Aliases for C8orf22 Gene
Aliases for C8orf22 Gene
External Ids for C8orf22 Gene
- HGNC: 31745
- Entrez Gene: 492307
- Ensembl: ENSG00000168333
- UniProtKB: Q8WWR9
Previous GeneCards Identifiers for C8orf22 Gene
- GC00U916963
- GC08P050148
- GC08U900617
- GC08P049984
- GC08P045448
Summaries for C8orf22 Gene
GeneCards Summary for C8orf22 Gene
C8orf22 (Chromosome 8 Open Reading Frame 22) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf22 Gene
Genomics for C8orf22 Gene
Regulatory Elements for C8orf22 Gene
Enhancers for C8orf22 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G049064 | 0.8 | ENCODE | 35 | +11.5 | 11537 | 2.2 | GTF2F1 TBP JUN MAX RAD21 BRCA1 RFX5 NFYB RCOR1 FOS | C8orf22 GC08M049134 |
| GH08G048918 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 10.4 | -132.2 | -132202 | 8.2 | FOXA2 ATF1 ARNT ARID4B SIN3A GLI4 BRCA1 ZNF48 YY1 GATA2 | C8orf22 SNAI2 GC08M048959 PIR61418 |
| GH08G049092 | 0.4 | ENCODE | 44.5 | +38.6 | 38635 | 1.1 | POU5F1 ID3 | C8orf22 GC08M049134 |
| GH08G049110 | 1 | ENCODE | 10.2 | +56.2 | 56164 | 0.9 | PKNOX1 ATF1 ARNT E2F7 YY1 TCF12 ZNF766 ELK1 GATA2 KLF13 | C8orf22 ENSG00000253688 GC08M049134 |
| GH08G048427 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 5.7 | -624.1 | -624104 | 6.3 | JUN TEAD4 MAX RBBP5 RAD21 FOSL1 GATA2 POLR2A NFE2 FOS | LOC101929268 C8orf22 RPL29P19 EFCAB1 MCM4 ENSG00000279881 LOC105375821 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C8orf22 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C8orf22 Gene
- Chromosome:
- 8
- Start:
- 49,054,311 bp from pter
- End:
- 49,076,090 bp from pter
- Size:
- 21,780 bases
- Orientation:
- Plus strand
Genomic View for C8orf22 Gene
Genes around C8orf22 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q11.21 by Ensembl
- 8q11.21 by Entrez Gene
- 8q11.21 by HGNC
C8orf22 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C8orf22 Gene
Proteins for C8orf22 Gene
-
Protein details for C8orf22 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWR9-PDPFL_HUMAN
- Recommended name:
- Pancreatic progenitor cell differentiation and proliferation factor-like protein
- Protein Accession:
- Q8WWR9
- G3V137
- Q8WVI1
Protein attributes for C8orf22 Gene
- Size:
- 84 amino acids
- Molecular mass:
- 9188 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for C8orf22 Gene
No Post-translational modifications
Other Protein References for C8orf22 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C8orf22
-
Abcam antibodies for C8orf22
- Invitrogen Antibodies for C8orf22
- Search GeneTex for Antibodies for C8orf22
Protein Products
-
OriGene Purified Proteins for C8orf22
- Search Origene for MassSpec and Protein Over-expression Lysates for C8orf22
- Origene Custom Protein Services for C8orf22
- Search GeneTex for Proteins for C8orf22
Assay Products
No data available for DME Specific Peptides for C8orf22 Gene
Domains & Families for C8orf22 Gene
Suggested Antigen Peptide Sequences for C8orf22 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WWR9- Family:
-
- Belongs to the PPDPF family.
