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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C7orf66 Gene

protein-coding   GIFtS: 32
GCID: GC07M108524          (predicted)

Chromosome 7 Open Reading Frame 66

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 7 Open Reading Frame 661 2
Putative Uncharacterized Protein LOC1549072
Uncharacterized Protein C7orf662

External Ids:    HGNC: 337121   Entrez Gene: 1549072   Ensembl: ENSG000002051747   UniProtKB: A4D0T23   

Export aliases for C7orf66 gene to outside databases

Previous GC identifers: GC07M108312 GC07M102892


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C7orf66 Gene: 
C7orf66 (chromosome 7 open reading frame 66) is a protein-coding gene. Diseases associated with C7orf66 include nicotine dependence.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C7orf66 gene promoter:
         Nkx3-1 v4   ATF-2   FOXD3   HSF1 (long)   POU3F2   Meis-1b   S8   HSF1short   Meis-1a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C7orf66

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf66


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.1

C7orf66 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C7orf66 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M108524:  view genomic region     (about GC identifiers)

Start:
108,524,032 bp from pter      End:
108,524,644 bp from pter
Size:
613 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 107,891,336-107,891,936     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CG066_HUMAN, A4D0T2 (See protein sequence)
Recommended Name: Uncharacterized protein C7orf66  
Size: 115 amino acids; 13234 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for C7orf66: NX_A4D0T2

Explore proteomics data for C7orf66 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A4D0T2

  • C7orf66 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C7orf66 Protein Expression
    REFSEQ proteins: NP_001019778.1  
    ENSEMBL proteins: 
     ENSP00000368292  

    Human Recombinant Protein Products for C7orf66: 
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    Cloud-Clone Corp. Proteins for C7orf66 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    C7orf66 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A4D0T2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for C7orf66:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C7orf66 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C7orf66

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C7orf66 (CG066)

    Search CenterWatch for drugs/clinical trials and news about C7orf66 / CG066

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C7orf66 gene: 
    NM_001024607.1  

    Unigene Clusters for C7orf66:

    Chromosome 7 open reading frame 66
    Hs.276325  [show with all ESTs], Hs.638689  [show with all ESTs]
    Unigene Representative Sequences: BG183820, DA930552
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379007(uc003vfo.3)
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C7orf66

    Additional mRNA sequence: 

    AB063840.1 AF022010.1 AF103078.2 AJ001408.1 AJ008184.1 AJ488539.1 AY423186.1 AY423189.1 
    AY423190.1 AY423192.1 AY423207.1 AY866754.1 DQ100724.1 DQ100738.1 DQ100950.1 DQ379472.1 
    DQ523973.1 EF175386.1 EF175430.1 HM774159.1 HM995754.1 HM995755.1 HM995758.1 HM995759.1 
    HQ378400.1 JN110666.1 U00520.1 X79170.1 X87889.1 

    14 DOTS entries:

    DT.75125496  DT.101985804  DT.101986874  DT.101987252  DT.121508006  DT.121508087  DT.121509296  DT.121509333 
    DT.92039773  DT.92364395  DT.95368001  DT.97866935  DT.95248569  DT.95257989 

    5 AceView cDNA sequences:

    AI126292 BG181745 BG211856 BG200786 BG208198 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C7orf66 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACGGCTGT
    C7orf66 Expression
    About this image


    See C7orf66 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene clusters: Hs.276325 Hs.638689
        SABiosciences Custom PCR Arrays for C7orf66
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C7orf66

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for C7orf66 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia C7H7orf661 chromosome 7 open reading frame, human C7orf66 97.92(n)
    96.25(a)
      744670  XM_001149623.2  XP_001149623.2 


    ENSEMBL Gene Tree for C7orf66 (if available)
    TreeFam Gene Tree for C7orf66 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/86 SNPs in C7orf66 are shown (see all 86)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8484021,2
    C,F,H--108523543(-) AAAATC/GAAGGT 1 -- ds500121Minor allele frequency- G:0.36NS EA NA WA CSA 1736
    rs1863838051,2
    --108523675(+) GAAATC/TTTCTG 1 -- ds50010--------
    rs797818431,2
    C,F--108523687(+) GAGTTC/ACAATA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs102743201,2
    C,F,A,H--108523718(+) TCTGCC/TTCATG 1 -- ds500112Minor allele frequency- T:0.16NS EA NA CSA WA 1380
    rs1910942201,2
    --108523768(+) CCAAAG/TAAACA 1 -- ds50010--------
    rs1140282341,2
    C,F--108523798(+) AGCTTG/TAACAT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs775962251,2
    F--108523833(+) CTGTAC/TGGAAG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1824543561,2
    --108523850(+) GTGGAA/GCTTGA 1 -- ds50010--------
    rs8484011,2
    C,F--108523860(-) GAAACA/TTTCTT 1 -- ds50016Minor allele frequency- T:0.05MN NA WA 428
    rs1495130291,2
    --108523904(+) ACCTTA/GTGCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for C7orf66 (108524032 - 108524644 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C7orf66: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing C7orf66
    DNA2.0 Custom Variant and Variant Library Synthesis for C7orf66

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for C7orf66:    About MalaCards
    nicotine dependence    


    C7orf66 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C7orf66

    Export disorders for C7orf66 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C7orf66 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C7orf66)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    2. Large-scale genome-wide association study of Asian pop ulation reveals genetic factors in FRMD4A and other loci influencing smoking ini tiation and nicotine dependence. (PubMed id 22006218)1, 4 Yoon D....Park T. (2012)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. (PubMed id 22318345)4 Cha P.C....Nakamura Y. (2012)
    5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    7. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. (PubMed id 9887257)1 de Wildt R.M....Winter G. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 154907 HGNC: 33712 AceView: LOC154907 Ensembl:ENSG00000205174 euGenes: HUgn154907
    ECgene: C7orf66 H-InvDB: C7orf66

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C7orf66 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C7orf66 gene:
    Search GeneIP for patents involving C7orf66

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Regulatory tfbs in C7orf66 promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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