C8orf17 Gene
protein-coding GIFtS: 27
GCID: GC08P141012
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chromosome 8 open reading frame 17
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Aliases
for C8orf17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Chromosome 8 Open Reading Frame 171 2 | | MOST-11 2 |
| External Ids: | HGNC: 177371 | Entrez Gene: 1005072492 | Ensembl: ENSG000002507337 | UniProtKB: Q9NRJ13 | | ORGUL members: | |
|---|
| NONCODE:n341621 | |
Export aliases for C8orf17 gene to outside databasesPrevious GC identifers: GC08P139904 GC08P141101 GC08P140627 GC08P140914 GC08U901089
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Summaries
for C8orf17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MOST1_HUMAN, Q9NRJ1Function: May be involved in cell survival, proliferation and progression of cancer cells
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Genomic Views
for C8orf17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NT_008046.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for C8orf17
Other transcription factors
Search SABiosciences Chromatin IP Primers for C8orf17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8orf17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3C8orf17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P141012: view genomic region
(about GC identifiers)
Start:
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140,943,416 bp from pter |
End:
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140,946,190 bp from pter |
Size:
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2,775 bases |
Orientation:
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plus strand |
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Proteins
for C8orf17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MOST1_HUMAN, Q9NRJ1 (See
protein sequence)Recommended Name: Protein MOST-1 Size: 99 amino acids; 11219 Da
Subunit: Interacts with TSPO, IGHM and IGHD
Subcellular location: Cytoplasm. Microsome membrane. Endoplasmic reticulum membraneExplore the universe of human proteins at neXtProt for C8orf17: NX_Q9NRJ1
C8orf17 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000428230
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0005792 | microsome |
-- | -- |
C8orf17 for ontologies About GeneDecksing
C8orf17 Antibody Products:
Assay Products for C8orf17: |
Protein
Domains /
Families
for C8orf17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NRJ1 |
Function
for C8orf17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MOST1_HUMAN, Q9NRJ1Function: May be involved in cell survival, proliferation and progression of cancer cells
1 GenomeRNAi human phenotype for C8orf17:
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Pathways & Interactions
for C8orf17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8orf17
|
Drugs & Compounds
for C8orf17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C8orf17
Search CenterWatch for drugs/clinical trials and news about C8orf17 / MOST1 
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Transcripts
for C8orf17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C8orf17 gene: NM_020237.1 Unigene Cluster for C8orf17: Chromosome 8 open reading frame 17 Hs.283098 Unigene Representative Sequence: AF2202641 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000507535
Additional cDNA sequence: AF220264.1
GeneLoc Exon Structure
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Expression
for C8orf17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C8orf17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCAGTTCTG
About this image
See C8orf17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C8orf17
SOURCE GeneReport for Unigene cluster: Hs.283098
UniProtKB/Swiss-Prot: MOST1_HUMAN, Q9NRJ1Tissue specificity: Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate andthymus. Expressed in all of the cancer cell lines tested
SABiosciences Custom PCR Arrays for C8orf17
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C8orf17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C8orf17 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C8orf17 |
Orthologs
for C8orf17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for C8orf17 (if available)
TreeFam Gene Tree for C8orf17 (if available) |
Paralogs
for C8orf17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C8orf17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for C8orf17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C8orf17 for disorders About GeneDecksing
2  diseases for C8orf17: About MalaCardsprostate cancer prostatitis
Export disorders for C8orf17 gene to outside databases
|
Publications
for C8orf17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C8orf17 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C8orf17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers. (PubMed id 17143515)1, 2, 3 Tan J.M.M. and Chow V.T.K. (2007)
- The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate. (PubMed id 12665628)1, 2 Tan J.M.M.... Chow V.T.K. (2003)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
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External Searches for C8orf17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C8orf17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C8orf17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C8orf17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C8orf17 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C8orf17 gene:
Search GeneIP for patents involving C8orf17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C8orf17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C8orf17 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C8orf17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8orf17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C8orf17 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C8orf17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C8orf17 |
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 |  |  |  | |
| | | | Search Tocris compounds for C8orf17 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for C8orf17 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C8orf17 |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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