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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C8A Gene

protein-coding   GIFtS: 59
GCID: GC01P057237

Complement Component 8, Alpha Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complement Component 8, Alpha Polypeptide1 2
Complement Component 8 Subunit Alpha2 3
Complement Component C8 Alpha Chain2

External Ids:    HGNC: 13521   Entrez Gene: 7312   Ensembl: ENSG000001571317   OMIM: 1209505   UniProtKB: P073573   

Export aliases for C8A gene to outside databases

Previous GC identifers: GC01P056235 GC01P056678 GC01P056690 GC01P057032 GC01P055432


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C8A Gene:
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene
encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC
assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization.
Mutations in this gene cause complement C8 alpha-gamma deficiency. (provided by RefSeq, Nov 2008)

GeneCards Summary for C8A Gene: 
C8A (complement component 8, alpha polypeptide) is a protein-coding gene. Diseases associated with C8A include complement component 8 deficiency type 1, and meningococcal infection, and among its related super-pathways are Immune response Lectin induced complement pathway and Complement Pathway. An important paralog of this gene is C9.

UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357
Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune
response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does
not form pores by itself




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C8A gene promoter:
         SRF   SRF (504 AA)   POU6F1 (c2)   HNF-3beta   Evi-1   HNF-4alpha1   Nkx6-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC8A promoter sequence
   Search SABiosciences Chromatin IP Primers for C8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.2   HGNC cytogenetic band: 1p32.2

C8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C8A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P057237:  view genomic region     (about GC identifiers)

Start:
57,320,443 bp from pter      End:
57,383,894 bp from pter
Size:
63,452 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357 (See protein sequence)
Recommended Name: Complement component C8 alpha chain precursor  
Size: 584 amino acids; 65163 Da
Subunit: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.
Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a
and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9
Subcellular location: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein.
Inserts into the cell membrane of target cells
4 PDB 3D structures from and Proteopedia for C8A:
2QOS (3D)        2QQH (3D)        2RD7 (3D)        3OJY (3D)    
Secondary accessions: A2RUI4 A2RUI5 Q13668 Q9H130

Explore the universe of human proteins at neXtProt for C8A: NX_P07357

Explore proteomics data for C8A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07357

  • C8A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C8A Protein Expression
    REFSEQ proteins: NP_000553.1  
    ENSEMBL proteins: 
     ENSP00000354458  
    Reactome Protein details: P07357
    Human Recombinant Protein Products for C8A: 
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    Novus Biologicals C8A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005579membrane attack complex IDA12413696
    GO:0005615extracellular space TAS6771072
    GO:0016020membrane TAS2820471

    C8A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    complement: Complement system

    5/6 InterPro protein domains (see all 6):
     IPR002172 LDrepeatLR_classA_rpt
     IPR000884 Thrombospondin_1_rpt
     IPR001862 MAC_perforin
     IPR023415 LDLR_class-A_CS
     IPR020864 MACPF

    Graphical View of Domain Structure for InterPro Entry P07357

    ProtoNet protein and cluster: P07357

    4 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB001862 Membrane attack complex component/perforin/complement C9
    IPB002172 Low density lipoprotein-receptor
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357
    Similarity: Belongs to the complement C6/C7/C8/C9 family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 1 MACPF domain
    Similarity: Contains 2 TSP type-1 domains


    C8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO8A_HUMAN, P07357
    Function: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune
    response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does
    not form pores by itself

         Genatlas biochemistry entry for C8A:
    complement component 8,gamma-1 globulin,alpha polypeptide,64.8kDa, (<2.5kb, 5' from C8B),complexing with other
    late components of the cascade to form the membrane attack complex

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    C8A for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for C8A:
     Increased G1 DNA content  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C8A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C8A 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate C8A:
    hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidC8A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for C8A About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Lectin induced complement pathway
    Immune response Lectin induced complement pathway0.56
    Immune response Classic complement pathway0.53
    Immune response Alternative complement pathway0.56
    Immune response Classical complement pathway0.52
    Immune response Lectin Induced complement pathway0.56
    Regulation of Complement cascade0.50
    2Classical Complement Pathway
    Classical Complement Pathway0.75
    Complement Activation, Classical Pathway0.68
    Complement Pathway0.75
    Lectin Induced Complement Pathway0.65
    3Terminal pathway of complement
    Terminal pathway of complement0.64
    Alternative Complement Pathway0.64
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    5Classical antibody-mediated complement activation
    Complement cascade0.76

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for C8A
        Immune response Alternative complement pathway
    Immune response Classic complement pathway
    Immune response Lectin Induced complement pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for C8A
        Alternative Complement Pathway
    Classical Complement Pathway
    Lectin Induced Complement Pathway
    Complement Pathway

    3 GeneGo (Thomson Reuters) Pathways for C8A
        Immune response Alternative complement pathway
    Immune response Classical complement pathway
    Immune response Lectin induced complement pathway

    1 BioSystems Pathway for C8A
        Complement Activation, Classical Pathway


    5        Reactome Pathways for C8A
        Terminal pathway of complement
    Regulation of Complement cascade
    Complement cascade
    Immune System
    Innate Immune System


    4         Kegg Pathways  (Kegg details for C8A):
        Complement and coagulation cascades
    Prion diseases
    Amoebiasis
    Systemic lupus erythematosus


