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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C7orf63 Gene

protein-coding GIFtS: 38
GCID: GC07P089874

chromosome 7 open reading frame 63

Explore 2 diseases affiliated with
C7orf63 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 7 Open Reading Frame 63¹ ²
FLJ21062¹
Uncharacterized Protein C7orf63²

External Ids:	HGNC: 26107¹	Entrez Gene: 79846²	Ensembl: ENSG00000105792⁷	UniProtKB: A5D8W1³

Export aliases for C7orf63 gene to outside databases

Previous GC identifers: GC07P089713 GC07P084484

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C7orf63 gene promoter:
TBP HFH-3 HNF-3beta Gfi-1 FOXI1 MEF-2A SRY aMEF-2 ZID TGIF
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C7orf63

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C7orf63

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.13 Ensembl cytogenetic band: 7q21.13 HGNC cytogenetic band: 7q21.13

C7orf63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C7orf63 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P089874: view genomic region (about GC identifiers)

Start:	89,874,488 bp from pter	End:	89,940,377 bp from pter
Size:	65,890 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 89,205,264-89,271,137

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CG063_HUMAN, A5D8W1 (See protein sequence)

Recommended Name: Uncharacterized protein C7orf63

Size: 941 amino acids; 105883 Da

Sequence caution: Sequence=BAB14972.1; Type=Erroneous initiation;

Secondary accessions: A3KMP9 B4DYW6 B4DZP7 B9EIM7 Q6V705 Q8IY89 Q9H7C2

Alternative splicing: 5 isoforms: A5D8W1-1 A5D8W1-2 A5D8W1-3 A5D8W1-4 A5D8W1-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C7orf63: NX_A5D8W1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A5D8W1

C7orf63 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001034795.2 NP_001153610.1

ENSEMBL proteins:

ENSP00000373948 ENSP00000411143 ENSP00000411234 ENSP00000419549 ENSP00000392365

ENSP00000393339 ENSP00000391571 ENSP00000415818 ENSP00000414772 ENSP00000321753

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C7orf63 for domains About GeneDecksing

1 InterPro domain/family:

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry A5D8W1

ProtoNet protein and cluster: A5D8W1

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C7orf63

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about C7orf63 / CG063

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C7orf63 gene (3 alternative transcripts):

NM_024788.2 NM_001039706.2 NM_001160138.1

Unigene Cluster for C7orf63:

Chromosome 7 open reading frame 63

Hs.657403 [show with all ESTs]

Unigene Representative Sequence: NM_001039706

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389297(uc003ukg.2 uc011khj.2 uc010lep.3 uc011khk.2)

ENST00000485791 ENST00000427396 ENST00000451029(uc003ukf.2) ENST00000497910

ENST00000463311 ENST00000457170 ENST00000418199 ENST00000475031 ENST00000449577

ENST00000491886 ENST00000412839 ENST00000445156 ENST00000316089(uc010leo.2)

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Additional cDNA sequence:

AK024715.1 AK093991.1 AK302636.1 AK303034.1 AY349356.1 BC036351.1 BC132771.1 BC140742.1

BC141834.1 BC142655.1

11 DOTS entries:

DT.75100839 DT.430482 DT.100021230 DT.100751143 DT.121046720 DT.437324 DT.100642433 DT.100673533

DT.87015101 DT.97795876 DT.100021231

24/61 AceView cDNA sequences (see all 61):

AA633464 AA028171 AI491957 AI697506 BC036613 AI251801 BE219137 AW008475

BE046313 AA372120 AI435058 BC036351 NM_024788 AI968139 AI690091 BI829569

W86347 BX280619 BU627350 BX498730 AY349356 AI860796 AK024715 AL833446

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C7orf63 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCAAATGG

About this image

C7orf63 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See C7orf63 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C7orf63

SOURCE GeneReport for Unigene cluster: Hs.657403

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C7orf63 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	A330021E22Rik^{1 , 5}	RIKEN cDNA A330021E22 gene^{1, 5}	84.7(n)¹ 83.95(a)¹		5 (3.07 cM)⁵ 207686¹ NM_172447.2¹ NP_766035.1¹ 5579278⁵
chicken (Gallus gallus)	Aves	C2H7orf63¹	chromosome 2 open reading frame, human C7orf63	68.81(n) 59.77(a)		420542 XM_418644.3 XP_418644.3
lizard (Anolis carolinensis)	Reptilia	C7orf63⁶	--	62(a)	1 ↔ 1	6(20340521-20363960)

ENSEMBL Gene Tree for C7orf63 (if available)
TreeFam Gene Tree for C7orf63 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for C7orf63 gene

C7orf63 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for C7orf63
PGOHUM00000248898 PGOHUM00000244420

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187887895^1,2		--	89872704(+)	`GAGTTA/CGAGTT`	2	--	us2k¹		0	--	--	--	--
rs140512408^1,2	C,	--	89872830(+)	`GGCAAC/TAACAT`	2	--	us2k¹		0	--	--	--	--
rs193175345^1,2		--	89872960(+)	`GTCAAA/CAGGCA`	2	--	us2k¹		0	--	--	--	--
rs185027724^1,2		--	89873055(+)	`TGTGAA/GTCTTC`	2	--	us2k¹		0	--	--	--	--
rs189353169^1,2		--	89873146(+)	`ATTACA/CGTCCC`	2	--	us2k¹		0	--	--	--	--
rs112665221^1,2		--	89873432(+)	`ACAAAA/GGTTAT`	2	--	us2k¹		2		CSA	3
rs6955123^1,2	C,F,A,H,	--	89873469(+)	`AACTCT/CTGCCT`	2	--	us2k¹		9		NS EA WA CSA	660
rs150398209^1,2		--	89873569(+)	`TCAGTC/TGTTGA`	2	--	us2k¹		0	--	--	--	--
rs184685255^1,2		--	89873615(+)	`GTGGCA/TTGTGC`	2	--	us2k¹		0	--	--	--	--
rs17869672^1,2	H	--	89873616(+)	`TGGCAT/GGTGCA`	2	--	us2k¹		4		NS EA	416

HapMap Linkage Disequilibrium report for C7orf63 (89874488 - 89940377 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for C7orf63
3 CNVs: 8573 7654 69996

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C7orf63 for disorders About GeneDecksing

2 diseases for C7orf63: About MalaCards

diffuse large b-cell lymphoma b-cell lymphomas

Human Genome Epidemiology (HuGE) Navigator: C7orf63 (1 document)

Export disorders for C7orf63 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C7orf63 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C7orf63)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status. (PubMed id 18288132)¹ Pike B.L....Hacia J.G. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (2003)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79846	HGNC: 26107	AceView: FLJ21062	Ensembl:ENSG00000105792	euGenes: HUgn79846
ECgene: C7orf63	H-InvDB: C7orf63

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C7orf63	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C7orf63 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C7orf63 gene:
Search GeneIP for patents involving C7orf63

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C7orf63 gene at Home site.

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C7orf63 Gene

chromosome 7 open reading frame 63

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C7orf63 Gene

chromosome 7 open reading frame 63

Aliasesfor C7orf63 gene

Summariesfor C7orf63 gene

Genomic Viewsfor C7orf63 gene

Proteinsfor C7orf63 gene

Protein Domains /Familiesfor C7orf63 gene

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for C7orf63 gene

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for C7orf63 gene

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for C7orf63 gene

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for C7orf63 gene

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for C7orf63 gene

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for C7orf63 gene

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