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Aliases for C8orf34 Gene

Aliases for C8orf34 Gene

  • Chromosome 8 Open Reading Frame 34 2 3 5
  • Protein VEST-1 3 4
  • Uncharacterized Protein C8orf34 3
  • Vestibule-1 Protein 3
  • Vestibule 1 2
  • VEST-1 3
  • VEST1 3

External Ids for C8orf34 Gene

Previous GeneCards Identifiers for C8orf34 Gene

  • GC08P069406
  • GC08P069242
  • GC08P064842

Summaries for C8orf34 Gene

Entrez Gene Summary for C8orf34 Gene

  • This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment. [provided by RefSeq, Mar 2017]

GeneCards Summary for C8orf34 Gene

C8orf34 (Chromosome 8 Open Reading Frame 34) is a Protein Coding gene.

Additional gene information for C8orf34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf34 Gene

Genomics for C8orf34 Gene

Regulatory Elements for C8orf34 Gene

Enhancers for C8orf34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H068260 0.4 Ensembl 17.5 -69.6 -69573 1 PKNOX1 EBF1 C8orf34 C8orf34-AS1 GC08P068234 RPL31P40
GH08H068256 0.6 Ensembl ENCODE 10.9 -73.8 -73805 0 CEBPB C8orf34 C8orf34-AS1 GC08P068234 RPL31P40
GH08H068257 0.6 Ensembl 10.9 -73.0 -73021 0 CTCF PRDM6 ARNT MAFG FEZF1 NFE2 ZIC2 C8orf34 C8orf34-AS1 GC08P068234 RPL31P40
GH08H068229 0.5 Ensembl ENCODE 10.5 -100.8 -100780 1 C8orf34 C8orf34-AS1 GC08P068234 ENSG00000252210
GH08H068182 0.5 FANTOM5 10.3 -148.5 -148508 0 ZNF316 MAFG CREB1 NFE2 C8orf34 C8orf34-AS1 ENSG00000254051 ENSG00000252210
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C8orf34 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000225553 278 401 PKNOX1 ZSCAN4 KLF17 ZNF391 EGR2 ZEB2 ZNF398 ZNF843 ZFP69B ZNF610

Genomic Location for C8orf34 Gene

Chromosome:
8
Start:
68,330,722 bp from pter
End:
68,819,023 bp from pter
Size:
488,302 bases
Orientation:
Plus strand

Genomic View for C8orf34 Gene

Genes around C8orf34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf34 Gene

Proteins for C8orf34 Gene

  • Protein details for C8orf34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49A92-CH034_HUMAN
    Recommended name:
    Uncharacterized protein C8orf34
    Protein Accession:
    Q49A92
    Secondary Accessions:
    • A8K5X1
    • G3XAM6
    • Q8N1X0
    • Q8N9M7
    • Q8ND19
    • Q96Q28

    Protein attributes for C8orf34 Gene

    Size:
    452 amino acids
    Molecular mass:
    50489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41961.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH41961.1; Type=Frameshift; Positions=429; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf34 Gene

neXtProt entry for C8orf34 Gene

Post-translational modifications for C8orf34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C8orf34 Gene

Domains & Families for C8orf34 Gene

Gene Families for C8orf34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C8orf34 Gene

Suggested Antigen Peptide Sequences for C8orf34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf34: view

No data available for UniProtKB/Swiss-Prot for C8orf34 Gene

Function for C8orf34 Gene

Phenotypes From GWAS Catalog for C8orf34 Gene

genes like me logo Genes that share phenotypes with C8orf34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C8orf34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf34 Gene

Localization for C8orf34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf34 gene
Compartment Confidence
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf34 Gene

Pathways & Interactions for C8orf34 Gene

SuperPathways for C8orf34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C8orf34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf34 Gene

Drugs & Compounds for C8orf34 Gene

(1) Drugs for C8orf34 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1148
genes like me logo Genes that share compounds with C8orf34: view

Transcripts for C8orf34 Gene

Unigene Clusters for C8orf34 Gene

Chromosome 8 open reading frame 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C8orf34
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf34 Gene

