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Aliases for C8orf34 Gene

Aliases for C8orf34 Gene

  • Chromosome 8 Open Reading Frame 34 2 3 5
  • Protein VEST-1 3 4
  • Vestibule 1 2 3
  • Vestibule-1 Protein 3
  • VEST-1 3
  • VEST1 3

External Ids for C8orf34 Gene

Previous GeneCards Identifiers for C8orf34 Gene

  • GC08P069406
  • GC08P069242
  • GC08P064842

Summaries for C8orf34 Gene

GeneCards Summary for C8orf34 Gene

C8orf34 (Chromosome 8 Open Reading Frame 34) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf34 Gene

Genomics for C8orf34 Gene

Regulatory Elements for C8orf34 Gene

Genomic Location for C8orf34 Gene

Chromosome:
8
Start:
68,330,722 bp from pter
End:
68,819,023 bp from pter
Size:
488,302 bases
Orientation:
Plus strand

Genomic View for C8orf34 Gene

Genes around C8orf34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf34 Gene

Proteins for C8orf34 Gene

  • Protein details for C8orf34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49A92-CH034_HUMAN
    Recommended name:
    Uncharacterized protein C8orf34
    Protein Accession:
    Q49A92
    Secondary Accessions:
    • A8K5X1
    • G3XAM6
    • Q8N1X0
    • Q8N9M7
    • Q8ND19
    • Q96Q28

    Protein attributes for C8orf34 Gene

    Size:
    452 amino acids
    Molecular mass:
    50489 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH41961.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH41961.1; Type=Frameshift; Positions=429; Evidence={ECO:0000305};

    Alternative splice isoforms for C8orf34 Gene

neXtProt entry for C8orf34 Gene

Proteomics data for C8orf34 Gene at MOPED

Post-translational modifications for C8orf34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf34 Gene

No data available for DME Specific Peptides for C8orf34 Gene

Domains & Families for C8orf34 Gene

Protein Domains for C8orf34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf34: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf34 Gene

Function for C8orf34 Gene

genes like me logo Genes that share phenotypes with C8orf34: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf34 Gene

Localization for C8orf34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf34 Gene COMPARTMENTS Subcellular localization image for C8orf34 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf34 Gene

Pathways & Interactions for C8orf34 Gene

SuperPathways for C8orf34 Gene

No Data Available

Interacting Proteins for C8orf34 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000427820%0d%0a9606.ENSP00000307288%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000392057%0d%0a
Selected Interacting proteins: ENSP00000427820 for C8orf34 Gene via STRING

Gene Ontology (GO) - Biological Process for C8orf34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf34 Gene

Drugs & Compounds for C8orf34 Gene

(1) Drugs for C8orf34 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1044
genes like me logo Genes that share compounds with C8orf34: view

Transcripts for C8orf34 Gene

Unigene Clusters for C8orf34 Gene

Chromosome 8 open reading frame 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf34 Gene

No ASD Table

Relevant External Links for C8orf34 Gene

GeneLoc Exon Structure for
C8orf34
ECgene alternative splicing isoforms for
C8orf34

Expression for C8orf34 Gene

mRNA expression in normal human tissues for C8orf34 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf34 Gene

This gene is overexpressed in Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for C8orf34 Gene

This gene is overexpressed in Adipocyte (25.4), Rectum (25.2), and Prostate (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C8orf34 Gene



SOURCE GeneReport for Unigene cluster for C8orf34 Gene Hs.491941

genes like me logo Genes that share expression patterns with C8orf34: view

Protein tissue co-expression partners for C8orf34 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C8orf34 Gene

Orthologs for C8orf34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf34 35
  • 99.57 (n)
  • 99.26 (a)
C8H8orf34 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C14H8orf34 36
  • 83 (a)
OneToOne
C14H8orf34 35
  • 86.85 (n)
  • 85.05 (a)
dog
(Canis familiaris)
Mammalia C29H8orf34 35
  • 92.09 (n)
  • 91.8 (a)
C29H8orf34 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A830018L16Rik 16
A830018L16Rik 36
  • 89 (a)
OneToOne
A830018L16Rik 35
  • 87.7 (n)
  • 91.11 (a)
oppossum
(Monodelphis domestica)
Mammalia C8orf34 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1564053 35
  • 87.41 (n)
  • 90.22 (a)
chicken
(Gallus gallus)
Aves C8ORF34 35
  • 79.63 (n)
  • 81.73 (a)
C8orf34 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf34 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492224 35
  • 75.77 (n)
  • 77.43 (a)
zebrafish
(Danio rerio)
Actinopterygii C24H8orf34 36
  • 46 (a)
OneToOne
zgc:162928 35
  • 70.58 (n)
  • 71.47 (a)
Species with no ortholog for C8orf34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf34 Gene

ENSEMBL:
Gene Tree for C8orf34 (if available)
TreeFam:
Gene Tree for C8orf34 (if available)

Paralogs for C8orf34 Gene

No data available for Paralogs for C8orf34 Gene

Variants for C8orf34 Gene

Sequence variations from dbSNP and Humsavar for C8orf34 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_042690 A colorectal cancer sample
rs16935065 - 68,787,521(+) TGGAA(A/G)CAGAA reference, missense
rs763845 -- 68,668,440(-) TTGAA(A/G)GAAAG intron-variant
rs959451 -- 68,672,073(-) CTCCT(C/T)TCTCT intron-variant
rs892705 -- 68,583,799(-) TGAGA(C/T)CACGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf34 Gene

Variant ID Type Subtype PubMed ID
dgv7804n71 CNV Loss 21882294
nsv508512 CNV Loss 20534489
esv2088334 CNV Deletion 18987734
nsv820237 CNV Gain 19587683
nsv890981 CNV Loss 21882294
esv2587232 CNV Deletion 19546169
esv2178446 CNV Deletion 18987734
esv2737127 CNV Deletion 23290073
esv2664364 CNV Deletion 23128226
nsv397515 CNV Loss 16902084
nsv890982 CNV Gain 21882294
nsv890983 CNV Loss 21882294
nsv890984 CNV Loss 21882294
esv2670093 CNV Deletion 23128226
nsv520587 CNV Loss 19592680
nsv890985 CNV Gain 21882294
nsv831349 CNV Gain 17160897
esv269339 CNV Insertion 20981092
nsv818636 CNV Gain 17921354
nsv465703 CNV Gain 19166990
nsv890986 CNV Loss 21882294
nsv519549 CNV Gain 19592680
esv27776 CNV Loss 19812545
esv2737129 CNV Deletion 23290073
esv2737130 CNV Deletion 23290073

Variation tolerance for C8orf34 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf34 Gene

HapMap Linkage Disequilibrium report
C8orf34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf34 Gene

Disorders for C8orf34 Gene

Relevant External Links for C8orf34

Genetic Association Database (GAD)
C8orf34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf34

No disorders were found for C8orf34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf34 Gene

Publications for C8orf34 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  5. A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer. (PMID: 22664479) Han J.Y. … Lee J.S. (Pharmacogenomics J. 2013) 3

Products for C8orf34 Gene

Sources for C8orf34 Gene

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