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Aliases for C8orf22 Gene

Aliases for C8orf22 Gene

  • Chromosome 8 Open Reading Frame 22 2 3 5
  • Exocrine Differentiation And Proliferation Factor-Like Protein 4

External Ids for C8orf22 Gene

Previous GeneCards Identifiers for C8orf22 Gene

  • GC00U916963
  • GC08P050148
  • GC08U900617
  • GC08P049984
  • GC08P045448

Summaries for C8orf22 Gene

GeneCards Summary for C8orf22 Gene

C8orf22 (Chromosome 8 Open Reading Frame 22) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf22 Gene

Genomics for C8orf22 Gene

Regulatory Elements for C8orf22 Gene

Enhancers for C8orf22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C8orf22 on UCSC Golden Path with GeneCards custom track

Genomic Location for C8orf22 Gene

Chromosome:
8
Start:
49,054,311 bp from pter
End:
49,076,090 bp from pter
Size:
21,780 bases
Orientation:
Plus strand

Genomic View for C8orf22 Gene

Genes around C8orf22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf22 Gene

Proteins for C8orf22 Gene

  • Protein details for C8orf22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWR9-PDPFL_HUMAN
    Recommended name:
    Pancreatic progenitor cell differentiation and proliferation factor-like protein
    Protein Accession:
    Q8WWR9
    Secondary Accessions:
    • G3V137
    • Q8WVI1

    Protein attributes for C8orf22 Gene

    Size:
    84 amino acids
    Molecular mass:
    9188 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf22 Gene

Proteomics data for C8orf22 Gene at MOPED

Post-translational modifications for C8orf22 Gene

No Post-translational modifications

Other Protein References for C8orf22 Gene

No data available for DME Specific Peptides for C8orf22 Gene

Domains & Families for C8orf22 Gene

Protein Domains for C8orf22 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C8orf22 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWR9

UniProtKB/Swiss-Prot:

PDPFL_HUMAN :
  • Belongs to the PPDPF family.
Family:
  • Belongs to the PPDPF family.
genes like me logo Genes that share domains with C8orf22: view

No data available for Gene Families for C8orf22 Gene

Function for C8orf22 Gene

Phenotypes for C8orf22 Gene

GenomeRNAi human phenotypes for C8orf22:
genes like me logo Genes that share phenotypes with C8orf22: view

Animal Model Products

CRISPR Products

miRNA for C8orf22 Gene

miRTarBase miRNAs that target C8orf22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf22 Gene

Localization for C8orf22 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8orf22 Gene COMPARTMENTS Subcellular localization image for C8orf22 gene
Compartment Confidence
mitochondrion 2
peroxisome 2
cytosol 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C8orf22 Gene

Pathways & Interactions for C8orf22 Gene

SuperPathways for C8orf22 Gene

No Data Available

Interacting Proteins for C8orf22 Gene

Gene Ontology (GO) - Biological Process for C8orf22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification IBA --
GO:0007275 multicellular organism development IEA --
GO:0031017 exocrine pancreas development IBA --
genes like me logo Genes that share ontologies with C8orf22: view

No data available for Pathways by source and SIGNOR curated interactions for C8orf22 Gene

Drugs & Compounds for C8orf22 Gene

No Compound Related Data Available

Transcripts for C8orf22 Gene

mRNA/cDNA for C8orf22 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C8orf22 Gene

Chromosome 8 open reading frame 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf22 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - -
SP3:

Relevant External Links for C8orf22 Gene

GeneLoc Exon Structure for
C8orf22
ECgene alternative splicing isoforms for
C8orf22

Expression for C8orf22 Gene

mRNA expression in normal human tissues for C8orf22 Gene

mRNA differential expression in normal tissues according to GTEx for C8orf22 Gene

This gene is overexpressed in Muscle - Skeletal (x51.0).

SOURCE GeneReport for Unigene cluster for C8orf22 Gene Hs.49890

genes like me logo Genes that share expression patterns with C8orf22: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C8orf22 Gene

Orthologs for C8orf22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8orf22 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C29H8orf22 35
  • 85.23 (n)
  • 81.01 (a)
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf22 35
  • 100 (n)
  • 100 (a)
C8orf22 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C14H8orf22 36
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C8orf22 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8orf22 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8orf22 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C8orf22 36
  • 52 (a)
OneToOne
Species with no ortholog for C8orf22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf22 Gene

ENSEMBL:
Gene Tree for C8orf22 (if available)
TreeFam:
Gene Tree for C8orf22 (if available)

Paralogs for C8orf22 Gene

No data available for Paralogs for C8orf22 Gene

Variants for C8orf22 Gene

Sequence variations from dbSNP and Humsavar for C8orf22 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2137013 -- 49,068,532(-) TTACT(A/G)TGAAG intron-variant
rs2292399 -- 49,074,671(+) TAACC(A/G)TTGTC intron-variant, utr-variant-3-prime
rs2385127 -- 49,063,187(+) TGGTC(A/G)TAATG intron-variant
rs7844223 -- 49,054,101(+) CTACT(A/G)TCATG upstream-variant-2KB
rs2667293 -- 49,065,201(-) CCTCA(G/T)TATGT intron-variant

Variation tolerance for C8orf22 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8orf22 Gene

HapMap Linkage Disequilibrium report
C8orf22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C8orf22 Gene

Disorders for C8orf22 Gene

Relevant External Links for C8orf22

Genetic Association Database (GAD)
C8orf22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C8orf22

No disorders were found for C8orf22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf22 Gene

Publications for C8orf22 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington J.J. … Ducar M. (Nat. Biotechnol. 2001) 3

Products for C8orf22 Gene

Sources for C8orf22 Gene

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