External Ids for C8G Gene
Previous GeneCards Identifiers for C8G Gene
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
GeneCards Summary for C8G Gene
C8G (Complement Component 8, Gamma Polypeptide) is a Protein Coding gene. Diseases associated with C8G include immunodeficiency due to a late component of complement deficiency and acute salpingo-oophoritis. Among its related pathways are Complement and coagulation cascades and Immune System. GO annotations related to this gene include protein complex binding and complement binding.
UniProtKB/Swiss-Prot for C8G Gene
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.