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Aliases for C8orf31 Gene

Aliases for C8orf31 Gene

  • Chromosome 8 Open Reading Frame 31 2 3 5

External Ids for C8orf31 Gene

Previous GeneCards Identifiers for C8orf31 Gene

  • GC08P144193
  • GC08P139374
  • GC08P144120

Summaries for C8orf31 Gene

GeneCards Summary for C8orf31 Gene

C8orf31 (Chromosome 8 Open Reading Frame 31) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf31 Gene

Genomics for C8orf31 Gene

Regulatory Elements for C8orf31 Gene

Enhancers for C8orf31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F142990 1.6 FANTOM5 Ensembl ENCODE 18.4 -46.2 -46210 4.4 HDGF ATF1 PKNOX1 ARNT ZNF766 KLF13 MEF2D SMARCA4 PBX2 STAT3 C8orf31 LOC100133669 JRK CYP11B2 ENSG00000253715 LY6D ZNF696 TSNARE1 LYPD2 CDC42P3
GH08F143054 1.1 ENCODE 17.7 +16.4 16377 1.9 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 C8orf31 AK3P2 GC08P143054
GH08F143047 1 Ensembl ENCODE 17.2 +9.1 9066 1.3 CTCF CBX3 PKNOX1 WRNIP1 MAX ZNF384 ZIC2 RAD21 RFX5 DIDO1 C8orf31 ENSG00000243328 GC08P143054
GH08F143038 0.9 ENCODE 19 +0.2 208 1.7 ELF3 TBP HDAC1 PKNOX1 ZFP64 ARID4B SIN3A YBX1 GATA2 ZNF263 ENSG00000243328 C8orf31 GC08P143054
GH08F143042 0.8 ENCODE 20.8 +3.7 3656 1.4 SOX13 SAP130 ARID4B ZNF48 ZSCAN9 RARA ZNF7 GATAD1 POLR2A NR2F6 C8orf31 ENSG00000243328 GC08P143054
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C8orf31 on UCSC Golden Path with GeneCards custom track

Promoters for C8orf31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001403984 191 1601 ELF3 TBP HDAC1 PKNOX1 ZFP64 ARID4B SIN3A GATA2 SP3 SP5

Genomic Location for C8orf31 Gene

Chromosome:
8
Start:
143,039,209 bp from pter
End:
143,059,942 bp from pter
Size:
20,734 bases
Orientation:
Plus strand

Genomic View for C8orf31 Gene

Genes around C8orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf31 Gene

Proteins for C8orf31 Gene

  • Protein details for C8orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9H6-CH031_HUMAN
    Recommended name:
    Uncharacterized protein C8orf31
    Protein Accession:
    Q8N9H6
    Secondary Accessions:
    • Q6GMU7

    Protein attributes for C8orf31 Gene

    Size:
    132 amino acids
    Molecular mass:
    14527 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf31 Gene

Post-translational modifications for C8orf31 Gene

No Post-translational modifications

Other Protein References for C8orf31 Gene

No data available for DME Specific Peptides for C8orf31 Gene

Domains & Families for C8orf31 Gene

Protein Domains for C8orf31 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf31: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf31 Gene

Function for C8orf31 Gene

genes like me logo Genes that share phenotypes with C8orf31: view

Animal Model Products

miRNA for C8orf31 Gene

miRTarBase miRNAs that target C8orf31

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf31 Gene

Localization for C8orf31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf31 gene
Compartment Confidence
mitochondrion 2
nucleus 2
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf31 Gene

Pathways & Interactions for C8orf31 Gene

SuperPathways for C8orf31 Gene

No Data Available

Interacting Proteins for C8orf31 Gene

Gene Ontology (GO) - Biological Process for C8orf31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf31 Gene

Transcripts for C8orf31 Gene

Unigene Clusters for C8orf31 Gene

Chromosome 8 open reading frame 31:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: - -
SP3: -

Relevant External Links for C8orf31 Gene

GeneLoc Exon Structure for
C8orf31
ECgene alternative splicing isoforms for
C8orf31

Expression for C8orf31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C8orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of C8orf31 Gene:

C8orf31

SOURCE GeneReport for Unigene cluster for C8orf31 Gene:

Hs.660382
genes like me logo Genes that share expression patterns with C8orf31: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C8orf31 Gene

Orthologs for C8orf31 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C8orf31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8orf31 35
  • 96 (a)
OneToOne
C8H8orf31 34
  • 93.89 (n)
Species where no ortholog for C8orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf31 Gene

ENSEMBL:
Gene Tree for C8orf31 (if available)
TreeFam:
Gene Tree for C8orf31 (if available)

Paralogs for C8orf31 Gene

No data available for Paralogs for C8orf31 Gene

Variants for C8orf31 Gene

Sequence variations from dbSNP and Humsavar for C8orf31 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086405 -- 143,045,335(+) CATGG(A/C)CTGGA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs10089879 -- 143,038,705(+) CCTGA(A/C)TCCTC upstream-variant-2KB
rs10090102 -- 143,038,891(+) GTGGG(C/T)GGAGA upstream-variant-2KB
rs10098161 -- 143,054,231(+) cctag(G/T)aggca intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10103914 -- 143,050,626(+) CTATA(A/G)AAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf31 Gene

Variant ID Type Subtype PubMed ID
nsv6437 CNV insertion 18451855
nsv612717 CNV loss 21841781
nsv512976 CNV insertion 21212237
nsv465991 CNV loss 19166990
esv3619096 CNV loss 21293372
esv33872 CNV gain 17666407
esv2861234 CNV insertion 24192839
esv2737948 CNV deletion 23290073
esv2670756 CNV deletion 23128226
esv25583 CNV loss 19812545
esv1451224 CNV insertion 17803354

Variation tolerance for C8orf31 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf31 Gene

Disorders for C8orf31 Gene

Relevant External Links for C8orf31

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf31

No disorders were found for C8orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf31 Gene

Publications for C8orf31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C8orf31 Gene

Sources for C8orf31 Gene

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