No data available for Gene Families for C8orf22 Gene
Function for C8orf22 Gene
Phenotypes for C8orf22 Gene
- GenomeRNAi human phenotypes for C8orf22:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C8orf22
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C8orf22 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C8orf22 gene
- Search ViGene Biosciences for C8orf22
CRISPR Products
-
OriGene CRISPR knockouts for C8orf22
-
Santa Cruz Biotechnology (SCBT) CRISPR for C8orf22
- GenScript: Design CRISPR guide RNA sequences for C8orf22
miRNA for C8orf22 Gene
- miRTarBase miRNAs that target C8orf22
miRNA Products
- Search ViGene Biosciences for C8orf22
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C8orf22
- Browse OriGene Inhibitory RNA Products For C8orf22
-
ViGene Biosciences ready-to-package AAV shRNAs for C8orf22 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C8orf22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C8orf22
-
ViGene Biosciences adenoviral particle packaged cDNA for C8orf22 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C8orf22 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C8orf22 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf22 Gene
Localization for C8orf22 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| peroxisome | 2 |
| extracellular | 1 |
| nucleus | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf22 Gene
Pathways & Interactions for C8orf22 Gene
No Data Available
Interacting Proteins for C8orf22 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for C8orf22 Gene
Transcripts for C8orf22 Gene
mRNA/cDNA for C8orf22 Gene
- (4) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C8orf22 Gene
- Chromosome 8 open reading frame 22:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for C8orf22
-
Santa Cruz Biotechnology (SCBT) CRISPR for C8orf22
- GenScript: Design CRISPR guide RNA sequences for C8orf22
miRNA Products
- Search ViGene Biosciences for C8orf22
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C8orf22
- Browse OriGene Inhibitory RNA Products For C8orf22
-
ViGene Biosciences ready-to-package AAV shRNAs for C8orf22 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C8orf22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf22
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: |
Expression for C8orf22 Gene
mRNA differential expression in normal tissues according to GTEx for C8orf22 Gene
This gene is overexpressed in Muscle - Skeletal (x51.0).
NURSA nuclear receptor signaling pathways regulating expression of C8orf22 Gene:
C8orf22SOURCE GeneReport for Unigene cluster for C8orf22 Gene:
Hs.49890Evidence on tissue expression from TISSUES for C8orf22 Gene
- Muscle(4.5)
Primer Products
-
OriGene qPCR primer pairs for C8orf22
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf22 Gene
Orthologs for C8orf22 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C8H8orf22 34 |
|
||
| C8orf22 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C29H8orf22 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C8orf22 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C8orf22 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | C14H8orf22 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C8orf22 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C8orf22 35 |
|
OneToOne |
- Species where no ortholog for C8orf22 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C8orf22 Gene
No data available for Paralogs for C8orf22 Gene
Variants for C8orf22 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000054243 | -- | 49,063,837(+) | GGATT(C/G)GGGGG | intron-variant | |
| rs1000360788 | -- | 49,052,898(+) | TTAGC(A/C)AGAAT | upstream-variant-2KB | |
| rs1000531519 | -- | 49,064,160(+) | ATTCC(C/T)AGGTA | intron-variant | |
| rs1000571989 | -- | 49,068,429(+) | ACTTA(C/T)GAAGA | intron-variant | |
| rs1000772908 | -- | 49,052,631(+) | TCAAA(A/C)GGGAG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2736979 | CNV | deletion | 23290073 |
| nsv1025068 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.45;
9.74% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C8orf22 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C8orf22
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf22 Gene
Disorders for C8orf22 Gene
Relevant External Links for C8orf22
No disorders were found for C8orf22 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf22 Gene
Publications for C8orf22 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3 4 64
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
- DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for C8orf22 Gene
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- Browse Primary Antibodies
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- Custom Assay Services
- OriGene Purified Proteins for C8orf22
- Search Origene for MassSpec and Protein Over-expression Lysates for C8orf22
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C8orf22
- Browse OriGene Inhibitory RNA Products For C8orf22
- OriGene qPCR primer pairs for C8orf22
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for C8orf22 in any vector
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- GenScript: Design CRISPR guide RNA sequences for C8orf22
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- Novus Biologicals Antibodies for C8orf22
- Novus Biologicals proteins and lysates for C8orf22
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C8orf22 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C8orf22 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C8orf22 gene
- Search ViGene Biosciences for C8orf22
- Horizon Cell Lines for C8orf22
- Cyagen custom Knockout/knockin (KOKI) mouse models for C8orf22
- VectorBuilder custom plasmid, inducible vectors for C8orf22
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf22
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C8orf22 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (110) PathCards
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- (154) TISSUES
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