C8orf22 Gene
protein-coding GIFtS: 36
GCID: GC08P049984
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chromosome 8 open reading frame 22
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Aliases
for C8orf22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 8 Open Reading Frame 221 2 | | Exocrine Differentiation And Proliferation Factor-Like Protein2 3 | | Pancreatic Progenitor Cell Differentiation And Proliferation Factor-LikeProtein2 |
Export aliases for C8orf22 gene to outside databasesPrevious GC identifers: GC00U916963 GC08P050148 GC08U900617 GC08P045448 |
Summaries
for C8orf22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C8orf22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for C8orf22
Other transcription factors
Search SABiosciences Chromatin IP Primers for C8orf22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8orf22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q11 Ensembl cytogenetic band: 8q11.21 HGNC cytogenetic band: 8q11.21C8orf22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P049984: view genomic region
(about GC identifiers)
Start:
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49,966,870 bp from pter |
End:
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49,988,649 bp from pter |
Size:
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21,780 bases |
Orientation:
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plus strand |
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Proteins
for C8orf22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDPFL_HUMAN, Q8WWR9 (See
protein sequence)Recommended Name: Pancreatic progenitor cell differentiation and proliferation factor-like protein Size: 84 amino acids; 9188 Da
Secondary accessions: G3V137 Q8WVI1Alternative splicing: 3 isoforms: Q8WWR9-1 Q8WWR9-2 Q8WWR9-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C8orf22: NX_Q8WWR9
C8orf22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001007177.1 NP_001243525.1 NP_001243526.1 NP_001243527.1
ENSEMBL proteins: ENSP00000430392 ENSP00000428773 ENSP00000382561 ENSP00000304926
Human Recombinant Protein Products:
C8orf22 Antibody Products:
Assay Products for C8orf22: |
Protein
Domains /
Families
for C8orf22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C8orf22 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WWR9ProtoNet protein and cluster: Q8WWR9 UniProtKB/Swiss-Prot: PDPFL_HUMAN, Q8WWR9Similarity: Belongs to the PPDPF family |
Function
for C8orf22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf22
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf22
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf22 |
|
Pathways & Interactions
for C8orf22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf22
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
C8orf22 for ontologies About GeneDecksing
|
Drugs & Compounds
for C8orf22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C8orf22
Search CenterWatch for drugs/clinical trials and news about C8orf22 / PDPFL
|
Transcripts
for C8orf22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C8orf22 gene (4 alternative transcripts): NM_001007176.4 NM_001256596.1 NM_001256597.1 NM_001256598.1 Unigene Cluster for C8orf22: Chromosome 8 open reading frame 22 Hs.49890 [show with all ESTs]Unigene Representative Sequence: NM_0012565984 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000517663 ENST00000522267 ENST00000399653(uc003xqq.4) ENST00000303202
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf22
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8orf22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C8orf22 (NM_001007176) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C8orf22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf22 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C8orf22
Browse OriGene validated miRNA SYBR primer pairs
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Additional cDNA sequence: AJ276240.1 BC017981.1 4 DOTS entries: DT.97809210 DT.40113308 DT.40252905 DT.410749
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C8orf22 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C8orf22
|
Expression
for C8orf22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C8orf22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGCTCCC
About this image
See C8orf22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C8orf22
SOURCE GeneReport for Unigene cluster: Hs.49890
SABiosciences Custom PCR Arrays for C8orf22
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C8orf22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C8orf22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C8orf22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C8orf22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf22 |
Orthologs
for C8orf22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C8orf22 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
C8orf226 |
Uncharacterized protein |
58(a) |
1 ↔ 1 |
2(111813588-111815627) |
Species with no ortholog for C8orf22
ENSEMBL Gene Tree for C8orf22 (if available)
TreeFam Gene Tree for C8orf22 (if available) |
Paralogs
for C8orf22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C8orf22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C8orf22 (49966870 - 49988649 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C8orf22: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C8orf22 |
|
Disorders
/ Diseases
for C8orf22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C8orf22 for disorders About GeneDecksing
1  disease for C8orf22: About MalaCardspancreatitis
Export disorders for C8orf22 gene to outside databases
|
Publications
for C8orf22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C8orf22 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C8orf22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1, 2 Harrington J.J.... Ducar M. (2001)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for C8orf22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C8orf22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C8orf22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C8orf22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C8orf22 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C8orf22 gene:
Search GeneIP for patents involving C8orf22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C8orf22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8orf22 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8orf22 |
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