C8G Gene
protein-coding GIFtS: 59
GCID: GC09P139839
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|
complement component 8, gamma polypeptide
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Aliases
for C8G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Complement Component 8, Gamma Polypeptide1 2 | | C8C2 | | Complement Component C8 Gamma Chain2 |
Export aliases for C8G gene to outside databasesPrevious GC identifers: GC09U990012 GC09P131529 GC09P133280 GC09P135197 GC09P137115 GC09P138959 GC09P109299 |
Summaries
for C8G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for C8G:
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutescomplement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalentlyassociated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cellmembranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit isnot required for the bactericidal activity. (provided by RefSeq, Jul 2011)
UniProtKB/Swiss-Prot: CO8G_HUMAN, P07360Function: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex.C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol
|
Genomic Views
for C8G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C8G gene promoter:
USF1 p53 AML1a AP-2gamma HEN1 PPAR-gamma1 USF-1 STAT3 PPAR-gamma2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for C8G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9qC8G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P139839: view genomic region
(about GC identifiers)
Start:
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139,839,698 bp from pter |
End:
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139,841,426 bp from pter |
Size:
|
1,729 bases |
Orientation:
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plus strand |
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Proteins
for C8G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CO8G_HUMAN, P07360 (See
protein sequence)Recommended Name: Complement component C8 gamma chain precursor Size: 202 amino acids; 22277 Da
Subunit: C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded
Subcellular location: Secreted
6/8 PDB 3D structures from  and Proteopedia  for C8G (see all 8):1IW2 (3D)
1LF7 (3D)
2OVA (3D)
2OVD (3D)
2OVE (3D)
2QOS (3D)
Secondary accessions: Q14CT8 Q14CU0 Q5SQ07Explore the universe of human proteins at neXtProt for C8G: NX_P07360
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P07360
C8G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000597.2
ENSEMBL proteins: ENSP00000360697 ENSP00000224181 Reactome Protein details: P07360
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005579 | membrane attack complex |
IEA | -- | | GO:0005615 | extracellular space |
IEA | -- |
C8G for ontologies About GeneDecksing
C8G Antibody Products:
Assay Products for C8G: |
Protein
Domains /
Families
for C8G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C8G for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P07360ProtoNet protein and cluster: P07360 2 Blocks protein families: IPB002345 Lipocalin signature IPB002968 Alpha-1-microglobulin signature
UniProtKB/Swiss-Prot: CO8G_HUMAN, P07360Similarity: Belongs to the calycin superfamily. Lipocalin family |
Function
for C8G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CO8G_HUMAN, P07360Function: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex.C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol Genatlas biochemistry entry for C8G:complement component 8,gamma-1 globulin,complexing with other late components of the cascade to form the membraneattacks complex,gamma,(lipocalin family,Kernel group),associating with CD59,potential regulator of the complex helpingto protect host cells from lysis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8G
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8G |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
C8G for ontologies About GeneDecksing
|
Pathways & Interactions
for C8G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_Alternative complement pathway | | | 2 | Classical Complement Pathway | | | 3 | Immune response_Classical complement pathway | | | 4 | Terminal pathway of complement | | | 5 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for C8G
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for C8G
3  GeneGo (Thomson Reuters) Pathways for C8G
1  BioSystems Pathway for C8G
4 
Reactome Pathways for C8G
4 
Kegg Pathways (Kegg details for C8G):
C8G for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8G
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/8 Interacting proteins for C8G (P073603 ENSP000002241814) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006957 | complement activation, alternative pathway |
IEA | -- | | GO:0006958 | complement activation, classical pathway |
IEA | -- | | GO:0019835 | cytolysis |
IEA | -- | | GO:0045087 | innate immune response |
TAS | -- |
C8G for ontologies About GeneDecksing
|
Drugs & Compounds
for C8G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C8G
1 DrugBank Compound for C8G About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Citric Acid | -- | 77-92-9 | target | -- | -- |
Search CenterWatch for drugs/clinical trials and news about C8G / CO8G
|
Transcripts
for C8G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C8G gene: NM_000606.2 Unigene Cluster for C8G: Complement component 8, gamma polypeptide Hs.1285 [show with all ESTs]Unigene Representative Sequence: NM_0006064 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371634 ENST00000224181(uc004cka.2) ENST00000484376 ENST00000465773
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C8G (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C8G
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C8G (NM_000606) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C8G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8G |
Additional cDNA sequence: BC113624.1 BC113626.1 M17263.1 M17999.1 X06465.1 2 DOTS entries: DT.309324 DT.91654872 24/32 AceView cDNA sequences (see all 32): AA588777 BM790818 AW340666 AA894707 T28652 BM849587 NM_000606 BV198189 BV197486 BM790809 X06465 CB157535 BX282392 BV198286 M17999 BM790630 BM850834 BV198188 BM789876 AV684323 BM852158 AW080648 AV693786 AW304460
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C8G About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for C8G
|
Expression
for C8G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C8G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGTCAGTA
About this image
See C8G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C8G
SOURCE GeneReport for Unigene cluster: Hs.1285
SABiosciences Custom PCR Arrays for C8G
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C8G
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C8G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C8G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C8G | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8G |
Orthologs
for C8G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C8G gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for C8G (if available)
TreeFam Gene Tree for C8G (if available) |
Paralogs
for C8G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C8G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C8G (139839698 - 139841426 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for C8G
3 CNVs: 9631 30350 5415 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C8G |
|
Disorders
/ Diseases
for C8G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C8G for disorders About GeneDecksing
OMIM gene information: 120930
OMIM disorders: --
10  diseases for C8G: About MalaCardssalpingo-oophoritis oophoritis serous cystadenoma salpingitis
systemic lupus erythematosus cystadenoma lupus erythematosus prion disease
meningioma leukemia
2 diseases from the University of Copenhagen DISEASES database for C8G:salpingo-oophoritis Acute salpingitis Human Genome Epidemiology (HuGE) Navigator: C8G (4 documents)
Export disorders for C8G gene to outside databases
|
Publications
for C8G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C8G gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with C8G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family. (PubMed id 17452033)1, 2 Chiswell B....Sodetz J.M. (2007)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site. (PubMed id 12033936)1, 2 Ortlund E.... Lebioda L. (2002)
- Human complement protein C8 gamma. (PubMed id 11058761)1, 2 Schreck S.F.... Sodetz J.M. (2000)
- Genomic structure of the human complement protein C8 gamma: homology to the lipocalin gene family. (PubMed id 8172891)1, 2 Kaufman K.M. and Sodetz J.M. (1994)
- Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family. (PubMed id 1707134)1, 2 Haefliger J.-A.... Tschopp J. (1991)
- Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern. (PubMed id 2447883)1, 2 Haefliger J.-A.... Tschopp J. (1987)
- The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes. (PubMed id 3676249)1, 2 Ng S.C.... Sodetz J.M. (1987)
- The homology of complement factor C8 gamma chain and alpha-1- microglobulin. (PubMed id 2446620)1, 2 Hunt L.T.... Barker W.C. (1987)
- Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1 Han S....Kang D. (2010)
|
External Searches for C8G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C8G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C8G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C8G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C8G | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C8G gene:
Search GeneIP for patents involving C8G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C8G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | | | Recombinant Protein for C8G |
|
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8G |
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