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Aliases for C8G Gene

Aliases for C8G Gene

  • Complement C8 Gamma Chain 2 3 5
  • Complement Component 8, Gamma Polypeptide 2 3
  • Complement Component C8 Gamma Chain 3
  • C8C 3

External Ids for C8G Gene

Previous GeneCards Identifiers for C8G Gene

  • GC09U990012
  • GC09P131529
  • GC09P133280
  • GC09P135197
  • GC09P137115
  • GC09P138959
  • GC09P139839
  • GC09P109299

Summaries for C8G Gene

Entrez Gene Summary for C8G Gene

  • The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]

GeneCards Summary for C8G Gene

C8G (Complement C8 Gamma Chain) is a Protein Coding gene. Diseases associated with C8G include Immunodeficiency Due To A Late Component Of Complement Deficiency and Acute Salpingo-Oophoritis. Among its related pathways are Immune response Lectin induced complement pathway and Complement Pathway. GO annotations related to this gene include protein complex binding and complement binding.

UniProtKB/Swiss-Prot for C8G Gene

  • C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Additional gene information for C8G Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8G Gene

Genomics for C8G Gene

Regulatory Elements for C8G Gene

Enhancers for C8G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H136881 1.6 Ensembl ENCODE dbSUPER 11.6 -62.2 -62213 2.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS PHPT1 MAMDC4 C9orf172 TMEM141 LCN12 PRR31 C8G FBXW5 RABL6 ABCA2
GH09H136787 1.7 Ensembl ENCODE dbSUPER 10.8 -150.2 -150162 14.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 DPH7 LCN8 ANAPC2 ABCA2 SNHG7 LCN10 EXD3 LCN12 TMEM141 PRR31
GH09H136884 1.3 ENCODE dbSUPER 11.8 -58.6 -58601 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B ZNF207 ZNF143 FOS SP3 EHMT1 SDCCAG3 ANAPC2 PHPT1 SNHG7 LOC651337 MAMDC4 C9orf172 FBXW5 C8G
GH09H136784 0.9 ENCODE 10.8 -159.3 -159308 1.8 HDAC1 PKNOX1 ATF1 ARNT DMAP1 TCF12 ZNF766 EGR1 SIRT6 FOS LCN8 ABCA2 NDOR1 LCN10 RABL6 CCDC183-AS1 LCN12 PRR31 FBXW5 C8G
GH09H136822 0.4 ENCODE 11.6 -123.3 -123282 0 RING1 DPH7 INPP5E ARRDC1-AS1 EXD3 CCDC183 C9orf172 MAMDC4 PHPT1 SNAPC4 LCN12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C8G on UCSC Golden Path with GeneCards custom track

Promoters for C8G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243107 -575 1401 HDGF FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 CBX5 ZNF302

Genomic Locations for C8G Gene

Genomic Locations for C8G Gene
2,100 bases
Plus strand

Genomic View for C8G Gene

Genes around C8G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8G Gene

Proteins for C8G Gene

  • Protein details for C8G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement component C8 gamma chain
    Protein Accession:
    Secondary Accessions:
    • Q14CT8
    • Q14CU0
    • Q5SQ07

    Protein attributes for C8G Gene

    202 amino acids
    Molecular mass:
    22277 Da
    Quaternary structure:
    • C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

    Three dimensional structures from OCA and Proteopedia for C8G Gene

neXtProt entry for C8G Gene

Post-translational modifications for C8G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C8G Gene

Domains & Families for C8G Gene

Gene Families for C8G Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C8G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calycin superfamily. Lipocalin family.
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with C8G: view

Function for C8G Gene

Molecular function for C8G Gene

GENATLAS Biochemistry:
complement component 8,gamma-1 globulin,complexing with other late components of the cascade to form the membrane attacks complex,gamma,(lipocalin family,Kernel group),associating with CD59,potential regulator of the complex helping to protect host cells from lysis
UniProtKB/Swiss-Prot Function:
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Phenotypes From GWAS Catalog for C8G Gene

Gene Ontology (GO) - Molecular Function for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001848 complement binding IEA --
GO:0019841 retinol binding IEA --
GO:0032403 protein complex binding IEA --
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with C8G: view
genes like me logo Genes that share phenotypes with C8G: view

miRNA for C8G Gene

miRTarBase miRNAs that target C8G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8G Gene

Localization for C8G Gene

Subcellular locations from UniProtKB/Swiss-Prot for C8G Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8G gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005579 membrane attack complex IEA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with C8G: view

