284495  AI8404115  (see all 11)
About this table        Species with no ortholog for C8orf37

ENSEMBL Gene Tree for C8orf37
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/23 NCBI SNPs in C8orf37 are shown (see all 23 )
(Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 77)
ABGenomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 8 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
""
rs24524761,2
C,F,A,H91489985(-) CTATGG/CACAGT 1 -- ng51""20Minor allele frequency- C:0.49NS EA NA WA 1480""
""
rs25145571,2
C,F,A,H91490606(+) CTCTAG/TTTATT 1 -- ng51 tfbs3""20Minor allele frequency- T:0.48NS EA NA WA 1426""
""
rs24524751,2
C,F,A91490166(-) tatcaG/Ctgggt 1 -- ng51""15Minor allele frequency- C:0.49NS EA NA WA 1058""
""
rs78272111,2
C91488997(+) CGGCGC/TCCACG 1 -- ng51""0--------
""
rs78449931,2
C,F,A,H91475729(+) TGTGAT/CAGGAG 1 -- int1""15Minor allele frequency- C:0.35EA NA NS WA 1176""
""
rs21654981,2
C,F,A91471350(-) AAGGAC/TATGtt 1 -- int1""6Minor allele frequency- T:0.05NS EA NA WA 536""
""
rs78152551,2
C,F,A91482743(+) ATAGAA/GTAGGA 1 -- int1""26Minor allele frequency- G:0.30NS EA NA WA 1984""
""
rs78359211,2
C,F,A91483732(+) TATCTG/AAATTA 1 -- int1""12Minor allele frequency- A:0.38NA NS EA WA 772""
""
rs15302571,2
C,F,A91469211(-) tcgagC/Tagcta 1 -- int1""8Minor allele frequency- T:0.32EA NS NA 464""
""
rs44923371,2
C,F,A91474381(+) GACTAA/GAGAAA 1 -- int1""102Minor allele frequency- G:0.40NS EA PA EU CA WA NA 6474""
About this table

HapMap Linkage Disequilibrium images for C8orf37 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
Database of Genomic Variants (DGV): 1 variation for C8orf37
     1 CNV: 59499

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for C8orf37 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 157657 HGNC: 27232 AceView: LOC157657 Ensembl:ENSG00000156172 euGenes: HUgn157657
ECgene: C8orf37 H-InvDB: C8orf37
(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for C8orf37 gene: ""
Search GeneIP for patents involving C8orf37

GeneCards and IP: ""
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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""
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Products for C8orf37:
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"" "Your Favorite Gene" Pathways"" Browse ELISAs at Sigma-Aldrich
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