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C8A Gene

protein-coding   GIFtS: 60
GCID: GC01P057237

Complement Component 8, Alpha Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Component 8, Alpha Polypeptide1 2
Complement Component 8 Subunit Alpha2 3
Complement Component C8 Alpha Chain2

External Ids:    HGNC: 13521   Entrez Gene: 7312   Ensembl: ENSG000001571317   OMIM: 1209505   UniProtKB: P073573   

Export aliases for C8A gene to outside databases

Previous GC identifers: GC01P056235 GC01P056678 GC01P056690 GC01P057032 GC01P055432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for C8A Gene:
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene
encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC
assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization.
Mutations in this gene cause complement C8 alpha-gamma deficiency. (provided by RefSeq, Nov 2008)

GeneCards Summary for C8A Gene:
C8A (complement component 8, alpha polypeptide) is a protein-coding gene. Diseases associated with C8A include complement component 8 deficiency type 1, and complement component 5 deficiency. An important paralog of this gene is C9.

UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357
Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune
response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does
not form pores by itself




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the C8A gene promoter:
         SRF   SRF (504 AA)   POU6F1 (c2)   HNF-3beta   Evi-1   HNF-4alpha1   Nkx6-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC8A promoter sequence
   Search Chromatin IP Primers for C8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.2   HGNC cytogenetic band: 1p32.2

C8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P057237:  view genomic region     (about GC identifiers)

Start:
57,320,443 bp from pter      End:
57,383,894 bp from pter
Size:
63,452 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357 (See protein sequence)
Recommended Name: Complement component C8 alpha chain precursor  
Size: 584 amino acids; 65163 Da
Subunit: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.
Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a
and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9
4 PDB 3D structures from and Proteopedia for C8A:
2QOS (3D)        2QQH (3D)        2RD7 (3D)        3OJY (3D)    
Secondary accessions: A2RUI4 A2RUI5 Q13668 Q9H130

Explore the universe of human proteins at neXtProt for C8A: NX_P07357

Explore proteomics data for C8A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Trp44, Asn437, Trp542, Trp545, Trp548
  • Modification sites at PhosphoSitePlus

  • See C8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000553.1  
    ENSEMBL proteins: 
     ENSP00000354458  
    Reactome Protein details: P07357

    C8A Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    complement: Complement system

    Selected InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR023415 LDLR_class-A_CS
     IPR020864 MACPF
     IPR002172 LDrepeatLR_classA_rpt
     IPR001862 MAC_perforin

    Graphical View of Domain Structure for InterPro Entry P07357

    ProtoNet protein and cluster: P07357

    4 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001862 Membrane attack complex component/perforin/complement C9
    IPB002172 Low density lipoprotein-receptor
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357
    Similarity: Belongs to the complement C6/C7/C8/C9 family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 1 MACPF domain
    Similarity: Contains 2 TSP type-1 domains


    C8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO8A_HUMAN, P07357
    Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune
    response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does
    not form pores by itself

         Genatlas biochemistry entry for C8A:
    complement component 8,gamma-1 globulin,alpha polypeptide,64.8kDa, (<2.5kb, 5' from C8B),complexing with other
    late components of the cascade to form the membrane attack complex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001848complement binding IEA--
    GO:0005515protein binding ----
    GO:0032403protein complex binding IEA--
         
    C8A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for C8A:
     Increased G1 DNA content  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C8A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C8A

    miRNA
    Products:
        
    miRTarBase miRNAs that target C8A:
    hsa-mir-181a-5p (MIRT025047), hsa-mir-335-5p (MIRT017718)

    Block miRNA regulation of human, mouse, rat C8A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate C8A:
    hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidC8A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for C8A
    Predesigned siRNA for gene silencing in human, mouse, rat C8A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: C8A (NM_000562)
    Sino Biological Human cDNA Clone for C8A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CO8A_HUMAN, P07357: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein.
    Inserts into the cell membrane of target cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005579membrane attack complex IDA12413696
    GO:0005615extracellular space TAS6771072
    GO:0016020membrane TAS2820471
    GO:0072562blood microparticle IDA--

    C8A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for C8A About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Complement Pathway
    Immune response Lectin Induced complement pathway0.56
    Classical Complement Pathway0.00
    Immune response Classic complement pathway0.56
    Terminal pathway of complement0.00
    Immune response Alternative complement pathway0.56
    Lectin Induced Complement Pathway0.00
    Regulation of Complement cascade0.48
    Alternative Complement Pathway0.00
    2Complement and coagulation cascades
    Complement and coagulation cascades0.71
    Complement Activation, Classical Pathway0.00
    3Creation of C4 and C2 activators
    Complement cascade0.68
    4RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    5Prion diseases
    Prion diseases

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for C8A
        Alternative Complement Pathway
    Classical Complement Pathway
    Lectin Induced Complement Pathway
    Complement Pathway

    3 GeneGo (Thomson Reuters) Pathways for C8A
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for C8A
        Complement Activation, Classical Pathway


    2 Reactome Pathways for C8A
        Terminal pathway of complement
    Regulation of Complement cascade


    4 Kegg Pathways  (Kegg details for C8A):
        Complement and coagulation cascades
    Prion diseases
    Amoebiasis
    Systemic lupus erythematosus


    C8A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C8A
    Interactions:

