Aliases for C8orf17 Gene
Aliases for C8orf17 Gene
External Ids for C8orf17 Gene
- HGNC: 17737
- Entrez Gene: 100507249
- Ensembl: ENSG00000250733
- OMIM: 616992
- UniProtKB: Q9NRJ1
Previous GeneCards Identifiers for C8orf17 Gene
- GC08P139904
- GC08P141101
- GC08P140627
- GC08P140914
- GC08P141012
- GC08U901089
Summaries for C8orf17 Gene
GeneCards Summary for C8orf17 Gene
C8orf17 (Chromosome 8 Open Reading Frame 17) is a Protein Coding gene.
UniProtKB/Swiss-Prot for C8orf17 Gene
-
May be involved in cell survival, proliferation and progression of cancer cells.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf17 Gene
Genomics for C8orf17 Gene
Regulatory Elements for C8orf17 Gene
Enhancers for C8orf17 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G139990 | 1.1 | ENCODE | 10.8 | +60.0 | 60045 | 1.6 | ARNT CREB3L1 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF207 FOS KLF13 | C8orf17 GC08P140000 |
| GH08G140308 | 1.1 | Ensembl ENCODE | 9.5 | +378.8 | 378774 | 2.1 | SIN3A RAD21 ZSCAN9 RFX5 GATA2 RCOR1 FOS DEK CEBPB SMARCB1 | C8orf17 LOC105375778 LOC105375779 |
| GH08G139956 | 0.8 | ENCODE | 12 | +26.0 | 25950 | 1.1 | SOX13 FOXA2 SAP130 ZNF792 MAX ARID4B BMI1 THRB RAD21 YY1 | C8orf17 GC08P140000 |
| GH08G139821 | 0.9 | dbSUPER | 10.5 | -108.4 | -108392 | 1.9 | PKNOX1 SIN3A ZNF366 SCRT2 FOS DEK EGR2 SP3 MAFF PRDM6 | C8orf17 GC08P139797 LOC105375781 |
| GH08G140105 | 0.9 | ENCODE | 10.4 | +175.3 | 175259 | 1.8 | ELF3 HDGF PKNOX1 FOXA2 ZNF493 KLF17 RARA GLIS2 ZNF366 RELB | C8orf17 KCNK9 GC08M140101 GC08P140241 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C8orf17 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C8orf17 Gene
- Chromosome:
- 8
- Start:
- 139,931,172 bp from pter
- End:
- 139,933,946 bp from pter
- Size:
- 2,775 bases
- Orientation:
- Plus strand
Genomic View for C8orf17 Gene
Genes around C8orf17 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
C8orf17 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
No data available for RefSeq DNA sequence for C8orf17 Gene
Proteins for C8orf17 Gene
-
Protein details for C8orf17 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRJ1-MOST1_HUMAN
- Recommended name:
- Protein MOST-1
- Protein Accession:
- Q9NRJ1
Protein attributes for C8orf17 Gene
- Size:
- 99 amino acids
- Molecular mass:
- 11219 Da
- Quaternary structure:
-
- Interacts with TSPO, IGHM and IGHD.
Post-translational modifications for C8orf17 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for C8orf17
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C8orf17
- Origene Custom Protein Services for C8orf17
- Search GeneTex for Proteins for C8orf17
Assay Products
No data available for DME Specific Peptides for C8orf17 Gene
Domains & Families for C8orf17 Gene
Protein Domains for C8orf17 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for C8orf17 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C8orf17 Gene
Function for C8orf17 Gene
Molecular function for C8orf17 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in cell survival, proliferation and progression of cancer cells.
