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Aliases for C8G Gene

Aliases for C8G Gene

  • Complement Component 8, Gamma Polypeptide 2 3
  • Complement Component C8 Gamma Chain 3
  • C8C 3

External Ids for C8G Gene

Previous GeneCards Identifiers for C8G Gene

  • GC09U990012
  • GC09P131529
  • GC09P133280
  • GC09P135197
  • GC09P137115
  • GC09P138959
  • GC09P139839
  • GC09P109299

Summaries for C8G Gene

Entrez Gene Summary for C8G Gene

  • The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]

GeneCards Summary for C8G Gene

C8G (Complement Component 8, Gamma Polypeptide) is a Protein Coding gene. Diseases associated with C8G include acute salpingitis and salpingo-oophoritis. Among its related pathways are Complement and coagulation cascades and Complement and coagulation cascades. GO annotations related to this gene include protein complex binding and complement binding.

UniProtKB/Swiss-Prot for C8G Gene

  • C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8G Gene

Genomics for C8G Gene

Regulatory Elements for C8G Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C8G Gene

Start:
136,944,885 bp from pter
End:
136,946,974 bp from pter
Size:
2,090 bases
Orientation:
Plus strand

Genomic View for C8G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C8G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8G Gene

Proteins for C8G Gene

  • Protein details for C8G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07360-CO8G_HUMAN
    Recommended name:
    Complement component C8 gamma chain
    Protein Accession:
    P07360
    Secondary Accessions:
    • Q14CT8
    • Q14CU0
    • Q5SQ07

    Protein attributes for C8G Gene

    Size:
    202 amino acids
    Molecular mass:
    22277 Da
    Quaternary structure:
    • C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded

    Three dimensional structures from OCA and Proteopedia for C8G Gene

neXtProt entry for C8G Gene

Proteomics data for C8G Gene at MOPED

Post-translational modifications for C8G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C8G Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for C8G Gene

Domains for C8G Gene

Gene Families for C8G Gene

HGNC:

Suggested Antigen Peptide Sequences for C8G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07360

UniProtKB/Swiss-Prot:

CO8G_HUMAN :
  • P07360
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with C8G: view

Function for C8G Gene

Molecular function for C8G Gene

GENATLAS Biochemistry: complement component 8,gamma-1 globulin,complexing with other late components of the cascade to form the membrane attacks complex,gamma,(lipocalin family,Kernel group),associating with CD59,potential regulator of the complex helping to protect host cells from lysis
UniProtKB/Swiss-Prot Function: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol

Gene Ontology (GO) - Molecular Function for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001848 complement binding IEA --
GO:0019841 retinol binding IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with C8G: view

Animal Model Products

CRISPR Products

miRNA for C8G Gene

miRTarBase miRNAs that target C8G

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C8G

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C8G Gene

Localization for C8G Gene

Subcellular locations from UniProtKB/Swiss-Prot for C8G Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C8G Gene COMPARTMENTS Subcellular localization image for C8G gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005579 membrane attack complex IEA --
GO:0005615 extracellular space --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with C8G: view

Pathways for C8G Gene

genes like me logo Genes that share pathways with C8G: view

Gene Ontology (GO) - Biological Process for C8G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006957 complement activation, alternative pathway IEA --
GO:0006958 complement activation, classical pathway IEA --
GO:0019835 cytolysis IEA --
GO:0030449 regulation of complement activation TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with C8G: view

Compounds for C8G Gene

(1) Drugbank Compounds for C8G Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Citric Acid
77-92-9 target
genes like me logo Genes that share compounds with C8G: view

Transcripts for C8G Gene

mRNA/cDNA for C8G Gene

Unigene Clusters for C8G Gene

Complement component 8, gamma polypeptide:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C8G

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for C8G

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8G Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:
SP3: -

Relevant External Links for C8G Gene

GeneLoc Exon Structure for
C8G
ECgene alternative splicing isoforms for
C8G

Expression for C8G Gene

mRNA expression in normal human tissues for C8G Gene

mRNA differential expression in normal tissues according to GTEx for C8G Gene

This gene is overexpressed in Liver (47.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C8G Gene

SOURCE GeneReport for Unigene cluster for C8G Gene Hs.1285

genes like me logo Genes that share expressions with C8G: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C8G Gene

Orthologs for C8G Gene

This gene was present in the common ancestor of chordates.

Orthologs for C8G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8G 35
  • 92.93 (n)
  • 89.74 (a)
C8G 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C8G 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8G 35
  • 83.17 (n)
  • 77.72 (a)
C8G 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C8g 35
  • 77.23 (n)
  • 73.76 (a)
C8g 16
C8g 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C8G 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C8G 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia C8g 35
  • 81.62 (n)
  • 82.05 (a)
chicken
(Gallus gallus)
Aves C8G 35
  • 59.29 (n)
  • 47.54 (a)
C8G 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c8g 35
  • 59.09 (n)
  • 46.1 (a)
zebrafish
(Danio rerio)
Actinopterygii c8g 35
  • 47.62 (n)
  • 37.14 (a)
c8g 36
  • 30 (a)
OneToOne
Species with no ortholog for C8G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C8G Gene

ENSEMBL:
Gene Tree for C8G (if available)
TreeFam:
Gene Tree for C8G (if available)

Paralogs for C8G Gene

Selected SIMAP similar genes for C8G Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C8G: view

No data available for Paralogs for C8G Gene

Variants for C8G Gene

Sequence variations from dbSNP and Humsavar for C8G Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs884112 -- 136,947,106(-) GCCGC(C/T)GAAAT downstream-variant-500B
rs884113 -- 136,947,060(-) GGGAG(C/T)GCCGG downstream-variant-500B
rs4880077 -- 136,947,273(+) TCTCC(C/T)GTCAC downstream-variant-500B
rs11145938 -- 136,947,303(+) CGAGC(C/T)GAGCT downstream-variant-500B
rs36082500 -- 136,947,149(+) CATAT(A/G)CCCAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C8G Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8408n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv818738 CNV Gain 17921354
dgv8419n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894500 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894503 CNV Loss 21882294
dgv8424n71 CNV Loss 21882294

Relevant External Links for C8G Gene

HapMap Linkage Disequilibrium report
C8G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8G Gene

Disorders for C8G Gene

(2) University of Copenhagen DISEASES for C8G Gene

Relevant External Links for C8G

Genetic Association Database (GAD)
C8G
Human Genome Epidemiology (HuGE) Navigator
C8G
genes like me logo Genes that share disorders with C8G: view

No data available for UniProtKB/Swiss-Prot for C8G Gene

Publications for C8G Gene

  1. Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family. (PMID: 1707134) Haefliger J.-A. … Tschopp J. (Mol. Immunol. 1991) 3 4
  2. The homology of complement factor C8 gamma chain and alpha-1- microglobulin. (PMID: 2446620) Hunt L.T. … Barker W.C. (Biochem. Biophys. Res. Commun. 1987) 3 4
  3. Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern. (PMID: 2447883) Haefliger J.-A. … Tschopp J. (Biochem. Biophys. Res. Commun. 1987) 3 4
  4. The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes. (PMID: 3676249) Ng S.C. … Sodetz J.M. (Biochemistry 1987) 3 4
  5. Genomic structure of the human complement protein C8 gamma: homology to the lipocalin gene family. (PMID: 8172891) Kaufman K.M. … Sodetz J.M. (Biochemistry 1994) 3 4

Products for C8G Gene

Sources for C8G Gene

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