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C8G Gene

protein-coding   GIFtS: 60
GCID: GC09P139839

Complement Component 8, Gamma Polypeptide

  See C8G-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Component 8, Gamma Polypeptide1 2
C8C2
Complement Component C8 Gamma Chain2

External Ids:    HGNC: 13541   Entrez Gene: 7332   Ensembl: ENSG000001769197   OMIM: 1209305   UniProtKB: P073603   

Export aliases for C8G gene to outside databases

Previous GC identifers: GC09U990012 GC09P131529 GC09P133280 GC09P135197 GC09P137115 GC09P138959 GC09P109299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C8G Gene:
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes
complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a
non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on
bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the
gamma subunit is not required for the bactericidal activity. (provided by RefSeq, Jul 2011)

GeneCards Summary for C8G Gene:
C8G (complement component 8, gamma polypeptide) is a protein-coding gene. Diseases associated with C8G include salpingo-oophoritis, and oophoritis. GO annotations related to this gene include complement binding and protein complex binding.

UniProtKB/Swiss-Prot: CO8G_HUMAN, P07360
Function: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8
complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to
bind retinol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C8G gene promoter:
         USF1   p53   AML1a   AP-2gamma   HEN1   PPAR-gamma1   USF-1   STAT3   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC8G promoter sequence
   Search Chromatin IP Primers for C8G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C8G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q

C8G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8G gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139839:  view genomic region     (about GC identifiers)

Start:
139,839,698 bp from pter      End:
139,841,426 bp from pter
Size:
1,729 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CO8G_HUMAN, P07360 (See protein sequence)
Recommended Name: Complement component C8 gamma chain precursor  
Size: 202 amino acids; 22277 Da
Subunit: C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded
Selected PDB 3D structures from and Proteopedia for C8G (see all 8):
1IW2 (3D)        1LF7 (3D)        2OVA (3D)        2OVD (3D)        2OVE (3D)        2QOS (3D)    
Secondary accessions: Q14CT8 Q14CU0 Q5SQ07

Explore the universe of human proteins at neXtProt for C8G: NX_P07360

Explore proteomics data for C8G at MOPED


See C8G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000597.2  
ENSEMBL proteins: 
 ENSP00000360697   ENSP00000224181  
Reactome Protein details: P07360

C8G Human Recombinant Protein Products:

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Browse Proteins at Cloud-Clone Corp.

 
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antibodies-online proteins for C8G (4 products) 

 
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antibodies-online kits for C8G (9 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LCN: Lipocalins
complement: Complement system

Selected InterPro protein domains (see all 6):
 IPR012674 Calycin
 IPR011038 Calycin-like
 IPR002968 A1-microglobln
 IPR002345 Lipocalin
 IPR022272 Lipocalin_CS

Graphical View of Domain Structure for InterPro Entry P07360

ProtoNet protein and cluster: P07360

2 Blocks protein domains:
IPB002345 Lipocalin signature
IPB002968 Alpha-1-microglobulin signature


UniProtKB/Swiss-Prot: CO8G_HUMAN, P07360
Similarity: Belongs to the calycin superfamily. Lipocalin family


Find genes that share domains with C8G           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CO8G_HUMAN, P07360
Function: C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8
complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to
bind retinol

     Genatlas biochemistry entry for C8G:
complement component 8,gamma-1 globulin,complexing with other late components of the cascade to form the membrane
attacks complex,gamma,(lipocalin family,Kernel group),associating with CD59,potential regulator of the complex
helping to protect host cells from lysis

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001848complement binding IEA--
GO:0019841retinol binding IEA--
GO:0032403protein complex binding IEA--
     
Find genes that share ontologies with C8G           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C8G

miRNA
Products:
    
miRTarBase miRNAs that target C8G:
hsa-mir-335-5p (MIRT017056)

Block miRNA regulation of human, mouse, rat C8G using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate C8G
SwitchGear 3'UTR luciferase reporter plasmidC8G 3' UTR sequence
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Predesigned siRNA for gene silencing in human, mouse, rat C8G

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8G

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CO8G_HUMAN, P07360: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
plasma membrane3
cytosol1
golgi apparatus1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005579membrane attack complex IEA--
GO:0005615extracellular space ----
GO:0072562blood microparticle IDA--