Phenotypes for C8orf17 Gene
- GenomeRNAi human phenotypes for C8orf17:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C8orf17
-
- Search ViGene Biosciences for C8orf17
CRISPR Products
- Browse CRISPR knockouts for C8orf17
miRNA for C8orf17 Gene
- miRTarBase miRNAs that target C8orf17
-
- hsa-mir-6855-5p (MIRT634963)
- hsa-mir-3170 (MIRT634964)
- hsa-mir-193b-5p (MIRT634965)
- hsa-mir-4284 (MIRT634966)
- hsa-mir-7155-5p (MIRT634967)
- hsa-mir-637 (MIRT634968)
- hsa-mir-8089 (MIRT634969)
- hsa-mir-4700-5p (MIRT634970)
- hsa-mir-4667-5p (MIRT634971)
- hsa-mir-4772-3p (MIRT634972)
- hsa-mir-330-5p (MIRT634973)
- hsa-mir-326 (MIRT634974)
- hsa-mir-4638-5p (MIRT634975)
- hsa-mir-1307-3p (MIRT634976)
- hsa-mir-1304-3p (MIRT634977)
- hsa-mir-6741-3p (MIRT634978)
- hsa-mir-6890-3p (MIRT634979)
- hsa-mir-181c-3p (MIRT634980)
- hsa-mir-4536-5p (MIRT690304)
- hsa-mir-4728-3p (MIRT690305)
- hsa-mir-194-5p (MIRT690306)
- hsa-mir-590-5p (MIRT690307)
- hsa-mir-21-5p (MIRT690308)
miRNA Products
- Search ViGene Biosciences for C8orf17
Inhibitory RNA Products
- Origene shRNA and RNAi products in human, mouse, rat for C8orf17
- Browse OriGene Inhibitory RNA Products For C8orf17
- Search ViGene Biosciences for C8orf17
Clone Products
- GenScript: Custom all cDNA clones Services for C8orf17
- VectorBuilder custom plasmid, inducible vectors for C8orf17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for C8orf17
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf17 Gene
Localization for C8orf17 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C8orf17 Gene
- Cytoplasm. Microsome membrane. Endoplasmic reticulum membrane.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0031090 | organelle membrane | IEA | -- |
Transcripts for C8orf17 Gene
mRNA/cDNA for C8orf17 Gene
- (1) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for C8orf17
miRNA Products
- Search ViGene Biosciences for C8orf17
Inhibitory RNA Products
- Origene shRNA and RNAi products in human, mouse, rat for C8orf17
- Browse OriGene Inhibitory RNA Products For C8orf17
- Search ViGene Biosciences for C8orf17
Clone Products
- GenScript: Custom all cDNA clones Services for C8orf17
- VectorBuilder custom plasmid, inducible vectors for C8orf17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf17
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C8orf17 Gene
NURSA nuclear receptor signaling pathways regulating expression of C8orf17 Gene:
C8orf17SOURCE GeneReport for Unigene cluster for C8orf17 Gene:
Hs.283098mRNA Expression by UniProt/SwissProt for C8orf17 Gene:
Q9NRJ1-MOST1_HUMAN
Tissue specificity:
Expressed in the heart, kidney, liver, pancreas, small intestine, ovary, testis, prostate and thymus. Expressed in all of the cancer cell lines tested.
Primer Products
-
OriGene qPCR primer pairs for C8orf17
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf17 Gene
Orthologs for C8orf17 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C8orf17 35 |
|
OneToOne |
- Species where no ortholog for C8orf17 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C8orf17 Gene
(12) SIMAP similar genes for C8orf17 Gene using alignment to 1 proteins:
No data available for Paralogs for C8orf17 Gene
Variants for C8orf17 Gene
Gene Damage Index Score:
1.06;
21.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C8orf17 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C8orf17
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C8orf17 Gene
Disorders for C8orf17 Gene
Relevant External Links for C8orf17
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C8orf17
No disorders were found for C8orf17 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf17 Gene
Publications for C8orf17 Gene
- Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers. (PMID: 17143515) Tan J.M.M. … Chow V.T.K. (Int. J. Oncol. 2007) 2 3 4 64
- The novel human MOST-1 (C8orf17) gene exhibits tissue specific expression, maps to chromosome 8q24.2, and is overexpressed/amplified in high grade cancers of the breast and prostate. (PMID: 12665628) Tan J.M.M. … Chow V.T.K. (Mol. Pathol. 2003) 3 4 64
- High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas. (PMID: 18000363) van Duin M. … van Dekken H. (Cytogenet. Genome Res. 2007) 3 64
- The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64
Products for C8orf17 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C8orf17
- Origene Custom Protein Services for C8orf17
- Origene shRNA and RNAi products in human, mouse, rat for C8orf17
- Browse OriGene Inhibitory RNA Products For C8orf17
- OriGene qPCR primer pairs for C8orf17
- Browse CRISPR knockouts for C8orf17
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C8orf17
- GenScript: Custom all cDNA clones Services for C8orf17
- GenScript Custom Purified and Recombinant Proteins Services for C8orf17
- GenScript Custom Assay Services for C8orf17
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- Browse GenScript CRISPR for C8orf17
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for C8orf17
- VectorBuilder custom plasmid, inducible vectors for C8orf17
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C8orf17
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C8orf17 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
- (116) SCBT
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer