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Aliases for C8orf34 Gene

Aliases for C8orf34 Gene

  • Chromosome 8 Open Reading Frame 34 2 3 5
  • Protein VEST-1 3 4
  • Vestibule 1 2 3
  • Uncharacterized Protein C8orf34 3
  • Vestibule-1 Protein 3
  • VEST-1 3
  • VEST1 3

External Ids for C8orf34 Gene

Previous GeneCards Identifiers for C8orf34 Gene

  • GC08P069406
  • GC08P069242
  • GC08P064842

Summaries for C8orf34 Gene

GeneCards Summary for C8orf34 Gene

C8orf34 (Chromosome 8 Open Reading Frame 34) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf34 Gene

Genomics for C8orf34 Gene

Regulatory Elements for C8orf34 Gene

Enhancers for C8orf34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C8orf34 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C8orf34 Gene

68,330,722 bp from pter
68,819,023 bp from pter
488,302 bases
Plus strand

Genomic View for C8orf34 Gene

Genes around C8orf34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf34 Gene

Proteins for C8orf34 Gene

  • Protein details for C8orf34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C8orf34
    Protein Accession:
    Secondary Accessions:
    • A8K5X1
    • G3XAM6
    • Q8N1X0
    • Q8N9M7
    • Q8ND19
    • Q96Q28

    Protein attributes for C8orf34 Gene

    452 amino acids
    Molecular mass:
    50489 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH41961.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH41961.1; Type=Frameshift; Positions=429; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf34 Gene

neXtProt entry for C8orf34 Gene

Post-translational modifications for C8orf34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf34 Gene

No data available for DME Specific Peptides for C8orf34 Gene

Domains & Families for C8orf34 Gene

Protein Domains for C8orf34 Gene


Suggested Antigen Peptide Sequences for C8orf34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf34: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf34 Gene

Function for C8orf34 Gene

genes like me logo Genes that share phenotypes with C8orf34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf34 Gene

Localization for C8orf34 Gene

Subcellular locations from

Jensen Localization Image for C8orf34 Gene COMPARTMENTS Subcellular localization image for C8orf34 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf34 Gene

Pathways & Interactions for C8orf34 Gene

SuperPathways for C8orf34 Gene

No Data Available

Interacting Proteins for C8orf34 Gene

Gene Ontology (GO) - Biological Process for C8orf34 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf34 Gene

Drugs & Compounds for C8orf34 Gene

(1) Drugs for C8orf34 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1062
genes like me logo Genes that share compounds with C8orf34: view

Transcripts for C8orf34 Gene

Unigene Clusters for C8orf34 Gene

Chromosome 8 open reading frame 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf34 Gene

No ASD Table

Relevant External Links for C8orf34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf34 Gene

mRNA expression in normal human tissues for C8orf34 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf34 Gene

This gene is overexpressed in Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for C8orf34 Gene

This gene is overexpressed in Adipocyte (25.4), Rectum (25.2), and Prostate (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf34 Gene

Protein tissue co-expression partners for C8orf34 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf34 Gene:


SOURCE GeneReport for Unigene cluster for C8orf34 Gene:

genes like me logo Genes that share expression patterns with C8orf34: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C8orf34 Gene

Orthologs for C8orf34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C14H8orf34 34
  • 86.85 (n)
  • 85.05 (a)
C14H8orf34 35
  • 83 (a)
(Canis familiaris)
Mammalia C29H8orf34 34
  • 92.09 (n)
  • 91.8 (a)
C29H8orf34 35
  • 92 (a)
(Mus musculus)
Mammalia A830018L16Rik 34
  • 87.7 (n)
  • 91.11 (a)
A830018L16Rik 16
A830018L16Rik 35
  • 89 (a)
(Pan troglodytes)
Mammalia C8H8orf34 34
  • 99.57 (n)
  • 99.26 (a)
C8H8orf34 35
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1564053 34
  • 87.41 (n)
  • 90.22 (a)
(Monodelphis domestica)
Mammalia C8orf34 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
-- 35
  • 86 (a)
(Gallus gallus)
Aves C8ORF34 34
  • 79.63 (n)
  • 81.73 (a)
C8orf34 35
  • 55 (a)
(Anolis carolinensis)
Reptilia C8orf34 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492224 34
  • 75.77 (n)
  • 77.43 (a)
(Danio rerio)
Actinopterygii zgc:162928 34
  • 70.58 (n)
  • 71.47 (a)
C24H8orf34 35
  • 46 (a)
Species where no ortholog for C8orf34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf34 Gene

Gene Tree for C8orf34 (if available)
Gene Tree for C8orf34 (if available)

Paralogs for C8orf34 Gene

No data available for Paralogs for C8orf34 Gene

Variants for C8orf34 Gene

Sequence variations from dbSNP and Humsavar for C8orf34 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_042690 A colorectal cancer sample
rs16935065 - 68,787,521(+) TGGAA(A/G)CAGAA reference, missense
rs959451 -- 68,672,073(-) CTCCT(C/T)TCTCT intron-variant
rs961465 -- 68,657,248(+) CTGAA(C/T)GTTTG intron-variant
rs968826 -- 68,653,571(+) GAGAT(C/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf34 Gene

Variant ID Type Subtype PubMed ID
dgv7238n100 CNV gain 25217958
esv2088334 CNV deletion 18987734
esv2178446 CNV deletion 18987734
esv2587232 CNV deletion 19546169
esv2664364 CNV deletion 23128226
esv2670093 CNV deletion 23128226
esv2737127 CNV deletion 23290073
esv2737129 CNV deletion 23290073
esv2737130 CNV deletion 23290073
esv27776 CNV loss 19812545
esv3451031 CNV insertion 20981092
esv3543619 CNV deletion 23714750
esv3576584 CNV gain 25503493
esv3617519 CNV gain 21293372
esv3617522 CNV gain 21293372
esv3617523 CNV loss 21293372
esv3617525 CNV loss 21293372
esv3617526 CNV loss 21293372
esv3617532 CNV loss 21293372
esv3891408 CNV gain 25118596
nsv1023815 CNV loss 25217958
nsv1031040 CNV loss 25217958
nsv1068714 OTHER inversion 25765185
nsv1075143 CNV deletion 25765185
nsv1115104 CNV deletion 24896259
nsv1161769 CNV duplication 26073780
nsv397515 CNV deletion 16902084
nsv465703 CNV gain 19166990
nsv476532 CNV novel sequence insertion 20440878
nsv508512 CNV deletion 20534489
nsv519549 CNV gain 19592680
nsv520587 CNV loss 19592680
nsv611462 CNV gain 21841781
nsv818636 CNV gain 17921354
nsv820237 CNV gain 19587683
nsv831349 CNV gain 17160897
nsv957681 CNV deletion 24416366
nsv981949 CNV duplication 23825009

Variation tolerance for C8orf34 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf34 Gene

Disorders for C8orf34 Gene

Relevant External Links for C8orf34

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C8orf34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf34 Gene

Publications for C8orf34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  4. A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer. (PMID: 22664479) Han J.Y. … Lee J.S. (Pharmacogenomics J. 2013) 3 65
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 65

Products for C8orf34 Gene

Sources for C8orf34 Gene

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