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Aliases for C8orf33 Gene

Aliases for C8orf33 Gene

  • Chromosome 8 Open Reading Frame 33 2 3 5

External Ids for C8orf33 Gene

Previous GeneCards Identifiers for C8orf33 Gene

  • GC08P146249
  • GC08P141393

Summaries for C8orf33 Gene

GeneCards Summary for C8orf33 Gene

C8orf33 (Chromosome 8 Open Reading Frame 33) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf33 Gene

Genomics for C8orf33 Gene

Regulatory Elements for C8orf33 Gene

Enhancers for C8orf33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F145026 0.9 ENCODE 33.9 -25.0 -24988 1.2 ARID4B SIN3A ZNF48 SLC30A9 ELK1 ZNF143 MIER2 REST KAT8 MIER3 C8orf33 LOC100419763 ZNF517 ARHGAP39 ENSG00000255530
GH08F145000 0.6 ENCODE 21.1 -49.2 -49194 5.0 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF252P ZNF517 C8orf33 LRRC14 RPL8 COMMD5 ZNF250 LOC100419763 MIR6850 ADCK5
GH08F145029 0.4 ENCODE 11.8 -22.9 -22923 0.5 SOX13 ZFHX2 SP7 C8orf33 LOC100419763 ENSG00000255530
GH08F145057 0.2 ENCODE 11.4 +5.5 5458 1.4 RAD51 GATA3 RFX1 POLR2A USF2 BMI1 EBF1 C8orf33 GC08P145060 PIR40692
GH08F145062 0.5 ENCODE 11.3 +10.4 10400 1.4 C8orf33 ZNF252P GC08P145060
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C8orf33 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf33 Gene

145,052,378 bp from pter
145,065,864 bp from pter
13,487 bases
Plus strand

Genomic View for C8orf33 Gene

Genes around C8orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf33 Gene

Proteins for C8orf33 Gene

  • Protein details for C8orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0488 protein C8orf33
    Protein Accession:
    Secondary Accessions:
    • A6NGC0
    • Q96BT8

    Protein attributes for C8orf33 Gene

    229 amino acids
    Molecular mass:
    24993 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf33 Gene


neXtProt entry for C8orf33 Gene

Post-translational modifications for C8orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8orf33 Gene

Domains & Families for C8orf33 Gene

Protein Domains for C8orf33 Gene


Suggested Antigen Peptide Sequences for C8orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0488 family.
  • Belongs to the UPF0488 family.
genes like me logo Genes that share domains with C8orf33: view

No data available for Gene Families for C8orf33 Gene

Function for C8orf33 Gene

Gene Ontology (GO) - Molecular Function for C8orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19060904
genes like me logo Genes that share ontologies with C8orf33: view
genes like me logo Genes that share phenotypes with C8orf33: view

Animal Model Products

miRNA for C8orf33 Gene

miRTarBase miRNAs that target C8orf33

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf33 Gene

Localization for C8orf33 Gene

Subcellular locations from

Jensen Localization Image for C8orf33 Gene COMPARTMENTS Subcellular localization image for C8orf33 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf33 Gene

Pathways & Interactions for C8orf33 Gene

SuperPathways for C8orf33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C8orf33 Gene


No data available for Pathways by source and SIGNOR curated interactions for C8orf33 Gene

Transcripts for C8orf33 Gene

Unigene Clusters for C8orf33 Gene

Chromosome 8 open reading frame 33:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf33 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: -
SP3: -
SP5: -
SP6: - -

Relevant External Links for C8orf33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8orf33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C8orf33 Gene

Protein differential expression in normal tissues from HIPED for C8orf33 Gene

This gene is overexpressed in Lung (29.3), Breast (16.2), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C8orf33 Gene

Protein tissue co-expression partners for C8orf33 Gene

NURSA nuclear receptor signaling pathways regulating expression of C8orf33 Gene:


SOURCE GeneReport for Unigene cluster for C8orf33 Gene:

genes like me logo Genes that share expression patterns with C8orf33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C8orf33 Gene

Orthologs for C8orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C8orf33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC464479 34
  • 97.67 (n)
C8orf33 35
  • 96 (a)
(Mus musculus)
Mammalia 1110038F14Rik 34 16 35
  • 81.7 (n)
(Canis familiaris)
Mammalia C13H8orf33 34
  • 79.95 (n)
C8orf33 35
  • 56 (a)
(Bos Taurus)
Mammalia C14H8orf33 34
  • 79.79 (n)
C8orf33 35
  • 74 (a)
(Rattus norvegicus)
Mammalia LOC681282 34
  • 72.37 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
-- 35
  • 42 (a)
(Monodelphis domestica)
Mammalia C8orf33 35
  • 38 (a)
(Anolis carolinensis)
Reptilia C8orf33 35
  • 42 (a)
(Danio rerio)
Actinopterygii C24H8orf33 35
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14286 35
  • 23 (a)
Species where no ortholog for C8orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf33 Gene

Gene Tree for C8orf33 (if available)
Gene Tree for C8orf33 (if available)

Paralogs for C8orf33 Gene Pseudogenes for C8orf33 Gene

genes like me logo Genes that share paralogs with C8orf33: view

No data available for Paralogs for C8orf33 Gene

Variants for C8orf33 Gene

Sequence variations from dbSNP and Humsavar for C8orf33 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10105885 -- 145,050,924(+) tGCGt(G/T)ttttt upstream-variant-2KB
rs10105896 -- 145,050,948(+) TTTTA(A/G)ATGGA upstream-variant-2KB
rs111609333 -- 145,055,899(+) GGAGA(C/T)GGTTC upstream-variant-2KB, utr-variant-3-prime
rs111963907 -- 145,055,567(+) TTCCC(C/T)GGGGG upstream-variant-2KB, utr-variant-3-prime
rs113112308 -- 145,052,771(+) GAAGG(C/G)GGCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for C8orf33 Gene

Variant ID Type Subtype PubMed ID
dgv7338n100 CNV gain 25217958
dgv7339n100 CNV gain 25217958
dgv7340n100 CNV loss 25217958
dgv7341n100 CNV gain 25217958
dgv7342n100 CNV gain 25217958
esv2759653 CNV loss 17122850
esv2761199 CNV gain+loss 21179565
esv3619155 CNV loss 21293372
esv3619160 CNV loss 21293372
esv3619161 CNV gain 21293372
esv3891498 CNV gain 25118596
esv3891499 CNV gain 25118596
nsv1015720 CNV gain+loss 25217958
nsv1033208 CNV gain+loss 25217958
nsv466024 CNV gain 19166990
nsv466025 CNV gain 19166990
nsv508533 CNV deletion 20534489
nsv612974 CNV gain 21841781
nsv612978 CNV gain 21841781
nsv612980 CNV loss 21841781
nsv824811 CNV gain 20364138
nsv824812 CNV gain 20364138
nsv8399 CNV gain 18304495

Variation tolerance for C8orf33 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf33 Gene

Disorders for C8orf33 Gene

Relevant External Links for C8orf33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C8orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf33 Gene

Publications for C8orf33 Gene

  1. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for C8orf33 Gene

Sources for C8orf33 Gene

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