    C8A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for C8A (P073573 ENSP000003544584) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C8GP073603, ENSP000002241814I2D: score=2 STRING: ENSP00000224181
    CD59P139873, ENSP000003402104I2D: score=2 STRING: ENSP00000340210
    C8BP073583, ENSP000003602814I2D: score=1 STRING: ENSP00000360281
    C9P027483, ENSP000002634084I2D: score=1 STRING: ENSP00000263408
    C5ENSP000002236424STRING: ENSP00000223642
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS6771072
    GO:0006956complement activation IDA12413696
    GO:0006957complement activation, alternative pathway IEA--
    GO:0006958complement activation, classical pathway IEA--
    GO:0019835cytolysis IEA--

    C8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C8A (CO8A)

    Search CenterWatch for drugs/clinical trials and news about C8A / CO8A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C8A gene: 
    NM_000562.2  

    Unigene Cluster for C8A:

    Complement component 8, alpha polypeptide
    Hs.93210  [show with all ESTs]
    Unigene Representative Sequence: M16974
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361249(uc001cyo.2)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate C8A:
    hsa-miR-3133
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    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for C8A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C8A
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C8A
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    Primer
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    Additional mRNA sequence: 

    AK309596.1 BC020702.1 BC132911.1 BC132913.1 M16974.1 

    4 DOTS entries:

    DT.213748  DT.100786477  DT.95156351  DT.95156350 

    24/47 AceView cDNA sequences (see all 47):

    CB162713 T28622 CB164686 AW963056 BC020702 AW963046 AA699772 N93779 
    AA343585 BX346133 BX382940 AA343878 AI051231 AV650069 BX346132 NM_000562 
    T51917 CD366989 AV658742 AA344521 AV692569 W86807 BX114250 M16974 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C8A expression in normal human tissues (normalized intensities)      C8A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C8A Expression
    About this image


    C8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Human Hepatocyte (HH)   
     
     Kidney (Urinary System)

    See C8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C8A

    SOURCE GeneReport for Unigene cluster: Hs.93210
        SABiosciences Custom PCR Arrays for C8A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C8A gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia C8a1 , 5 complement component 8, alpha polypeptide1, 5 78.88(n)1
    72.6(a)1
      4 (48.69 cM)5
    2305581  NM_146148.21  NP_666260.11 
     1048156795 
    chicken
    (Gallus gallus)
    Aves C8A1 complement component 8, alpha polypeptide 60.96(n)
    54.95(a)
      429111  XM_426667.3  XP_426667.2 
    lizard
    (Anolis carolinensis)
    Reptilia C8A6
    Uncharacterized protein
    52(a)
    1 ↔ 1
    4(103177587-103222509)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX853138.12   -- 75.08(n)    BX853138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii c8a1 complement component 8, alpha polypeptide 52.1(n)
    44.12(a)
      445102  NM_001003496.1  NP_001003496.1 


    ENSEMBL Gene Tree for C8A (if available)
    TreeFam Gene Tree for C8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C8A gene
    C92  C62  C8B2  C72  
    2 SIMAP similar genes for C8A using alignment to 2 protein entries:     CO8A_HUMAN (see all proteins):
    C9    C8B

    C8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1543 SNPs in C8A are shown (see all 1543)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347482131,2
    C--55463013(+) TTTACA/GTAAAT 1 -- int13Minor allele frequency- G:0.12NA 124
    rs595671941,2
    --55463069(+) TTTACA/GTAAAT 1 -- int10--------
    rs1826857781,2
    --55463076(+) AAATAC/TATATT 1 -- int10--------
    rs1874135171,2
    --55463084(+) ATTTAC/TGTAAA 1 -- int10--------
    rs112069311,2
    C,H--55463085(+) tttatT/Gtaaat 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1929296331,2
    --55463097(+) TATATA/TTATAT 1 -- int10--------
    rs1854123121,2
    --55463100(+) ATTTAC/TATTTA 1 -- int10--------
    rs1886758911,2
    --55463122(+) ATTTAA/CATAAA 1 -- int10--------
    rs1932963551,2
    --55463130(+) AAATAC/TATATT 1 -- int10--------
    rs2011418441,2
    C--55463155(+) TTTAA-/ATATATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for C8A (57320443 - 57383894 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C8A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508215CNV Loss20534489


    Human Gene Mutation Database (HGMD): C8A
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120950    OMIM disorders: --

    UniProtKB/Swiss-Prot: CO8A_HUMAN, P07357
  • Complement component 8 deficiency, 1 (C8D1) [MIM:613790]: A rare defect of the complement classical
    pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or
    Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented
    in this entry

  • 13 diseases for C8A:    About MalaCards
    complement component 8 deficiency type 1    meningococcal infection    prion disease    age related macular degeneration
    macular degeneration    meningitis    meningioma    systemic lupus erythematosus
    lupus erythematosus    hepatitis b    hepatitis    endotheliitis
    leukemia


    C8A for disorders           About GeneDecksing

    Genetic Association Database (GAD): C8A
    Human Genome Epidemiology (HuGE) Navigator: C8A (11 documents)

    Export disorders for C8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C8A gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with C8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. (PubMed id 18842294)1, 4 Ennis S....Lotery A. (2008)
    6. Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. (PubMed id 18440555)1, 2 Slade D.J....Sodetz J.M. (2008)
    7. Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. (PubMed id 17872444)1, 2 Hadders M.A.... Gros P. (2007)
    8. [Detecting the DNA polymorphism of human complement component C8A by PCR-SSCP analysis] (PubMed id 16761437)1, 4 Yang Z.H....Jia J. (2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 731 HGNC: 1352 AceView: C8A Ensembl:ENSG00000157131 euGenes: HUgn731
    ECgene: C8A Kegg: 731 H-InvDB: C8A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C8A gene:
    Search GeneIP for patents involving C8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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