Find genes that share ontologies with C8G           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for C8G About   (see all 6)  
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Complement Pathway
Immune response Lectin Induced complement pathway0.56
Complement Activation Pathways0.30
Immune response Classic complement pathway0.56
Classical Complement Pathway0.00
Immune response Alternative complement pathway0.56
Lectin Induced Complement Pathway0.00
Regulation of Complement cascade0.48
Terminal pathway of complement0.00
2Complement and coagulation cascades
Complement and coagulation cascades0.71
Complement and Coagulation Cascades0.71
3Creation of C4 and C2 activators
Complement cascade0.68
4RNA Polymerase I Promoter Opening
Systemic lupus erythematosus0.40
5Prion diseases
Prion diseases


Find genes that share SuperPaths with C8G           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for C8G
    Alternative Complement Pathway
Classical Complement Pathway
Lectin Induced Complement Pathway
Complement Pathway

3 GeneGo (Thomson Reuters) Pathways for C8G
    Immune response Alternative complement pathway
Immune response Classical complement pathway
Immune response Lectin induced complement pathway

1 BioSystems Pathway for C8G
    Complement and Coagulation Cascades

1 Sino Biological Pathway for C8G
    Complement Activation Pathways

2 Reactome Pathways for C8G
    Terminal pathway of complement
Regulation of Complement cascade


4 Kegg Pathways  (Kegg details for C8G):
    Complement and coagulation cascades
Prion diseases
Amoebiasis
Systemic lupus erythematosus

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C8G
Interactions:

    Search GeneGlobe Interaction Network for C8G

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for C8G (P073603 ENSP000002241814) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
C8AP073573, ENSP000003544584I2D: score=2 STRING: ENSP00000354458
SH3GL2Q999623I2D: score=1 
C5ENSP000002236424STRING: ENSP00000223642
C8BENSP000003602814STRING: ENSP00000360281
C9ENSP000002634084STRING: ENSP00000263408
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006957complement activation, alternative pathway IEA--
GO:0006958complement activation, classical pathway IEA--
GO:0019835cytolysis IEA--
GO:0030449regulation of complement activation TAS--
GO:0045087innate immune response TAS--

Find genes that share ontologies with C8G           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C8G (CO8G)

1 DrugBank Compound for C8G    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Citric Acid-- 77-92-9target----



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C8G gene: 
NM_000606.2  

Unigene Cluster for C8G:

Complement component 8, gamma polypeptide
Hs.1285  [show with all ESTs]
Unigene Representative Sequence: NM_000606
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371634 ENST00000224181(uc004cka.2) ENST00000484376 ENST00000465773

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat C8G
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OriGene ORF clones in mouse, rat for C8G
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: C8G (NM_000606)
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Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for C8G
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C8G
  QuantiTect SYBR Green Assays in human, mouse, rat C8G
  QuantiFast Probe-based Assays in human, mouse, rat C8G

Additional mRNA sequence: 

BC113624.1 BC113626.1 M17263.1 M17999.1 X06465.1 

2 DOTS entries:

DT.309324  DT.91654872 

Selected AceView cDNA sequences (see all 32):

AA588777 BM790818 BM850834 AA894707 BV198188 BV198189 BM849587 NM_000606 
AW340666 BM790809 BV198286 BX282392 X06465 BM790630 BV197486 CB157535 
M17999 T28652 AW304460 AW080648 BM852158 M17263 BM789876 AV693786 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for C8G    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:                                                
SP2:                                                
SP3:              -                                 


ECgene alternative splicing isoforms for C8G

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C8G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTGTCAGTA
C8G Expression
About this image

C8G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C8G Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1285
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C8G gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia C8g1 , 5 complement component 8, gamma polypeptide1, 5 77.23(n)1
73.76(a)1
  2 (17.31 cM)5
693791  NM_027062.21  NP_081338.11 
 254986515 
chicken
(Gallus gallus)
Aves C8G1 complement component 8, gamma polypeptide 59.29(n)
47.54(a)
  770691  XM_001234026.3  XP_001234027.2 
tropical clawed frog
(Xenopus tropicalis)
Amphibia c8g1 complement component 8, gamma polypeptide 59.09(n)
46.1(a)
  100038157  XM_002942720.2  XP_002942766.2 
zebrafish
(Danio rerio)
Actinopterygii c8g1 complement component 8, gamma polypeptide 47.62(n)
37.14(a)
  393837  NM_200863.1  NP_957157.1 