No ASD Table

Relevant External Links for C8orf34 Gene

GeneLoc Exon Structure for
C8orf34
ECgene alternative splicing isoforms for
C8orf34

Expression for C8orf34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf34 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf34 Gene

This gene is overexpressed in Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for C8orf34 Gene

This gene is overexpressed in Adipocyte (25.4), Rectum (25.2), and Prostate (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C8orf34 Gene



Protein tissue co-expression partners for C8orf34 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf34 Gene:

C8orf34

SOURCE GeneReport for Unigene cluster for C8orf34 Gene:

Hs.491941

Evidence on tissue expression from TISSUES for C8orf34 Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with C8orf34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf34 Gene

Orthologs for C8orf34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf34 33 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia C29H8orf34 33 34
  • 92.09 (n)
oppossum
(Monodelphis domestica)
Mammalia C8orf34 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A830018L16Rik 33 16 34
  • 87.7 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564053 33
  • 87.41 (n)
cow
(Bos Taurus)
Mammalia C14H8orf34 33 34
  • 86.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves C8ORF34 33
  • 79.63 (n)
C8orf34 34
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf34 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492224 33
  • 75.77 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162928 33
  • 70.58 (n)
C24H8orf34 34
  • 46 (a)
OneToOne
Species where no ortholog for C8orf34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf34 Gene

ENSEMBL:
Gene Tree for C8orf34 (if available)
TreeFam:
Gene Tree for C8orf34 (if available)

Paralogs for C8orf34 Gene

No data available for Paralogs for C8orf34 Gene

Variants for C8orf34 Gene

Sequence variations from dbSNP and Humsavar for C8orf34 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_042690 A colorectal cancer sample
rs1517114 drug-response 68,476,982(+) ATAGC(C/G/T)CTTAT intron-variant
rs1000005405 -- 68,737,926(+) TGGAC(C/G)TGAGA intron-variant
rs1000006597 -- 68,696,560(+) ATCTA(A/T)TGAAT intron-variant
rs1000011350 -- 68,330,794(+) CACGG(-/ACACACAC)ACACA intron-variant, nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C8orf34 Gene

Variant ID Type Subtype PubMed ID
dgv7238n100 CNV gain 25217958
esv2088334 CNV deletion 18987734
esv2178446 CNV deletion 18987734
esv2587232 CNV deletion 19546169
esv2664364 CNV deletion 23128226
esv2670093 CNV deletion 23128226
esv2737127 CNV deletion 23290073
esv2737129 CNV deletion 23290073
esv2737130 CNV deletion 23290073
esv27776 CNV loss 19812545
esv3451031 CNV insertion 20981092
esv3543619 CNV deletion 23714750
esv3576584 CNV gain 25503493
esv3617519 CNV gain 21293372
esv3617522 CNV gain 21293372
esv3617523 CNV loss 21293372
esv3617525 CNV loss 21293372
esv3617526 CNV loss 21293372
esv3617532 CNV loss 21293372
esv3891408 CNV gain 25118596
nsv1023815 CNV loss 25217958
nsv1031040 CNV loss 25217958
nsv1068714 OTHER inversion 25765185
nsv1075143 CNV deletion 25765185
nsv1115104 CNV deletion 24896259
nsv1161769 CNV duplication 26073780
nsv397515 CNV deletion 16902084
nsv465703 CNV gain 19166990
nsv476532 CNV novel sequence insertion 20440878
nsv508512 CNV deletion 20534489
nsv519549 CNV gain 19592680
nsv520587 CNV loss 19592680
nsv611462 CNV gain 21841781
nsv818636 CNV gain 17921354
nsv820237 CNV gain 19587683
nsv831349 CNV gain 17160897
nsv957681 CNV deletion 24416366
nsv981949 CNV duplication 23825009

Variation tolerance for C8orf34 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf34 Gene

Disorders for C8orf34 Gene

Relevant External Links for C8orf34

Genetic Association Database (GAD)
C8orf34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf34

No disorders were found for C8orf34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf34 Gene

Publications for C8orf34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. The landscape of kinase fusions in cancer. (PMID: 25204415) Stransky N … Lengauer C (Nature communications 2014) 3 60

Products for C8orf34 Gene

Sources for C8orf34 Gene

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