        Search GeneGlobe Interaction Network for C8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for C8A (P073573 ENSP000003544584) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C8GP073603, ENSP000002241814I2D: score=2 STRING: ENSP00000224181
    CD59P139873, ENSP000003402104I2D: score=2 STRING: ENSP00000340210
    C8BP073583, ENSP000003602814I2D: score=1 STRING: ENSP00000360281
    C9P027483, ENSP000002634084I2D: score=1 STRING: ENSP00000263408
    C5ENSP000002236424STRING: ENSP00000223642
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS6771072
    GO:0006956complement activation IDA12413696
    GO:0006957complement activation, alternative pathway IEA--
    GO:0006958complement activation, classical pathway IEA--
    GO:0019835cytolysis IEA--

    C8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C8A (CO8A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C8A gene: 
    NM_000562.2  

    Unigene Cluster for C8A:

    Complement component 8, alpha polypeptide
    Hs.93210  [show with all ESTs]
    Unigene Representative Sequence: M16974
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361249(uc001cyo.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat C8A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate C8A:
    hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidC8A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat C8A
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    GenScript: all cDNA clones in your preferred vector: C8A (NM_000562)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C8A
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for C8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C8A
      QuantiTect SYBR Green Assays in human, mouse, rat C8A
      QuantiFast Probe-based Assays in human, mouse, rat C8A

    Additional mRNA sequence: 

    AK309596.1 BC020702.1 BC132911.1 BC132913.1 M16974.1 

    4 DOTS entries:

    DT.213748  DT.100786477  DT.95156351  DT.95156350 

    Selected AceView cDNA sequences (see all 47):

    CB164686 AW963056 AA699772 T28622 AA343585 CB162713 BC020702 N93779 
    AW963046 AA344521 AA343878 BX346132 CD366989 W86807 AV692569 CB154169 
    M16974 BG563768 BU942533 BX494600 BX382940 BX370270 T51917 AI051231 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C8A Expression
    About this image


    C8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Kidney (Urinary System)
    C8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C8A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.93210
        Custom PCR Arrays for C8A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C8A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C8a1 , 5 complement component 8, alpha polypeptide1, 5 78.88(n)1
    72.6(a)1
      4 (48.69 cM)5
    2305581  NM_146148.21  NP_666260.11 
     1048156795 
    chicken
    (Gallus gallus)
    Aves C8A1 complement component 8, alpha polypeptide 60.93(n)
    54.79(a)
      429111  XM_426667.4  XP_426667.2 
    lizard
    (Anolis carolinensis)
    Reptilia C8A6
    complement component 8, alpha polypeptide
    52(a)
    1 ↔ 1
    4(103177587-103222509)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853138.12   -- 75.08(n)    BX853138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii c8a1 complement component 8, alpha polypeptide 52.31(n)
    44.12(a)
      445102  NM_001003496.1  NP_001003496.1 


    ENSEMBL Gene Tree for C8A (if available)
    TreeFam Gene Tree for C8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C8A gene
    C92  C62  C8B2  C72  
    2 SIMAP similar genes for C8A using alignment to 2 protein entries:     CO8A_HUMAN (see all proteins):
    C9    C8B

    C8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C8A (see all 1543)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347482131,2
    C--55463013(+) TTTACA/GTAAAT 1 -- int13Minor allele frequency- G:0.12NA 124
    rs595671941,2
    --55463069(+) TTTACA/GTAAAT 1 -- int10--------
    rs1826857781,2
    --55463076(+) AAATAC/TATATT 1 -- int10--------
    rs1874135171,2
    --55463084(+) ATTTAC/TGTAAA 1 -- int10--------
    rs112069311,2
    C,H--55463085(+) tttatT/Gtaaat 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1929296331,2
    --55463097(+) TATATA/TTATAT 1 -- int10--------
    rs1854123121,2
    --55463100(+) ATTTAC/TATTTA 1 -- int10--------
    rs1886758911,2
    --55463122(+) ATTTAA/CATAAA 1 -- int10--------
    rs1932963551,2
    --55463130(+) AAATAC/TATATT 1 -- int10--------
    rs2011418441,2
    C--55463155(+) TTTAA-/ATATATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for C8A (57320443 - 57383894 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C8A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508215CNV Loss20534489

    Human Gene Mutation Database (HGMD): C8A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C8A
    DNA2.0 Custom Variant and Variant Library Synthesis for C8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 120950   
    OMIM disorders: 613790  
    UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357
  • Complement component 8 deficiency, 1 (C8D1) [MIM:613790]: A rare defect of the complement classical
    pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or
    Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented
    in this entry

  • 16 diseases for C8A:    
    About MalaCards
    complement component 8 deficiency type 1    complement component 5 deficiency    meningococcal infection    prion disease
    age related macular degeneration    meningitis    childhood leukemia    meningioma
    systemic lupus erythematosus    lupus erythematosus    hepatitis b    hepatitis
    endotheliitis    multiple myeloma    myeloma    leukemia


    C8A for disorders           About GeneDecksing

    Genetic Association Database (GAD): C8A
    Human Genome Epidemiology (HuGE) Navigator: C8A (11 documents)

    Export disorders for C8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C8A gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with C8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (Lancet 2008)
    6. Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. (PubMed id 18440555)1, 2 Slade D.J....Sodetz J.M. (J. Mol. Biol. 2008)
    7. Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. (PubMed id 17872444)1, 2 Hadders M.A.... Gros P. (Science 2007)
    8. [Detecting the DNA polymorphism of human complement component C8A by PCR-SSCP analysis]. (PubMed id 16761437)1, 4 Yang Z.H....Jia J. (Sichuan Da Xue Xue Bao Yi Xue Ban 2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 731 HGNC: 1352 AceView: C8A Ensembl:ENSG00000157131 euGenes: HUgn731
    ECgene: C8A Kegg: 731 H-InvDB: C8A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for C8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C8A gene:
    Search GeneIP for patents involving C8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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