ENSEMBL Gene Tree for C8G (if available)
TreeFam Gene Tree for C8G (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for C8G gene
1 SIMAP similar gene for C8G using alignment to 2 protein entries:     CO8G_HUMAN (see all proteins):
LCN15

Find genes that share paralogs with C8G           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C8G (see all 216)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1823044071,2
C--139874629(+) GCTGCA/GGCAGA 1 -- us2k10--------
rs1127899241,2
C--139874667(+) CCGTCA/C/GTCACC 1 -- us2k11CSA 1
rs1126966211,2
C--139874670(+) TCCTCA/G/TCCTTC 1 -- us2k11CSA 1
rs1478210011,2
C,F--139874678(+) TTCACA/GGTGCA 1 -- us2k11Minor allele frequency- G:0.00NA 4538
rs2001120081,2
--139874687(+) CAGTCC/TTTGGA 1 -- us2k10--------
rs1423202321,2
C,F--139874702(+) GACGCG/AAACTG 1 -- us2k11Minor allele frequency- A:0.00NA 4538
rs1512827441,2
F--139874750(+) TCTGTG/ATGTTC 1 -- us2k11Minor allele frequency- A:0.00NA 4530
rs1141808401,2
--139874819(+) TACCAA/GGACAT 1 -- us2k10--------
rs2010913131,2
--139874833(+) CGCTGC/TGGGTG 1 -- us2k10--------
rs22718721,2
C,F,A--139874861(-) AGGCCG/CGGGCC 1 -- us2k111Minor allele frequency- C:0.35NA WA CSA EA EU 545

HapMap Linkage Disequilibrium report for C8G (139839698 - 139841426 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for C8G (see all 17):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422220CNV Deletion17116639
nsv894483CNV Loss21882294
dgv8416n71CNV Loss21882294
nsv894503CNV Loss21882294
dgv8423n71CNV Loss21882294
nsv894469CNV Loss21882294
nsv524322CNV Loss19592680
nsv894502CNV Loss21882294
dgv8415n71CNV Loss21882294
nsv469918CNV Loss18288195

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing C8G
DNA2.0 Custom Variant and Variant Library Synthesis for C8G

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 120930    OMIM disorders: --

6 diseases for C8G:    
About MalaCards
salpingo-oophoritis    oophoritis    acute salpingitis    salpingitis
complement component 5 deficiency    childhood leukemia

2 diseases from the University of Copenhagen DISEASES database for C8G:
salpingo-oophoritis     Acute salpingitis

Find genes that share disorders with C8G           About GenesLikeMe

Genetic Association Database (GAD): C8G
Human Genome Epidemiology (HuGE) Navigator: C8G (4 documents)

Export disorders for C8G gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C8G gene, integrated from 10 sources (see all 27):
(articles sorted by number of sources associating them with C8G)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
  2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
  3. Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family. (PubMed id 17452033)1, 2 Chiswell B....Sodetz J.M. (Biochim. Biophys. Acta 2007)
  4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  5. Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site. (PubMed id 12033936)1, 2 Ortlund E.... Lebioda L. (Biochemistry 2002)
  6. Human complement protein C8 gamma. (PubMed id 11058761)1, 2 Schreck S.F.... Sodetz J.M. (Biochim. Biophys. Acta 2000)
  7. Genomic structure of the human complement protein C8 gamma: homology to the lipocalin gene family. (PubMed id 8172891)1, 2 Kaufman K.M. and Sodetz J.M. (Biochemistry 1994)
  8. Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family. (PubMed id 1707134)1, 2 Haefliger J.-A.... Tschopp J. (Mol. Immunol. 1991)
  9. Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern. (PubMed id 2447883)1, 2 Haefliger J.-A.... Tschopp J. (Biochem. Biophys. Res. Commun. 1987)
  10. The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes. (PubMed id 3676249)1, 2 Ng S.C.... Sodetz J.M. (Biochemistry 1987)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 733 HGNC: 1354 AceView: C8G Ensembl:ENSG00000176919 euGenes: HUgn733
ECgene: C8G Kegg: 733 H-InvDB: C8G

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C8G Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C8G gene:
Search GeneIP for patents involving C8G

GeneCards and IP:
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