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Aliases for C7orf73 Gene

Aliases for C7orf73 Gene

  • Chromosome 7 Open Reading Frame 73 2 3 5
  • Uncharacterized Protein C7orf73 3
  • PL-5283 3

External Ids for C7orf73 Gene

Previous GeneCards Identifiers for C7orf73 Gene

  • GC07P135350

Summaries for C7orf73 Gene

GeneCards Summary for C7orf73 Gene

C7orf73 (Chromosome 7 Open Reading Frame 73) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf73 Gene

Genomics for C7orf73 Gene

Regulatory Elements for C7orf73 Gene

Enhancers for C7orf73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F135672 0.9 Ensembl ENCODE 51.3 +10.7 10734 1.7 CTCF TFAP4 ZNF654 STAT1 BHLHE40 REST RAD21 ZNF664 JUND KLF16 C7orf73 RPL15P11 FAM180A C7orf49 GC07P135677 GC07M135666 RNU6-1154P
GH07F135661 0.7 ENCODE 43.6 +0.6 648 3.8 CREB3L1 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 C7orf73 RPL15P11 ENSG00000273219 GC07M135666 RNU6-1154P
GH07F135560 0.8 Ensembl ENCODE 36.8 -100.6 -100552 3.1 PKNOX1 DDX20 TEAD4 MAX SIN3A ZNF2 GATA3 CTBP1 ZNF366 SCRT2 C7orf73 RPL15P11 WDR91 NUP205 LOC101027084
GH07F135557 1.1 ENCODE 36.1 -104.3 -104273 2.1 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 C7orf73 RPL15P11 FAM180A ENSG00000273219 NUP205 LOC101027084
GH07F135507 0.2 ENCODE 35.5 -153.1 -153119 3.5 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 C7orf73 FAM180A ENSG00000231794 ENSG00000273219 CNOT4 GC07P135445
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C7orf73 on UCSC Golden Path with GeneCards custom track

Promoters for C7orf73 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001406810 427 1801 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5

Genomic Location for C7orf73 Gene

Chromosome:
7
Start:
135,662,473 bp from pter
End:
135,693,418 bp from pter
Size:
30,946 bases
Orientation:
Plus strand

Genomic View for C7orf73 Gene

Genes around C7orf73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf73 Gene

Proteins for C7orf73 Gene

  • Protein details for C7orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E0CX11-CG073_HUMAN
    Recommended name:
    Uncharacterized protein C7orf73
    Protein Accession:
    E0CX11

    Protein attributes for C7orf73 Gene

    Size:
    47 amino acids
    Molecular mass:
    5265 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C7orf73 Gene

Post-translational modifications for C7orf73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf73 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C7orf73 Gene

Domains & Families for C7orf73 Gene

Protein Domains for C7orf73 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf73: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf73 Gene

Function for C7orf73 Gene

Phenotypes for C7orf73 Gene

GenomeRNAi human phenotypes for C7orf73:
genes like me logo Genes that share phenotypes with C7orf73: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C7orf73 Gene

Localization for C7orf73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C7orf73 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C7orf73 Gene COMPARTMENTS Subcellular localization image for C7orf73 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for C7orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with C7orf73: view

Pathways & Interactions for C7orf73 Gene

SuperPathways for C7orf73 Gene

No Data Available

Interacting Proteins for C7orf73 Gene

Gene Ontology (GO) - Biological Process for C7orf73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C7orf73 Gene

Transcripts for C7orf73 Gene

mRNA/cDNA for C7orf73 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C7orf73 Gene

Chromosome 7 open reading frame 73:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf73 Gene

No ASD Table

Relevant External Links for C7orf73 Gene

GeneLoc Exon Structure for
C7orf73
ECgene alternative splicing isoforms for
C7orf73

Expression for C7orf73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C7orf73 Gene

Protein differential expression in normal tissues from HIPED for C7orf73 Gene

This gene is overexpressed in Oral epithelium (29.5), Fetal ovary (22.8), and Testis (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C7orf73 Gene



Protein tissue co-expression partners for C7orf73 Gene

NURSA nuclear receptor signaling pathways regulating expression of C7orf73 Gene:

C7orf73

SOURCE GeneReport for Unigene cluster for C7orf73 Gene:

Hs.200022
genes like me logo Genes that share expression patterns with C7orf73: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C7orf73 Gene

Orthologs for C7orf73 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C7orf73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7orf73 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PL-5283 35
  • 96 (a)
OneToMany
Species where no ortholog for C7orf73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C7orf73 Gene

ENSEMBL:
Gene Tree for C7orf73 (if available)
TreeFam:
Gene Tree for C7orf73 (if available)

Paralogs for C7orf73 Gene

Pseudogenes.org Pseudogenes for C7orf73 Gene

genes like me logo Genes that share paralogs with C7orf73: view

No data available for Paralogs for C7orf73 Gene

Variants for C7orf73 Gene

Sequence variations from dbSNP and Humsavar for C7orf73 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10240427 -- 135,668,842(+) CATCT(C/T)GTGCC intron-variant
rs10258155 -- 135,660,571(+) GTGCC(A/G)TAAGT upstream-variant-2KB
rs10808282 -- 135,664,507(+) CACTA(C/T)CACCC intron-variant
rs111386451 -- 135,663,314(+) GCATT(C/G)AAAAC intron-variant
rs111622780 -- 135,673,068(+) TTAGC(C/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf73 Gene

Variant ID Type Subtype PubMed ID
nsv608460 CNV gain 21841781
nsv966890 CNV duplication 23825009

Variation tolerance for C7orf73 Gene

Gene Damage Index Score: 0.66; 14.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf73 Gene

Disorders for C7orf73 Gene

Relevant External Links for C7orf73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C7orf73

No disorders were found for C7orf73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf73 Gene

Publications for C7orf73 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. Identification of membrane proteins by tandem mass spectrometry of protein ions. (PMID: 17720804) Carroll J. … Walker J.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C7orf73 Gene

Sources for C7orf73 Gene

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