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Aliases for C7orf72 Gene

Aliases for C7orf72 Gene

  • Chromosome 7 Open Reading Frame 72 2 3 5

External Ids for C7orf72 Gene

Summaries for C7orf72 Gene

GeneCards Summary for C7orf72 Gene

C7orf72 (Chromosome 7 Open Reading Frame 72) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C7orf72 Gene

Genomics for C7orf72 Gene

Regulatory Elements for C7orf72 Gene

Enhancers for C7orf72 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G050145 1.1 FANTOM5 ENCODE 30 +52.4 52365 5.1 HDGF PKNOX1 NFIB ZNF143 RELB IKZF2 CREM CEBPB JUNB GATAD2B C7orf72 ZPBP IKZF1 ENSG00000228005 ENSG00000231681
GH07G050067 1 Ensembl ENCODE 29.1 -26.7 -26721 3.0 CTCF PKNOX1 TEAD4 RBBP5 CBX5 ZNF652 BHLHE40 HLF MNT REST C7orf72 ZPBP GNL2P1
GH07G050381 2.3 VISTA dbSUPER 10.1 +286.3 286253 0.8 ATF1 CREB3L1 E2F7 ARID4B SIN3A DMAP1 ZNF48 ZNF2 TCF12 GLIS2 RNU6-1091P ENSG00000228005 ZPBP C7orf72 GC07P050382 IKZF1
GH07G050392 1.4 FANTOM5 ENCODE dbSUPER 10.4 +299.8 299801 7.0 CTCF KLF1 ZMYM3 BMI1 EBF1 RELA FOSL1 RELB IKZF2 MTA2 FIGNL1 ENSG00000228005 C7orf72 ZPBP IKZF1 GC07P050382 GC07P050435
GH07G050378 1.4 Ensembl ENCODE dbSUPER 10.1 +283.6 283579 1.6 PKNOX1 INSM2 ZNF2 ZEB1 GATA2 ZNF366 SCRT2 ZSCAN5C FOS CREM RNU6-1091P ENSG00000228005 ZPBP C7orf72 GC07P050382 IKZF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C7orf72 on UCSC Golden Path with GeneCards custom track

Genomic Location for C7orf72 Gene

Chromosome:
7
Start:
50,095,861 bp from pter
End:
50,159,830 bp from pter
Size:
63,970 bases
Orientation:
Plus strand

Genomic View for C7orf72 Gene

Genes around C7orf72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C7orf72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C7orf72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C7orf72 Gene

Proteins for C7orf72 Gene

  • Protein details for C7orf72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4D263-CG072_HUMAN
    Recommended name:
    Uncharacterized protein C7orf72
    Protein Accession:
    A4D263
    Secondary Accessions:
    • A6NDX9

    Protein attributes for C7orf72 Gene

    Size:
    438 amino acids
    Molecular mass:
    49672 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C7orf72 Gene

Post-translational modifications for C7orf72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C7orf72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C7orf72 Gene

Domains & Families for C7orf72 Gene

Protein Domains for C7orf72 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C7orf72: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C7orf72 Gene

Function for C7orf72 Gene

Gene Ontology (GO) - Molecular Function for C7orf72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C7orf72: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C7orf72 Gene

Localization for C7orf72 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C7orf72 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C7orf72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C7orf72: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C7orf72 Gene

Pathways & Interactions for C7orf72 Gene

SuperPathways for C7orf72 Gene

No Data Available

Interacting Proteins for C7orf72 Gene

Gene Ontology (GO) - Biological Process for C7orf72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C7orf72: view

No data available for Pathways by source and SIGNOR curated interactions for C7orf72 Gene

Drugs & Compounds for C7orf72 Gene

No Compound Related Data Available

Transcripts for C7orf72 Gene

mRNA/cDNA for C7orf72 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C7orf72 Gene

Chromosome 7 open reading frame 72:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C7orf72 Gene

No ASD Table

Relevant External Links for C7orf72 Gene

GeneLoc Exon Structure for
C7orf72
ECgene alternative splicing isoforms for
C7orf72

Expression for C7orf72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C7orf72 Gene

mRNA differential expression in normal tissues according to GTEx for C7orf72 Gene

This gene is overexpressed in Testis (x36.8) and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for C7orf72 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C7orf72 Gene



Protein tissue co-expression partners for C7orf72 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C7orf72 Gene:

C7orf72

SOURCE GeneReport for Unigene cluster for C7orf72 Gene:

Hs.99248
genes like me logo Genes that share expression patterns with C7orf72: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C7orf72 Gene

Orthologs for C7orf72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C7orf72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C7H7orf72 34
  • 99.47 (n)
C7orf72 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C4H7orf72 34
  • 86.76 (n)
C7orf72 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309870 34
  • 80.98 (n)
mouse
(Mus musculus)
Mammalia 4930415F15Rik 34 16 35
  • 80.31 (n)
dog
(Canis familiaris)
Mammalia C7orf72 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C7orf72 35
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C7orf72 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H7orf72 34
  • 62.89 (n)
C7orf72 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491044 34
  • 51.72 (n)
Species where no ortholog for C7orf72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C7orf72 Gene

ENSEMBL:
Gene Tree for C7orf72 (if available)
TreeFam:
Gene Tree for C7orf72 (if available)

Paralogs for C7orf72 Gene

No data available for Paralogs for C7orf72 Gene

Variants for C7orf72 Gene

Sequence variations from dbSNP and Humsavar for C7orf72 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000000584 -- 50,094,801(+) ACCCT(C/T)GACAG upstream-variant-2KB
rs1000055926 -- 50,135,091(+) GGTTG(C/T)GTGCT intron-variant
rs1000077558 -- 50,140,621(+) AGTAC(A/C)TTATC intron-variant
rs1000078502 -- 50,109,072(+) AGTTG(A/C)TTTAG intron-variant
rs1000102925 -- 50,123,970(+) AAGAC(A/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C7orf72 Gene

Variant ID Type Subtype PubMed ID
esv1003850 CNV deletion 20482838
esv3302485 CNV tandem duplication 20981092
esv3393617 CNV insertion 20981092
nsv1114936 CNV deletion 24896259
nsv1117712 CNV deletion 24896259
nsv606897 CNV gain 21841781
nsv830997 CNV gain 17160897
nsv830998 CNV loss 17160897

Variation tolerance for C7orf72 Gene

Gene Damage Index Score: 9.08; 87.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C7orf72 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C7orf72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C7orf72 Gene

Disorders for C7orf72 Gene

Relevant External Links for C7orf72

Genetic Association Database (GAD)
C7orf72
Human Genome Epidemiology (HuGE) Navigator
C7orf72
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C7orf72

No disorders were found for C7orf72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C7orf72 Gene

Publications for C7orf72 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 46 64
  5. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 46 64

Products for C7orf72 Gene

Sources for C7orf72 Gene

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