Pathways & Interactions for C8G Gene

genes like me logo Genes that share pathways with C8G: view

Gene Ontology (GO) - Biological Process for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006957 complement activation, alternative pathway IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0019835 cytolysis IEA --
GO:0030449 regulation of complement activation TAS --
genes like me logo Genes that share ontologies with C8G: view

No data available for SIGNOR curated interactions for C8G Gene

Drugs & Compounds for C8G Gene

(3) Drugs for C8G Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma Target 2359
lauric acid Experimental Pharma Agonist, Target 0
Citric Acid Vet_approved Nutra Agonist, Activator, Target 1200
genes like me logo Genes that share compounds with C8G: view

Transcripts for C8G Gene

Unigene Clusters for C8G Gene

Complement component 8, gamma polypeptide:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP3: -

Relevant External Links for C8G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C8G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C8G Gene

This gene is overexpressed in Liver (x47.9).

Protein differential expression in normal tissues from HIPED for C8G Gene

This gene is overexpressed in Serum (18.6), Plasma (15.8), and Synovial fluid (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C8G Gene

Protein tissue co-expression partners for C8G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C8G Gene:


SOURCE GeneReport for Unigene cluster for C8G Gene:


Evidence on tissue expression from TISSUES for C8G Gene

  • Liver(4.5)
  • Blood(4.2)
  • Intestine(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for C8G Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • meninges
  • mouth
  • neck
  • pharynx
  • esophagus
  • heart
  • lung
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
  • fallopian tube
  • ovary
  • prostate
  • rectum
  • testicle
  • urethra
  • vagina
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • blood
  • lymph node
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with C8G: view

No data available for mRNA Expression by UniProt/SwissProt for C8G Gene

Orthologs for C8G Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C8G 33 34
  • 92.93 (n)
(Canis familiaris)
Mammalia C8G 33 34
  • 83.17 (n)
(Rattus norvegicus)
Mammalia C8g 33
  • 81.62 (n)
(Mus musculus)
Mammalia C8g 33 16 34
  • 77.23 (n)
(Monodelphis domestica)
Mammalia C8G 34
  • 56 (a)
(Bos Taurus)
Mammalia C8G 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia C8G 34
  • 42 (a)
(Gallus gallus)
Aves C8G 33 34
  • 59.29 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia c8g 33
  • 59.09 (n)
(Danio rerio)
Actinopterygii c8g 33 34
  • 47.62 (n)
Species where no ortholog for C8G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8G Gene

Gene Tree for C8G (if available)
Gene Tree for C8G (if available)

Paralogs for C8G Gene

(1) SIMAP similar genes for C8G Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C8G: view

No data available for Paralogs for C8G Gene

Variants for C8G Gene

Sequence variations from dbSNP and Humsavar for C8G Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000090562 -- 136,947,040(+) CACCC(C/T)GCCTC downstream-variant-500B
rs1000096153 -- 136,944,601(+) CGGCC(A/G)CCTCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000862310 -- 136,943,052(+) GCCAC(C/T)AGGGA intron-variant, upstream-variant-2KB
rs1001147315 -- 136,943,759(+) GGCCT(A/C)TATCA intron-variant, upstream-variant-2KB
rs1001178432 -- 136,943,836(+) AGCGC(A/T)GGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C8G Gene

Variant ID Type Subtype PubMed ID
nsv951206 CNV deletion 24416366
nsv818738 CNV gain 17921354
nsv615987 CNV loss 21841781
nsv524322 CNV loss 19592680
nsv469918 CNV loss 18288195
esv2422220 CNV deletion 17116639

Variation tolerance for C8G Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C8G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8G Gene

Disorders for C8G Gene

MalaCards: The human disease database

(3) MalaCards diseases for C8G Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
immunodeficiency due to a late component of complement deficiency
  • deficiency of complement of terminal pathway
acute salpingo-oophoritis
  • acute salpingitis and oophoritis
  • salpingitis/oophoritis
- elite association - COSMIC cancer census association via MalaCards
Search C8G in MalaCards View complete list of genes associated with diseases

Relevant External Links for C8G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C8G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C8G Gene

Publications for C8G Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 45 60
  3. Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family. (PMID: 17452033) Chiswell B … Sodetz JM (Biochimica et biophysica acta 2007) 3 4 60
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  5. Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site. (PMID: 12033936) Ortlund E … Lebioda L (Biochemistry 2002) 3 4 60

Products for C8G Gene

Sources for C8G Gene

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