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Aliases for C8orf33 Gene

Aliases for C8orf33 Gene

  • Chromosome 8 Open Reading Frame 33 2 3 5

External Ids for C8orf33 Gene

Previous GeneCards Identifiers for C8orf33 Gene

  • GC08P146249
  • GC08P141393

Summaries for C8orf33 Gene

GeneCards Summary for C8orf33 Gene

C8orf33 (Chromosome 8 Open Reading Frame 33) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf33 Gene

Genomics for C8orf33 Gene

Regulatory Elements for C8orf33 Gene

Promoters for C8orf33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C8orf33 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf33 Gene

Chromosome:
8
Start:
145,052,378 bp from pter
End:
145,065,864 bp from pter
Size:
13,487 bases
Orientation:
Plus strand

Genomic View for C8orf33 Gene

Genes around C8orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf33 Gene

Proteins for C8orf33 Gene

  • Protein details for C8orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7E9-CH033_HUMAN
    Recommended name:
    UPF0488 protein C8orf33
    Protein Accession:
    Q9H7E9
    Secondary Accessions:
    • A6NGC0
    • Q96BT8

    Protein attributes for C8orf33 Gene

    Size:
    229 amino acids
    Molecular mass:
    24993 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf33 Gene

Proteomics data for C8orf33 Gene at MOPED

Post-translational modifications for C8orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8orf33 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C8orf33 Gene

Domains & Families for C8orf33 Gene

Protein Domains for C8orf33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7E9

UniProtKB/Swiss-Prot:

CH033_HUMAN :
  • Belongs to the UPF0488 family.
Family:
  • Belongs to the UPF0488 family.
genes like me logo Genes that share domains with C8orf33: view

No data available for Gene Families for C8orf33 Gene

Function for C8orf33 Gene

genes like me logo Genes that share phenotypes with C8orf33: view

Animal Model Products

CRISPR Products

miRNA for C8orf33 Gene

miRTarBase miRNAs that target C8orf33

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf33 Gene

Localization for C8orf33 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf33 Gene COMPARTMENTS Subcellular localization image for C8orf33 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf33 Gene

Pathways & Interactions for C8orf33 Gene

SuperPathways for C8orf33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C8orf33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf33 Gene

Drugs & Compounds for C8orf33 Gene

No Compound Related Data Available

Transcripts for C8orf33 Gene

Unigene Clusters for C8orf33 Gene

Chromosome 8 open reading frame 33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf33 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6: - -

Relevant External Links for C8orf33 Gene

GeneLoc Exon Structure for
C8orf33
ECgene alternative splicing isoforms for
C8orf33

Expression for C8orf33 Gene

mRNA expression in normal human tissues for C8orf33 Gene

Protein differential expression in normal tissues from HIPED for C8orf33 Gene

This gene is overexpressed in Lung (29.3), Breast (16.2), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C8orf33 Gene



SOURCE GeneReport for Unigene cluster for C8orf33 Gene Hs.169615

genes like me logo Genes that share expression patterns with C8orf33: view

Protein tissue co-expression partners for C8orf33 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C8orf33 Gene

Orthologs for C8orf33 Gene

This gene was present in the common ancestor of animals.

Orthologs for C8orf33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC464479 35
  • 97.67 (n)
  • 95.63 (a)
C8orf33 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8orf33 36
  • 74 (a)
OneToOne
C14H8orf33 35
  • 79.79 (n)
  • 75.53 (a)
dog
(Canis familiaris)
Mammalia C13H8orf33 35
  • 79.95 (n)
  • 77.54 (a)
C8orf33 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110038F14Rik 16
1110038F14Rik 36
  • 65 (a)
OneToOne
1110038F14Rik 35
  • 81.7 (n)
  • 77.78 (a)
oppossum
(Monodelphis domestica)
Mammalia C8orf33 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC681282 35
  • 72.37 (n)
  • 63.96 (a)
lizard
(Anolis carolinensis)
Reptilia C8orf33 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C24H8orf33 36
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14286 36
  • 23 (a)
OneToOne
Species with no ortholog for C8orf33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8orf33 Gene

ENSEMBL:
Gene Tree for C8orf33 (if available)
TreeFam:
Gene Tree for C8orf33 (if available)

Paralogs for C8orf33 Gene

Pseudogenes.org Pseudogenes for C8orf33 Gene

genes like me logo Genes that share paralogs with C8orf33: view

No data available for Paralogs for C8orf33 Gene

Variants for C8orf33 Gene

Sequence variations from dbSNP and Humsavar for C8orf33 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1134051 -- 145,055,932(+) gtctt(A/G)tatcc utr-variant-3-prime, utr-variant-5-prime
rs6599557 -- 145,051,458(+) TGCCC(C/T)CCTGA upstream-variant-2KB
rs6599558 -- 145,056,198(+) tgaca(A/G)gagat downstream-variant-500B, utr-variant-5-prime
rs6599559 -- 145,056,240(+) taagc(A/G/T)tgagc downstream-variant-500B, utr-variant-5-prime
rs6599560 -- 145,059,697(+) attca(C/T)tgggc intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C8orf33 Gene

Variant ID Type Subtype PubMed ID
dgv7986n71 CNV Gain 21882294
dgv2265e1 CNV Complex 17122850
nsv466024 CNV Gain 19166990
nsv508533 CNV Loss 20534489
nsv891936 CNV Gain 21882294
nsv466025 CNV Gain 19166990
dgv7988n71 CNV Loss 21882294
nsv824811 CNV Gain 20364138
nsv824812 CNV Gain 20364138
nsv8399 CNV Gain 18304495

Variation tolerance for C8orf33 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf33 Gene

HapMap Linkage Disequilibrium report
C8orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf33 Gene

Disorders for C8orf33 Gene

Relevant External Links for C8orf33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf33

No disorders were found for C8orf33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf33 Gene

Publications for C8orf33 Gene

  1. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for C8orf33 Gene

Sources for C8orf33 Gene

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