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Aliases for C8orf33 Gene

Aliases for C8orf33 Gene

  • Chromosome 8 Open Reading Frame 33 2 3 5

External Ids for C8orf33 Gene

Previous GeneCards Identifiers for C8orf33 Gene

  • GC08P146249
  • GC08P141393

Summaries for C8orf33 Gene

GeneCards Summary for C8orf33 Gene

C8orf33 (Chromosome 8 Open Reading Frame 33) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf33 Gene

Genomics for C8orf33 Gene

Regulatory Elements for C8orf33 Gene

Enhancers for C8orf33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C8orf33 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf33 Gene

Chromosome:
8
Start:
145,052,378 bp from pter
End:
145,065,864 bp from pter
Size:
13,487 bases
Orientation:
Plus strand

Genomic View for C8orf33 Gene

Genes around C8orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf33 Gene

Proteins for C8orf33 Gene

  • Protein details for C8orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7E9-CH033_HUMAN
    Recommended name:
    UPF0488 protein C8orf33
    Protein Accession:
    Q9H7E9
    Secondary Accessions:
    • A6NGC0
    • Q96BT8

    Protein attributes for C8orf33 Gene

    Size:
    229 amino acids
    Molecular mass:
    24993 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf33 Gene

Post-translational modifications for C8orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf33 Gene

Domains & Families for C8orf33 Gene

Protein Domains for C8orf33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7E9

UniProtKB/Swiss-Prot:

CH033_HUMAN :
  • Belongs to the UPF0488 family.
Family:
  • Belongs to the UPF0488 family.
genes like me logo Genes that share domains with C8orf33: view

No data available for Gene Families for C8orf33 Gene

Function for C8orf33 Gene

Gene Ontology (GO) - Molecular Function for C8orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21900206
genes like me logo Genes that share ontologies with C8orf33: view
genes like me logo Genes that share phenotypes with C8orf33: view

Animal Model Products

CRISPR Products

miRNA for C8orf33 Gene

miRTarBase miRNAs that target C8orf33

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf33 Gene

Localization for C8orf33 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf33 Gene COMPARTMENTS Subcellular localization image for C8orf33 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf33 Gene

Pathways & Interactions for C8orf33 Gene

SuperPathways for C8orf33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C8orf33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf33 Gene

Drugs & Compounds for C8orf33 Gene

No Compound Related Data Available

Transcripts for C8orf33 Gene

Unigene Clusters for C8orf33 Gene

Chromosome 8 open reading frame 33:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf33 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for C8orf33 Gene

GeneLoc Exon Structure for
C8orf33
ECgene alternative splicing isoforms for
C8orf33

Expression for C8orf33 Gene

mRNA expression in normal human tissues for C8orf33 Gene

Protein differential expression in normal tissues from HIPED for C8orf33 Gene

This gene is overexpressed in Lung (29.3), Breast (16.2), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C8orf33 Gene



Protein tissue co-expression partners for C8orf33 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf33 Gene:

C8orf33

SOURCE GeneReport for Unigene cluster for C8orf33 Gene:

Hs.169615
genes like me logo Genes that share expression patterns with C8orf33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C8orf33 Gene

Orthologs for C8orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C8orf33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C14H8orf33 34
  • 79.79 (n)
  • 75.53 (a)
C8orf33 35
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C13H8orf33 34
  • 79.95 (n)
  • 77.54 (a)
C8orf33 35
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110038F14Rik 34
  • 81.7 (n)
  • 77.78 (a)
1110038F14Rik 16
1110038F14Rik 35
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC464479 34
  • 97.67 (n)
  • 95.63 (a)
C8orf33 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681282 34
  • 72.37 (n)
  • 63.96 (a)
oppossum
(Monodelphis domestica)
Mammalia C8orf33 35
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia C8orf33 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C24H8orf33 35
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14286 35
  • 23 (a)
OneToOne
Species where no ortholog for C8orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf33 Gene

ENSEMBL:
Gene Tree for C8orf33 (if available)
TreeFam:
Gene Tree for C8orf33 (if available)

Paralogs for C8orf33 Gene

Pseudogenes.org Pseudogenes for C8orf33 Gene

genes like me logo Genes that share paralogs with C8orf33: view

No data available for Paralogs for C8orf33 Gene

Variants for C8orf33 Gene

Sequence variations from dbSNP and Humsavar for C8orf33 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1134051 -- 145,055,932(+) gtctt(A/G)tatcc utr-variant-3-prime, utr-variant-5-prime
rs7828404 -- 145,055,085(+) GGTTT(C/T)CCTTT utr-variant-3-prime, utr-variant-5-prime
rs7832236 -- 145,059,389(+) aggcg(A/G)ctttt intron-variant, utr-variant-5-prime
rs7843096 -- 145,056,157(+) tgtga(A/G)gttgc downstream-variant-500B, utr-variant-5-prime
rs7845295 -- 145,059,087(+) tcctg(C/T)taatg intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C8orf33 Gene

Variant ID Type Subtype PubMed ID
dgv7338n100 CNV gain 25217958
dgv7339n100 CNV gain 25217958
dgv7340n100 CNV loss 25217958
dgv7341n100 CNV gain 25217958
dgv7342n100 CNV gain 25217958
esv2759653 CNV loss 17122850
esv2761199 CNV gain+loss 21179565
esv3619155 CNV loss 21293372
esv3619160 CNV loss 21293372
esv3619161 CNV gain 21293372
esv3891498 CNV gain 25118596
esv3891499 CNV gain 25118596
nsv1015720 CNV gain+loss 25217958
nsv1033208 CNV gain+loss 25217958
nsv466024 CNV gain 19166990
nsv466025 CNV gain 19166990
nsv508533 CNV deletion 20534489
nsv612974 CNV gain 21841781
nsv612978 CNV gain 21841781
nsv612980 CNV loss 21841781
nsv824811 CNV gain 20364138
nsv824812 CNV gain 20364138
nsv8399 CNV gain 18304495

Variation tolerance for C8orf33 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf33 Gene

Disorders for C8orf33 Gene

Relevant External Links for C8orf33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf33

No disorders were found for C8orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf33 Gene

Publications for C8orf33 Gene

  1. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 65
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65

Products for C8orf33 Gene

Sources for C8orf33 Gene

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